1. A compound of formula (I):
or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein:
R1 is selected from \u2014COOH or \u2014C(\u2550O)NHSO2R12;
R2 is H or C1-6 alkyl;
R4 is H, C1-4 alkyl, C1-4 alkoxy, or aryl wherein the C1-4 alkyl, C1-4 alkoxy and aryl may be optionally substituted with one or more R4a’s;
R4a is independently \u2014OH, C1-4 alkoxy, \u2014NHC(\u2550O)C1-6 alkyl, aryl, or aryloxy;
R6 is selected from H, \u2014OH or C1-4 alkyl;
R12 is C1-6 alkyl, haloC1-6 alkyl or aryl;
T is H, C1-4 alkyl, haloC1-4 alkyl, C1-4 alkoxy, or halo;
W is H, C1-4 alkyl, haloC1-4 alkyl, halo or aryl;
X is H, C1-4 alkyl, C1-4 alkoxy, or halo;
Y is H, C1-4 alkyl, haloC1-4 alkyl, C1-4 alkoxy, halo or aryl;
Z is selected from H, Cl, C1-2 alkyl and C1-2 alkoxy;
or alternatively any two adjacent T, W, X, Y and Z can be taken together to form a fused cycloalkyl, heteroaryl, heterocyclyl ring, which may be optionally substitute with one or more R4a’s;
provided that:
(1) R2, R4, T, W, X, Y and Z are not all H;
(2) X is not propyl or t-butyl when R2, T, W, X, Y and Z are H and R4 and R6 are methyl;
(3) R4 is not methyl or phenyl, when R2, T, Y and Z are H, R6 is methyl, and X and W are both chloro;
(4) W and Y are not both aryl; or
(5) the compound is not
2. The compound of claim 1, wherein the compound is a compound of formula (Ia):
3. The compound of claim 1, wherein:
R1 is selected from \u2014COOH or \u2014C(\u2550O)NHSO2R12;
R2 is H or C1-2 alkyl;
R4 is H, C1-2 alkyl, C1-2 alkoxy, or aryl wherein the C1-2 alkyl, C1-2 alkoxy and aryl may be optionally substituted with one or more R4a’s;
R4a is independently \u2014OH, C1-4 alkoxy, \u2014NHC(\u2550O)C1-6 alkyl, aryl, or aryloxy;
R6 is selected from H, \u2014OH or C1-2 alkyl;
R12 is C1-2 alkyl, haloC1-6 alkyl or phenyl;
T is H, C1-2 alkyl, haloC1-2 alkyl, or C1-2 alkoxy;
W is H, C1-2 alkyl, haloC1-2 alkyl, halo or aryl;
X is H, C1-2 alkyl, C1-2 alkoxy, or halo;
Y is H, C1-2 alkyl, haloC1-2 alkyl, halo or aryl;
Z is H;
or alternatively any two T, W, X, and Y can be taken together to form a fused cycloalkyl, heteroaryl, heterocyclyl ring, which may be optionally substitute with one or more R4a’s.
4. The compound of claim 1, wherein:
R1 is selected from \u2014COOH or \u2014C(\u2550O)NHSO2R12;
R2 is H or C1-2 alkyl;
R4 is H or C1-2 alkyl, wherein the C1-2 alkyl may be optionally substituted with one or more R4a’s;
R4a is independently \u2014OH, C1-4 alkoxy, aryl, \u2014NHC(\u2550O)C1-6 alkyl or aryloxy;
R6 is selected from H or C1-2 alkyl;
R12 is C1-2 alkyl, haloC1-2 alkyl or phenyl;
T is H, C1-2 alkyl, haloC1-2 alkyl, or C1-2 alkoxy;
W is H, C1-2 alkyl, haloC1-2 alkyl, halo or aryl;
X is H, C1-2 alkyl, C1-2 alkoxy, or halo;
Y is H, C1-2 alkyl, haloC1-2 alkyl, halo or aryl;
Z is H;
or alternatively any two T, W, X, and Y can be taken together to form a fused cycloalkyl, heteroaryl, heterocyclyl ring, which may be optionally substitute with one or more R4a’s.
