Author: claimsbot

1. A pressure sensor comprising:
a sensor membrane formed from conductive material for exposure to fluid at a pressure to be sensed;
a compensation membrane formed from conductive material and sealed from the fluid at the pressure to be sensed; and,
associated circuitry connected to the sensor membrane for converting deflection into an output signal indicative of the fluid pressure and connected to the compensation membrane for converting deflection into an adjustment to the output signal that compensates for membrane deflection due to thermal expansion; wherein,
each membrane is less than 0.1 grams.
2. A pressure sensor according to claim 1 wherein the sensor membrane partially defines a first chamber containing fluid at a reference pressure, the compensation membrane is in a chamber sealed from the fluid at a pressure to be sensed.
3. A pressure sensor according to claim 2 further comprising:
a first recess defined in a substrate covered by the first membrane so as to define the first chamber, the first chamber containing a fluid at a reference pressure such that the first membrane deflects due to a pressure difference between the reference pressure and the fluid pressure; and
a second recess defined in the substrate covered by a capping member so as to define, and seal from the fluid pressure, the second chamber, the second membrane dividing the second chamber into sections fluidically sealed from each other such that the second membrane deflects at a predetermined pressure difference between the sections.
4. A pressure sensor according to claim 3 wherein the sensor is a capacitative sensor, with a conductive layer deposited in each of the first and second chambers and the first and second membranes are conductive, such that the conductive layer in the first chamber and the first membrane form capacitor electrodes and the deflection of the first membrane changes the capacitance which the associated circuitry converts to the output signal.
5. A pressure sensor according to claim 1 wherein the fluid pressure is air pressure within a pneumatic tire.
6. A pressure sensor according to claim 1 wherein the membranes are at least partially made from a metal-nitride compound.
7. A pressure sensor according to claim 1 wherein each membrane is approximately 0.5 \u03bcm thick.
8. A pressure sensor according to claim 1 wherein each membrane is circular with a diameter less than 500 microns.
9. A pressure sensor according to claim 1 wherein the membranes are laminates having at least two layers, at least one of the layers being at least partially formed from conductive material.
10. A pressure sensor according to claim 9 wherein the layers within the laminate are be formed from the deposition of different metal ceramics.
11. A pressure sensor according to claim 10 wherein the metal ceramics are metal nitrides or mixed metal nitrides.
12. A pressure sensor according to claim 9 wherein one or more of the layers of the laminate is metal.
13. A pressure sensor according to claim 1 wherein the membranes are non-planar.
14. A pressure sensor according to claim 13 wherein the membranes are corrugated.
15. A pressure sensor according to claim 14 wherein the flexible corrugated membranes each have a corrugation factor of 8.
16. A pressure sensor according to claim 15 wherein the sensor has a linear response up to about 1 MPa.
17. A pressure sensor according to claim 15 wherein the membrane corrugations have a period of between 5 microns and 15 microns.
18. A pressure sensor according to claim 17 wherein the membranes are substantially circular and the corrugations are annular.
19. A pressure sensor according to claim 14 wherein the corrugations have a substantially square-shaped cross-sectional profile.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A computer-implemented method performed with a computing system for exploring social connections in an in-memory database, the method comprising:
identifying an attribute in a user profile associated with a first user;
executing a query against a data element stored in an in-memory database, the query including the attribute in the user profile;
identifying a second user from results of the query, the second user associated with the data element based on a relationship between the second user and the first user defined by the attribute; and
generating displayable information associated with the second user.
2. The method of claim 1, wherein the data element is a data cube.
3. The method of claim 1 further comprising performing at least one of:
presenting an interface operable to allow the first user to email the second user;
presenting an interface operable to allow the first user to send an invitation to the second user;
presenting an interface operable to allow the first user to export information to the second user; or
presenting an interface to allow additional searches of data elements in the in-memory database based on the information associated with the second user.
