Author: claimsbot

1. A method for processing an attached command response, the method comprising:
sending, by a user agent node in a first HTTP request to a server node, a first HTTP request-line identifying a first command;
sending, by the user agent node, in a second HTTP request, a second HTTP request-line identifying a second command different from the first command, wherein the second HTTP request is sent separately from the first HTTP request;
receiving, by the user agent node, a second HTTP response to the second HTTP request, the second HTTP response including at least a portion of a second command response to the second command, wherein the user agent node does not receive a complete response to the first HTTP request prior to receiving the second HTTP response; and
determining, by the user agent node, that the second HTTP response includes an attached command response including at least a portion of a first command response to the first command, wherein the attached command response is attached based on attach-request information received from the user agent node.
2. The method of claim 1 further includes receiving, as a response to the first HTTP request, a first HTTP response including at most a portion of the first command response.
3. The method of claim 1 wherein determining that the second HTTP response includes the attached command response includes receiving attach-response information for detecting the attached command response in the second HTTP response.
4. The method of claim 1 further includes receiving no HTTP response as a response for the first HTTP request.
5. The method of claim 1 further comprises:
sending, to the server node, the attach-request information at least one of indicating that the first command response is attachable and indicating that the second HTTP response is attachable.
6. The method of claim 5 wherein the attach-request information identifies at least one of a MIME type and an HTTP method token for indicating that the first command is attachable.
7. A method for processing an attached command response, the method comprising:
receiving, by a server node in a first HTTP request from a user agent node, a first HTTP request-line identifying a first command;
receiving, by a server node in a second HTTP request from the user agent node, a second HTTP request-line identifying a second command different than the first command, wherein the second HTTP request is received separately from the first HTTP request;
receiving, by the server node, attach-request information indicating that at least one of the first command response and a second HTTP response is attachable; and
sending, to the user agent node by a server node in the second HTTP response to the second HTTP request, an attached command response including at least a portion of a first command response to the first command, based on the attach-request information, wherein the second HTTP response includes at least a portion of a second command response to the second command.
8. The method of claim 7 where in determining the first command is attached includes determining the first command is attachable based on determining that the second HTTP response is attachable.
9. The method of claim 7 further includes sending, in a first HTTP response to the first HTTP request, less than the entire first command response, in response to determining the first command response is attachable.
10. The method of claim 9 wherein the first HTTP response includes attach-response information for indicating that the less than the entire first command response is included in the first HTTP response.
11. The method of claim 7 further includes, in response to determining that the first command is attachable sending no HTTP response for the first HTTP request.
12. The method of claim 7 further comprises:
receiving, in a third HTTP request from the user agent node, an HTTP request-line identifying a third command;
determining that a third HTTP response to the third HTTP request is not attachable; and
sending the third HTTP response including, for the third command, a third command response at least partially generated while processing at least one of the first command and the second command, and not including, based on determining the third HTTP response is not attachable, the attached command response.
13. The method of claim 7 wherein receiving the attach-request information includes receiving attach request information from the user agent.
14. The method of claim 13 wherein the attach-request information identifies at least one of a MIME type and an HTTP method token specified for indicating the first command is attachable.
15. The method of claim 13 wherein sending the attached command response includes sending the attached command response in the second HTTP response, in response to determining that the second HTTP response is attachable.
16. The method of claim 15 further includes, in response to receiving the attach-request information, at least one of performing the first command and generating the attached command response.
17. The method of claim 7 wherein sending the attached command response includes sending attach-response information indicating that the second HTTP response includes the attached command response.
18. A system for processing an attached command response, the system comprising:
an execution environment including a hardware processor, wherein an instruction included in at least one of a request-out component, a response-in component, and an attached response component is executed by the hardware processor;
the request-out component configured for sending, by a user agent node in a first HTTP request to a server node, a first HTTP request-line identifying a first command;
the request-out component configured for sending, by the user agent node, in a second HTTP request, a second HTTP request-line identifying a second command different from the first command, wherein the second HTTP request is sent separately from the first HTTP request;
the response-in component configured for receiving, by the user agent node, a second HTTP response to the second HTTP request, the second HTTP response including at least a portion of a second command response to the second command, wherein the user agent node does not receive a complete response to the first HTTP request prior to receiving the second HTTP response; and
the attached response component configured for determining, by the user agent node, that the second HTTP response includes an attached command response including at least a portion of a first command response to the first command, wherein the attached command response is attached based on attach-request information received from the user agent node.
