Author: claimsbot

1. An implantable facet arthroplasty device for association with a first vertebra and a second vertebra comprising:
(a) a crossbar;
(b) a first component having a first attachment mechanism adapted to attach to a first location of a spinal fusion device attached to a first vertebra and a second attachment mechanism adapted to engage the crossbar; and
(c) a second component having a second attachment mechanism adapted to attach to a second location of a spinal fusion device attached to the first vertebra and a second attachment mechanism adapted to engage the crossbar,
wherein, the first component articulates relative to the second component; further wherein the first vertebra articulates relative to the facet arthroplasty device.
2. The implantable facet arthroplasty device of claim 1 further comprising a first arm having a bone engaging end adapted to attach to a vertebral body at a first end and adapted to engage the crossbar at a second end.
3. The implantable facet arthroplasty device of claim 2 wherein the first arm is configured to engage a caudal vertebral body.
4. The implantable facet arthroplasty device of claim 2 wherein the first arm is configured to engage a cephalad vertebral body.
5. The implantable facet arthroplasty device of claim 1 further comprising a spinal fusion device.
6. The implantable facet arthroplasty device of claim 5 wherein the spinal fusion device comprises a pair of elongated members configured to extend along a portion of the spine adjacent a cephalad vertebra and a caudal vertebra and a plurality of attachment mechanism for mounting the spinal fusion device to the cephalad vertebra and the caudal vertebra.
7. The implantable facet arthroplasty device of claim 2 further comprising a second arm having a bone engaging end adapted to attach to a vertebral body at a first end and adapted to engage the crossbar at a second end.
8. The implantable facet arthroplasty device of claim 7 wherein the second arm is configured to engage a caudal vertebral body.
9. The implantable facet arthroplasty device of claim 7 wherein the second arm is configured to engage a cephalad vertebral body.
10. The implantable facet arthroplasty device of claim 7 wherein the first arm articulates relative to the second arm.
11. An implantable spinal restoration device comprising:
(a) an elongated member configured to extend along a portion of a length of a spine adjacent a cephalad vertebra and a caudal vertebra;
(b) an attachment mechanism adapted to attach the elongated member to a portion of the spine;
(c) a facet arthroplasty element;
(d) a support component having a first end and a second end sized to span a portion of the vertebral body and adapted to receive the facet arthroplasty element at the first end and the second end; and
(e) a connector adapted to connect the support component to the elongated member.
12. The implantable spinal restoration device of claim 11, further comprising an arm with a bone engaging end adapted to attach to a vertebra at a first end and adapted to attach to the support component at a second end.
13. The implantable spinal restoration device of claim 12, wherein the arm is configured to engage a caudal vertebral body.
14. The implantable spinal restoration device of claim 12, wherein the arm is configured to engage a cephalad vertebral body.
15. The implantable spinal restoration device of claim 12, further comprising a second arm having a first end adapted to engage a vertebral body at a first end and second end adapted to engage the crossbar.
16. The implantable spinal restoration device of claim 15, wherein the first arm articulates relative to the second arm.
17. The implantable spinal restoration device of claim 11, wherein the support component is sized to span a portion of a vertebral body between a left lamina and a right lamina.
18. The implantable spinal restoration device of claim 11, wherein the support component is sized to span a portion of a vertebral body between a left pedicle and a right pedicle.
19. The implantable spinal restoration device of claim 11, wherein the support component is further adapted to have an adjustable width.
20. The implantable spinal restoration device of claim 11, wherein the facet arthroplasty element is positioned relative to the support component to provide a symmetric anatomical solution.
21. The implantable spinal restoration device of claim 11, wherein the facet arthroplasty element is positioned relative to the support component to provide an asymmetrical anatomical solution.
22. The implantable spinal restoration device of claim 11, wherein the ends of the support component are adapted to receive an opening in the facet arthroplasty element.
23. The implantable spinal restoration device of claim 11, wherein the facet arthroplasty element is selected from a plurality of facet arthroplasty elements each having an opening with a different depth.
24. The implantable spinal restoration device of claim 11, further comprising evenly distributing the weight on the vertebral body using the support component.
25. An adaptable implantable spine stabilization device, comprising:
(a) a crossbar having a first end and a second end;
(b) a pair of vertebral engaging elements each having a bone engaging end and an end adapted to couple to the crossbar; and
(c) a pair of anchoring elements each having a first end having a surface adapted to receive a crossbar end and second end adapted to fix the anchoring element to a spinal fusion system.
