Author: claimsbot

What is claimed is:

1. An amide selected from the group consisting of a compound of the formula:
31
wherein
R1 and R2 are independently hydrogen, halo, cyano, nitro, lower alkylthio, perfluoro loweralkylthio, lower alkyl sulfonyl, or perfluoro-lower alkyl sulfonyl;
R3 is lower alkyl having from 2 to 4 carbon atoms or a 5 to 7-membered ring which is cycloalkyl, cycloalkenyl, or heterocycloalkyl having one heteroatom selected from oxygen and sulfur;
R4 is C(O)NHR5;
R5 is hydrogen, lower alkyl, lower alkenyl, hydroxy lower alkyl, halo lower alkyl, (CH2)nC(O)OR7, C(O)(CH2)nC(O)OR8;
IR6 is an unsubstituted or mono-substituted five- or six-membered heteroaromatic ring connected by a ring carbon atom to the amide group shown, which five- or six-membered heteroaromatic ring contains from 1 to 3 heteroatoms selected from sulfur, oxygen or nitrogen, with one heteroatom being nitrogen which is adjacent to the connecting ring carbon atom; with said mono-substituted heteroaromatic ring being monosubstituted at a position on a ring carbon atom other than adjacent to said connecting carbon atom with a substituent selected from the group consisting of lower alkyl, halo, nitro, cyano, (CH2)nOR9, (CH2)nC(O)OR10, (CH2)nC(O)NHR11, C(O)C(O)OR12, (CH2)nNHR13; n is 0, 1, 2, 3 or 4;
R7, R8, R9, R10, R11, R12 and R13 are independently hydrogen or lower alkyl;
X is oxygen, sulfur, sulfonyl or carbonyl;
the * indicates an asymmetric carbon atom;
and its pharmaceutically acceptable salts.
2. An amide of claim 1 wherein said compound is
32
wherein
R1 and R2 are independently hydrogen, halo, lower alkyl sulfonyl, or perfluoro-lower alkyl sulfonyl;
R3 is a 5 to 7-membered ring which is cycloalkyl, cycloalkenyl, or heterocycloalkyl having one heteroatom selected from oxygen and sulfur;
R5 is lower alkyl;
X is oxygen, sulfur, sulfonyl or carbonyl;
the * indicates an asymmetric carbon atom,
and its pharmaceutically acceptable salts.
3. A compound of claim 2 wherein R1 and R2 are independently halo or lower alkyl sulfonyl and R3 is a 5 to 7-membered ring which is cyclopentyl, cyclohexyl, cyclohexenyl, or a six-membered heterocycloalkyl having one heteroatom selected from oxygen and sulfur.