19. A system for processing an attached command response, the system comprising:
an execution environment including a processor, wherein an instruction included in at least one of a request-in component, an attach detector component, and an attach director component is executed by the processor;
the request-in component configured for receiving, by a server node in a first HTTP request from a user agent node, a first HTTP request-line identifying a first command;
the request-in component configured for receiving, by a server node in a second HTTP request from the user agent node, a second HTTP request-line identifying a second command different than the first command, wherein the second HTTP request is received separately from the first HTTP request;
the attach detector component configured for receiving, by the server node and from the user agent node, attach-request information indicating that at least one of the first command response and a second HTTP response is attachable; and
the attach director component configured for sending, to the user agent node by a server node in the second HTTP response to the second HTTP request, an attached command response including at least a portion of a first command response to the first command, based on the attach-request information, wherein the second HTTP response includes at least a portion of a second command response to the second command.
20. A non-transitory computer readable storage medium embodying a computer program, executable by a machine, for processing an attached command response, the computer program comprising executable instructions for:
sending, by a user agent node in a first HTTP request to a server node, a first HTTP request-line identifying a first command;
sending, by the user agent node, in a second HTTP request, a second HTTP request-line identifying a second command different from the first command, wherein the second HTTP request is sent separately from the first HTTP request;
receiving, by the user agent node, a second HTTP response to the second HTTP request, the second HTTP response including at least a portion of a second command response to the second command, wherein the user agent node does not receive a complete response to the first HTTP request prior to receiving the second HTTP response; and
determining, by the user agent node, that the second HTTP response includes an attached command response including at least a portion of a first command response to the first command, wherein the attached command response is attached based on attach-request information received from the user agent node.
21. A non-transitory computer readable storage medium embodying a computer program, executable by a machine, for processing an attached command response, the computer program comprising executable instructions for:
receiving, by a server node in a first HTTP request from a user agent node, a first HTTP request-line identifying a first command;
receiving, by a server node in a second HTTP request from the user agent node, a second HTTP request-line identifying a second command different than the first command, wherein the second HTTP request is received separately from the first HTTP request;
receiving, by the server node, attach-request information indicating that at least one of the first command response and a second HTTP response is attachable; and
sending, to the user agent node by a server node in the second HTTP response to the second HTTP request, an attached command response including at least a portion of a first command response to the first command, based on the attach-request information, wherein the second HTTP response includes at least a portion of a second command response to the second command.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method of mounting a face plate on a female-die that is constructed a stamping machine; and the stamping machine has a male-die that is opposite side of the female-die; and the male-die has a stamp-blade according to outline of a unfolded box body and a rule-blade according to a valley fold-line of the unfolded box body; and the face plate such as a plate or a film sheet that has a groove to accept a projection according a hill fold-line as to be opposed the valley fold-line; and the face plate is stick on the female-die; and the stamping machine stamping out a sheet inserted and making the fold-line on the sheet at once;
wherein the male-die has two or more positioning-holes at a given interval for positioning the face plate, wherein the face plate has two or more through-holes that a one-to-one correspond to the positioning-holes, and two or more marking-members that has an adhesive layer at the back and stick the adhesive layer on the female-die at the through-hole positions used by the positioning-jig that has the marking-member detachably, and further provides a positioning method comprising the following steps; set the positioning-jigs on each positioning-holes and set the marking-members on each positioning-jigs exposed the adhesive layer; and test run the stamping machine to attaches the male-die and the female-die, and adhered the marking-members on the female-die; and adhered the face plate on the female-die for the marking-members inside each through-holes.
