Author: claimsbot

1. A golf club pointing aid for attachment to golf club shaft, comprising:
a pair of mating block sections that form a main body assembly;
a thumb screw combination for gripping and tightening said pair of mating blocks using a tension spring located between said pair of mating block sections; and
an adjustable pointer attached to said mating block sections wherein said adjustable pointer is located to be centered over the \u201csweet spot\u201d of the putter and at an adjustable angle to the putter face.
2. The golf club pointing aid according to claim 1, wherein said pair of blocks further defining a pair of passageways providing appropriate threaded communication means said thumb screw combination.
3. The golf club pointing aid according to claim 1, wherein loosening or tightening said thumb screw combination allows the golf aid to be positioned anywhere along the length of the club shaft.
4. The golf club pointing aid according to claim 1, wherein said adjustable pointer is formed by two sections of bars which are screwed together using a pair of washers.
5. The golf club pointing aid according to claim 1, wherein a pointer holder defining an aperture in which said adjustable pointer is assembled and located.
6. The golf club pointing aid according to claim 1, wherein said pointer runs parallel along a side of said block assembly.
7. The golf club pointing aid according to claim 1, wherein a pointer bar assembly is gripped by an annular passageway defined by a groove in one of said block sections for holding and aligning said pointer.
8. The golf club pointing aid according to claim 1, wherein said pointer bar is rotatably and axially adjusted in relation to by sliding along an annular grooved passageway so that the length of said pointer bar is properly positioned over the club head
9. The golf club pointing aid according to claim 1, wherein the golfer lines up said pointer with the center of gravity or \u201csweet spot\u201d of the clubface.
10. A golfing aid that attaches to a club shaft using clamping means and is adjustable in two (2) areas for aligning a club shaft and head for proper striking of a golf ball.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A phenothiazine conjugate comprising a phenothiazine attached to a group that is either a bulky group of greater than 200 daltons or a charged group of less than 200 daltons, wherein said phenothiazine conjugate has anti-proliferative activity in vivo and either enhanced activity in a neoplasm or reduced activity in the central nervous system in comparison to said phenothiazine without said group.
2. The phenothiazine conjugate of claim 1, wherein said phenothiazine is covalently attached via a linker to said group.
3. The phenothiazine conjugate of claim 2 having formula (I):
wherein
R2 is selected from the group consisting of: CF3, halogen, OCH3, COCH3, CN, OCF3, COCH2CH3, CO(CH2)2CH3, S(O)2CH3, S(O)2N(CH3)2, and SCH2CH3;
A1 is selected from the group consisting of G1,
each of R1, R3, R4, R5R6, R7, and R8 is independently H, OH, F, OCF3, or OCH3;
R32, R33, R34, and R35, are each, independently, selected from H or C1-6 alkyl;
W is selected from the group consisting of: NO,
G1 is a bond between the phenothiazine and the linker.
4. The phenothiazine conjugate of claim 3, wherein said linker is described by formula (II):
G1-(Z1)o(Y1)u(Z2)s-(R9)-(Z3)t-(Y2)(Z4)p-G2\u2003\u2003(II)

wherein
G1 is a bond between said phenothiazine and said linker;
G2 is a bond between said linker and said bulky group or between said linker and said charged group;
Z1, Z2, Z3, and Z4 each, independently, is selected from O, S, and NR39;
R39 is hydrogen or a C1-6 alkyl group;
Y1 and Y2 are each, independently, selected from carbonyl, thiocarbonyl, sulphonyl, or phosphoryl;
o, p, s, t, u, and v are each, independently, 0 or 1; and
R9 is C1-10 alkyl, C1-10 heteroalkyl, C2-10 alkenyl, a C2-10 alkynyl, C5-10 aryl, a cyclic system of 3 to 10 atoms, or a chemical bond linking G1-(Z1)o-(Y1)u-(Z2)s- to -(Z3)t-(Y2)v-(Z4)p-G2.
5. The phenothiazine conjugate of claim 1, wherein said bulky group comprises a naturally occurring polymer or a synthetic polymer.
6. The phenothiazine conjugate of claim 5, wherein said naturally occurring polymer is a glycoprotein, a polypeptide, or a polysaccharide.
7. The phenothiazine conjugate of claim 5, wherein said bulky group comprises hyaluronic acid or alpha-1-acid glycoprotein.
8. The phenothiazine conjugate of claim 5, wherein said synthetic polymer is a polyethylene glycol or N-hxg.
9. The phenothiazine conjugate of claim 1, wherein said charged group is a polyanion comprising at least three negatively charged moieties.
10. The phenothiazine conjugate of claim 1, wherein said charged group is a polycation comprising at least three positively charged moieties.