4. A compound of claim 3 wherein the heteroatom is oxygen.
5. The amide of claim 4 wherein R5 is methyl.
6. The amide of claim 5 where X is oxygen.
7. The amide of claim 6 wherein R1 and R2 are independently chloro or methyl sulfonyl.
8. The amide of claim 7 wherein R1 and R2 are chloro.
9. The amide of claim 8 which is 1-cyclopentyloxy-(3,4-dichloro-phenyl)-acetyl-3-methyl-urea.
10. The amide of claim 8 which is 1-cyclohexyloxy-(3,4-dichloro-phenyl)-acetyl-3-methyl-urea.
11. The amide of claim 8 which is 1-(cyclohex-2-enyloxy)-(3,4-dichloro-phenyl)-acetyl-3-methyl-urea.
12. The amide of claim 8 which is 1-(3,4-dichloro-phenyl)-(tetrahydro-pyran-4-yloxy)-acetyl-3-methyl-urea.
13. The amide of claim 7 wherein R1 is chloro and R2 is methyl sulfonyl.
14. The amide of claim 13 which is 1-(3-chloro-4-methanesulfonyl-phenyl)-cyclopentyloxy-acetyl-3-methyl-urea.
15. The amide of claim 13 which is 1-(3-chloro-4-methanesulfonyl-phenyl)-(cyclohex-2-enyloxy)-acetyl-3-methyl-urea.
16. The amide of claim 1 wherein said compound is
33
wherein
R1 and R2 are independently hydrogen, halo, lower alkyl sulfonyl, or perfluoro-lower alkyl sulfonyl;
R3 is a 5 to 7-membered ring which is cycloalkyl, cycloalkenyl, or heterocycloalkyl having one heteroatom selected from oxygen and sulfur;
R6 is an unsubstituted five- or six-membered heteroaromatic ring connected by a ring carbon atom to the amide group shown, which five- or six-membered heteroaromatic ring contains from 1 to 3 heteroatoms selected from sulfur, oxygen or nitrogen, with one heteroatom being nitrogen which is adjacent to the connecting ring carbon atom X is oxygen, sulfur, sulfonyl or carbonyl;
the * indicates an asymmetric carbon atom;
and its pharmaceutically acceptable salts.
17. An amide selected from the group consisting of a compound of the formula:
34
wherein
R1 and R2 are independently hydrogen, halo, cyano, nitro, lower alkylthio, perfluoro loweralkylthio, lower alkyl sulfonyl, or perfluoro-lower alkyl sulfonyl;
R3 is lower alkyl having from 2 to 4 carbon atoms;
R4 is C(O)NHR5, or is R6;
R5 is hydrogen, lower alkyl, lower alkenyl, hydroxy lower alkyl, halo lower alkyl, (CH2)nC(O)OR7, C(O)(CH2)nC(O)OR8;
R6 is an unsubstituted or mono-substituted five- or six-membered heteroaromatic ring connected by a ring carbon atom to the amide group shown, which five- or six-membered heteroaromatic ring contains from 1 to 3 heteroatoms selected from sulfur, oxygen or nitrogen, with one heteroatom being nitrogen which is adjacent to the connecting ring carbon atom; with said mono-substituted heteroaromatic ring being monosubstituted at a position on a ring carbon atom other than adjacent to said connecting carbon atom with a substituent selected from the group consisting of lower alkyl, halo, nitro, cyano, (CH2)nOR9, (CH2)nC(O)OR10, (CH2)nC(O)NHR11, C(O)C(O)OR12, (CH2)nNHR13; n is 0, 1, 2, 3 or 4;
R7, R8, R9, R10, R11, R12 and R13 are independently hydrogen or lower alkyl;
X is oxygen, sulfur, sulfonyl or carbonyl;
the * indicates an asymmetric carbon atom;
and its pharmaceutically acceptable salts.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A stairway tread support device for use on a set of stairs, the tread support device comprising:
a pivot point;
a first lower part, the lower part having a vertical fin;
a second upper part, the upper part and the lower part pivoting relative to one another about the pivot point;
a first riser height H measured at a first edge of the device distal from the pivot point, the riser height H having a plurality of values;
a first plurality of holes passing through the fin of the lower part;
a second plurality of holes passing through the upper part;
a first pair of holes including a first hole of the first plurality of holes and a second hole of the second plurality of holes which are overlapping when the riser height H is a first riser height H1;
the first and second plurality of holes arranged so that as the riser height H increases by a first increment X from H1 to a riser height H2, the first pair of holes are no longer overlapping and a second pair of holes including a third hole of the first plurality of holes and a fourth hole of the second plurality of holes do overlap;
a fastener dimensioned and configured to pass through the overlapping pairs of holes and disposed within an overlapping pair of holes;
a second tread support device, the second tread support device having a second tread support device pivot point;
a second tread support device lower part, the second tread support device lower part having a second tread support device vertical fin;
a second tread support device upper part, the second tread support device upper part and the second tread support device lower part pivoting relative to one another about the second tread support device pivot point;
a second tread support device first riser height H measured at a second tread support device second edge distal from the second tread support device pivot point, the second tread support device riser height H having a plurality of values;
a second tread support device first plurality of holes passing through the second tread support device fin of the second tread support device lower part;
a second tread support device second plurality of holes passing through the second tread support device upper part;
a third pair of holes including a fifth hole of the second tread support device first plurality of holes and a sixth hole of the second tread support device second plurality of holes which are overlapping when the second tread support device riser height H is the first riser height H1;
the second tread support device first and second plurality of holes arranged so that as the second tread support device riser height H increases by the first increment X from H1 to the riser height H2, the third pair of holes are no longer overlapping and a fourth pair of holes including a seventh hole of the second tread support device first plurality of holes and an eighth hole of the second tread support device second plurality of holes do overlap;
a second fastener dimensioned and configured to pass through the overlapping pairs of holes of the second tread support device and disposed within an overlapping pair of holes;
the second tread support device further comprising:
a height adjustment mechanism separate from the pluralities of holes, the height adjustment mechanism providing a second independent adjustment to the riser height H of the second tread support device, the height adjustment mechanism located on the second tread support device second edge;
the second edge being shorter than the first edge.
