claimsbot – Page 3890 – All The Claims

1461104671-64c6e68f-b3a9-499b-b260-da29c9ce889f

1. A compound of formula I:
or a pharmaceutically acceptable salt thereof, wherein:
R1 and R2 are each independently hydrogen or a nitrogen protecting group;
one of R3 or R4 is \u2014R and the other one of R3 or R4 is \u2014Q1\u2014A\u2014Q2\u2014Y,
wherein Q1 is a valence bond, \u2014NRA\u2014, \u2014C(RA)2\u2014, \u2014S\u2014, \u2014O\u2014, \u2014SO2\u2014 or \u2014CO\u2014, wherein each occurrence of RA is independently hydrogen or optionally substituted C1-4aliphatic, or two occurrences of RA on the same carbon atom are taken together to form an optionally substituted 3\u20136-membered carbocyclic ring;
A is an optionally substituted group selected from a 5\u20137-membered monocyclic or 8\u201310-membered bicyclic aryl, heteroaryl, heterocyclic or carbocyclic ring;
Q2 is NRC, S, O, or C(RC)2, wherein each occurrence of RC is independently hydrogen or optionally substituted C1-4aliphatic;
Y is an optionally substituted group selected from a 5\u20137-membered monocyclic or 8\u201310 membered bicyclic aryl, heteroaryl, heterocyclic or carbocyclic ring;
R5 is \u2014R;
Z is CR6, wherein R6 is \u2014R; and
each occurrence of \u2014R is independently hydrogen, Q(n)halogen, Q(n)CN, Q(n)NO2, or Q(n)R7, wherein n is zero or one, Q is an optionally substituted C1-4alkylidene chain wherein one or more methylene units of Q is optionally replaced by \u2014O\u2014, \u2014S\u2014, \u2014NR7\u2014, \u2014NR7CO\u2014, \u2014NR7CONR7\u2014, \u2014NR7CO2\u2014, \u2014CO\u2014, \u2014CO2\u2014, \u2014CONR7\u2014, \u2014OC(O)NR7\u2014, \u2014SO2\u2014, \u2014SO2NR7\u2014, \u2014NR7SO2\u2014, \u2014NR7SO2NR7\u2014, \u2014C(O)C(O)\u2014, or \u2014C(O)C(R7)2C(O)\u2014, and each occurrence of R7 is independently hydrogen, an optionally substituted group selected from aliphatic, heteroaliphatic, aryl or heteroaryl, or two occurrences of R7 on the same nitrogen atom are taken together with the nitrogen atom to form an optionally substituted group selected from a 5\u20138-membered heterocyclic or 5\u20138-membered heteroaryl ring;
wherein one or more optional substituents on the unsaturated carbon atom of an aryl or heteroaryl group are independently selected from halogen \u2014R\xb0; \u2014OR\xb0; \u2014SR\xb0; 1,2-methylenedioxy; 1,2-ethylenedioxy, phenyl (Ph) optionally substituted with R\xb0; \u2014O(Ph) optionally substituted with R\xb0; \u2014(CH2)1-2(Ph), optionally substituted with R\xb0; \u2014CH\u2550CH(Ph), optionally substituted with R\xb0; \u2014NO2; \u2014CN; \u2014N(R\xb0)2; \u2014NR\xb0C(O)R\xb0; \u2014NR\xb0C(S)R\xb0; \u2014NR\xb0C(O)N(R\xb0)2; \u2014NR\xb0C(S)N(R\xb0)2; \u2014NR\xb0CO2R\xb0; \u2014NR\xb0NR\xb0C(O)R\xb0; \u2014NR\xb0NR\xb0C(O)N(R\xb0)2; \u2014NR\xb0NR\xb0CO2R\xb0; \u2014C(O)C(O)R\xb0; \u2014C(O)CH2C(O)R\xb0; \u2014CO2R\xb0; \u2014C(O)R\xb0; \u2014C(S)R\xb0; \u2014C(O)N(R\xb0)2; \u2014C(S)N(R\xb0)2; \u2014OC(O)N(R\xb0)2; \u2014OC(O)R\xb0; \u2014C(O)N(OR\xb0) R\xb0; \u2014C(NOR\xb0)R\xb0; \u2014S(O)2R\xb0; \u2014S(O)3R\xb0; \u2014SO2N(R\xb0)2; \u2014S(O)R\xb0; \u2014NR\xb0SO2N(R\xb0)2, \u2014NR\xb0SO2R\xb0; \u2014N(OR\xb0)R\xb0; \u2014C(\u2550NH)\u2014N(R\xb0)2; or \u2014(CH2)0-2NHC(O)R\xb0, wherein each independent occurrence of R\xb0 is selected from hydrogen optionally substituted C1-6aliphatic, an unsubstituted 5\u20136 membered heteroaryl or heterocyclic ring, phenyl, \u2014O(Ph), or \u2014CH2(Ph), or, two independent occurrences of R\xb0, on the same substituent or different substituents, taken together with the atom(s) to which each R\xb0group is bound, optionally form a 5\u20138-membered heterocyclyl, aryl, or heteroaryl ring or a 3\u20138-membered cycloalkyl ring having 0\u20133 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein one or more optional substituents on the aliphatic group of R\xb0 are selected from NH2, NH(C1-4aliphatic), N(C1-4aliphatic)2, halogen, C1-4aliphatic, OH, O(C1-4aliphatic), NO2, CN, CO2H, CO2(C1-4aliphatic), O(haloC1-4aliphatic), or haloC1-4aliphatic, wherein each of the foregoing C1-4aliphatic groups of R\xb0 is unsubstituted;
wherein one or more optional substituents on an aliphatic or heteroaliphatic group, or on a non-aromatic heterocyclic ring are independently selected from halogen; \u2014R\xb0; \u2014OR\xb0; \u2014SR\xb0; 1,2-methylenedioxy; 1,2-ethylenedioxy; phenyl (Ph) optionally substituted with R\xb0; \u2014O(Ph) optionally substituted with R\xb0; \u2014CH\u2550CH(Ph), optionally substituted with R\xb0; \u2014NO2; \u2014CN; \u2014N(R\xb0)2; \u2014NR\xb0C(O)R\xb0; \u2014NR\xb0C(S)R\xb0; \u2014NR\xb0C(O)N(R\xb0)2; \u2014NR\xb0C(S)N(R\xb0)2; \u2014NR\xb0CO2R\xb0; \u2014NR\xb0NR\xb0C(O)R\xb0; \u2014NR\xb0NR\xb0C(O)N(R\xb0)2; \u2014NR\xb0NR\xb0CO2R\xb0; \u2014C(O)C(O)R\xb0; \u2014C(O)CH2C(O)R\xb0; \u2014CO2R\xb0; \u2014C(O)R\xb0; \u2014C(S)R\xb0; \u2014C(O)N(R\xb0)2; \u2014C(S)N(R\xb0)2; \u2014OC(O)N(R\xb0)2; \u2014OC(O)R\xb0; \u2014C(O)N(OR\xb0)R\xb0; \u2014C(NOR\xb0)R\xb0; \u2014S(O)2R\xb0; \u2014S(O)3R\xb0; \u2014SO2N(R\xb0)2; \u2014S(O)R\xb0; \u2014NR\xb0SO2N(R\xb0)2; \u2014NR\xb0SO2R\xb0; \u2014N(OR\xb0)R\xb0; \u2014C(\u2550NH)\u2014N(R\xb0)2; or \u2014(CH2)0-2NHC(O)R\xb0, \u2550O, \u2550S, \u2550NNHR*, \u2550NN(R*)2, \u2550NNHC(O)R*, \u2550NNHCO2(alkyl), \u2550NNHSO2(alkyl), or \u2550NR*, where each R* is independently selected from hydrogen or an optionally substituted C1-6 aliphatic, wherein one or more optional substituents on the aliphatic group of R* are selected from NH2, NH(C1-4aliphatic), N(C1-4aliphatic)2, halogen, C1-4 aliphatic, OH, O(C1-4 aliphatic), NO2, CN, CO2H, CO2(C1-4 aliphatic), O(halo C1-4aliphatic), or halo(C1-4aliphatic), wherein each of the foregoing C1-4aliphatic groups of R* is unsubstituted;