11. The phenothiazine conjugate of claim 1, wherein said bulky group comprises a compound of formula (III):
wherein B1 is
wherein
each of X and Y is, independently, O, NR19, or S,
each of R14 and R19 is, independently, H, C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, C2-6 heterocyclyl, C6-12 aryl, C7-14 alkaryl, C3-0 alkheterocyclyl, or C1-7 heteroalkyl, each of R15, R16, R7, and R18 is, independently, H, halogen, C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, C2-6 heterocyclyl, C6-12 aryl, C7-14 alkaryl, C3-10 alkheterocyclyl, alkoxy, arlyoxy, or C1-7 heteroalkyl,
p is an integer between 2 and 6, inclusive,
each of m and n is, independently, an integer between 0 and 2, inclusive,
each of R10 and R11 is
wherein R21 is H, C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, C2-6 heterocyclyl, C6-12 aryl, C7-14 alkaryl, C3-10 alkheterocyclyl, acyl, or C1-7 heteroalkyl, R20 is H, OH, or acyl, or R20 and R21 together represent
wherein each of R23, R24, and R25 is, independently, H, halogen, trifluoromethyl, C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, C2-6 heterocyclyl, C6-12 aryl, C7-14 alkaryl, C3-10 alkheterocyclyl, alkoxy, arlyoxy, or C1-7 heteroalkyl, each of R26, R27, R28, and R29 is, independently, H, C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, C2-6 heterocyclyl, C6-12 aryl, C7-14 alkaryl, C3-10 alkheterocyclyl, or C1-7 heteroalkyl, and R30 is H, halogen, trifluoromethyl, OCF3, NO2, C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, C2-6 heterocyclyl, C6-12 aryl, C7-14 alkaryl, C3-10 alkheterocyclyl, alkoxy, arlyoxy, or C1-7 heteroalkyl,
each of R12 and R13 is, independently, H, Cl, Br, OH, OCH3, OCF3, NO2, and NH2, or R12 and R13 together form a single bond; and G2 is a bond between the compound of formula (III) and the linker.
12. A liposomal composition comprising a phenothiazine conjugate of any of claims 1-11.
13. The liposomal composition of claims 12, further comprising an antiproliferative agent.
14. A liposomal composition comprising:
(a) a compound of formula (IV):
or a pharmaceutically acceptable salt thereof,
wherein
R42 is selected from the group consisting of: CF3, halogen, OCH3, COCH3, CN, OCF3, COCH2CH3, CO(CH2)2CH3, S(O)2CH3, S(O)2N(CH3)2, and SCH2CH3;
R49 is selected from the group consisting of:
each of R41, R43, R44 R45, R46, R47, and R48 is independently H, OH, F, OCF3, or OCH3; and W is selected from the group consisting of: NO,
(b) an antiproliferative agent,
wherein said compound of formula (IV) and antiproliferative agent are each present in amounts that together are sufficient to treat or inhibit the development of a neoplasm in a patient.
15. The liposomal composition of claim 14, wherein said compound of formula (IV) is selected from acepromazine, chlorpromazine, cyamemazine, fluphenazine, mepazine, methotrimeprazine, methoxypromazine, perazine, perphenazine, prochlorperazine, promethazine, propiomazine, thiethylperazine, thiopropazate, thioridazine, trifluoperazine, and triflupromazine.
16. The liposomal composition of any of claims 13-15, wherein said antiproliferative agent is a compound of formula (V):
or a pharmaceutically acceptable salt thereof,
wherein B2 is
wherein
each of X and Y is, independently, O, NR59, or S,
each of R54 and R59 is, independently, H, C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, C2-6 heterocyclyl, C6-12 aryl, C7-14 alkaryl, C3-10 alkheterocyclyl, or C1-7 heteroalkyl, each of R55, R56, R57, and R58 is, independently, H, halogen, C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, C2-6 heterocyclyl, C6-12 aryl, C7-14 alkaryl, C3-10 alkheterocyclyl, alkoxy, arlyoxy, or C1-7 heteroalkyl,
p is an integer between 2 and 6, inclusive,
each of m and n is, independently, an integer between 0 and 2, inclusive,
each of R50 and R51 is
wherein R61 is H, C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, C2-6 heterocyclyl, C6-12 aryl, C7-14 alkaryl, C3-10 alkheterocyclyl, acyl, or C1-7 heteroalkyl, R62 is H, C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, C2-6 heterocyclyl, C6-12 aryl, C7-14 alkaryl, C3-10 alkheterocyclyl, acyl; alkoxy, aryloxy, or C1-7 heteroalkyl, and R60 is H, OH, or acyl, or R60 and R61 together represent
wherein each of R63, R64, and R65 is, independently, H, halogen, trifluoromethyl, C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, C2-6 heterocyclyl, C6-12 aryl, C7-14 alkaryl, C3-10 alkheterocyclyl, alkoxy, arlyoxy, or C1-7 heteroalkyl, each of R66, R67, R68, and R69 is, independently, H, C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, C2-6 heterocyclyl, C6-12 aryl, C7-14 alkaryl, C3-10 alkheterocyclyl, or C1-7 heteroalkyl, and R30 is H, halogen, trifluoromethyl, OCF3, NO2, C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, C2-6 heterocyclyl, C6-12 aryl, C7-14 alkaryl, C3-10 alkheterocyclyl, alkoxy, arlyoxy, or C1-7 heteroalkyl,
each of R52 and R53 is, independently, H, Cl, Br, OH, OCH3, OCF3, NO2, and NH2, or R52 and R53 together form a single bond.