26. The adaptable implantable spine stabilization device of claim 25, further comprising an arm with a bone engaging end adapted to attach to a vertebra at a first end and adapted to attach to the support component at a second end.
27. The adaptable implantable spine stabilization device of claim 25, wherein the arm is configured to engage a caudal vertebral body.
28. The adaptable implantable spine stabilization device of claim 25, wherein the arm is configured to engage a cephalad vertebral body.
29. The adaptable implantable spine stabilization device of claim 25, further comprising a second arm having a first end adapted to engage a vertebral body at a first end and second end adapted to engage the crossbar.
30. The adaptable implantable spine stabilization device of claim 25, wherein the first arm articulates relative to the second arm.
31. The adaptable implantable spine stabilization device of claim 25, wherein the support component is sized to span a portion of a vertebral body between a left lamina and a right lamina.
32. The adaptable implantable spine stabilization device of claim 25, wherein the support component is sized to span a portion of a vertebral body between a left pedicle and a right pedicle.
33. The adaptable implantable spine stabilization device of claim 25, wherein the support component is further adapted to have an adjustable width.
34. The adaptable implantable spine stabilization device of claim 25, wherein the facet arthroplasty element is positioned relative to the support component to provide a symmetric anatomical solution.
35. The adaptable implantable spine stabilization device of claim 25, wherein the facet arthroplasty element is positioned relative to the support component to provide an asymmetrical anatomical solution.
36. The adaptable implantable spine stabilization device of claim 25, wherein the ends of the support component are adapted to receive an opening in the facet arthroplasty elements.
37. The adaptable implantable spine stabilization device of claim 25, wherein the facet arthroplasty element is selected from a plurality of facet arthroplasty elements each having an opening with a different depth.
38. The adaptable implantable spine stabilization device of claim 25, further comprising evenly distributing the weight on the vertebral body using the support component.
39. A method for revising spinal fusion surgery to provide support to adjacent vertebra comprising:
(d) accessing a spinal location having a spinal fusion device, comprising a pair of elongated members, attached adjacent a caudal vertebral body and a cephalad vertebral body;
(e) attaching a facet arthroplasty device comprising an articulating attachment mechanism adapted to receive a crossbar and an attachment mechanism adapted to connected to the elongated member of the spinal fusion device; and
(f) closing the wound.
40. The method for revising spinal fusion surgery of claim 39 wherein the vertebra adjacent the spinal fusion device are stabilized.
41. An implantable adjacent level arthroplasty device for implantation between a first vertebra and a second vertebra having a vertebra engaging a fusion device comprising:
(g) a crossbar;
(h) a first component having a first attachment mechanism adapted to attach to a first location of a spinal fusion device attached to a first vertebra and a second attachment mechanism adapted to attach to the crossbar; and
(i) a second component having a second attachment mechanism adapted to attach to a second location of a spinal fusion device attached to the first vertebra and a second attachment mechanism adapted to attach to the crossbar,
wherein, the first component articulates relative to the second component; further wherein the first vertebra articulates relative to the facet arthroplasty device.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A toner for developing a latent electrostatic image, comprising:
toner particles,
wherein each toner particle comprises at least:
a releasing agent; and
a modified layered inorganic mineral in which at least a part of ions present in between layers of a layered inorganic mineral is replaced with an organic ion,
wherein the toner satisfies one of the following conditions (1) and (2):
(1) the releasing agent has an average dispersed particle diameter of 0.1 \u03bcm to 0.5 \u03bcm in the toner particle, and the toner has a ratio AB of 0.2 to 2.0 where A denotes the average dispersed particle diameter of the releasing agent and B denotes an average dispersed particle diameter of the modified layered inorganic mineral; and
(2) the releasing agent has an average dispersed particle diameter of 0.1 \u03bcm to 0.5 \u03bcm, a proportion of the dispersed particles of the releasing agent having a diameter of 1 \u03bcm or more in the dispersed particles of the releasing agent having a diameter of 0.5 \u03bcm or more is 20% by number or less, and
wherein the toner is obtained by a method comprising:
dissolving or dispersing at least a binder resin or a precursor of a binder resin, a colorant, the releasing agent, and the modified layered inorganic mineral in an organic solvent so as to prepare an oil phase;
dispersing the oil phase in an aqueous medium so as to prepare an emulsified dispersion; and
removing the solvent from the emulsified dispersion so as to yield the toner particles.