4. The method of claim 1, wherein the attribute is related to a current project of the first user.
5. The method of claim 4, wherein the query includes an identification of the current project and the relationship is determined based on identification of members participating in the current project.
6. The method of claim 1, wherein the information associated with the second user includes a user profile of the second user.
7. The method of claim 1, further comprising:
identifying a change to the data element; and
updating the displayable information associated with the second user based on the change to the data element.
8. The method of claim 1, wherein the query is executed against a plurality of data elements in the in-memory database, wherein at least two of the plurality of data elements are from different data sources in the in-memory database, and
prior to executing the query against the data element stored in the in-memory database, the different data sources are replicated to the in-memory database from one or more enterprise systems communicably coupled to the in-memory database.
9. The method of claim 8, wherein executing a query against a data element stored in an in-memory database comprises executing a query against a data element stored in an in-memory database with an in-memory computational engine in the in-memory database.
10. The method of claim 1, further comprising:
identifying a plurality of additional users from results of the query, the additional users associated with the data element based on a relationship between each of the additional users and the first user defined by the attribute;
dynamically generating a graphical network representing the first user, the plurality of additional users, and the relationship between each of the additional users and the first user defined by the attribute, where the first user and the plurality of additional users are represented as nodes in the graphical network and the relationship between each of the additional users and the first user defined by the attribute are represented as connections between nodes.
11. An apparatus comprising instructions embodied on a tangible, non-transitory computer-readable media, the instructions operable when executed to cause a computing system to perform operations comprising:
identifying an attribute in a user profile associated with a first user;
executing a query against a data element stored in an in-memory database, the query including the attribute in the user profile;
identifying a second user from results of the query, the second user associated with the data element based on a relationship between the second user and the first user defined by the attribute; and
generating displayable information associated with the second user.
12. The apparatus of claim 11, wherein the data element is a data cube.
13. The apparatus of claim 11, wherein the operations further comprise performing at least one of:
presenting an interface operable to allow the first user to email the second user;
presenting an interface operable to allow the first user to send an invitation to the second user;
presenting an interface operable to allow the first user to export information to the second user; or
presenting an interface to allow additional searches of data elements in the in-memory database based on the information associated with the second user.
14. The apparatus of claim 11, wherein the attribute is related to a current project of the first user.
15. The apparatus of claim 14, wherein the query includes an identification of the current project and the relationship is determined based on identification of members participating in the current project.
16. The apparatus of claim 11, wherein the information associated with the second user includes a user profile of the second user.
17. The apparatus of claim 11, wherein the operations further comprise:
identifying a change to the data element; and
updating the displayable information associated with the second user based on the change to the data element.
18. The apparatus of claim 11, wherein the query is executed against a plurality of data elements in the in-memory database, wherein at least two of the plurality of data elements are from different data sources in the in-memory database, and
prior to executing the query against the data element stored in the in-memory database, the different data sources are replicated to the in-memory database from one or more enterprise systems communicably coupled to the in-memory database.
19. The apparatus of claim 18, wherein executing a query against a data element stored in an in-memory database comprises executing a query against a data element stored in an in-memory database with an in-memory computational engine in the in-memory database.
20. The apparatus of claim 11, wherein the operations further comprise:
identifying a plurality of additional users from results of the query, the additional users associated with the data element based on a relationship between each of the additional users and the first user defined by the attribute;
dynamically generating a graphical network representing the first user, the plurality of additional users, and the relationship between each of the additional users and the first user defined by the attribute, where the first user and the plurality of additional users are represented as nodes in the graphical network and the relationship between each of the additional users and the first user defined by the attribute are represented as connections between nodes.
21. A computing system, comprising a memory, one or more processors, and instructions stored on the memory and operable when executed by the one or more processors to cause the computing system to perform operations comprising:
identifying an attribute in a user profile associated with a first user;
executing a query against a data element stored in an in-memory database, the query including the attribute in the user profile;
identifying a second user from results of the query, the second user associated with the data element based on a relationship between the second user and the first user defined by the attribute; and
generating displayable information associated with the second user.
