Author: claimsbot

1. A design structure embodied in a machine readable storage medium for at least one of designing, manufacturing, and testing a design, the design structure comprising:
a memory module comprising:
a plurality of memories, each memory comprising a memory controller coupled to a memory array of memory pages, each of the memory pages comprising a corresponding locality tendency state;
a memory bank coupled to a sense amplifier and configured to latch selected ones of the memory pages responsive to the memory controller; and,
open page policy management logic coupled to the memory controller, the logic comprising program code enabled to granularly change open page policy management of the memory bank responsive to identifying a locality tendency state for a page loaded in the memory bank.
2. The design structure of claim 1, wherein the memories are dynamic random access memories (DRAMs).
3. The design structure of claim 1, wherein the tendency state is selected from a group of states comprising an open state, a weakly opened state, a strongly opened state and a closed state.
4. The design structure of claim 3, further comprising a locality tendency state machine managed by the open page policy management logic, wherein the locality tendency state for a memory page in the memory bank is determined by the state machine according to an occurrence of either a page hit or a page miss for the memory bank in satisfying a memory request in the memory controller.
5. The design structure of claim 1, further comprising a last page record for the memory bank indicating a last memory page closed from the memory bank.
6. The design structure of claim 1, wherein the design structure comprises a netlist, which describes the memory module.
7. The design structure of claim 1, wherein the design structure resides on the machine readable storage medium as a data format used for the exchange of layout data of integrated circuits.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method of diagnosing cancer comprising:
obtaining an expression level of at least one Bcl-2 antagonist of cell death (BAD) pathway gene in a sample suspected of being cancerous or pre-cancerous;
using the expression level of the at least one Bcl-2 antagonist of cell death (BAD) pathway gene to obtain a BAD Pathway Gene Expression Signature (BPGES) score of the sample using Principal Component Analysis (PCA);
obtaining an expression level of a control;
using the expression level of the control to obtain a BAD Pathway Gene Expression Signature (BPGES) score of the control; and
comparing the BPGES score of the sample suspected of being cancerous or pre-cancerous to the BPGES score of the control sample;
wherein a lower BAD Pathway Gene Expression Signature (BPGES) score for the sample suspected of being cancerous or pre-cancerous as compared to the control sample is indicative of cancer;
wherein the cancer is selected from the group consisting of breast cancer, ovarian cancer, endometrial cancer, colon cancer, lung cancer, leukemia, brain cancer and melanoma.
2. The method of claim 1, wherein the at least one BAD pathway gene is selected from the group consisting of those genes listed in FIGS. 6 and 7.
3. The method of claim 1, wherein the cancer being diagnosed is pre-cancerous tissue, pre-invasive cancerous tissue, or invasive cancerous tissue.
4. A method of determining survival from cancer comprising:
identifying at least one BAD pathway gene differentially expressed in cells sensitive to at least one chemotherapeutic versus cells resistant to the at least one chemotherapeutic; and
comparing the least one BAD pathway gene in a sample suspected of being cancerous or pre-cancerous to a control sample;
wherein a lower differential expression of the at least one BAD pathway gene of the sample suspected of being cancerous or pre-cancerous as compared to the control sample is indicative of cancer non-survival;
wherein the cancer is selected from the group consisting of breast cancer, ovarian cancer, endometrial cancer, colon cancer, lung cancer, leukemia, brain cancer and melanoma.
5. The method of claim 4, wherein the chemotherapeutic is carboplatin, cyclophosphamide, topotecan, docetaxel, paclitaxel, or gemcitabine.
6. The method of claim 4, wherein the at least one BAD pathway gene is selected from the group consisting of genes listed in FIGS. 6 and 7.
7. A method of identifying cancer sensitivity to chemotherapeutics comprising:
obtaining a BAD Pathway Gene Expression Signature (BPGES) score of a sample suspected of being cancerous or pre-cancerous; and
comparing the BAD Pathway Gene Expression Signature (BPGES) score of the sample suspected of being cancerous or pre-cancerous to a control sample;
wherein the BAD Pathway Gene Expression Signature (BPGES) score identifies the chemosensitivity of cancerous or pre-cancerous cells to at least one chemotherapeutic;
wherein a low BAD Pathway Gene Expression Signature (BPGES) score is indicative of chemoresistant cancer.