2. The toner according to claim 1, wherein the toner is obtained by a method comprising:
dissolving or dispersing at least a polymer having a site reactive with a compound having an active hydrogen group, a binder resin or a precursor of a binder resin, a colorant, the releasing agent, a kneaded composite of the binder resin and a modified layered inorganic mineral in which at least a part of ions present in between layers of a layered inorganic mineral is replaced with an organic ion, in an organic solvent so as to prepare an oil phase;
dispersing the oil phase in an aqueous medium containing resin fine particles so as to allow the polymer to react; and
removing the solvent after or during the reaction so as to yield the toner particles.
3. The toner according to claim 1, wherein the modified layered inorganic mineral has an average dispersed particle diameter of 0.1 \u03bcm to 0.55 \u03bcm.
4. The toner according to claim 1, wherein the modified layered inorganic mineral is added to the oil phase as a kneaded lo composite with the binder resin, and the modified layered inorganic mineral has an average dispersed particle diameter of 0.1 \u03bcm to 0.55 \u03bcm in the kneaded composite.
5. The toner according to claim 1, wherein the precursor of the binder resin is a modified polyester resin, and
wherein a compound which is capable of being elongated or crosslinked with the modified polyester resin is dissolved in the oil phase, the oil phase is dispersed in the aqueous medium in the presence of fine particle dispersant so as to prepare the emulsified dispersion, the modified polyester is allowed to proceed a crosslinking reaction or an elongation reaction in the emulsified dispersion, and the organic solvent is removed from the emulsified dispersion so as to yield the toner particles.
6. The toner according to claim 1, wherein the toner comprises 0.05% by mass to 5.0% by mass of the modified layered inorganic mineral.
7. The toner according to claim 1, wherein the modified layered inorganic mineral is a layered inorganic mineral in which at least a part of metallic cations present in between layers of the layered inorganic mineral is replaced with an organic cation.
8. The toner according to claim 1, wherein the toner has a volume average particle diameter Dv of 3.0 \u03bcm to 7.0 \u03bcm, and a ratio DvDn of 1.00 to 1.30, where Dv denotes the volume average particle diameter and Dn denotes a number average particle diameter.
9. The toner according to claim 1, wherein the dispersed particles of the releasing agent having a particle diameter of 0.5 \u03bcm or more has an aspect ratio of the particle of 0.800 or less, and a proportion of the dispersed particles of the releasing agent having a particle diameter of 1 \u03bcm or more in the dispersed particles of the releasing agent having a particle diameter of 0.5 \u03bcm or more is 20% by number or less.
10. The toner according to claim 1, wherein the toner comprises 1% by mass to 10% by mass of the releasing agent.
11. The toner according to claim 1, wherein the modified layered inorganic mineral is added as a kneaded composite with the binder resin to the oil phase, the modified layered inorganic mineral has an average dispersed particle diameter of 0.1 \u03bcm to 0.55 \u03bcm in the kneaded composite, and the modified layered inorganic mineral having a particle diameter of 1 \u03bcm or more accounts for 15% by volume or less in the kneaded composite.
12. The toner according to claim 1, wherein the toner has an average circularity of 0.93 to 0.97.
13. The toner according to claim 1, wherein the toner particles having a circularity of 0.950 or less account for 20% by number to 80% by number in the entire toner particles.
14. The toner according to claim 1, wherein the toner has a shape factor SF-1 of 110 to 200 and a shape factor SF-2 of 110 to 300.
15. The toner according to claim 7, wherein the organic cation is a quaternary ammonium ion.
16. The toner according to claim 1, wherein the toner particles having a diameter of 2 \u03bcm or less account for 1% by number to 20% by number in the entire toner particles.
17. The toner according to claim 1, wherein the binder resin comprises a polyester resin.
18. The toner according to claim 2, wherein the polymer having a site reactive with a compound having an active hydrogen group has a weight-average molecular weight of 3,000 to 20,000.
19. A toner manufacturing method, comprising:
dissolving or dispersing at least a binder resin or a precursor of a binder resin, a colorant, a releasing agent, and a modified layered inorganic mineral in which at least a part of ions present in between layers of a layered inorganic mineral is replaced with an organic ion in an organic solvent so as to prepare an oil phase;
dispersing the oil phase in an aqueous medium so as to prepare an emulsified dispersion; and
removing the solvent from the emulsified dispersion so as to yield the toner particles,
wherein the toner satisfies one of the following conditions (1) and (2):
(1) the releasing agent has an average dispersed particle diameter of 0.1 \u03bcm to 0.5 \u03bcm in the toner particle, and the toner has a ratio AB of 0.2 to 2.0 where A denotes the average dispersed particle diameter of the releasing agent and B denotes an average dispersed particle diameter of the modified layered inorganic mineral; and
(2) the releasing agent has an average dispersed particle diameter of 0.1 \u03bcm to 0.5 \u03bcm, a proportion of the dispersed particles of the releasing agent having a diameter of 1 \u03bcm or more in the dispersed particles of the releasing agent having a diameter of 0.5 \u03bcm or more is 20% by number or less.