17. The liposomal composition of claim 16, wherein said compound of formula (V) is selected from pentamidine, propamidine, butamidine, heptamidine, nonamidine, stilbamidine, hydroxystilbamidine, diminazene, dibrompropamidine, 2,5-bis(4-amidinophenyl)furan, 2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime, 2,5-bis(4-amidinophenyl)furan-bis-O-4-fluorophenyl, 2,5-bis(4-amidinophenyl)furan-bis-O-4-methoxyphenyl, 2,4-bis(4-amidinophenyl)furan, 2,4-bis(4-amidinophenyl)furan-bis-O-methylamidoxime, 2,4-bis(4-amidinophenyl)furan-bis-O-4-fluorophenyl, 2,4-bis(4-amidinophenyl)furan-bis-O-4-methoxyphenyl, 2,5-bis(4-amidinophenyl) thiophene, 2,5-bis(4-amidinophenyl) thiophene-bis-O-methylamidoxime, 2,4-bis(4-amidinophenyl)thiophene, and 2,4-bis(4-amidinophenyl)thiophene-bis-O-methylamidoxime.
18. The liposomal composition of claim 17, wherein said compound of formula (IV) is chlorpromazine, perphenazine or promethazine and said compound of formula (V) is pentamidine, 2,5-bis(4-amidinophenyl)furan, or 2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime.
19. A liposomal composition comprising:
a) a first compound selected from acepromazine, chlorfenethazine, chlorpromazine, cyamemazine, fluphenazine, mepazine, methotrimeprazine, methoxypromazine, norchlorpromazine, perazine, perphenazine, prochlorperazine, promethazine, propiomazine, putaperazine, thiethylperazine, thiopropazate, thioridazine, trifluoperazine, and triflupromazine, or a pharmaceutically acceptable salt thereof, and
b) a second compound selected from pentamidine, propamidine, butamidine, heptamidine, nonamidine, stilbamidine, hydroxystilbamidine, diminazene, benzamidine, phenamidine, dibrompropamidine, 1,3-bis(4-amidino-2-methoxyphenoxy)propane, netropsin, distamycin, phenamidine, amicarbalide, bleomycin, actinomycin, daunorubicin, 1,3-bis(4-amidino-2-methoxyphenoxy) propane, phenamidine, amicarbalide, 1,5-bis(4\u2032-(N-hydroxyamidino)phenoxy)pentane, 1,3-bis(4\u2032-(N-hydroxyamidino)phenoxy)propane, 1,3-bis(2\u2032-methoxy-4\u2032-(N-hydroxyamidino)phenoxy)propane, 1,4-bis(4\u2032-(N-hydroxyamidino)phenoxy)butane, 1,5-bis(4\u2032-(N-hydroxyamidino)phenoxy)pentane, 1,4-bis(4\u2032-(N-hydroxyamidino)phenoxy)butane, 1,3-bis(4\u2032-(4-hydroxyamidino)phenoxy)propane, 1,3-bis(2\u2032-methoxy-4\u2032-(N-hydroxyamidino)phenoxy)propane, 2,5-bis4-amidinophenylfuran, 2,5-bis4-amidinophenylfuran-bis-amidoxime, 2,5-bis4-amidinophenylfuran-bis-O-methylamidoxime, 2,5-bis4-amidinophenylfuran-bis-O-ethylamidoxime, 2,5-bis(4-amidinophenyl)furan-bis-O-4-fluorophenyl, 2,5-bis(4-amidinophenyl)furan-bis-O-4-methoxyphenyl, 2,4-bis(4-amidinophenyl)furan, 2,4-bis(4-amidinophenyl)furan-bis-O-methylamidoxime, 2,4-bis(4-amidinophenyl)furan-bis-O-4-fluorophenyl, 2,4-bis(4-amidinophenyl)furan-bis-O-4-methoxyphenyl, 2,5-bis(4-amidinophenyl) thiophene, 2,5-bis(4-amidinophenyl) thiophene-bis-O-methylamidoxime, 2,4-bis(4-amidinophenyl)thiophene, 2,4-bis(4-amidinophenyl)thiophene-bis-O-methylamidoxime, 2,8-diamidinodibenzothiophene, 2,8-bis(N-isopropylamidino)carbazole, 2,8-bis(N-hydroxyamidino)carbazole, 2,8-bis(2-imidazolinyl)dibenzothiophene, 2,8-bis(2-imidazolinyl)-5,5-dioxodibenzothiophene, 3,7-diamidinodibenzothiophene, 3,7-bis(N-isopropylamidino)dibenzothiophene, 3,7-bis(N-hydroxyamidino)dibenzothiophene, 3,7-diaminodibenzothiophene, 3,7-dibromodibenzothiophene, 3,7-dicyanodibenzothiophene, 2,8-diamidinodibenzofuran, 2,8-di(2-imidazolinyl)dibenzofuran, 2,8-di(N-isopropylamidino)dibenzofuran, 2,8-di(N-hydroxylamidino)dibenzofuran, 