1. A method of preparing a compound of formula (II):
or a pharmaceutically acceptable salt thereof, as a single stereoisomer or enantiomer or a mixture thereof;
wherein the method comprises:
a) treating a compound of formula (14):
or a pharmaceutically acceptable salt thereof, with an alkylating agent under suitable conditions to form a compound of formula (15):
or a pharmaceutically acceptable salt thereof; and
b) treating the compound of formula (15), or a pharmaceutically acceptable salt thereof, with a compound of formula (16):
or a pharmaceutically acceptable salt thereof, under suitable conditions to provide the compound of formula (II), or a pharmaceutically acceptable salt thereof, as a single stereoisomer or enantiomer or a mixture thereof.
2. The method of claim 1 further comprising a preparation of the compound of formula (14), or a pharmaceutically acceptable salt thereof, wherein the method comprises treating a compound of formula (13):
or a pharmaceutically acceptable salt thereof, under suitable conditions to form the compound of formula (14), or a pharmaceutically acceptable salt thereof.
3. The method of claim 2 further comprising a preparation of the compound of formula (13), or a pharmaceutically acceptable salt thereof, wherein the method comprises:
c) reacting a compound of formula (12):
with a Grignard reagent of formula (3):
under suitable conditions to form an intermediate product; and
d) reacting the intermediate product of c) with a compound of formula (I):
or a pharmaceutically acceptable salt thereof, under suitable conditions to form the compound of formula (13), or a pharmaceutically acceptable salt thereof.
4. The method of claim 3 further comprising a preparation of the compound of formula (12), or a pharmaceutically acceptable salt thereof, wherein the method comprises treating a compound of formula (II):
with an oxidizing agent under suitable conditions to form the compound of formula (12), or a pharmaceutically acceptable salt thereof.
5. The method of claim 4 further comprising a preparation of the compound of formula (II), wherein the method comprises treating a compound of formula (10):
with a suitable alkylating reagent under suitable conditions to form the compound of formula (II).
6. The method of claim 1 further comprising resolving a compound of formula (II) under suitable conditions to yield a compound of formula (II-S):
or a pharmaceutically acceptable salt thereof; and a compound of formula (II-R):
or a pharmaceutically acceptable salt thereof.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A stent having a proximal end and a distal end, the stent comprising a plurality of interconnected circumferential bands with a flowpath therethrough,
at least one of the bands including at least one substantially M-shaped segment selected from the group consisting of convex M-shaped segments and concave M-shaped segments.
2. The stent of claim 1 wherein the at least one M-shaped segment is a convex M-shaped segment.
3. The stent of claim 2 wherein the convex M-shaped segment comprises a first convex outer leg, a second convex outer leg and a connector connecting the first convex outer leg and the second convex outer leg.
4. The stent of claim 2 wherein the at least one band comprises a plurality of convex M-shaped segments.
5. The stent of claim 2 comprising a first band having a plurality of interconnected convex M-shaped segments and a second band having a plurality of interconnected convex M-shaped segments.
6. The stent of claim 5 wherein adjacent convex M-shaped segments in the first band are interconnected via a loop extending therebetween.
7. The stent of claim 6 wherein the loop is formed of a concave first portion and a concave second portion.
8. The stent of claim 5 wherein the convex M-shaped segments of the first band are inverted relative to the convex M-shaped segments of the second band.
9. The stent of claim 8 wherein the convex M-shaped segments of the first bands at least partially abut and are connected.
10. The stent of claim 1 wherein the at least one M-shaped segment is a concave M-shaped segment.
11. The stent of claim 10 wherein the concave M-shaped segment comprises a first concave outer leg, a second concave outer leg and a connector connecting the first concave outer leg and the second concave outer leg.
12. The stent of claim 10 wherein the at least one band comprises a plurality of concave M-shaped segments.
13. The stent of claim 12 wherein the first portion is substantially parallel to the first concave leg of the first concave M-shaped segment and the second portion is substantially parallel to the second concave leg of the second concave M-shaped segment.
14. The stent of claim 10 comprising a first band having a plurality of interconnected concave M-shaped segments and a second band having a plurality of interconnected concave M-shaped segments.
15. The stent of claim 14 wherein adjacent concave M-shaped segments in the first band are interconnected via a loop extending therebetween.
16. The stent of claim 15 wherein the loop is formed of a convex first portion and a convex second portion.
17. The stent of claim 14 wherein the concave M-shaped segments of the first band are inverted relative to the concave M-shaped segments of the second band.
18. The stent of claim 17 wherein the concave M-shaped segments of the first bands at least partially abut and are connected.
19. The stent of claim 1 comprising a plurality of interconnected convex M-shaped segments and concave M-shaped segments.
20. A stent comprising a plurality of connected tubular bands, at least one of the tubular bands comprising a repeating pattern of three or more substantially parallel interconnected segments with a first curvature and three or more substantially parallel interconnected segments with a second curvature, one of the segments with the first curvature connected to one of the segments with the second curvature.
21. The stent of claim 20 wherein the first curvature is opposite the second curvature.
22. The stent of claim 20 wherein a plurality of the tubular bands each comprise a repeating pattern of three or more-substantially parallel interconnected segments with a first curvature and three or more substantially parallel interconnected segments with a second curvature, one of the segments of the first curvature connected to one of the segments with the second curvature.
23. The stent of claim 22 wherein adjacent tubular bands are out of phase with one another.
24. The stent of claim 22 wherein adjacent tubular bands are out of phase with one another by ninety degrees.