2. A method of mounting a face plate on a female-die that is constructed a stamping machine; and the stamping machine has a male-die that is opposite side of the female-die; and the male-die has a stamp-blade according to outline of a unfolded box body and a rule-blade according to a valley fold-line of the unfolded box body; and the face plate such as a plate or a film sheet that has a groove to accept a projection according a hill fold-line as to be opposed the valley fold-line; and the face plate is stick on the female-die; and the stamping machine stamping out a sheet inserted and making the fold-line on the sheet at once;
wherein the male-die has two or more positioning-holes at a given interval for positioning the face plate, wherein the face plate has two or more through-holes that a one-to-one correspond to the positioning-holes, and two or more marking-members that has a magnetic layer at the back and stick the magnetic layer on the female-die via magnetic force themselves at the through-hole positions used by positioning-jig that has the marking-member detachably, and further provides a positioning method comprising the following steps; set the positioning-jigs on each positioning-holes and set the marking-members on each positioning-jigs exposed the magnetic layer; and test run the stamping machine to attaches the male-die and the female-die, and stick the marking-members on the female-die by magnetic force themselves; and adhered the face plate on the female-die for the marking-members inside each through-holes.
3. A positioning-jig used to mount a face plate on the female-die that is constructed a stamping machine; and the stamping machine has a male-die that is opposite side of the female-die; and the male-die has a stamp-blade according to outline of a unfolded box body and a rule-blade according to a valley fold-line of the unfolded box body; and the face plate such as a plate or a film sheet that has a groove to accept a projection according a hill fold-line as to be opposed the valley fold-line; and the face plate is stick on the female-die; and the stamping machine stamping out a sheet inserted and making the fold-line on the sheet at once;
wherein the male-die has two or more positioning-holes at a given interval for positioning the face plate, wherein the face plate has two or more through-holes that a one-to-one correspond to the positioning-holes, and two or more marking-members that has an adhesive layer at the back and stick the adhesive layer on the female-die at the through-hole positions used by the positioning-jig that has the marking-member detachably, and further provides a positioning method comprising the following steps; set the positioning-jigs on each positioning-holes and set the marking-members on each positioning-jigs exposed the adhesive layer; and test run the stamping machine to attaches the male-die and the female-die, and adhered the marking-members on the female-die; and adhered the face plate on the female-die for the marking-members inside each through-holes.
4. A positioning-jig used to mount a face plate on the female-die that is constructed a stamping machine; and the stamping machine has a male-die that is opposite side of the female-die; and the male-die has a stamp-blade according to outline of a unfolded box body and a rule-blade according to a valley fold-line of the unfolded box body; and the face plate such as a plate or a film sheet that has a groove to accept a projection according a hill fold-line as to be opposed the valley fold-line; and the face plate is stick on the female-die; and the stamping machine stamping out a sheet inserted and making the fold-line on the sheet at once;
wherein the male-die has two or more positioning-holes at a given interval for positioning the face plate, wherein the face plate has two or more through-holes that a one-to-one correspond to the positioning-holes, and two or more marking-members that has a magnetic layer at the back and stick the magnetic layer on the female-die via magnetic force themselves at the through-hole positions used by positioning-jig that has the marking-member detachably, and further provides a positioning method comprising the following steps; set the positioning-jigs on each positioning-holes and set the marking-members on each positioning-jigs exposed the magnetic layer; and test run the stamping machine to attaches the male-die and the female-die, and stick the marking-members on the female-die by magnetic force themselves; and adhered the face plate on the female-die for the marking-members inside each through-holes.
5. A positioning-jig according to claim 3, wherein the positioning-jig comprises a female-part which has a concave part and is attached into the positioning-holes at the male-die detachably, a male-part which comprises an axial part inserted detachably into the concave part of the female-part and a dish-shaped head part connected to the axial part, and an elastic body disposed between the female-part and the male-part so as to suppress the marking-members to the female-die with an elastic force.
6. A positioning-jig according to claim 5, wherein the female-part has formed the longitudinal-thin-wall parts on symmetrical positions in a cylindrical inner wall as well as a lateral thin wall part extending from an intermediate part between the longitudinal-thin-wall-parts, and the male-part has formed the locking part which is put in the longitudinal and lateral thin wall parts as well as a concavity and a convexity formed, at a external wall on the head part, for preventing fingers from slipping.