22. The system of claim 21, wherein the data element is a data cube.
23. The system of claim 21, wherein the operations further comprise performing at least one of:
presenting an interface operable to allow the first user to email the second user;
presenting an interface operable to allow the first user to send an invitation to the second user;
presenting an interface operable to allow the first user to export information to the second user; or
presenting an interface to allow additional searches of data elements in the in-memory database based on the information associated with the second user.
24. The system of claim 21, wherein the attribute is related to a current project of the first user.
25. The system of claim 24, wherein the query includes an identification of the current project and the relationship is determined based on identification of members participating in the current project.
26. The system of claim 21, wherein the information associated with the second user includes a user profile of the second user.
27. The system of claim 21, wherein the operations further comprise:
identifying a change to the data element; and
updating the displayable information associated with the second user based on the change to the data element.
28. The system of claim 21, wherein the query is executed against a plurality of data elements in the in-memory database, wherein at least two of the plurality of data elements are from different data sources in the in-memory database, and
prior to executing the query against the data element stored in the in-memory database, the different data sources are replicated to the in-memory database from one or more enterprise systems communicably coupled to the in-memory database.
29. The system of claim 28, wherein executing a query against a data element stored in an in-memory database comprises executing a query against a data element stored in an in-memory database with an in-memory computational engine in the in-memory database.
30. The system of claim 21, wherein the operations further comprise:
identifying a plurality of additional users from results of the query, the additional users associated with the data element based on a relationship between each of the additional users and the first user defined by the attribute;
dynamically generating a graphical network representing the first user, the plurality of additional users, and the relationship between each of the additional users and the first user defined by the attribute, where the first user and the plurality of additional users are represented as nodes in the graphical network and the relationship between each of the additional users and the first user defined by the attribute are represented as connections between nodes.

1. A polymer-supported metal cluster composition comprising a transition metal and a cross-linked polymer, wherein the transition metal is supported by the cross-linked polymer and the cross-linked polymer is obtained by cross-linking a cross-linkable polymer wherein the cross-linkable polymer contains at least one hydrophobic side chain and at least one hydrophilic side chain, wherein at least one hydrophilic side chain has a cross-linkable functional group, and wherein each hydrophobic side chain is free of hydrophilic substituents and cross-linkable functional groups, and wherein the composition is prepared, in a solution, by forming a micelle wherein clusters of the metal are supported by the cross-linkable polymer and then cross-linking the cross-linkable polymer.
2. The composition as in claim 1, wherein the cross-linkable polymer contains a hydrophobic side chain containing an aromatic group, and the micelle is formed by supporting a transition metal by the cross-linkable polymer using a ligand exchange reaction between a transition metal chelate and the aromatic group of the cross-linkable polymer.
3. The composition as in claim 1, wherein the metal clusters are 20 nm or smaller in diameter.
4. The composition as in claim 1, wherein the transition metal is at least one selected from the group consisting of palladium, cobalt, nickel, rhodium, ruthenium, iridium, gold and platinum.
5. The composition as in claim 1, wherein the transition metal is at least one selected from the group consisting of palladium, ruthenium, iridium, gold and platinum.
6. The composition as in claim 1, wherein the transition metal has zero valence.
7. The composition as in claim 1, wherein the cross-linkable polymer contains a hydrophilic side chain having an epoxy group, a carboxyl group, an isocyanate group or a thioisocyanate group.
8. The composition as in claim 7, wherein the cross-linkable polymer further contains at least one type of a hydrophilic side chain having a hydroxyl group, a primary or secondary amino group, or a thiol group.