8. The method of claim 7, wherein the chemotherapeutic is carboplatin, topotecan, docetaxel, gemcitabine and paclitaxel.
9. The method of claim 7, wherein the BAD Pathway Gene Expression Signature (BPGES) score is determined by obtaining an expression level of at least one BAD pathway gene selected from the group consisting of genes listed in FIGS. 6 and 7 and applying Principal Component Analysis (PCA).
10. A method of treating cancer comprising:
administering a therapeutically effective amount of an agent that targets the Bcl-2 antagonist of cell death (BAD) pathway;
wherein the cancer is selected from the group consisting of breast cancer, ovarian cancer, endometrial cancer, colon cancer, lung cancer, leukemia, brain cancer and melanoma.
11. The method of claim 10, wherein the agent modulates phosphorylation of BAD protein.
12. The method of claim 10, wherein the agent reduces level of active CDK1 or increases level of PP2C.
13. A method of monitoring neoplasia progression from one biological state to another in a tumor sample comprising:
obtaining a first BAD Pathway Gene Expression Signature (BPGES) score from a tumor sample at a first timepoint;
obtaining a second BPGES score from the tumor sample at a second timepoint wherein the second timepoint is at a given interval after the first timepoint; and
comparing the first and the second BPGES score to each other;
wherein a decrease in the second BPGES score as compared to the first BPGES score is indicative of neoplasia progression and an increase in the second BPGES score as compared to the first BPGES score is indicative of neoplasia regression;
wherein the neoplasia is selected from the group consisting of breast cancer, ovarian cancer, endometrial cancer, colon cancer, lung cancer, leukemia, brain cancer and melanoma.
14. The method of claim 13, wherein the BAD Pathway Gene Expression Signature (BPGES) score is determined by obtaining an expression level of at least one BAD pathway gene selected from the group consisting of genes listed in FIGS. 6 and 7 and applying Principal Component Analysis (PCA).
15. The method of claim 13, wherein the neoplasia progression being monitored is normal tissue to pre-cancerous tissue, normal to pre-invasive cancerous tissue, pre-cancerous tissue to pre-invasive cancerous tissue, or pre-invasive cancerous tissue to invasive cancerous tissue.

1. A feed injector system comprising:
a plurality of annular channels substantially concentric about a longitudinal axis that define corresponding fluid flow paths that direct a flow of fluid substantially axially therethrough from a respective source to a reaction zone; and
a plurality of swirl members extending into the fluid flow path defined in at least one of said plurality of annular channels, wherein at least one of said plurality of swirl members is movable axially within said at least one annular channel, wherein at least one of said plurality of swirl members comprises a plurality of blades aligned in a helical path spaced axially and circumferentially with respect to an adjacent swirl member in the helical path, and wherein at least one of said plurality of swirl members is configured to impart a first circumferential flow direction to fluid flowing through at least one of said plurality of annular channels, and at least one of said plurality of swirl members is configured to impart a second circumferential flow direction to fluid flowing through at least one of said plurality of annular channels, wherein the second circumferential flow direction is different than the first circumferential flow direction, and wherein a tangential velocity of the fluid is based on at least one of a pitch and a position of said plurality of swirl members.
2. A system in accordance with claim 1 wherein at least one of said plurality of swirl members comprises a body extending into at least one of said plurality of annular channels obliquely with respect to the longitudinal axis.
3. A system in accordance with claim 1 wherein said plurality of substantially concentric annular channels comprises:
a first conduit substantially cylindrically shaped about a longitudinal axis, said first conduit comprising a radially outer surface and a radially inner surface, said first conduit further comprising a supply end, a discharge end and a length extending therebetween;
a second conduit at least partially within and substantially concentrically aligned with said first conduit, said second conduit substantially cylindrically shaped about the longitudinal axis, said second conduit comprising a radially outer surface and a radially inner surface, said second conduit further comprising a supply end, a discharge end, and a length extending therebetween.