1. An apparatus for treating a perfluoro-compound, which apparatus is to purify an exhaust gas containing a perfluoro-compound, the apparatus comprising:
a pre-cleaner for decomposing the perfluoro-compound and removing a first acid gas produced by the decomposition;
a filter for filtering out dust particles contained in the exhaust gas;
a dust-collector for electrifying the dust particles contained in the exhaust gas by electrical discharge and collecting dusts;
a catalytic reactor for decomposing the perfluoro-compound through a regenerativecatalytic reaction;
a post-cleaner for eliminating a second acid gas generated by the regenerativecatalytic reaction; and
a fan for letting the exhaust gas out,
wherein the pre-cleaner, the filter, the dust-collector, the catalytic reactor, the post-cleaner, and the fan are arranged in series and sequentially put into operation.
2. The apparatus as claimed in claim 1, wherein the pre-cleaner, the filter, the dust-collector, the catalytic reactor, the post-cleaner, and the fan are arranged outside a clean room equipped with devices for performing a semiconductor process.
3. The apparatus as claimed in claim 1, wherein the pre-cleaner comprises first and second pre-treatment wet scrubbers arranged in series,
wherein the first and second pre-treatment wet scrubbers independently comprise:
a housing provided with an inlet opening for the exhaust gas on the bottom end thereof and an outlet opening for the exhaust gas on the top end thereof;
a spray for supplying water into the housing;
a filler member disposed inside the housing for increasing a contact area between the exhaust gas and the water to allow decomposition of the perfluoro-compound contained in the exhaust gas with the water and absorption of the first acid gas by the water; and
a mist removing member arranged on the top of the filler member to remove a mist of the first acid gas.
4. The apparatus as claimed in claim 1, wherein the filter comprises a wet filter made of any one material selected from a fiber-reinforced plastic, a polyvinyl chloride (PVC) resin, a polytetrafluoroethylene (PTFE) resin, Inconel, and S.T.S.
5. The apparatus as claimed in claim 1, wherein the dust-collector comprises first and second electric dust-collectors arranged in parallel between the filter and the catalytic reactor,
wherein the first and second electric dust-collectors independently comprise:
a housing provided with an inlet opening for the exhaust gas on the bottom end thereof and an outlet opening for the exhaust gas on the top end thereof;
a filler member disposed inside the housing;
a plurality of dust-collecting plates having a cylindrical shape with the top and bottom thereof open, and being arranged on the top of the filler member;
a plurality of discharge rods each disposed inside the respective dust-collecting plates; and
a power supply member for applying power to the dust-collecting plates and the discharge rods.
6. The apparatus as claimed in claim 1, wherein the catalytic reactor comprises:
a housing providing an inlet opening and an outlet opening for the exhaust gas;
a catalyst member disposed inside the housing and used to decompose the perfluoro-compound;
a pre-heating member disposed under the catalyst member and used to pre-heat the exhaust gas; and
a heating member disposed over the catalyst member and used to heat the catalyst member to a processing temperature.
7. The apparatus as claimed in claim 1, wherein the post-cleaner comprises first and second post-treatment wet scrubbers arranged in series,
wherein the first post-treatment wet scrubber eliminates the second acid gas using an alkaline solution, the second post-treatment wet scrubber eliminating the alkaline solution and the second acid gas using water.
8. The apparatus as claimed in claim 7, wherein the first post-treatment wet scrubber comprises:
a first housing provided with an inlet opening for the exhaust gas on the bottom end thereof and an outlet opening for the exhaust gas on the top end thereof;
a first spray for supplying the alkaline solution into the first housing;
a first filler member disposed inside the first housing for increasing a contact area between the second acid gas contained in the exhaust gas and the alkaline solution; and
a first mist removing member arranged on the top of the first filler member and used to remove a mist of the second acid gas.