wherein one or more optional substituents on a nitrogen of a non-aromatic heterocyclic ring are independently selected from \u2014R+, \u2014N(R+)2, \u2014C(O)R+, \u2014CO2R+, \u2014C(O)C(O)R+, \u2014C(O)CH2C(O)R+, \u2014SO2R+, \u2014SO2N(R+)2, \u2014C(\u2550S)N(R+)2, \u2014C(\u2550NH)\u2014N(R+)2, or \u2014NR+SO2R+; wherein R+ is hydrogen, an optionally substituted C1-6 aliphatic, optionally substituted phenyl, optionally substituted \u2014O(Ph), optionally substituted \u2014CH2(Ph), optionally substituted \u2014(CH2)1-2(Ph); optionally substituted \u2014CH\u2550CH(Ph); or an unsubstituted 5\u20136 membered heteroaryl or heterocyclic ring having one to four heteroatoms independently selected from oxygen, nitrogen, or sulfur, or, two independent occurrences of R+, on the same substituent or different substituents, taken together with the atom(s) to which each R+ group is bound, optionally form a 5\u20138-membered heterocyclyl, aryl or heteroaryl ring or a 3\u20138-membered cycloalkyl ring having 0\u20133 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein one or more optional substituents on the aliphatic group or the phenyl ring of R+ are selected from NH2, NH(C1-4 aliphatic), N(C1-4 aliphatic)2, halogen, C1-4 aliphatic, OH, O(C1-4 aliphatic), NO2, CN, CO2H, CO2(C1-4 aliphatic), O(halo C1-4 aliphatic), or halo(C1-4 aliphatic), wherein each of the foregoing C1-4aliphatic groups of R30 is unsubstituted.
2. The compound of claim 1, wherein either of R3 or R4 is \u2014Q1\u2014A\u2014Q2\u2014Y, wherein A is a substituted or unsubstituted aryl or heteroaryl moiety and compounds have the general formula IIa or IIb:
wherein Z1 is N or CRV, Z2 is N or CRW, Z3 is N or CRX and Z4 is N or CRY, wherein RV, RW, RX and RY are each independently R8, or RX and RY, or RV and RY are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5\u20138 membered ring having 0\u20133 ring heteroatoms selected from oxygen, sulfur, or nitrogen, wherein any substitutable carbon on said fused ring formed by RX and RY or by RV and RY is substituted by oxo or R8, and any substitutable nitrogen on said ring formed by RX and RY or by RV and RY is substituted by R9;
wherein each occurrence of R8 is independently \u2014R; and
each occurrence of R9 is independently hydrogen, \u2014R\u2032, \u2014COR\u2032, \u2014CO2(R\u2032), \u2014CON(R\u2032)2, or \u2014SO2R\u2032, wherein each occurrence of R\u2032 is independently hydrogen, optionally substituted aliphatic, heteroaliphatic, aryl or heteroaryl, or two occurrences of R\u2032 on the same nitrogen atom are taken together with the nitrogen to form an optionally substituted 5\u20138 membered heterocyclic or heteroaryl ring.
3. The compound of claim 2, wherein A represents one of the following moieties:
4. The compound of claim 3, wherein ring A is one of formulas i, ii, iii or x.
5. The compound of claim 2, wherein Ring A is one of groups II-A through II-DD, wherein Z1 is nitrogen or CRV, Z2 is nitrogen or CRW, and p is 0\u20134:
6. The compound of claim 5, wherein ring A is one of II-A, II-B, II-C, II-D, II-E, II-F, II-H, II-I, II-J, II-K, II-L, II-N, II-O, or II-DD.