2. A set of stairs including the tread support device of claim 1, the set of stairs further comprising:
a stringer, the stringer supported at a first end and at a second end, the first end higher than the second end, the stringer having a top surface disposed at an angle due to the first end being supported higher than the second end, the stringer having a side surface;
the tread support device disposed upon the top surface, the first lower part fastened to the stringer, the fastener disposed through the first pair of holes such that the riser height H has the value H1;
a tread, the tread disposed upon the second upper part of the tread support device, the tread fastened to the second upper part.
3. The tread support device of claim 1, wherein the increment X is \u215b inch (3 mm).
4. (canceled)
5. The tread support device of claim 1 wherein the height adjustment mechanism further comprises:
a bolt, secured to the second tread support device second edge with the bolt parallel to the second edge, whereby a step is additionally supported.
6. The tread support device of claim 5, wherein the bolt is secured to the second edge by passing through a bracket attached to the second tread support device lower part, the bolt passing through a bracket nut attached to the bracket and further passing through a jam nut, whereby the bolt is locked in place.
7. The tread support device of claim 1, wherein the second plurality of holes on the upper part are arranged in a first pivot line, the first pivot line passing through the pivot point, while the first plurality of holes on the lower part are arranged in a group, the group not confined to the first pivot line.
8. The tread support device of claim 1, wherein the pivot point further comprises: a rivet.
9. The tread support device of claim 1, wherein the fastener further comprises: a rivet.
10. The tread support device of claim 1, wherein the first edge further comprises:
an alignment guide, the alignment guide having a series of markings, the series of markings bearing indicia indicating the value of the riser heights H1 and H2, measured to the nearest increment X.
11. The tread support device of claim 10 wherein the alignment guide is sufficiently accurate that when riser height H1 is indicated, the overlap of the first and second holes is visible and the first and second holes overlap, and when riser height H2 is indicated, the overlap of the third and fourth holes is visible and the third and fourth holes overlap;
whereby the overlap is sufficiently accurate that the fastener may pass through the visibly overlapping holes.
12. The tread support device of claim 2 wherein the lower part further comprises a flat-to-stringer-support portion, the flat-to-stringer-support portion disposed upon the stringer top.
13. The tread support device of claim 12, wherein the lower part further comprises a side-of-stringer-support portion, the side-to-stringer-support portion disposed upon the stringer side.
14. The tread support device of claim 12, wherein the flat-to-stringer-support portion further comprises: a fastening hole allowing fastening of the tread support device to the stringer.
15. The tread support device of claim 2, wherein the upper part further comprises a tread support part, the tread support part having the tread disposed thereon and fastened thereto.
16. (canceled)

1. A method at a network device, the method comprising:
at a network switch:
receiving a previous advertisement including a host network layer address of a host and an existing sequence value associated with the host network layer address;
after the receiving, detecting that the host is associated with the network switch, the host being a device or a program application that provides a service;
generating a sequence value at the network switch based on the detecting, the generating including changing the received existing sequence value to a next sequential value that represents the sequence value;
associating the sequence value with the host network layer address of the host; and
transmitting an advertisement to a different network switch, the advertisement including the host network layer address and the sequence value.