20. An image forming apparatus, comprising:
a transferring unit configured to transfer a toner image formed of a toner and carried on a toner image bearing member to a transfer material; and
a cleaning unit configured to clean the toner remained on the toner image bearing member after the transferring, by using a blade,
wherein the toner comprises:
toner particles,
wherein each toner particle comprises at least:
a releasing agent; and
a modified layered inorganic mineral in which at least a part of ions present in between layers of a layered inorganic mineral is replaced with an organic ion,
wherein the toner satisfies one of the following conditions (1) and (2):
(1) the releasing agent has an average dispersed particle diameter of 0.1 \u03bcm to 0.5 \u03bcm in the toner particle, and the toner has a ratio AB of 0.2 to 2.0 where A denotes the average dispersed particle diameter of the releasing agent and B denotes an average dispersed particle diameter of the modified layered inorganic mineral; and
(2) the releasing agent has an average dispersed particle diameter of 0.1 \u03bcm to 0.5 \u03bcm, a proportion of the dispersed particles of the releasing agent having a diameter of 1 \u03bcm or more in the dispersed particles of the releasing agent having a diameter of 0.5 \u03bcm or more is 20% by number or less, and
wherein the toner is obtained by a method comprising:
dissolving or dispersing at least a binder resin or a precursor of a binder resin, a colorant, the releasing agent, and the modified layered inorganic mineral in an organic solvent so as to prepare an oil phase;
dispersing the oil phase in an aqueous medium so as to prepare an emulsified dispersion; and
removing the solvent from the emulsified dispersion so as to yield the toner particles.

1-30. (canceled)
31. An ultra-wideband (UWB) network comprising a plurality of UWB devices each forming a node of said network, pairs of said UWB devices being configured for communication with one another using one of a plurality of UWB channels, each said UWB device comprising:
a UWB transceiver for bidirectional communication over one or more of said UWB channels with at least one other of said UWB devices; and
a device controller coupled to said UWB transceiver, said controller being configured to determine a said UWB channel for use in establishing a communication link with each other UWB device;
whereby said network is configured for automatic construction of a set of communications links between said nodes of said network.
32. A UWB network as claimed in claim 31 wherein said UWB transceiver of each said UWB device is configured for bidirectional communication with a plurality of other UWB devices over a plurality of said channels, and wherein said device controller of each said UWB device is further configured to store connection data associating a first of said channels bearing incoming data with a second of said channels for use in forwarding said incoming data to another of said UWB devices.
33. An ultra-wideband (UWB) network comprising a plurality of UWB devices each forming a node of said network, pairs of said UWB devices being configured for communication with one another using one of a plurality of UWB channels, each said UWB device comprising:
a UWB transceiver for bidirectional communication over a plurality of said UWB channels with a plurality of other UWB devices; and
a connection table configured to store connection data associating a first of said channels bearing incoming data with a second of said channels for use in forwarding said incoming data to another of said UWB devices.
34. A data packet for UWB communication between nodes of a packet data UWB network, the network having a plurality of UWB channels for communication between said network nodes, said data packet including payload data and UWB channel identification data, whereby a said network node receiving said data packet is able to determine a UWB channel to use when forwarding said data packet.
35. A data packet as claimed in claim 34 further comprising destination identification data.
36. An ultra-wideband (UWB) device for a node of a UWB network, the device comprising:
an interface to a UWB transceiver for bidirectional communication over one or more UWB channels with one or more other UWB devices; and
a controller coupled to said UWB transceiver interface, said controller being configured to control said UWB transceiver to communicate with said one or more other UWB devices to determine a said UWB channel to employ for communicating with each of said other UWB devices.
37. A UWB device as claimed in claim 36 wherein said controller is configured to control said UWB transceiver to broadcast a connection request to request a connection to a selected one of said one or more other UWB devices, to receive a connection response from said selected UWB device, and to determine a said UWB channel to employ for communicating with said selected UWB device responsive to said connection response.