4. A system in accordance with claim 3 wherein at least one of said plurality of swirl members comprises a body extending radially inwardly from said inner surface of said first conduit into at least one of the plurality of annular channels, said at least one swirl member extending helically with respect to the longitudinal axis.
5. A system in accordance with claim 3 wherein at least one of said plurality of swirl members comprises a body extending radially outwardly from said outer surface of said second conduit into at least one of the plurality of annular channels, said at least one swirl member extending helically with respect to the longitudinal axis.
6. A system in accordance with claim 1 wherein said plurality of swirl members are spaced circumferentially about at least one of said plurality of channels, said swirl members aligned obliquely with respect to the longitudinal axis.
7. A system in accordance with claim 1 wherein said plurality of swirl members are spaced circumferentially about two of said plurality of channels, said swirl members in a first of the channels are aligned obliquely with respect to the longitudinal axis, said swirl members in a second of the channels are aligned obliquely in an opposite direction from the swirl members in the first channel.
8. A system in accordance with claim 1 wherein at least one of said plurality of swirl members comprises an elongated blade integral with and extending outwardly into at least one of said plurality of annular channels for a substantial length of said at least one channel.
9. A system in accordance with claim 8 wherein at least one of said plurality of swirl members is aligned along at least one of a helical path and a helical path having a variable pitch.
10. A system in accordance with claim 1 wherein said plurality of blades extend outwardly into at least one of said plurality of annular channels.
11. A system in accordance with claim 1 further comprising an actuator coupled to at least one of said plurality of swirl members, said actuator configured to move said at least one swirl member axially in a respective one of said plurality of annular channels.
12. A system in accordance with claim 1 further comprising an actuator coupled to at least one of said plurality of swirl members, said actuator configured to rotate said at least one swirl member such that a pitch of said at least one swirl member with respect to the longitudinal axis is changed.
13. A system in accordance with claim 1 further comprising:
a first conduit having a first radially outwardly diverging tip; and
a second conduit concentrically aligned about a longitudinal axis of said first conduit and radially outward from said first conduit, forming at least one of said plurality of annular channels;
wherein a radially outer diameter of said first conduit proximate said tip is less than an inner diameter of second conduit such that said tip is axially removable through said second conduit.
14. A system in accordance with claim 1 further comprising:
a first conduit comprising a first radially outwardly diverging tip; and
a second conduit substantially concentrically aligned about said first conduit and spaced radially outward from said first conduit, said second conduit forming at least one of said plurality of annular channels,
wherein said second conduit comprises a second diverging tip having an inner diameter that is larger than an inner diameter of said second conduit,
wherein a radially outer diameter of said first conduit proximate said tip is greater than an inner diameter of said second conduit such that said tip of said first conduit interferes with the inner diameter of said second conduit during removal of said first conduit axially through said second conduit, and wherein said first diverging tip imparts an angular trajectory to fluid exiting said first diverging-tip.
15. A method of assembling a gasifier feed injector comprising:
providing a first feed pipe having a first outside diameter about a longitudinal axis, the first pipe including a supply end, a discharge end, and a length extending therebetween;
providing a second feed pipe having a first inside diameter, the second pipe including a supply end, a discharge end, and a length extending therebetween;
providing a plurality of swirl members at a position along the length of at least one of the first pipe and the second pipe, wherein at least one of the plurality of swirl members is movable axially within at least one of the first pipe and the second pipe, at least one of the plurality of swirl members extends along a surface of the first pipe at an oblique angle with respect to the longitudinal axis such that the at least one swirl member imparts a first circumferential flow direction to a fluid that flows through the first pipe, and at least one of the plurality of swirl members extends along a surface of the second pipe such that the at least one swirl member imparts a second circumferential flow direction to a fluid that flows through the second pipe that is different in direction than the first circumferential flow direction, wherein at least one of the plurality of swirl members has a blade-shaped body that is formed integrally with an outer surface of the first pipe, and wherein the a tangential velocity of the fluid is based on at least one of the position and the angle of the swirl member; and
inserting the first pipe into the second pipe such that the first pipe and the second pipe are substantially concentrically aligned.