3,7-di(2-imidazolinyl)dibenzofuran, 3,7-di(isopropylamidino)dibenzofuran, 3,7-di(N-hydroxylamidino)dibenzofuran, 2,8-dicyanodibenzofuran, 4,4\u2032-dibromo-2,2\u2032-dinitrobiphenyl, 2-methoxy-2\u2032-nitro-4,4\u2032-dibromobiphenyl, 2-methoxy-2\u2032-amino-4,4\u2032-dibromobiphenyl, 3,7-dibromodibenzofuran, 3,7-dicyanodibenzofuran, 2,5-bis(5-amidino-2-benzimidazolyl)pyrrole, 2,5-bis5-(2-imidazolinyl)-2-benzimidazolylpyrrole, 2,6-bis5-(2-imidazolinyl)-2-benzimidazolylpyridine, 1-methyl-2,5-bis(5-amidino-2-benzimidazolyl)pyrrole, 1-methyl-2,5-bis5-(2-imidazolyl)-2-benzimidazolylpyrrole, 1-methyl-2,5-bis5-(1,4,5,6-tetrahydro-2-pyrimidinyl)-2-benzimidazolylpyrrole, 2,6-bis(5-amidino-2-benzimidazoyl)pyridine, 2,6-bis5-(1,4,5,6-tetrahydro-2-pyrimidinyl)-2-benzimidazolylpyridine, 2,5-bis(5-amidino-2-benzimidazolyl)furan, 2,5-bis-5-(2-imidazolinyl)-2-benzimidazolylfuran, 2,5-bis-(5-N-isopropylamidino-2-benzimidazolyl)furan, 2,5-bis-(4-guanylphenyl)furan, 2,5-bis(4-guanylphenyl)-3,4-dimethylfuran, 2,5-bis {p-2-(3,4,5,6-tetrahydropyrimidyl)phenyl}furan, 2,5-bis4-(2-imidazolinyl)phenylfuran, 2,5bis-{4-(2-tetrahydropyrimidinyl)}phenyl-3-(p-tolyloxy)furan, 2,5bis{4-(2-imidazolinyl)}phenyl-3-(p-tolyloxy)furan, 2,5-bis {4-5-(N-2-aminoethylamido)benzimidazol-2-ylphenyl}furan, 2,5-bis4-(3a,4,5,6,7,7a-hexahydro-1H-benzimidazol-2-yl)phenylfuran, 2,5-bis4-(4,5,6,7-tetrahydro-1H-1,3-diazepin-2-yl)phenylfuran, 2,5-bis(4-N,N-dimethylcarboxhydrazidephenyl)furan, 2,5-bis{4-2-(N-2-hydroxyethyl)imidazolinylphenyl}furan, 2,5-bis4-(N-isopropylamidino)phenylfuran, 2,5-bis{4-3-(dimethylaminopropyl)amidinophenyl}furan, 2,5-bis {4-N-(3-aminopropyl)amidinophenyl}furan, 2,5-bis2-(imidzaolinyl)phenyl-3,4-bis(methoxymethyl)furan, 2,5-bis4-N-(dimethylaminoethyl)guanylphenylfuran, 2,5-bis {4-(N-2-hydroxyethyl)guanylphenyl}furan, 2,5-bis4-N-(cyclopropylguanyl)phenylfuran, 2,5-bis4-(N,N-diethylaminopropyl)guanylphenylfuran, 2,5-bis{4-2-(N-ethylimidazolinyl)phenyl}furan, 2,5-bis {4-N-(3-pentylguanyl)}phenylfuran, 2,5-bis4-(2-imidazolinyl)phenyl-3-methoxyfuran, 2,5-bis4-(N-isopropylamidino)phenyl-3-methylfuran, bis5-amidino-2-benzimidazolylmethane, bis5-(2-imidazolyl)-2-benzimidazolylmethane, 1,2-bis5-amidino-2-benzimidazolylethane, 1,2-bis5-(2-imidazolyl)-2-benzimidazolylethane, 1,3-bis5-amidino-2-benzimidazolylpropane, 1,3-bis5-(2-imidazolyl)-2-benzimidazolylpropane, 1,4-bis5-amidino-2-benzimidazolylpropane, 1,4-bis5-(2-imidazolyl)-2-benzimidazolylbutane, 1,8-bis5-amidino-2-benzimidazolyloctane, trans-1,2-bis5-amidino-2-benzimidazolylethene, 1,4-bis5-(2-imidazolyl)-2-benzimidazolyl-1-butene, 1,4-bis5-(2-imidazolyl)-2-benzimidazolyl-2-butene, 1,4-bis5-(2-imidazolyl)-2-benzimidazolyl-1-methylbutane, 1,4-bis5-(2-imidazolyl)-2-benzimidazolyl-2-ethylbutane, 1,4-bis5-(2-imidazolyl)-2-benzimidazolyl-1-methyl-1-butene, 1,4-bis5-(2-imidazolyl)-2-benzimidazolyl-2,3-diethyl-2-butene, 1,4-bis5-(2-imidazolyl)-2-benzimidazolyl-1,3-butadiene, 1,4-bis5-(2-imidazolyl)-2-benzimidazolyl-2-methyl-1,3-butadiene, bis5-(2-pyrimidyl)-2-benzimidazolylmethane, 1,2-bis5-(2-pyrimidyl)-2-benzimidazolylethane, 1,3-bis5-amidino-2-benzimidazolylpropane, 1,3-bis5-(2-pyrimidyl)-2-benzimidazolylpropane, 1,4-bis5-(2-pyrimidyl)-2-benzimidazolylbutane, 1,4-bis5-(2-pyrimidyl)-2-benzimidazolyl-1-butene, 1,4-bis5-(2-pyrimidyl)-2-benzimidazolyl-2-butene, 1,4-bis5-(2-pyrimidyl)-2-benzimidazolyl-1-methylbutane, 1,4-bis5-(2-pyrimidyl)-2-benzimidazolyl-2-ethylbutane, 1,4-bis5-(2-pyrimidyl)-2-benzimidazolyl-1-methyl-1-butene, 1,4-bis5-(2-pyrimidyl)-2-benzimidazolyl-2,3-diethyl-2-butene, 