2. The method of claim 1, wherein the advertisement includes a network layer address of the network switch, the host being in communication with the network switch.
3. The method of claim 1, wherein the generating the sequence value comprises:
incrementing the received existing sequence value to the next sequential value.
4. The method of claim 1, wherein the generating the sequence value comprises:
decreasing the received existing sequence value to the next sequential value.
5. The method of claim 1, wherein the existing sequence value includes a letter, and the changing the sequence value includes changing the letter to a next sequential letter that represents the sequence value.
6. The method of claim 5, wherein the changing the letter includes increasing the letter to the next sequential letter that represents the sequence value.
7. The method of claim 5, wherein the changing the letter includes decreasing the letter to the next sequential letter that represents the sequence value.
8. An apparatus comprising:
a network switch including:
a processor; and
a memory in communication with the processor, the memory comprising instructions executable by the processor, when the instructions are executed the processor being operable to:
receive a previous advertisement including a host network layer address of a host and an existing sequence value associated with the host network layer address;
after the previous advertisement is received, generate, based on detecting that the host is associated with the network switch, a sequence value at the network switch, wherein the processor is configured to generate by changing the received existing sequence value to a next sequential value that represents the sequence value, the host being a device or a program application that provides a service;
associate the sequence value with the host network layer address of the host; and
transmit an advertisement to a different network switch, the advertisement including the host network layer address and the sequence value.
9. The apparatus of claim 8, wherein the advertisement includes a network layer address of the network switch, the host being in communication with the network switch.
10. The apparatus of claim 8, wherein the processor is further operable to:
increment the received existing sequence value to the next sequential value.
11. The apparatus of claim 8, wherein the processor is further operable to:
decrease the received existing sequence value to the next sequential value.
12. A non-transitory machine-readable storage medium comprising instructions that, when executed by one or more processors of a network switch, cause the network switch to perform operations comprising:
receiving a previous advertisement including a host network layer address of a host and an existing sequence value associated with the host network layer address;
after the receiving, detecting that the host is associated with the network switch, the host being a device or a program application that provides a service;
generating a sequence value at the network switch based on the detecting, the generating including changing the received existing sequence value to a next sequential value that represents the sequence value;
associating the sequence value with the host network layer address of the host; and
transmitting an advertisement to a different network switch, the advertisement including the host network layer address and the sequence value.
13. The storage medium of claim 12, wherein the advertisement includes a network layer address of the network switch, the host being in communication with the network switch.
14. The storage medium of claim 12, wherein the generating the sequence value comprises:
incrementing the received existing sequence value to the next sequential value.
15. The storage medium of claim 12, wherein the generating the sequence value comprises:
decreasing the received existing sequence value to the next sequential value.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A biological buffer of the following structure:
where A, D, and E are independently chosen from \u2014H, \u2014CH3, \u2014CH2CH3, and \u2014CH2OH, and G is chosen from \u2014H, \u2014CH3, \u2014OH, where A, E and D may not all equal \u2014H.
2. The biological buffer of claim 1 where A\u2550D\u2550E\u2550\u2014CH2OH, and G\u2550\u2014CH3.
3. The biological buffer of claim 1 where A\u2550D\u2550E\u2550\u2014CH2OH, and G\u2550\u2014H.
4. The biological buffer of claim 1 where A\u2550D\u2550\u2014CH3 and E\u2550\u2014CH2OH and G\u2550\u2014CH3.
5. The biological buffer of claim 1 where A\u2550D\u2550\u2014CH3 and E\u2550\u2014CH2OH and G\u2550\u2014H.
6. A Biological Buffer of the following structure:
where A and D are independently chosen from \u2014H, \u2014CH3, \u2014CH2CH3, and \u2014CH2OH, E is chosen from \u2014CH2CH3 and \u2014CH2OH.
7. The biological buffer of claim 6 where A\u2550D\u2550E\u2550\u2014CH2OH.
8. The biological buffer of claim 6 where A\u2550D\u2550\u2014CH3 and E\u2550\u2014CH2OH.