16. A method in accordance with claim 15 wherein providing a plurality of swirl members comprises at least one of coupling at least one of the plurality of swirl members having a blade-shaped body to an inner surface of the second pipe and coupling at least one of the plurality of swirl members with a blade-shaped body to an outside surface of the first pipe.
17. A method in accordance with claim 15 wherein providing a plurality of swirl members comprises providing at least one of the plurality of swirl members with a blade-shaped body formed integrally in an inner surface of the second pipe.
18. A method in accordance with claim 15 wherein providing a plurality of swirl members comprises coupling at least one of the plurality of swirl members along a helical path about at least one of the first pipe and the second pipe.
19. A method in accordance with claim 18 wherein coupling at least one of the plurality of swirl members along a helical path about at least one of the first pipe and the second pipe comprises coupling at least one of the plurality of swirl members along a helical path having a variable pitch about at least one of the first pipe and the second pipe.
20. A method in accordance with claim 15 wherein providing a plurality of swirl members comprises coupling a plurality of swirl members adjacently aligned along a helical path about at least one of the first pipe and the second pipe.
21. A method in accordance with claim 20 wherein coupling a plurality of swirl members adjacently aligned along a helical path about at least one of the first pipe and the second pipe comprises coupling at least one of the plurality of swirl members along a helical path having a variable pitch about at least one of the first pipe and the second pipe.
22. A method in accordance with claim 15 further comprising changing the axial position of at least one of the plurality of swirl members using an actuator coupled to the at least one swirl member.
23. A gasification system comprising:
a pressure vessel for partially oxidizing a fuel;
a feed injector configured to inject a fuel into the pressure vessel;
wherein the feed injector further comprises:
a plurality of annular channels that define corresponding fluid flow paths that direct a flow of fluid substantially axially therethrough from a respective source to a reaction zone; and
a plurality of swirl members extending into the fluid flow path defined in at least one of said plurality of annular channels, at least one of said plurality of swirl members comprises a plurality of blades extending outwardly into said at least one of said plurality of annular channels, at least one of said plurality of swirl members is configured to impart a first circumferential flow direction to fluid flowing through at least one of said annular channels, and at least one of said plurality of swirl members is configured to impart a second circumferential flow direction to fluid flowing through at least one of said annular channels that is different than the first circumferential flow direction, and wherein a tangential velocity of the fluid is based on at least one of a pitch and a position of said plurality of swirl members.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method of operating a network element in a wireless communications network, the method comprising:
identifying, by at least a network element, a channel state information reference signal (CSI-RS) that is orthogonal to CSI-RSs transmitted by each of a first network cell and a set of neighbor cells that interfere with the first network cell, wherein the first network cell has a coverage containing a coverage of a second network cell, wherein the network element is associated with the second network cell; and
transmitting, by the network element, the identified CSI-RS.
2. The method of claim 1, wherein the set of interfering neighbor cells is a subset of a CSI-RS network cell group, and the CSI-RS transmitted by the network element is the same as a CSI-RS transmitted by a network cell that is a member of the CSI-RS network cell group, but not a member of the set of interfering neighbor cells.
3. The method of claim 2, wherein the CSI-RS network cell group consists of the first network cell, the second network cell, and the set of interfering neighbor cells.
4. The method of claim 1, wherein the set of interfering neighbor cells is a subset of a CSI-RS network cell group and the CSI-RS transmitted by the network element is orthogonal to each of the CSI-RSs transmitted by each network cell of the CSI-RS network cell group.
5. The method of claim 4, wherein the CSI-RS network cell group consists of the first network cell and the set of interfering neighbor cells.