7. The compound of claim 5, wherein ring A is one of II-A, II-B, II-C, II-D, II-E, II-H, or II-K.
8. The compound of claim 5, wherein ring A is one of II-A or II-B.
9. The compound of claim 5, wherein Z1 is CRV and Z2 is CRW.
10. The compound of claim 5, wherein Z1 is N and Z2 is N.
11. The compound of claim 5, wherein Z1 is N and Z2 is CRW.
12. The compound of claim 5, wherein Z1 is CRV and Z2 is N.
13. The compound of claim 2, wherein A is a monocyclic ring system and RX groups, when present, are selected from hydrogen, alkyl- or dialkylamino, acetamido, or a C1-4 aliphatic group; RY groups, when present, are selected from hydrogen, an optionally substituted group selected from C1-6 aliphatic, C1-6 heteroaliphatic, aryl, or heteroaryl, \u2014Q(n)N(R7)2, \u2014Q(n)OR7, \u2014Q(n)SR7, \u2014Q(n)(C\u2550O)O(R7), \u2014Q(n)C(O)N(R7)2, \u2014Q(n)NHC(O)R7, \u2014Q(n)NHSO2R7, or \u2014Q(n)SO2N(R7)2, wherein n is 0 or 1, and wherein Q is preferably \u2014(C(R\u2033)2)\u2014, wherein R\u2033 is hydrogen or C1-3alkyl, and wherein each occurrence of R7 is independently hydrogen, optionally substituted aliphatic, heteroaliphatic, aryl or heteroaryl, or two occurrences of R7 on the same nitrogen atom are taken together with the nitrogen atom to form an optionally group selected from a 5\u20138 membered heterocyclic or 5\u20138 membered heteroaryl ring.
14. The compound of claim 13, wherein RY is one of the following groups: optionally substituted 5\u20136 membered heteroaryl or heterocyclyl rings, optionally substituted aryl or cycloalkyl rings; optionally substituted C1-6 aliphatic; alkoxyalkylamino alkoxyalkyl; aminoalkyl; alkyl- or dialkylamino; alkyl- or dialkylaminoalkoxy; alkyl- or dialkylaminoalkoxyalkyl; or acetamido.
15. The compound of claim 2, wherein A is a bicyclic ring system and the bicyclic ring system A may be substituted by one or more occurrences of oxo, R8 or R9, wherein R8 is \u2014R7, halo, \u2014O(CH2)2-4\u2014N(R7)2, \u2014O(CH2)2-4\u2014R7, \u2014OR7, \u2014N(R7)\u2014(CH2)2-4\u2014N(R7)2, \u2014N(R7)\u2014(CH2)2-4\u2014R7, \u2014C(\u2550O)R7, \u2014CO2R7, \u2014COCOR7, \u2014NO2, \u2014CN, \u2014S(O)R7, \u2014SO2R7, \u2014SR7, \u2014N(R7)2, \u2014CON(R7)2, \u2014SO2N(R7)2, \u2014OC(\u2550O)R7, \u2014N(R7)COR7, \u2014N(R7)CO2(optionally substituted C1-6 aliphatic), \u2014N(R7)N(R7)2, \u2014C\u2550NN(R7)2, \u2014C\u2550N\u2014OR, \u2014NHOR7, \u2014N(R7)CON(R7)2, \u2014N(R7)SO2N(R7)2, \u2014N(R7)SO2R7, or \u2014OC(\u2550O)N(R7)2, wherein each occurrence of R7 is independently hydrogen, an optionally substituted group selected from aliphatic, heteroaliphatic, aryl or heteroaryl, or two occurrences of R7 on the same nitrogen atom are taken together with the nitrogen atom to form an optionally substituted group selected from a 5\u20138 membered heterocyclic or 5\u20138 membered heteroaryl ring.