9. The composition as in claim 1, wherein the cross-linkable polymer is: (i) a polymer or a copolymer obtained by polymerizing or copolymerizing at least one type of A1) monomer having an aromatic group as a hydrophobic side chain, a hydrophilic side chain having a cross-linkable functional group and a polymerizable double bond; or (ii) a copolymer obtained by copolymerizing at least two types of monomers selected from the group consisting of B1) monomer, B2) monomer, and B3) monomer, wherein the B1) monomer is a monomer having an aromatic group as a hydrophobic side chain, a hydrophilic side chain having a cross-linkable functional group and a polymerizable double bond, the B2) monomer is a monomer having an aromatic group as a hydrophobic side chain and a polymerizable double bond, and the B3) monomer is a monomer containing a hydrophilic side chain having a cross-linkable functional group and a polymerizable double bond.
10. The composition as in claim 9, wherein the cross-linkable polymer is a copolymer obtained by copolymerizing at least two types of monomers selected from B1) monomer, B2) monomer, and B3) monomer, wherein the B1) monomer is a monomer represented by chemical formula 1:
wherein R1 is a hydrogen atom or an alkyl group having 1-6 carbon atom(s), R2 is an aryl group having 6-14 carbon atoms, R3 is a covalent bond, an alkylene group having 1-6 carbon atom(s), \u2014R9(OR10)m\u2014, \u2014R9(COOR10)n\u2014 or R9(COOR10)o(OR10)p\u2014,
wherein R9 is independently a covalent bond or an alkylene group having 1-6 carbon atom(s), R10 is independently an alkylene group having 2-4 carbon atoms, m, n and p are integers of 1-10 and o is 1 or 2,
R4 is a carboxyl group, an isocyanate group, an isothiocyanate group, a hydroxyl group, a primary or secondary amino group, a thiol group or a group represented by chemical formula 2:
or chemical formula 3:
wherein R5 is independently an alkylene group having 1-6 carbon atom(s), R6 and R7 are each independently a hydrogen atom or an alkyl group having 1-6 carbon atom(s),
and R6 may form a 3-6 membered ring with R5 or R7,
the B2) monomer is a monomer represented by chemical formula 4:
wherein R1 and R2 are independently as defined above, R11 is a hydrogen atom or an alkyl group having 1-6 carbon atom(s),
and the B3) monomer is a monomer represented by chemical formula 5:
wherein R1, R3, R4 and R11 are independently as defined above.
11. A method for performing a hydrogenation reaction, a dehydrogenation reaction, an oxidation reaction, an allylic substitution reaction, a coupling reaction or a carbonylation reaction, wherein the method comprises catalyzing the reaction with a composition of claim 1.
12. The composition as in claim 9, wherein the cross-linkable polymer is a polymer obtained by polymerizing one type of A1) monomer represented by chemical formula 1:
wherein R1 is a hydrogen atom or an alkyl group having 1-6 carbon atom(s), R2 is an aryl group having 6-14 carbon atoms, R3 is a covalent bond, an alkylene group having 1-6 carbon atom(s), \u2014R9(OR10)m\u2014, \u2014R9(COOR10)n\u2014 or R9(COOR10)o(OR10)p\u2014,
wherein R9 is independently a covalent bond or an alkylene group having 1-6 carbon atom(s), R10 is independently an alkylene group having 2-4 carbon atoms, m, n and p are integers of 1-10 and o is 1or 2,