1,4-bis5-(2-pyrimidyl)-2-benzimidazolyl-1,3-butadiene, and 1,4-bis5-(2-pyrimidyl)-2-benzimidazolyl-2-methyl-1,3-butadiene, 2,4-bis(4-guanylphenyl)pyrimidine, 2,4-bis(4-imidazolin-2-yl)pyrimidine, 2,4-bis(tetrahydropyrimidinyl-2-yl)phenylpyrimidine, 2-(4-N-1-propylguanylphenyl)-4-(2-methoxy-4-N-1-propylguanylphenyl)pyrimidine, 4-(N-cyclopentylamidino)-1,2-phenylene diamine, 2,5-bis-2-(5-amidino)benzimidazoylfuran, 2,5-bis2-{5-(2-imidazolino)}benzimidazoylfuran, 2,5-bis2-(5-N-isopropylamidino)benzimidazoylfuran, 2,5-bis2-(5-N-cyclopentylamidino)benzimidazoylfuran, 2,5-bis2-(5-amidino)benzimidazoylpyrrole, 2,5-bis2-{5-(2-imidazolino)}benzimidazoylpyrrole, 2,5-bis2-(5-N-isopropylamidino)benzimidazoylpyrrole, 2,5-bis2-(5-N-cyclopentylamidino)benzimidazoylpyrrole, 1-methyl-2,5-bis2-(5-amidino)benzimidazoylpyrrole, 2,5-bis2-{5-(2-imidazolino)}benzimidazoyl-1-methylpyrrole, 2,5-bis2-(5-N-cyclopentylamidino)benzimidazoyl-1-methylpyrrole, 2,5-bis2-(5-N-isopropylamidino)benzimidazoylthiophene, 2,6-bis2-{5-(2-imidazolino)}benzimidazoylpyridine, 2,6-bis2-(5-amidino)benzimidazoylpyridine, 4,4\u2032-bis2-(5-N-isopropylamidino)benzimidazoyl-1,2-diphenylethane, 4,4\u2032-bis2-(5-N-cyclopentylamidino)benzimidazoyl-2,5-diphenylfuran, 2,5-bis2-(5-amidino)benzimidazoylbenzofuran, 2,5-bis2-(5-N-cyclopentylamidino)benzimidazoylbenzofuran, 2,7-bis2-(5-N-isopropylamidino)benzimidazoylfluorene, 2,5-bis4-(3-(N-morpholinopropyl)carbamoyl)phenylfuran, 2,5-bis4-(2-N,N-dimethylaminoethylcarbamoyl)phenylfuran, 2,5-bis4-(3-N,N-dimethylaminopropylcarbamoyl)phenylfuran, 2,5-bis4-(3-N-methyl-3-N-phenylaminopropylcarbamoyl)phenylfuran, 2,5-bis4-(3-N,N8,N11-trimethylaminopropylcarbamoyl)phenylfuran, 2,5-bis3-amidinophenylfuran, 2,5-bis3-(N-isopropylamidino)amidinophenylfuran, 2,5-bis3(N-(2-dimethylaminoethyl)amidinophenylfuran, 2,5-bis4-(N-2,2,2-trichloroethoxycarbonyl)amidinophenylfuran, 2,5-bis4-(N-thioethylcarbonyl) amidinophenylfuran, 2,5-bis4-(N-benzyloxycarbonyl)amidinophenylfuran, 2,5-bis4-(N-phenoxycarbonyl)amidinophenylfuran, 2,5-bis4-(N-(4-fluoro)-phenoxycarbonyl)amidinophenylfuran, 2,5-bis4-(N-(4-methoxy)phenoxycarbonyl)amidinophenylfuran, 2,5-bis4(1-acetoxyethoxycarbonyl)amidinophenylfuran, and 2,5-bis4-(N-(3-fluoro)phenoxycarbonyl)amidinophenylfuran,
wherein said first compound and said second compound are each present in amounts that together are sufficient to treat or inhibit the development of a neoplasm in said patient.
20. A method for treating a patient who has a neoplasm, or inhibiting the development of a neoplasm in a patient who is at risk for developing a neoplasm by administering to the patient an effective amount of a composition of any of claims 1-19.
21. A method for treating a patient who has a neoplasm, or inhibiting the development of a neoplasm in a patient who is at risk for developing a neoplasm by administering to the patient a phenothiazine conjugate of claim 1 and an antiproliferative agent, wherein each are administered in amounts that together are effective to inhibit the growth of a neoplasm in said patient.
22. The method of claim 21, wherein said phenothiazine conjugate and said antiproliferative agent are administered within thirty days of each other.
23. The method of claim 22, wherein said phenothiazine conjugate and said antiproliferative agent are administered within five days of each other.
24. The method of claim 23, wherein said phenothiazine conjugate and said antiproliferative agent are administered within twenty-four hours of each other.
