1461106998-d1114104-9bda-4ef6-b457-24550f553491

1. A method for updating at least a portion of a bi-stable display in successive frame periods, the method comprising:
accessing data defining at least one voltage waveform for the successive frame periods; and
driving the at least a portion of the bi-stable display (310) during the successive frame periods according to the accessed data so that at least one longer frame period (FT, 1302, 1304, 1402, 1502, 1602, 1702, 1802) is used during at least a first portion of the voltage waveforms, and at least one shorter frame period (FT\u2032) is used during at least a second portion of the voltage waveforms.
2. The method of claim 1, wherein:
the accessing data defining the at least one voltage waveform comprises accessing data defining a plurality of voltage waveforms.
3. The method of claim 2, wherein:
the driving the at least a portion of the bi-stable display comprises driving the at least a portion of the bi-stable display so that the at least one longer frame period comprises at least one elongated frame period (1302, 1304, 1402, 1502, 1602, 1702, 1802), during which each of the voltage waveforms has a respective constant voltage value.
4. The method of claim 3, wherein:
the driving the at least a portion of the bi-stable display comprises driving the at least a portion of the bi-stable display so that the at least one elongated frame period is the longest period during which each of the voltage waveforms has its respective constant voltage value.
5. The method of claim 3, wherein:
the driving the at least a portion of the bi-stable display comprises driving the at least a portion of the bi-stable display so that the at least one elongated frame period occurs during a reset portion (RE) of the voltage waveforms.
6. The method of claim 3, wherein:
the driving the at least a portion of the bi-stable display comprises driving the at least a portion of the bi-stable display so that the at least one elongated frame period occurs during a drive portion (DR, DR1) of the voltage waveforms.
7. The method of claim 2, wherein:
the driving the at least a portion of the bi-stable display comprises driving the at least a portion of the bi-stable display so that the at least one shorter frame period occurs during at least a terminal portion of a drive portion (DR, DR1) of the voltage waveforms.
8. The method of claim 2, wherein:
the driving the at least a portion of the bi-stable display comprises driving the at least a portion of the bi-stable display so that the at least one shorter frame period occurs during at least a shaking pulse portion (S1) of the voltage waveforms.
9. The method of claim 2, wherein:
the voltage waveforms include at least one rest portion (R, R1, R2) immediately prior to a frame period rate change in the successive frame periods.
10. The method of claim 2, wherein:
each of the voltage waveforms include first drive portions, and time-aligned second drive portions with a reduced range of voltage values.
11. The method of claim 2, wherein:
each of the voltage waveforms includes a drive portion for providing a direct image transition without reset to an optical rail state; and
the driving the at least a portion of the bi-stable display comprises driving the at least a portion of the bi-stable display so that the at least one shorter frame period is used during at least a terminal portion of the drive portion.
12. The method of claim 2, wherein:
the bi-stable display comprises an electrophoretic display.
13. A program storage device tangibly embodying a program of instructions executable by a machine to perform a method for updating at least a portion of a bi-stable display in successive frame periods, the method comprising:
accessing data defining a set of voltage waveforms for the successive frame periods; and
driving the at least a portion of the bi-stable display (310) during the successive frame periods according to the accessed data so that at least one longer frame period (FT, 1302, 1304, 1402, 1502, 1602, 1702, 1802) is used during at least a first portion of the voltage waveforms, and at least one shorter frame period (FT\u2032) is used during at least a second portion of the voltage waveforms.
14. The program storage device of claim 13, wherein:
the driving the at least a portion of the bi-stable display comprises driving the at least a portion of the bi-stable display so that the at least one longer frame period comprises at least one elongated frame period (1302, 1304, 1402, 1502, 1602, 1702, 1802), during which each of the voltage waveforms has a respective constant voltage value.
15. The program storage device of claim 14, wherein:
the driving the at least a portion of the bi-stable display comprises driving the at least a portion of the bi-stable display so that the at least one elongated frame period is the longest period during which each of the voltage waveforms has its respective constant voltage value.
16. The program storage device of claim 13, wherein:
the bi-stable display comprises an electrophoretic display.
17. An display device, comprising:
a bi-stable display (310); and
a control (100) for updating at least a portion of the bi-stable display in successive frame periods by: (a) accessing data defining a set of voltage waveforms for the successive frame periods, and (b) driving the at least a portion of the bi-stable display (310) during the successive frame periods according to the accessed data so that at least one longer frame period (FT, 1302, 1304, 1402, 1502, 1602, 1702, 1802) is used during at least a first portion of the voltage waveforms, and at least one shorter frame period (FT\u2032) is used during at least a second portion of the voltage waveforms.
18. The display device of claim 17, wherein:
the control drives the at least a portion of the bi-stable display by driving the at least a portion of the bi-stable display so that the at least one longer frame period comprises at least one elongated frame period (1302, 1304, 1402, 1502, 1602, 1702, 1802), during which each of the voltage waveforms has a respective constant voltage value.
19. The display device of claim 18, wherein:
the control drives the at least a portion of the bi-stable display by driving the at least a portion of the bi-stable display so that the at least one elongated frame period is the longest period during which each of the voltage waveforms has its respective constant voltage value.
20. The display device of claim 17, wherein:
the bi-stable display comprises an electrophoretic display.
21. A controller (330) comprising a processor and a program of instructions executable by the processor, the program of instructions comprising computer code device means for accessing data defining a set of voltage waveforms for successive frame periods during updating of at least a portion of a bi-stable display (310) and means for driving the at least a portion of the bi-stable display (310) during the successive frame periods according to the accessed data so that at least one longer frame period (FT, 1302, 1304, 1402, 1502, 1602, 1702, 1802) is used during at least a first portion of the voltage waveforms, and at least one shorter frame period (FT\u2032) is used during at least a second portion of the voltage waveforms.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1-36. (canceled)
37. A method for generating an immune response in a vertebrate, the method comprising administering to the vertebrate an immunomer comprising at least two oligonucleotides linked together by a non-nucleotidic linker, wherein at least one of the oligonucleotides is an immunostimulatory oligonucleotide having an accessible 5\u2032 end and comprising an immunostimulatory dinucleotide.
38. A method for generating an immune response in a vertebrate, the method comprising administering to the vertebrate an immunomer conjugate comprising an immunomer, comprising at least two oligonucleotides linked together by a non-nucleotidic linker, wherein at least one of the oligonucleotides is an immunostimulatory oligonucleotide having an accessible 5\u2032 end and comprising an immunostimulatory dinucleotide and an antigen conjugated to the immunomer at a position other than the accessible 5\u2032 end.
39. The method of claim 37 further comprising administering a vaccine.
40. The method of claim 39, wherein the immunomer or the vaccine, or both, are linked to an immunogenic protein.
41. The method of claim 37 further comprising administering an adjuvant.