R4 is a carboxyl group, an isocyanate group, an isothiocyanate group, a hydroxyl group, a primary or secondary amino group, a thiol group or a group represented by chemical formula 2:
or chemical formula 3:
wherein R5 is independently an alkylene group having 1-6 carbon atom(s), R6 and R7 are each independently a hydrogen atom or an alkyl group having 1-6 carbon atom(s),
and R6 may form a 3-6 membered ring with R5 or R7.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A compound of formula I
in which
R1 is Hal, NO2, CF3, COOH, COOR or H,
R2 is R, Hal, CN, NO2, NHR, NRR, NHCOR, NHSO2R, OR, CO\u2014R, CO\u2014NHR, CF3, OCF3, SCF3, SO3R, SO2R, SO2NR, SR, COOH or COOR,
R3 is Hal or CO\u2014NHR,
R is H or unsubstituted or mono-, di-, tri- or tetra-R4-substituted A, Ar, Het, (CH2)qHet or (CH2)qAr,
A is unbranched, branched or cyclic alkyl having 1-14 C atoms, in which one or two CH2 groups are each optionally replaced by O, S, or \u2014CH\u2550CH\u2014 andor 1-7 H atoms are each optionally replaced by F or Cl,
Ar is phenyl, naphthyl or biphenyl, each of which is unsubstituted or mono-, di- or trisubstituted by A, Hal, OH, OA, CN, NO2, NH2, NHA, NA2, NHCOA, SCF3, SO2A, COOH, COOA, CONH2, CONHA, CONA2, NHSO2A, SO2NH2, SO2NHA, SO2NA2, CHO or COA,
Het is a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O andor S atoms, which may be unsubstituted or mono-, di- or trisubstituted by carbonyl oxygen, Hal, A,\u2014(CH2)b\u2014Ar, \u2014(CH2)b-cycloalkyl, OH, OA, NH2, NHA, NA2, NO2, CN, COOH, COOA, CONH2, CONHA, CONA2, NHCOA, NHCONH2, NHSO2A, CHO, COA, SO2NH2 andor S(O)gA,
Hal is F, Cl, Br or I,
R4 is Hal, OH, CN, NO2, CF3, OCF3, SCF3, SO2A or OA,
X is O, S, or NH,
{circle around (Y)} is phenyl or a monocyclic aromatic heterocycle having 1 to 4 N, O andor S atoms,
b is 0, 1, 2, 3 or 4,
g is 0, 1 or 2,
n, m, p, q are each, independently of one another, 1, 2, 3, or 4,
or a pharmaceutically acceptable salt, or stereoisomer thereof, including mixtures of stereoisomers in all ratios.
2. A compound according to claim 1, in which R2 is H.
3. A compound according to claim 1, in which {circle around (Y)} is phenyl, furyl, thienyl, pyrrolyl, imidazolyl, pyridyl or pyrimidinyl.
4. A compound according to claim 1, in which
R2 is H,
{circle around (Y)} is phenyl, furyl, thienyl, pyrrolyl, imidazolyl, pyridyl or pyrimidinyl,
X is O, S, or NH,
n, p, are each, independently of one another, 1, 2, 3 or 4,
m is 1.
5. A compound according to claim 1, wherein A is methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, 1-, 2- or 3-methylbutyl, 1,1-, 1,2- or 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1-, 2-, 3- or 4-methylpentyl, 1,1-, 1,2-, 1,3-, 2,2-, 2,3- or 3,3-dimethylbutyl, 1- or 2-ethylbutyl, 1-ethyl-l-methylpropyl, 1-ethyl-2-methylpropyl, 1,1,2- or 1,2,2-trimethylpropyl, linear or branched heptyl, octyl, nonyl, decyl, trifluoromethyl, pentafluoroethyl, 1,1,1-trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, or cycloheptyl.
6. A compound according to claim 5, wherein A is methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, or tert-butyl.
7. A compound according to claim 5, wherein A is methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, hexyl, trifluoromethyl, pentafluoroethyl, or 1,1,1-trifluoroethyl.
8. A compound according to claim 1, wherein A is alkyl having 1, 2, 3, 4, 5 or 6 C atoms, in which one or two CH2 groups are each optionally replaced by O, S, or by \u2014CH\u2550CH\u2014, and 1-7 H are each optionally replaced by F or Cl.