25. The method of claim 24, wherein said phenothiazine conjugate and said antiproliferative agent are administered simultaneously.
26. The method of claims 20-25, wherein said neoplasm is cancer.
27. The method of claim 26, wherein said cancer is selected from the group consisting of acute leukemia, acute lymphocytic leukemia, acute myelocytic leukemia, acute myeloblastic leukemia, acute promyelocytic leukemia, acute myelomonocytic leukemia, acute monocytic leukemia, acute erythroleukemia, chronic leukemia, chronic myelocytic leukemia, chronic lymphocytic leukemia, polycythemia vera, Hodgkin’s disease, non-Hodgkin’s disease, Waldenstrom’s macroglobulinemia, heavy chain disease, fibrosarcoma, myxosarcoma, liposarcoma, chondrosarcoma, osteogenic sarcoma, chordoma, angiosarcoma, endotheliosarcoma, lymphangiosarcoma, lymphangioendotheliosarcoma, synovioma, mesothelioma, Ewing’s tumor, leiomyosarcoma, rhabdomyosarcoma, colon carcinoma, pancreatic cancer, breast cancer, ovarian cancer, prostate cancer, squamous cell carcinoma, basal cell carcinoma, adenocarcinoma, sweat gland carcinoma, sebaceous gland carcinoma, papillary carcinoma, papillary adenocarcinomas, cystadenocarcinoma, medullary carcinoma, bronchogenic carcinoma, renal cell carcinoma, hepatoma, bile duct carcinoma, choriocarcinoma, seminoma, embryonal carcinoma, Wilm’s tumor, cervical cancer, uterine cancer, testicular cancer, lung carcinoma, small cell lung carcinoma, bladder carcinoma, epithelial carcinoma, glioma, astrocytoma, medulloblastoma, craniopharyngioma, ependymoma, pinealoma, hemangioblastoma, acoustic neuroma, oligodendriglioma, schwannoma, meningioma, melanoma, neuroblastoma, retinoblastoma, gastric cancer, esophageal cancer, head and neck cancer, and thyroid cancer.
28. A method for inhibiting passage across the blood-brain barrier of a phenothiazine, said method comprising covalently attaching a group that is a bulky group of greater than 200 daltons or a charged group of less than 200 daltons, wherein said group increases the size, or alters the charge, of the phenothiazine sufficiently to inhibit passage across the blood-brain barrier without destroying the antiproliferative activity of said phenothiazine.
29. A method for reducing the CNS activity of phenothiazine, said method comprising covalently attaching a group that is a bulky group of greater than 200 daltons or a charged group of less than 200 daltons, wherein said group increases the size, or alters the charge, of the phenothiazine sufficiently to reduce the CNS activity.

1. In a communications receiver having a decision feedback equalizer filter, the communications receiver responsive to a received signal that is over-sampled with respect to a symbol rate, an apparatus comprising:
a forward filter that receives the over-sampled signal and is adaptive based on a first feedback signal;
a first adder that sums an output of the forward filter with a second feedback signal to produce a new over-sampled signal;
a de-interleaver, clocked at an over-sampling rate associated with the over-sampled signal, that receives the new over-sampled signal;
a slicer, coupled to the de-interleaver, for quantizing on-baud samples from the new over-sampled signal;
an estimator, coupled to receive off-baud samples from the de-interleaver and receive the guantized samples from the slicer, for calculating approximate mid-level voltages for off-baud samples from the new over-sampled signal; an error term calculator, coupled to receive the on-baud samples and the quantized samples from the new over-sampled signal, for calculating the first feedback signal;
an interleaver, clocked at the over-sampling rate, and coupled to the de-interleaver, wherein the interleaver receives the quantized samples and receives off-baud samples from the new over-sampled signal; and
a feedback filter coupled to receive an output signal from the interleaver and to produce the second feedback signal for the first adder, wherein the feedback filter is adaptive based on the first feedback signal from the error term calculator.
2. In a communications receiver having a decision feedback equalizer filter, the communications receiver responsive to a received signal that is over-sampled with respect to a symbol rate, an apparatus comprising:
a forward filter that receives the over-sampled signal and is adaptive based on a first feedback signal;
a first adder that sums an output of the forward filter with a second feedback signal to produce a new over-sampled signal;
a de-interleaver, clocked at an over-sampling rate associated with the over- sampled signal, that receives the new over-sampled signal;
a slicer, coupled to the de-interleaver, for quantizing on-baud samples from the new over-sampled signal;
an error term calculator, coupled to receive the on-baud samples and the quantized samples from the new over-sampled signal, for calculating the first feedback signal;
an interleaver, clocked at the over-sampling rate, and coupled to the de-interleaver, wherein the interleaver receives the quantized samples and receives off-baud samples from the new over-sampled signal; and
a feedback filter coupled to receive an output signal from the interleaver and to produce the second feedback signal for the first adder, wherein the feedback filter is adaptive based on the first feedback signal from the error term calculator;
a first multiplier, coupled to the de-interleaver, for multiplying the on-baud samples from the new over-sampled signal with a first error term from the error term calculator;
a second multiplier, coupled to the slicer, for multiplying the quantized samples from the new over-sampled signal with a second error term from the error term calculator;
a third multiplier, coupled to the de-interleaver, for multiplying the on-baud samples from the new over-sampled signal with a third error term from the error term calculator;
a fourth multiplier, coupled to an output of the second multiplier, for multiplying the quantized samples from the new over-sampled signal with a fourth error term from the error term calculator; and
a second adder for summing outputs from the third and fourth multipliers to produce an input signal to the interleaver.