38. A UWB device as claimed in claim 37 wherein said determined channel comprises a channel on which said connection response is received.
39. A UWB device as claimed claim 37 in further comprising a connection table for storing connection data, said connection data comprising data associating said selected UWB device with said determined channel.
40. A UWB device as claimed in claim 39 for communicating with a plurality of other UWB devices, communication with at least one indirectly linked device of said other UWB devices being via an intermediary UWB device, and wherein said connection data for said indirectly linked UWB device comprises data associating said indirectly linked device with a channel for communicating with said intermediary device.
41. A UWB device as claimed in claim 36 wherein said UWB transceiver is configured for bidirectional communication with a plurality of other UWB devices over a plurality of said channels, and wherein said controller is further configured to store connection data associating a first of said channels bearing incoming data with a second of said channels for use in forwarding said incoming data to another of said UWB devices.
42. A UWB device as claimed in claim 41 further comprising a data store to store said incoming data for forwarding.
43. A UWB device as claimed in claim 41 configured to receive and forward said incoming data, and wherein said controller is configured to control said transceiver to reply to a sender of said incoming data with a connection disconnect message where a recipient for incoming data is not found.
44. A UWB device as claimed in claim 36 wherein said controller is further configured to control said transceiver to broadcast an alert to said one or more other UWB devices on initiation of said UWB device.
45. A UWB device as claimed in claim 44 wherein said alert comprises an identifier for said broadcasting device, and wherein said controller is further configured to receive a response to said alert and, responsive to said response, to modify said device identifier.
46. A UWB device as claimed in claim 37 wherein said controller is further configured to receive a said connection request and respond with a said connection response.
47. A UWB device as claimed in claim 46 wherein a said connection request includes communication quality data, and wherein said controller is further configured to receive a plurality of said connection requests, to compare said quality data for said connection requests, and to respond to selected said request responsive to said comparison.
48. A UWB device as claimed in claim 36 including said UWB transceiver.
49. A controller for controlling a UWB device for a node of a UWB network, the UWB device including a UWB transceiver for bidirectional communication over one or more UWB channels with a plurality of other network devices, communication with at least one indirectly linked device of said other UWB devices being via an intermediary UWB device, the controller comprising;
an interface for said UWB transceiver;
data memory for storing network communication link connection data comprising data associating each said network device with a said UWB channel;
program memory storing computer program code; and
a processor coupled to said interface, said data memory, and to said program memory for loading and implementing said program code;
wherein said connection data for said indirectly linked UWB device comprises data associating said indirectly linked device with a channel for communicating with said intermediary device; and
wherein said code comprises code to send network data to said indirectly linked device by accessing said connection data for said indirectly linked device to determine said channel associated with said intermediary device, and controlling said UWB transceiver to transmit said network data over said determined channel.
50. A controller for an ultra-wideband (UWB) network node, the controller comprising:
a processor having a processor control bus and a processor data bus;
processor memory coupled to said processor data bus; buffer memory coupled to a second data bus;
a memory access controller coupled to said second data bus and to said processor control bus; and
a UWB interface for interfacing to a UWB communications device, coupled to said processor control bus and to said second data bus; and
wherein said processor is master of said processor control bus and said memory access controller is master of said second data bus.
51. A UWB network having a mesh topology and comprising a plurality of UWB devices configured for mutual UWB communication with one another, a first of said devices being configured for communicating with a second of said devices via a third of said devices when said second device is out of range, and wherein said third device is configured to use a first UWB communication channel for communicating with said first UWB device and a second UWB communication channel for communicating with said second UWB device.
52. A method of sending data from a first data processor to a second data processor in a network of data processors having a variable network topology, said topology being defined by communications links between processors of said network, the method comprising:
broadcasting a connection request message from said first processor to substantially all other processors to which it is linked;
receiving a connection established message from said second data processor via an intermediary processor with which said first processor is linked; and
sending said data to said intermediary processor for forwarding to said second processor.
53. A method as claimed in claim 52 wherein said first and second processors are linked by a plurality of intermediary processors, wherein each of said intermediary processors receives and rebroadcasts said connection request, and wherein said connection established message propagates through each of said intermediary processors in turn to form a chain of processors to establish a chained connection, and wherein said sending sends said data over said chained connection.
54. A method as claimed in claim 53 wherein each said communications link uses at least one of a plurality of communications channels, the method further comprising storing, at a said intermediary processor, a table linking an incoming data channel to an outgoing data channel to define a said chained connection.