6. The method of any of claims 1 to 5, wherein the second network cell is a small cell including at least one of a femto cell, a relay cell, or a pico cell.
7. The method of any of claims 1 to 6, wherein the first network cell is a macro cell.
8. The method of any of claims 1 to 7, wherein the coverage of the first network cell includes at least a portion of a coverage of a third network cell, and:
when the second network cell is moving, the CSI-RS transmitted by the second network cell is orthogonal to a CSI-RS transmitted by the third network cell;
when the coverage of the second network cell overlaps the coverage of the third network cell, the CSI-RS broadcast by the second network cell is orthogonal to the CSI-RS transmitted by the third network cell; and
when the second network cell and the third network cell are stationary and the coverage of the second network cell does not overlap the coverage of the third network cell, the CSI-RS broadcast by second network cell is not orthogonal to the CSI-RS transmitted by the third network cell.
9. The method of claim 8, wherein the CSI-RS broadcast by second network cell is the same as the CSI-RS transmitted by the third network cell.
10. The method of any of claims 1 to 9, wherein the set of interfering neighbor cells is empty.
11. A base station for use in a wireless communication network, the base station comprising a processor configured to perform the method of any of claims 1 to 10.
12. The base station of claim 11, wherein the set of interfering neighbor cells is a subset of a CSI-RS network cell group, and the CSI-RS transmitted by the second network cell is the same as a CSI-RS transmitted by a network cell that is a member of the CSI-RS network cell group, but not a member of the set of interfering neighbor cells.
13. The base station of claim 12, wherein the CSI-RS network cell group consists of the first network cell, the second network cell, and the set of interfering neighbor cells.
14. The base station of claim 11, wherein the set of interfering neighbor cells is a subset of a CSI-RS network cell group and the CSI-RS transmitted by the second network cell is orthogonal to each of the CSI-RSs transmitted by each network cell of the CSI-RS network cell group.
15. The base station of claim 14, wherein the CSI-RS network cell group consists of the first network cell and the set of interfering neighbor cells.
16. The base station of claim 11, wherein the second network cell is a small cell including at least one of a femto cell, a relay cell, and a pico cell.
17. The base station of claim 11, wherein the first network cell is a macro cell.
18. The base station of claim 11, wherein the coverage of the first network cell includes at least a portion of a coverage of a third network cell, and:
when the second network cell is moving, the CSI-RS transmitted by the second network cell is orthogonal to a CSI-RS transmitted by the third network cell;
when the coverage of the second network cell overlaps the coverage of the third network cell, the CSI-RS broadcast by the second network cell is orthogonal to the CSI-RS transmitted by the third network cell; and
when the second network cell and the third network cell are stationary and the coverage of the second network cell does not overlap the coverage of the third network cell, the CSI-RS broadcast by second network cell is not orthogonal to the CSI-RS transmitted by the third network cell.
19. The base station of claim 18, wherein the CSI-RS broadcast by second network cell is the same as the CSI-RS transmitted by the third network cell.
20. The base station of claim 11, wherein the set of interfering neighbor cells is empty.
21. A user equipment, comprising:
a processor configured to communicate with a memory, the memory storing instructions, which when executed by the processor, cause the processor to perform the steps of:
receiving, from a network element, a channel state information reference signal (CSI-RS) that is orthogonal to CSI-RSs transmitted by each of a first network cell and a set of neighbor cells that interfere with the first network cell, wherein the first network cell has a coverage containing a coverage of a second network cell, and the network element is associated with the second network cell.
22. The user equipment of claim 21, wherein the set of interfering neighbor cells is a subset of a CSI-RS network cell group, and the CSI-RS received from the network element is the same as a CSI-RS transmitted by a network cell that is a member of the CSI-RS network cell group, but not a member of the set of interfering neighbor cells.
23. The user equipment of claim 21, wherein the set of interfering neighbor cells is a subset of a CSI-RS network cell group and the CSI-RS received from the network element is orthogonal to each of the CSI-RSs transmitted by each network cell of the CSI-RS network cell group.