9. A compound according to claim 1, wherein Ar is phenyl, naphthyl or biphenyl, which in each case is mono-, di- or trisubstituted by substituents selected from A, fluorine, chlorine, bromine, iodine, hydroxyl, methoxy, ethoxy, propoxy, butoxy, pentyloxy, hexyloxy, nitro, cyano, formyl, acetyl, propionyl, tri-fluoromethyl, amino, methylamino, ethylamino, dimethylamino, diethylamino, benzyloxy, sulfonamido, methylsulfonamido, ethylsulfonamido, propylsulfonamido, butylsulfonamido, dimethylsulfonamido, phenylsulfonamido, carboxyl, methoxycarbonyl, ethoxycarbonyl, and aminocarbonyl.
10. A compound according to claim 1, wherein Het is 2- or 3-furyl, 2- or 3-thienyl, 1-, 2- or 3-pyrrolyl, 1-, 2, 4- or 5-imidazolyl, 1-, 3-, 4- or 5-pyrazolyl, 2-, 4- or 5-oxazolyl, 3-, 4- or 5-isoxazolyl, 2-, 4- or 5-thiazolyl, 3-, 4- or 5-iso-thiazolyl, 2-, 3- or 4-pyridyl, 2-, 4-, 5- or 6-pyrimidinyl, furthermore preferably 1,2,3-triazol-1-, -4- or -5-yl, 1,2,4-triazol-1-, -3- or 5-yl, 1- or 5-tetrazolyl, 1,2,3-oxadiazol-4- or -5-yl, 1,2,4-oxadiazol-3- or -5-yl, 1,3,4-thiadiazol-2- or -5-yl, 1,2,4-thiadiazol-3- or -5-yl, 1,2,3-thiadiazol-4- or -5-yl, 3- or 4-pyridazinyl, pyrazinyl, 1-, 2-, 3-, 4-, 5-, 6- or 7-indolyl, 4- or 5-isoindolyl, 1-, 2-, 4- or 5-benzimidazolyl, 1-, 3-, 4-, 5-, 6- or 7-benzopyrazolyl, 2-, 4-, 5-, 6- or 7-benzoxazolyl, 3-, 4-, 5-, 6- or 7- benzisoxazolyl, 2-, 4-, 5-, 6- or 7-benzothiazolyl, 2-, 4-, 5-, 6- or 7-benzisothiazolyl, 4-, 5-, 6- or 7-benz-2,1,3-oxadiazolyl, 2-, 3-, 4-, 5-, 6-, 7- or 8-quinolyl, 1-, 3-, 4-, 5-, 6-, 7- or 8-isoquinolyl, 3-, 4-, 5-, 6-, 7- or 8-cinnolinyl, 2-, 4-, 5-, 6-, 7- or 8-quinazolinyl, 5- or 6-quinoxalinyl, 2-, 3-, 5-, 6-, 7- or 8-2H-benzo-1,4-oxazinyl, furthermore preferably 1,3-benzodioxo1-5-yl, 1,4-benzodioxan-6-yl, 2,1,3-benzothiadiazol-4-or -5-yl, or 2,1,3-benzoxadiazol-5-yl, which in each case is unsubstituted or mono-, di- or trisubstituted by substituents selected from carbonyl oxygen, F, Cl, Br, methyl, ethyl, propyl, phenyl, benzyl, -CH2-cyclohexyl, hydroxyl, methoxy, ethoxy, amino, methylamino, dimethylamino, nitro, cyano, carboxyl, methoxycarbonyl, aminocarbonyl, methylaminocarbonyl, dimethylaminocarbonyl, acetamino, ureido, methylsulfonylamino, formyl, acetyl, aminosulfonyl, and methylsulfonyl, or