55. A method as claimed in claim 54 further comprising sending a chain broken message from a said intermediary processor to said first processor when said intermediary processor is unable to forward said data.
56. A method as claimed in claim 52 further comprising broadcasting an alert message, including an identifier for said second processor, from second processor substantially throughout said network, and wherein said connection request message includes said second processor identifier.
57. A method as claimed in claim 52 wherein said network comprises a network having a mesh topology, and wherein said communications links comprise ultra wideband (UWB) communications links.
58. Processor control code to, when running, implement the method of claim 52.
59. A carrier carrying the processor control code of claim 58.
60. A network communications device including a processor and the carrier of claim 59.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A process of preparing a formulation of a sirolimus derivative, comprising the steps of:
mixing a sirolimus derivative with water, an organic solvent, or a mixed solvent thereof; and
contacting the obtained solution of the sirolimus derivative with a water-soluble carrier, to disperse the sirolimus derivative in the water-soluble carrier.
2. The process according to claim 1, wherein the step of contacting the obtained solution of the sirolimus derivative with the water-soluble carrier, to disperse the sirolimus derivative in the water-soluble carrier, is carried out by using a high speed shearing mixer or a fluid bed granulator.
3. The process according to claim 1, wherein the sirolimus derivative is one or more selected from the group consisting of sirolimus, 16-O-substituted sirolimus derivatives, 40-O-substituted sirolimus derivatives, ester derivatives of a carboxylic acid substituted sirolimus, carbamate substituted sirolimus derivatives, fluorinated ester substituted sirolimus derivatives, acetal substituted sirolimus derivatives, silyl ether substituted sirolimus derivatives, methylene substituted sirolimus derivatives, methoxy substituted sirolimus derivative, hydroxyethyl substituted sirolimus derivatives, alkenyl substituted sirolimus derivatives, 32-O-dihydro or 32-O-substituted sirolimus derivatives, 32-deoxorapamycin, and 16-pent-2-ynyloxy-32(S)-dihydrorapamycin.
4. The process according to claim 3, wherein the sirolimus derivative is one or more selected from the group consisting of sirolimus and everolimus.
5. The process according to claim 1, wherein the water-soluble carrier is one or more selected from the group consisting of hydroxy propyl methylcellulose (HPMC), hydroxy propyl methylcellulose phthalate, polyvinyl pyrrolidone (PVP), hydroxypropyl cellulose (HPC) or its derivatives, polyethylene glycol (PEG), saturated polyglycolised glycerides, cycicodextrines, polyvinyl alcohol, polyethylene oxide, polyethylene glycol, hydroxypropyl cellulose, hydroxyethyl cellulose, vinyl pyrrolidone-vinyl acetate copolymer, arginate, calcium carboxymethyl cellulose, sodium carboxymethyl cellulose, carbomer, carrageenan, chitosan, guar gum, and dimethyl aminoethyl methacrylate-buthyl methacrylate-methyl methacrylate copolymer.
6. The process according to claim 1, wherein the organic solvent is one or more selected from the group consisting of a linear or branched alcohol having 1 to 10 carbon atoms, an ester having 3 to 10 carbon atoms, a polar or non-polar ether having 3 to 10 carbon atoms, a polar or non-polar ketone having 1 to 10 carbon atoms, and a halogenated hydrocarbon having 1 to 10 carbon atoms.
7. The process according to claim 6, wherein the organic solvent is one or more selected from the group consisting of a linear or branched alcohol having 1 to 5 carbon atoms, an ester having 3 to 6 carbon atoms, a polar or non-polar ether having 3 to 6 carbon atoms, a polar or non-polar ketone having 1 to 5 carbon atoms, and a halogenated hydrocarbon having 1 to 5 carbon atoms
8. The process according to claim 1, wherein the solvent is used in the amount of 0.05 to 500 ml per 1 g of the sirolimus derivative.
9. The process according to claim 1, wherein the ratio between the used amounts of the solution of the sirolimus derivative and the water-soluble carrier is 1:0.05 to 1:500 based on the weight.
10. A formulation of a sirolimus derivative prepared from the preparation process of claim 1, wherein
the content of the sirolimus derivative is 0.01 to 40% by weight based on the total weight of the formulation;
the content of the sirolimus derivative after a 60 hour storage at 80\xb0 C. is no less than 80% by weight with respect to the initial content; and
it is in the form of granules having a uniform average particle size.
11. The formulation of a sirolimus derivative of claim 10, wherein the average particle size is 0.01 to 500 \u03bcm.