5. The compound of claim 1, wherein:
R1 is selected from \u2014COOH or \u2014C(\u2550O)NHSO2R12;
R2 is H or C1-2 alkyl;
R4 is H or C1-2 alkyl;
R6 is C1-2 alkyl;
R12 is C1-2 alkyl, haloC1-2 alkyl or phenyl;
T is H, C1-2 alkyl, haloC1-2 alkyl, or C1-2 alkoxy;
W is H, C1-2 alkyl, haloC1-2 alkyl, halo or aryl;
X is H, C1-2 alkyl, C1-2 alkoxy, or halo;
Y is H, C1-2 alkyl, haloC1-2 alkyl, halo or aryl;
Z is H;
or alternatively any two T, W, X, and Y can be taken together to form a fused cycloalkyl, heteroaryl, heterocyclyl ring.
6. The compound of claim 1, wherein:
R1 is selected from \u2014COOH or \u2014C(\u2550O)NHSO2R12;
R2 is H or methyl;
R4 is H or methyl;
R6 is methyl;
R12 is C1-2 alkyl, haloC1-2 alkyl or phenyl;
T is H, C1-2 alkyl, haloC1-2 alkyl, or C1-2 alkoxy;
W is H, C1-2 alkyl, haloC1-2 alkyl, halo or aryl;
X is H, C1-4 alkyl, C1-4 alkoxy, or halo;
Y is H, C1-2 alkyl, haloC1-4 alkyl, halo or aryl;
Z is H;
or alternatively any two T, W, X, and Y can be taken together to form a fused cycloalkyl, heteroaryl, heterocyclyl ring.
7. The compound of claim 1, wherein:
R1 is \u2014COOH;
R2 is H or methyl;
R4 is H or methyl;
R6 is methyl;
T is H, methyl, \u2014CF3, or methoxy;
W is H, methyl, \u2014CF3, Cl, F or phenyl;
X is H, C1-2 alkyl, or halo;
Y is H, C1-2 alkyl, haloC1-4 alkyl, or halo;
Z is H;
or alternatively any two T, W, X, and Y can be taken together to form a fused cycloalkyl, heteroaryl, heterocyclyl ring.
8. The compound of claim 1, wherein:
Rl is \u2014COOH;
R2 is H or methyl;
R4 is H or methyl;
R6 is methyl;
T is H, methyl, \u2014CF3, or methoxy;
W is H, methyl, \u2014CF3, Cl, F or phenyl;
X is H, methyl, Cl, or F;
Y is H, methyl, CF3, Cl, F;
Z is H;
or alternatively any two T, W, X, and Y can be taken together to form a fused cycloalkyl, heteroaryl, heterocyclyl ring.
9. A compound or a stereoisomer or pharmaceutically acceptable salt thereof, wherein the compound is selected from:
6-(3,4-dichlorophenyl)-6-methylcyclohex-1-enecarboxylic acid,
6-(4-chlorophenyl)-6-methylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-6-(3-phenylphenyl)-4,6-dimethylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-6-(3-chloro-4-methylphenyl)-4,6-dimethylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-6-(3,4-difluorophenyl)-4,6-dimethylcyclohex-1-enecarboxylic acid,
6-(2-methoxyphenyl)-6-methyl methylcyclohex-1-enecarboxylic acid,
6-(3,4-dimethylphenyl)-6-methylcyclohex-1-enecarboxylic acid,
6-(3-chlorophenyl)-6-methylcyclohex-1-enecarboxylic acid,
6-methyl-6-(3-(trifluoromethyl)-phenyl)cyclohex-1-enecarboxylic acid,
(4RS,6RS)-4,6-dimethyl-6-(3-(trifluoro-methyl)phenyl)cyclohex-1-enecarboxylic acid,
(4RS,6RS)-6-(4-chloro-3-(trifluoromethyl)-phenyl)-4,6-dimethylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-6-(3,5-bis(trifluoromethyl)-phenyl)-4,6-dimethylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-6-(3,4-dimethylphenyl)-4,6-dimethylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-4,6-dimethyl-6-(napthalen-1-yl)cyclohex-1-enecarboxylic acid,
(4RS,6RS)-4,6-dimethyl-6-p-tolylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-4,6-dimethyl-6-m-tolylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-6-(2,3-dimethylphenyl)-4,6-dimethylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-4,6-dimethyl-6-(naphthalen-2-yl)cyclohex-1-enecarboxylic acid,
(4RS,6RS)-6-(4-chlorophenyl)-4,6-dimethylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-6-(4-fluorophenyl)-4,6-dimethylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-6-(3-fluorophenyl)-4,6-dimethylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-6-(4-fluoro-3-methylphenyl)-4,6-dimethylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-6-(2,5-dimethylphenyl)-4,6-dimethylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-6-(4-chloro-3,5-dimethylphenyl)-4,6-dimethylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-4,6-dimethyl-6-(4-methyl-naphthalen-l-yl)cyclohex-1-enecarboxylic acid,
(4RS,6RS)-6-(3,5-dimethylphenyl)-4,6-dimethylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-6-(3,5-dichlorophenyl)-4,6-dimethylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-6-(3,4-dichlorophenyl)-4,6-dimethyl-N-(methylsulfonyl)cyclohex-1-enecarboxamide,
(4RS,6RS)-6-(3,4-dichlorophenyl)-4,6-dimethyl-N-(trifluoromethylsulfonyl)-cyclohex-1-enecarboxamide,
(4RS,6RS)-6-(3,4-dichlorophenyl)-4,6-dimethyl-N-(phenylsulfonyl)cyclohex-1-enecarboxamide,