Het is 2,3-dihydro-2-, -3-, -4- or -5-furyl, 2,5-dihydro-2-, -3-, -4- or 5-furyl, tetrahydro-2- or -3-furyl, 1,3-dioxolan-4-yl, tetrahydro-2- or -3-thienyl, 2,3-dihydro-1-, -2-, -3-, -4- or -5-pyrrolyl, 2,5-dihydro-1-, -2-, -3-, -4- or -5-pyrrolyl, 1-, 2- or 3-pyrrolidinyl, tetrahydro-1-, -2- or -4-imidazolyl, 2,3-dihydro-1-, -2-, -3-, -4- or -5-pyrazolyl, tetrahydro-1-, -3- or -4-pyrazolyl, 1,4-dihydro-1-, -2-, -3- or -4-pyridyl, 1,2,3,4-tetrahydro-1-, -2-, -3-, -4-, -5- or -6-pyridyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, tetrahydro-2-, -3- or -4-pyranyl, 1,4-dioxanyl, 1,3-dioxan-2-, -4- or -5-yl, hexahydro-1-, -3- or -4-pyridazinyl, hexahydro-1-, -2-, -4- or -5-pyrimidinyl, 1-, 2- or 3-piperazinyl, 1,2,3,4-tetrahydro-1-, -2-, -3-, -4-, -5-, -6-, -7- or -8-quinolyl, 1,2,3,4-tetrahydro-1-,-2-,-3-, -4-, -5-, -6-, -7- or -8-isoquinolyl, 2-, 3-, 5-, 6-, 7- or 8- 3,4-dihydro-2H-benzo-1,4-oxazinyl, furthermore preferably 2,3-methylenedioxyphenyl, 3,4-methylenedioxyphenyl, 2,3-ethylenedioxyphenyl, 3,4-ethylenedioxyphenyl, 3,4-(difluoromethylenedioxy)phenyl, 2,3-dihydrobenzofuran-5- or 6-yl, 2,3-(2-oxomethylenedioxy)phenyl, 3,4-dihydro-2H-1,5-benzodioxepin-6- or -7-yl, 2,3-dihydrobenzofuranyl, 2,3-dihydro-2-oxofuranyl, 2-oxopiperidin-l-yl, 2-oxopyrrolidin-l-yl, 2-oxo-1H-pyridin-l-yl, 3-oxomorpholin-4-yl, 4-oxo-1H-pyridin-l-yl, 2,6-dioxopiperidinl-yl, 2-oxopiperazin-l-yl, 2,6-dioxopiperazin-l-yl, 2,5-dioxopyrrolidin-l-yl, 2-oxo-1,3-oxazolidin-3-yl, 3-oxo-2H-pyridazin-2-yl, 2-caprolactam-l-yl, 2-hydroxy-6-oxopiperazin-l-yl, 2-methoxy-6-oxopiperazin-l-yl, or 2-azabicyclo2.2.2octan-3-on-2-yl.
11. A compound according to claim 10, wherein
A is methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, 1-, 2- or 3-methylbutyl, 1,1-, 1,2- or 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1-, 2-, 3- or 4-methylpentyl, 1,1-, 1,2-, 1,3-, 2,2-, 2,3- or 3,3-dimethylbutyl, 1- or 2-ethylbutyl, 1-ethyl-l-methylpropyl, 1-ethyl-2-methylpropyl, 1,1,2- or 1,2,2-trimethylpropyl, linear or branched heptyl, octyl, nonyl, decyl, trifluoromethyl, pentafluoroethyl, 1,1,1-trifluoroethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, or cycloheptyl; and
Ar is phenyl, naphthyl or biphenyl, which in each case is mono-, di- or trisubstituted by substituents selected from A, fluorine, chlorine, bromine, iodine, hydroxyl, methoxy, ethoxy, propoxy, butoxy, pentyloxy, hexyloxy, nitro, cyano, formyl, acetyl, propionyl, tri-fluoromethyl, amino, methylamino, ethylamino, dimethylamino, diethylamino, benzyloxy, sulfonamido, methylsulfonamido, ethylsulfonamido, propylsulfonamido, butylsulfonamido, dimethylsulfonamido, phenylsulfonamido, carboxyl, methoxycarbonyl, ethoxycarbonyl, and aminocarbonyl.