9. The apparatus as claimed in claim 8, wherein the second post-treatment wet scrubber comprises:
a second housing provided with an inlet opening for the exhaust gas on the bottom end thereof and an outlet opening for the exhaust gas on the top end thereof;
a second spray for supplying the water into the second housing;
a second filler member disposed inside the second housing for increasing a contact area between the second acid gas and an alkaline gas contained in the exhaust gas and the water; and
a second mist removing member arranged on the top of the second filler member and used to remove a mist of the second acid gas and the alkaline gas.
10. A method for treating a perfluoro-compound, which method is to purify an exhaust gas containing a perfluoro-compound, the method comprising:
(a) decomposing the perfluoro-compound using water and eliminating a first acid gas generated by the decomposition;
(b) filtering out dust particles from the exhaust gas removed of the first acid gas;
(c) electrifying the filtered dust particles in the exhaust gas by electrical discharge and collecting dusts;
(d) decomposing the perfluoro-compound through a regenerativecatalytic reaction;
(e) eliminating a second acid gas generated by the regenerativecatalytic reaction; and
(f) letting the purified exhaust gas out.
11. The method as claimed in claim 10, wherein the step (a) is repeatedly conducted multiple times.
12. The method as claimed in claim 10, wherein the step (e) comprises:
eliminating the second acid gas using an alkaline solution; and
eliminating an alkaline gas of the alkaline solution and the remainder of the second acid gas using water.
13. The method as claimed in claim 10, wherein the step (d) comprises:
pre-heating the exhaust gas;
supplying water vapor for the pre-heated exhaust gas;
heating a catalyst layer at a processing temperature; and
allowing the catalyst layer to decompose the perfluoro-compound contained in the exhaust gas.
14. The apparatus as claimed in claim 2, wherein the pre-cleaner comprises first and second pre-treatment wet scrubbers arranged in series,
wherein the first and second pre-treatment wet scrubbers independently comprise:
a housing provided with an inlet opening for the exhaust gas on the bottom end thereof and an outlet opening for the exhaust gas on the top end thereof;
a spray for supplying water into the housing;
a filler member disposed inside the housing for increasing a contact area between the exhaust gas and the water to allow decomposition of the perfluoro-compound contained in the exhaust gas with the water and absorption of the first acid gas by the water; and
a mist removing member arranged on the top of the filler member to remove a mist of the first acid gas.
15. The apparatus as claimed in claim 2, wherein the filter comprises a wet filter made of any one material selected from a fiber-reinforced plastic, a polyvinyl chloride (PVC) resin, a polytetrafluoroethylene (PTFE) resin, Inconel, and S.T.S.
16. The apparatus as claimed in claim 2, wherein the dust-collector comprises first and second electric dust-collectors arranged in parallel between the filter and the catalytic reactor,
wherein the first and second electric dust-collectors independently comprise:
a housing provided with an inlet opening for the exhaust gas on the bottom end thereof and an outlet opening for the exhaust gas on the top end thereof;
a filler member disposed inside the housing;
a plurality of dust-collecting plates having a cylindrical shape with the top and bottom thereof open, and being arranged on the top of the filler member;
a plurality of discharge rods each disposed inside the respective dust-collecting plates; and
a power supply member for applying power to the dust-collecting plates and the discharge rods.
17. The apparatus as claimed in claim 2, wherein the catalytic reactor comprises:
a housing providing an inlet opening and an outlet opening for the exhaust gas;
a catalyst member disposed inside the housing and used to decompose the perfluoro-compound;
a pre-heating member disposed under the catalyst member and used to pre-heat the exhaust gas; and
a heating member disposed over the catalyst member and used to heat the catalyst member to a processing temperature.
18. The apparatus as claimed in claim 2, wherein the post-cleaner comprises first and second post-treatment wet scrubbers arranged in series,
wherein the first post-treatment wet scrubber eliminates the second acid gas using an alkaline solution, the second post-treatment wet scrubber eliminating the alkaline solution and the second acid gas using water.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method for treating or preventing an autoimmune disease in a subject, the method comprising:
administering to the subject an effective amount of an agent that blocks histamine H1 receptor (HIR), wherein the agent is not cyproheptadine or hydroxyzine.