(4S,6S)-6-(4-chloro-3-(trifluoromethyl)-phenyl)-4,6-dimethylcyclohex-1-enecarboxylic acid,
(4R,6R)-6-(4-chloro-3-(trifluoromethyl)phenyl)-4,6-dimethylcyclohex-1-enecarboxylic acid,
(4RS,6SR)-6-(3,4-dichlorophenyl)-6-hydroxy-2,4,-dimethylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-6-(3,4-dichlorophenyl)-2,4,6-trimethylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-6-(4-chloro-3-(trifluoromethyl)-phenyl)-4-(hydroxymethyl)-6-methylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-6-(4-chloro-3-(trifluoromethyl)-phenyl)-4-(hydroxymethyl)-6-methylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-4-(tert-butoxymethyl)-6-(4-chloro-3-(trifluoromethyl)phenyl)-6-methylcyclohex-1-enecarboxylic acid,
(4RS,6RS)-4-(acetamidomethyl)-6-(4-chloro-3-(trifluoromethyl)phenyl)-6-methylcyclohex-1-enecarboxylic acid, and
(4RS,6RS)-4-(benzyloxy)-6-(4-chloro-3-(trifluoromethyl)phenyl)-6-methylcyclohex-1-enecarboxylic acid.
10. A pharmaceutical composition comprised of a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 1.
11. A pharmaceutical composition comprised of a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 3.
12. A pharmaceutical composition comprised of a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 4.
13. A pharmaceutical composition comprised of a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 5.
14. A pharmaceutical composition comprised of a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 6.
15. A pharmaceutical composition comprised of a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 8.
16. A pharmaceutical composition comprised of a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 9.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A lens module comprising:
a barrel comprising a first cylindrical part and a first threaded part connected to the first cylindrical part in an order from an image side to an object side, the first threaded part comprising a plurality of external threads, the barrel further comprising a bottom surface facing the image side;
a holder comprising a second cylindrical part and a second threaded part connected to the second cylindrical part in an order from the image side to the object side, the second threaded part comprising a plurality of internal threads, the second cylindrical part comprising a collar protruding from the inner cylindrical surface, the collar comprising a top surface facing the object side, the barrel being coupled to the holder through clearance fit engagement between the internal threads and the external threads; and
an elastic member sandwiched between the bottom surface of the barrel and the top surface of the collar, the elastic member being configured for exerting a first elastic force to the barrel and a second elastic force to the holder so that the barrel is secured to the holder.
2. The lens module of claim 1, wherein the holder comprising a central axis, and the first and second elastic forces are in a direction parallel to the central axis of the holder.
3. The lens module of claim 1, wherein the inner cylindrical surface of the second cylindrical part is in contact with the outer cylindrical surface of the first cylindrical part.
4. The lens module of claim 1, wherein an outer diameter of the first cylindrical part is less than that of the external threads, and an inner diameter of the second cylindrical part is larger than an outer diameter of the internal threads.
5. The lens module of claim 1, wherein the elastic member is ring-shaped.
6. The lens module of claim 5, wherein the elastic member comprises a ring-shaped part and a plurality of elongated spring tabs stamped out from the ring-shaped part, one end of each spring tab is connected to the ring-shaped part, and another end of each spring tab is curved in a direction away from the ring-shaped part, thus forming a free end.
7. The lens module of claim 1, wherein the first elastic force is substantially perpendicular to the bottom surface of the barrel, and the second elastic force is substantially perpendicular to the top surface of the collar.
8. The lens module of claim 1, wherein the first and the second elastic forces are in reverse directions.
9. The lens module of claim 1, wherein the first threaded part consists of 2-3 external threads.
10. The lens module of claim 1, wherein the second threaded part consists of 2-3 internal threads.