12. A compound according to claim 1, wherein {circle around (Y)} is phenyl, pyridyl or pyrimidinyl.
13. A compound according to claim 1, in which
R1 is Hal, NO2, CF3, COOH, COOR or H,
R2 is H,
Y is phenyl, furyl, thienyl, pyrrolyl, imidazolyl, pyridyl or pyrimidinyl, and
X is O, S, or NH.
14. A compound selected from:
benzoxazol-2-yl-4-(pyridin-4-yloxy)phenyllamine,
benzoxazol-2-yl-4-(pyridin-4-ylsulfanyl)phenyllamine,
N-benzoxazol-2-yl-N\u2032-pyridin-4-ylbenzene- 1,4-diamine,
2-4-(pyridin-4-ylsulfanyl)phenylaminobenzoxazole-5-carboxylic acid,
2-4-(pyridin-4-yloxy)phenylaminobenzoxazole-6-carboxylic acid,
2-4-(pyridin-4-ylsulfanyl)phenylaminobenzoxazole-6-carboxylic acid,
methyl 2-4-(pyridin-4-ylamino)phenylaminobenzoxazole-6-carboxylate,
(5-nitrobenzoxazol-2-yl)-4-(pyridin-4-ylsulfanyl)phenylamine,
(5-nitrobenzoxazol-2-yl)-4-(pyridin-4-yloxy)phenylamine,
N-(5-nitrobenzoxazol-2-yl)-N\u2032-pyridin-4-ylbenzene-1,4-diamine,
(6-nitrobenzoxazol-2-yl)-4-(pyridin-4-yloxy)phenylamine,
(6-nitrobenzoxazol-2-yl)-4-(pyridin-4-ylsulfanyl)phenylamine,
N-(6-nitrobenzoxazol-2-yl)-N\u2032-pyridin-4-ylbenzene-1,4-diamine,
(5-chloro-7-nitrobenzoxazol-2-yl)-4-(pyridin-4-yloxy)phenylamine,
(5-chloro-7-nitrobenzoxazol-2-yl)-4-(pyridin-4-ylsulfanyl)phenyl-amine,
N-(5-chloro-7-nitrobenzoxazol-2-yl)-N\u2032-pyridin-4-ylbenzene-1,4-diamine,
(7-bromo-5-trifluoromethylbenzoxazol-2-yl)-4-(pyridin-4-yloxy)phenyl-amine,
(7-bromo-5-trifluoromethylbenzoxazol-2-yl)-4-(pyridin-4-ylsulfanyl)phenyl-amine,
(7-bromo-5-trifluoromethylbenzoxazol-2-yl)-4-(4-fluorophenylsulfanyl)-phenylamine,
N-4-(bromotrifluoromethylbenzoxazol-2-ylamino)phenyl-4-fluoro-benzenesulfonamide, 4-(2-amino-6-methylpyrimidin-4-yloxy)phenyl-(7-bromo-5- trifluoro-methylbenzoxazol-2-yl)amine,
N-methyl-4-4-(bromotrifluoromethylbenzoxazol-2-ylamino)phenoxyl-pyridine-2-carboxamide,
N-methyl-4-4-(bromotrifluoromethylbenzoxazol-2-ylamino)phenylsulfanyl-pyridine-2-carboxamide, and
(7-bromo-5-trifluoromethylbenzoxazol-2-yl)-4-(2,4-difluorophenylsulfanyl)-phenylamine,
and pharmaceutically acceptable salts, and stereoisomers thereof, including mixtures of stereoisomers in all ratios.
15. A pharmaceutical composition comprising at least one compound according to claim 1 and one or more excipients andor adjuvants.
16. A pharmaceutical composition comprising at least one compound according to claim 1, and at least one active ingredient in addition to said one compound according to claim 1.
17. A kit consisting of separate packs of a) an effective amount of a compound according to claim 1, and b) an effective amount of an active ingredient in addition to said compound according to claim 1.
18. A process for preparation of a compound according to claim 1, said process comprising:
reacting a compound of formula II
with a compound of formula III