2. The method of claim 1, wherein the agent is an H1-antihistamine.
3. The method of claim 2, wherein the H1-antihistamine is selected from the group consisting of an alkylamine, an ethanolamine, an ethylenediamine, a phenothiazine, a piperidine, and a piperazine.
4. The method of claim 3, wherein the H1-antihistamine is an ethylenediamine.
5. The method of claim 4, wherein the ethylenediamine is pyrilamine.
6. The method of claim 2, wherein the H1-antihistamine is a first generation H1-antihistamine.
7. The method of claim 6, wherein the first generation H1-antihistamine is pyrilamine.
8. The method of claim 1, wherein the autoimmune disease is Th1-mediated.
9. The method of claim 8, wherein the Th1-mediated autoimmune disease is an autoimmune demyelinating disease.
10. The method of claim 9, wherein the autoimmune demyelinating disease is multiple sclerosis.
11. The method of claim 9, wherein the agent is an H1-antihistamine not having a carboxylate group.
12. The method of claim 1, wherein the autoimmune disease is selected from the group consisting of rheumatoid arthritis, graft-versus host disease (GvHD), inflammatory bowel disease (IBD), insulin dependent diabetes mellitus (IDDM), multiple sclerosis, primary biliary cirrhosis, systemic sclerosis, psoriasis, autoimmune thyroiditis, and autoimmune thrombocytopenic purpura.
13. The method of claim 1, wherein the agent is administered by a route selected from the group consisting of intramuscular, subcutaneous, intravenous, parenteral, intranasal, intrapulmonary, and oral routes of administration.
14. The method of claim 1, wherein the H1R-blocking agent is not co-administered with a second active agent selected from the group consisting of dithiocarbamate disulfide derivatives, substituted 1,4-dihydropyridine bradykinin antagonists, heteroaryl substituted 1,4-dihydropyridine bradykinin antagonists, LTB-receptor antagonists comprising disubstituted phenyl-benzamidine derivatives, and small molecule antagonists of chemokine receptor CCR1.
15. The method of claim 1, wherein the agent does not substantially block serotonin receptor or mast cell biogenic amine secretion.
16. The method of claim 15, wherein the ED50 dose for inhibition of the serotonin receptor by the agent is at least about 0.5 mgkg.
17. The method of claim 16, wherein the ED50 dose for inhibition of the serotonin receptor by the agent is at least about 0.6 mgkg.
18. The method of claim 17, wherein the ED50 dose for inhibition of the serotonin receptor by the agent is at least about 0.8 mgkg.
19. The method of claim 1, wherein the subject does not have a second disease or disorder that requires treatment with the H1R-blocking agent.
20. The method of claim 1, wherein the subject has been diagnosed with an autoimmune disease.
21. The method of claim 1, further comprising monitoring the subject for a change in a symptom of the autoimmune disease.
22. The method of claim 1, wherein the H1R-blocking agent is co-administered with a second active agent.
23. The method of claim 22, wherein the second active agent is selected from the group consisting of
(a) a self-vector comprising a polynucleotide encoding a self-polypeptide associated with the disease;
(b) an immunomodulatory protein; and
(c) a vector encoding (b).
24. The method of claim 23, wherein the self-vector and the vector encoding an immunomodulatory protein are co-administered.
25. The method of claim 23, wherein the second active agent is the self-vector and further comprising co-administration of an immune modulatory sequence.
26. The method of claim 25, wherein the immune modulatory sequence is selected from the group consisting of
(a) 5\u2032-Purine-Pyrimidine-X-Y-Pyrimidine-Pyrimidine-3\u2032 and
(b) 5\u2032-Purine-Purine-X-Y-Pyrimidine-Pyrimidine-3\u2032,
wherein X and Y are any naturally occurring or synthetic nucleotide, except that X and Y cannot be cytosine-guanine.