3. In a communications receiver having a decision feedback equalizer filter, the communications receiver responsive to a received signal that is over-sampled with respect to a symbol rate, an apparatus comprising:
a forward filter that receives the over-sampled signal and is adaptive based on a first feedback signal;
a first adder that sums an output of the forward filter with a second feedback signal to produce a new over-sampled signal;
a de-interleaver, clocked at an over-sampling rate associated with the over-sampled signal, that receives the new over-sampled signal;
a slicer, coupled to the de-interleaver, for quantizing on-baud samples from the new over-sampled signal;
an error term calculator, coupled to receive the on-baud samples and the quantized samples from the new over-sampled signal, for calculating the first feedback signal;
an interleaver, clocked at the over-sampling rate, and coupled to the de-interleaver, wherein the interleaver receives the quantized samples and receives off-baud samples from the new over-sampled signal; and
a feedback filter coupled to receive an output signal from the interleaver and to produce the second feedback signal for the first adder, wherein the feedback filter is adaptive based on the first feedback signal from the error term calculator;
a first multiplier, coupled to the de-interleaver, for multiplying the on-baud samples from the new over-sampled signal with a first error term from the error term calculator;
a second multiplier, coupled to the slicer, for multiplying the quantized samples from the new over-sampled signal with a second error term from the error term calculator; and
a second adder for summing outputs from the first and second multipliers to produce an input signal to the interleaver.
4. In a communications receiver responsive to a received signal that is over-sampled with respect to a symbol rate of the received signal, an apparatus for at least combating inter-symbol interference (ISI) in the received signal, the apparatus comprising:
a decision feedback equalizer, wherein the decision feedback equalizer includes:
an error term calculator that determines error values based on the over-sampled signal; a slicer for quantizing samples in a feedback signal that are on-baud;
an estimator configured to estimate quantized samples from the received signal when the received signal includes symbols that are off-baud with respect to an ideal symbol rate for the received signal;
a fractionally-spaced forward, transversal filter that processes the over-sampled signal, wherein the fractionally-spaced forward, transversal filter is adaptive based on the error values produced by the error term calculator; and
a fractionally-spaced feedback filter that processes the over-sampled signal, wherein the fractionally-spaced feedback filter is coupled to the fractionally-spaced forward, transversal filter, and is adaptive based on the error values produced by the error term calculator.
5. The apparatus of claim 4, wherein the apparatus employs samples in the feedback signal that are off-baud under a linear, infinite impulse response (IIR) filter.
6. The apparatus of claim 4 wherein the fractionally-spaced forward, transversal filter and fractionally-spaced feedback filter are adaptive only at baud instances.
7. The apparatus of claim 4, further comprising an initializing section configured to generate initial feedback filter coefficients for at least the fractionally-spaced feedback filter.
8. The apparatus of claim 4, further comprising:
a tuner configured to receive a digital television signal;
a front end processor configured to process the digital television signal; and
a decoder for decoding the processed digital television signal.
9. In a communications receiver that receives a signal, a method for at least combating inter-symbol interference (ISI) in the received signal, the method comprising:
receiving an input signal that is over-sampled with respect to a symbol rate of the received signal; and
decision feedback equalizing the over-sampled input signal, wherein the decision feedback equalizing includes:
forward, transversal filtering the over-sampled input signal based on first equalizer coefficients, wherein first equalizer coefficients adjacent in time are less than a symbol interval apart with respect to the received signal;
feedback filtering the over-sampled input signal with second equalizer coefficients, wherein second equalizer coefficients adjacent in time are less than a symbol interval apart with respect to the received signal, calculating error values based on the over-sampled input signal;
adapting the forward, transversal filtering and the feedback filtering based at least in part on the calculated error values; and

wherein the method further comprises quantizing samples in a feedback signal that are on-baud with respect to an ideal symbol rate for the received signal, and wherein the feedback filtering includes infinite impulse response (IIR) filtering employing samples off-baud with respect to the ideal symbol rate for the received signal.
10. The method of claim 9 wherein the adapting is performed only at the symbol rate.
11. The method of claim 9 further comprising estimating quantized samples from the received signal when the received signal includes symbols that are off-rate with respect to an ideal symbol rate for the received signal.
12. The method of claim 9 further comprising initializing at least the feedback filtering.
13. The method of claim 9 further comprising:
tuning to a desired frequency to receive a digital television signal;
front end processing the received digital television signal; and
decoding the processed digital television signal.