1461106988-28498beb-6180-43fc-a919-2c6ed4db838a

1. A recording medium feeding unit, comprising:
a recording medium loading plate configured to load a recording medium;
a main body configured to hold the recording medium loading plate;
a pair of positioning members configured to position the recording medium in a widthwise direction perpendicular to a conveyance direction for the recording medium;
a pair of racks respectively provided on the pair of positioning members, extending along the widthwise direction, and configured to move in the widthwise direction integrally with the pair of positioning members;
a pinion rotatably provided on the main body and configured to be engaged with each of the racks and to rotate in association with movement of the racks; and
a boss protruding toward the recording medium loading plate from the main body; and
an adjustment pin protruding on the recording medium loading plate, inserted in an insertion hole formed at a center of the pinion, and configured to rotatably attach the pinion to the boss,
wherein the adjustment pin applies a rotation load to the pinion by allowing the pinion to be in contact therewith, and is capable of adjusting the rotation load of the pinion in a manner to move in a thickness direction of the recording medium loading plate.
2. A recording medium feeding unit according to claim 1,
wherein the adjustment pin includes:
a shaft having a thread portion on which a thread ridge is formed and a cylindrical portion on which no thread ridge is formed; and
a head formed at one end of the shaft on a side of the cylindrical portion, the head having a diameter larger than a diameter of the shaft,

the boss has a threaded hole having a thread groove to be engaged with the thread ridge of the shaft, and
the pinion is rotatably supported on the cylindrical portion of the adjustment pin and is sandwiched between a seat surface of the head and an end surface of the boss, and the rotation load of the pinion being adjusted by a screw force of the adjustment pin.
3. A recording medium feeding unit according to claim 2,
wherein an operating groove for rotating the shaft is formed on a top surface of the head of the adjustment pin.
4. A recording medium feeding unit according to claim 3,
wherein an opening for inserting the adjustment pin is formed on the recording medium loading plate, and
the top surface of the head of the adjustment pin is exposed on the opening of the recording medium loading plate.
5. A recording medium feeding unit according to claim 4,
wherein a scale corresponding to a level of the rotation load is formed around the opening of the recording medium loading plate, and the rotation load is adjustable by setting the operating groove of the adjustment pin to face the scale.
6. A recording medium feeding unit according to claim 1,
wherein the rotation load of the pinion is adjustable in three or more levels.
7. A recording medium feeding unit according to claim 1,
wherein the adjustment pin is rotated for adjusting the rotation load of the pinion in accordance with a type of the recording medium.
8. An image forming apparatus, comprising:
a recording medium feeding unit according to claim 1; and
an image forming section configured to form an image on a recording medium fed from the recording medium feeding unit.
9. An image forming apparatus according to claim 8,
wherein the adjustment pin includes:
a shaft having a thread portion on which a thread ridge is formed and a cylindrical portion on which no thread ridge is formed; and
a head formed at one end of the shaft on a side of the cylindrical portion and having a diameter larger than a diameter of the shaft,