27. The method of claim 23, wherein the immunomodulatory protein is a cytokine or a chemokine.
28. The method of claim 27, wherein the cytokine is selected from the group consisting of IL-4, IL-10, and IL-13.
29. The method of claim 1, wherein the autoimmune disease is a relapsing-remitting form of the disease.
30. The method of claim 29, wherein the administration of the agent decreases the relapse rate of the disease.
31. A method for treating or preventing multiple sclerosis in a subject, the method comprising:
administering to the subject an effective amount of an agent that blocks histamine H1 receptor (HIR), wherein the agent is not cyproheptadine or hydroxyzine
32. A method for treating or preventing multiple sclerosis in a subject, the method comprising:
administering to the subject an effective amount of an agent that blocks histamine 1 receptor (HIR), wherein the agent does not substantially block serotonin receptor or mast cell biogenic amine secretion.
33. A method for treating or preventing multiple sclerosis in a subject, the method comprising:
administering to the subject an effective amount of an agent that blocks histamine H1 receptor (HIR), wherein the agent does not substantially block serotonin receptor or mast cell biogenic amine secretion and is not co-administered with a second active agent.
34. A method for treating or preventing an autoimmune disease in a subject, the method comprising:
co-administering to the subject effective amounts of
(a) an agent that blocks histamine H1 receptor (H1R) and
(b) a second active agent.
35. The method of claim 34, wherein the second active agent is not an agent selected from the group consisting of dithiocarbamate disulfide derivatives, substituted 1,4-dihydropyridine bradykinin antagonists, heteroaryl substituted 1,4-dihydropyridine bradykinin antagonists, LTB-receptor antagonists comprising disubstituted phenyl-benzamidine derivatives, and small molecule antagonists of chemokine receptor CCR1.
36. The method of claim 34, wherein the second active agent is selected from the group consisting of
(a) a self-vector comprising a polynucleotide encoding a self-polypeptide associated with the disease;
(b) an immunomodulatory protein; and
(c) a vector encoding (b).
37. The method of claim 36, wherein the autoimmune disease is multiple sclerosis and the self-polypeptide is selected from the group consisting of myelin basic protein (MBP), proteolipid protein (PLP), myelin associated glycoprotein (MAG), cyclic nucleotide phosphodiesterase (CNPase), myelin-associated oligodendrocytic basic protein (MBOP), myelin oligodendrocyte protein (MOG), and alpha-B crystalline.
38. The method of claim 36, wherein the autoimmune disease is insulin dependent diabetes mellitus and the self-polypeptide is selected from the group consisting of insulin, insulin B chain, preproinsulin, proinsulin, glutamic acid decarboxylase 65 kDa and 67 kDa forms, tyrosine phosphatase IA2 or IA-2b, carboxypeptidase H, heat shock proteins, glima 38, islet cell antigen 69 kDa, p52, and islet cell glucose transporter (GLUT 2).
39. The method of claim 36, wherein the self-vector and the vector encoding the immunomodulatory protein are co-administered.
40. The method of claim 36, wherein the second active agent is the self-vector and further comprising the administration of an immune modulatory sequence.
41. The method of claim 40, wherein the immune modulatory sequence is selected from the group consisting of
(a) 5\u2032-Purine-Pyrimidine-X-Y-Pyrimidine-Pyrimidine-3\u2032 and
(b) 5\u2032-Purine-Purine-X-Y-Pyrimidine-Pyrimidine-3\u2032,
wherein X and Y are any naturally occurring or synthetic nucleotide, except that X and Y cannot be cytosine-guanine.
42. The method of claim 36, wherein the immunomodulatory protein is a cytokine or chemokine.
43. The method of claim 42, wherein the cytokine is selected from the group consisting of IL-4, IL-10, and IL-13.
44. The method of claim 34, wherein the autoimmune disease is a relapsing-remitting form of the disease.
45. The method of claim 44, wherein the administration of the agent decreases the relapse rate of the disease.
46. The method of claim 44, wherein the relapsing-remitting autoimmune disease is a relapsing-remitting form of multiple sclerosis.
47. A method for treating or preventing an autoimmune disease in a subject, the method comprising:
co-administering to the subject effective amounts of
(a) a self-vector comprising a polynucleotide encoding a self-polypeptide associated with the disease and
(b) a means for blocking histamine H1 receptor (H1R).
48. The method of claim 47, wherein the H1R-blocking means is pyrilamine.
49. The method of claim 47, wherein the autoimmune disease is multiple sclerosis.