14. a communications receiver that receives a signal, a method for at least combating inter-symbol interference (ISI) in the received signal, the method comprising:
receiving an input signal that is over-sampled with respect to a symbol rate of the received signal; and
decision feedback equalizing the over-sampled input signal, wherein the decision feedback equalizing includes:
forward, transversal filtering the over-sampled input signal based on first equalizer coefficients, wherein first equalizer coefficients adjacent in

time are less than a symbol interval apart with respect to the received signal;
feedback filtering the over-sampled input signal with second equalizer coefficients, wherein second equalizer coefficients adjacent in time are less than a symbol interval apart with respect to the received signal,
calculating error values based on the over-sampled input signal;
adapting the forward, transversal filtering and the feedback filtering based at least in part on the calculated error values; wherein the method further comprises quantizing samples in a feedback signal that are on-baud with respect to an ideal symbol rate for the received signal; and
wherein the method further comprises estimating quantized samples from the received signal when the received signal includes symbols that are off-baud with respect to an ideal symbol baud for the received signal.
15. The method of claim 14, wherein the feedback filtering includes infinite impulse response (IIR) filtering employing samples off-baud with respect to the ideal symbol rate for the received signal.
16. The method of claim 14 wherein the adapting is performed only at the symbol rate.
17. The method of claim 14, further comprising initializing at least the feedback filtering.
18. The method of claim 14, further comprising:
tuning to a desired frequency to receive a digital television signal;
front end processing the received digital television signal; and
decoding the processed digital television signal.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A display device, comprising:
a front side with a screen mounted thereon;
a rear side opposite to the front side;
a stand mounted on the rear side, the stand comprising a first supporting piece pivotably connected with the rear side and a second supporting piece inclinedly connected to the first supporting piece; and
a circuit board mounted on the first supporting piece.
2. The display device of claim 1, wherein the first supporting piece defines a plurality of securing holes, the circuit board defines a plurality of through holes, the plurality of through holes are aligned to the plurality of securing holes, and a plurality of fasteners are mounted in the plurality of through holes and the plurality of securing holes to mount the circuit board on the first supporting piece.
3. The display device of claim 1, wherein a cover is mounted on the first supporting piece to shield the circuit board.
4. The display device of claim 3, wherein the cover comprises a shield plate and a pair of side walls inclinedly connected to opposite edges of the shield plate, the shield plate and the pair of side walls together surrounds a receiving space, the pair of side walls is located on the first supporting piece, and the circuit board is received in the receiving space.
5. The display device of claim 4, wherein the receiving space comprises an opening, the circuit board comprises a plurality of connectors, a plurality of cables extends through the opening to connect to the plurality of connectors.
6. The display device of claim 1, wherein a mounting portion is protruded on the rear side, the mounting portion defines a pivot hole, and a shaft is mounted on the first supporting piece and pivotably received in the pivot hole.
7. The display device of claim 6, wherein the first supporting piece defines a first cutout, the mounting portion is received in the first cutout, the first supporting piece comprises a pair of ear pieces, each of the pair of ear pieces defines a fixing hole, and opposite ends of the shaft are inserted in the fixing holes of the pair of ear pieces to fix the shaft on the stand.
8. The display device of claim 7, wherein the first supporting piece comprises two first clips located on opposite sides of the first cutout, a cover comprises two second clips, and the two first clips engage with the second clips.
9. The display device of claim 1, wherein the second supporting piece is mounted with a skid-proof sleeve, and a bottom edge of the display device is mounted with a skid-proof cushion.
10. The display device of claim 1, wherein the screen is a touch screen.
11. A display device, comprising:
a front side comprising a screen;
a rear side opposite to the front side, a stand mounted on the rear side, the stand comprising a first supporting piece and a second supporting piece inclinedly connected to the first supporting piece, the first supporting piece pivotably connected with the rear side;
wherein the stand is configured to support the screen between a first position and a second position; in the first position, the second supporting piece is parallel placed on a work surface, and the rear side is configured to rotate with respect to the first supporting piece; in the second position, the first supporting piece is located on the rear side, an end of the second support piece and an bottom edge of the display device is located on the work surface to support the display device.
12. The display device of claim 11, wherein the end of second supporting piece is mounted with a skid-proof sleeve, and the bottom edge of the display device is mounted with a skid-proof cushion.
13. The display device of claim 11, wherein the screen is a touch screen.
14. The display device of claim 11, wherein a circuit board is mounted on the first supporting piece.
15. The display device of claim 14, wherein a cover is mounted on the first supporting piece to shield the circuit board.
16. The display device of claim 15, wherein the cover comprises a shield plate and a pair of side walls inclinedly connected to opposite edges of the shield plate, the shield plate and the pair of side walls together surrounds a receiving space, the pair of side walls is located on the first supporting piece, and the circuit board is received in the receiving space.
17. The display device of claim 16, wherein the receiving space comprises an opening, the circuit board comprises a plurality of connectors, a plurality of cables extends through the opening to connect to the plurality of connectors.
18. The display device of claim 11, wherein a mounting portion is protruded on the rear side, the mounting portion defines a pivot hole, and a shaft is mounted on the first supporting piece and pivotably mounted in the pivot hole.
19. The display device of claim 18, wherein the first supporting piece defines a first cutout, the mounting portion is received in the first cutout, the first supporting piece comprises a pair of ear pieces, each of the pair of ear pieces defines a fixing hole, and opposite ends of the shaft are inserted in the fixing holes of the pair of ear pieces to fix the shaft on the stand.
20. The display device of claim 19, wherein the first supporting piece comprises two first clips located on opposite sides of the first cutout, a cover comprises two second clips, and the two first clips engage with the second clips.