a threaded hole having a thread groove to be engaged with the thread ridge of the shaft is formed in the boss, and
the pinion is rotatably supported on the cylindrical portion of the adjustment pin and is sandwiched between a seat surface of the head and an end surface of the screw portion, the rotation load of the pinion being adjusted by a screw force of the adjustment pin.
10. An image forming apparatus according to claim 9,
wherein an operating groove for catching a jig for rotating the shaft is formed on a top surface of the head of the adjustment pin.
11. An image forming apparatus according to claim 10,
wherein an opening for inserting the adjustment pin is formed in the recording medium loading plate, and
the top surface of the head of the adjustment pin is exposed on the opening of the recording medium loading plate.
12. An image forming apparatus according to claim 11,
wherein a scale corresponding to a level of the rotation load is formed around the opening of the recording medium loading plate, and the rotation load is adjustable by setting the operating groove of the adjustment pin to face the scale.
13. An image forming apparatus according to claim 8,
wherein the rotation load of the pinion is adjustable in three or more levels.
14. An image forming apparatus according to claim 8,
wherein the adjustment pin is rotated for adjusting the rotation load of the pinion in accordance with a type of the recording medium.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

What is claimed is:

1. An electric bending endoscope comprising:
a bending portion arranged to an inserting portion; and
a bending driving unit which bends the bending portion,
wherein the bending driving unit comprises:
a motor which generates driving force for bending the bending portion;
a first unit which holds the motor;
a driving force transmitting member which transmits the driving force of the motor; and
a second unit which bends the bending portion by the driving force of the motor, and

the electric bending endoscope further comprising:
a first holding member which detachably supports, to the first unit, a rotating shaft arranged to the driving force transmitting member of the second unit.
2. An electric bending endoscope according to claim 1, wherein the first unit comprises an outer frame and an inner frame for holding the motor, and a universal code for connecting an outer member of the inserting portion to the inner frame and for connecting the electric bending endoscope to a peripheral device is connected to the inner frame via a second holding member for holding the universal code.
3. An electric bending endoscope according to claim 1, wherein the first unit has an attaching hole which attaches the rotating shaft and at least three positioning holes arranged near the attaching hole, and the first holding member has a mounting hole which is fit into the rotating shaft, a projecting and positioning piece which is fit into the attaching hole, and at least three projecting and positioning pins which are fit into the positioning holes.
4. An electric bending endoscope according to claim 3, wherein the first unit further has an opening which connectably accommodates the second unit to the motor and the driving force transmitting member, and the attaching hole has a guide hole which guides and accommodates the rotating shaft upon mounting the second unit via the opening and which is formed by notching the bottom surface of the first unit.
5. An electric bending endoscope according to claim 2, wherein the inner frame is accommodated in the outer frame so that both opposed side surfaces thereof are exposed, and the second holding member is fixed to both the exposed opposed side surfaces.
6. An electric bending endoscope according to claim 5, wherein the second holding member has a ring-shaped holding portion for fitting the universal code and a fixing portion for fixing the holding portion to the inner frame by at least three supporting members.
7. An electric bending endoscope according to claim 6, wherein the holding portion has a plurality of screw holes at predetermined positions on the peripheral surface and the universal code is fit by screw operation of a screw via a screw hole arranged to a connector at an edge portion of the universal code and the screw holes of the holding portion.
8. An electric bending endoscope according to claim 4, further comprising:
a fixing member which fixes the inner frame to a main frame in the second unit.
9. An electric bending endoscope according to claim 4, the main frame is positioned to the inner frame by using a positioning tool for positioning the main frame in the second unit in three-axis directions to the inner frame, and the inner frame and the main frame in the second unit are fixed by using a fixing member for fixing them.
10. An electric bending endoscope according to claim 4, wherein positioning and fixing member for positioning, connecting, and fixing the main frame in the second unit in three-axis directions to the inner frame is arranged to a connecting portion of the inner frame and the main frame.
11. An electric bending endoscope according to claim 4, wherein the main frame in the second unit is arranged so that a sliding member for the bending operation, a signal cable for transmitting an endoscope image pick-up signal, and a light guide are detached in the endoscope operating portion.
12. An electric bending endoscope comprising
bending driving unit which bends a bending portion arranged at an edge side of an inserting portion of the electric bending endoscope,
wherein the bending driving unit comprises:
a frame unit which holds a motor as a driving force for bending the bending portion; and
a bending and stretch mechanism unit having a driving force transmitting member for bending the bending portion by using rotation driving force from the motor, and
the frame unit has holding member which detachably holds a rotating shaft arranged to the driving force transmitting member of the bending and stretch mechanism unit.
13. An electric bending endoscope according to claim 12, wherein the frame unit comprises an outer frame and an inner frame which holds the motor and which is made of a hard member stronger than the outer frame, connects an outer member of the inserting portion to the inner frame, and further connects a universal code by arranging holding member for holding the universal code to the inner frame.
14. An electric bending endoscope comprising:
a bending portion arranged to an inserting portion; and
bending driving means which bends the bending portion,
wherein the bending driving means comprises:
driving force generating means which generates driving force for bending the bending portion;
a first unit which holds the driving force generating means;
a driving force transmitting member which transmits the driving force of the driving force generating means; and
a second unit which bends the bending portion by the driving force of the driving force generating means, and

the electric bending endoscope further comprising:
first holding means which detachably supports, to the first unit, a rotating shaft arranged to the driving force transmitting member of the second unit.