16. The compound of claim 15 wherein each occurrence of R8 is independently -halo, \u2014R7, \u2014OR7, \u2014COR7, \u2014CO2R7, \u2014CON(R7)2, \u2014O(C\u2550O)N(R7)2, \u2014CN, \u2014O(CH2)2-4\u2014N(R7)2, \u2014O(CH2)2-4\u2014R7, \u2014NO2, \u2014N(R7)2, \u2014NR7COR7, \u2014NR7SO2R7, \u2014SO2N(R7)2 wherein each occurrence of R7 is independently hydrogen, an optionally substituted group selected from aliphatic, heteroaliphatic, aryl or heteroaryl, or two occurrences of R7 on the same nitrogen atom are taken together with the nitrogen atom to form an optionally substituted group selected from a 5\u20138 membered heterocyclic or 5\u20138 membered heteroaryl ring.
17. The compound of claim 2, wherein Y is an optionally substituted heteroaryl moiety.
18. The compound of claim 2, wherein Y is selected from one of the following heteroaryl moieties a\u2013y:
wherein q is 0\u20134, R10 is \u2014R, and wherein each occurrence of R11 is independently hydrogen, \u2014R\u2032, \u2014COR\u2032, \u2014CO2(R\u2032), \u2014CON(R\u2032)2, or \u2014SO2R\u2032, wherein each occurrence of R\u2032 is independently hydrogen, an optionally substituted group selected from aliphatic, heteroaliphatic, aryl or heteroaryl, or two occurrences of R\u2032 on the same nitrogen atom are taken together with the nitrogen to form an optionally substituted group selected from a 5\u20138 membered heterocyclic or 5\u20138 membered heteroaryl ring.
19. The compound of claim 18, wherein Y is one of the following heteroaryl moieties:
wherein q is 0\u20134, R10 is \u2014R, and wherein each occurrence of R11 is independently hydrogen, \u2014R\u2032, \u2014COR\u2032, \u2014CO2(R\u2032), \u2014CON(R\u2032)2, or \u2014SO2R\u2032, wherein each occurrence of R\u2032 is independently hydrogen, optionally substituted group selected from aliphatic, heteroaliphatic, aryl or heteroaryl, or two occurrences of R\u2032 on the same nitrogen atom are taken together with the nitrogen to form an optionally substituted group selected from a 5\u20138 membered heterocyclic or 5\u20138 membered heteroaryl ring.
20. The compound of claim 18, wherein Y is a pyrazole moiety, h.
21. The compound of claim 18, wherein each R10 is independently hydrogen, C1-4aliphatic, alkoxycarbonyl, optionally substituted phenyl, hydroxyalkyl, alkoxyalkyl, aminocarbonyl, mono- or dialkylaminocarbonyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, phenylaminocarbonyl, or (N-heterocycle)carbonyl.
22. The compound of claim 18, wherein each occurrence of R10 is independently methyl, cyclopropyl, ethyl, isopropyl, propyl, t-butyl, cyclopentyl, phenyl, CO2H, CO2CH3, CH2OH, CH2OCH3, CH2CH2CH2OH, CH2CH2CH2OCH3, CH2CH2CH2OCH2Ph, CH2CH2CH2NH2, CH2CH2CH2NHCOOC(CH3)3, CONHCH(CH3)2, CONHCH2CH\u2550CH2, CONHCH2CH2OCH3, CONHCH2Ph, CONH(cyclohexyl), CON(Et)2, CON(CH3)CH2Ph, CONH(n-C3H7), CON(Et)CH2CH2CH3, CONHCH2CH(CH3)2, CON(n-C3H7)2, CO(3-methoxymethylpyrrolidin-1-yl), CONH(3-tolyl), CONH(4-tolyl), CONHCH3, CO(morpholin-1-yl), CO(4-methylpiperazin-1-yl), CONHCH2CH2OH, CONH2, or CO(piperidin-1-yl).
23. The compound of claim 18, wherein, Y is a pyrazole moiety, h\u2032, wherein the pyrazole is substituted with two occurrences of R10 (R10a and R10b)
wherein R10a is hydrogen, C1-4aliphatic, alkoxycarbonyl, optionally substituted phenyl, hydroxyalkyl, alkoxyalkyl, aminocarbonyl, mono- or dialkylaminocarbonyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, phenylaminocarbonyl, and (N-heterocycle)carbonyl; and R10b is hydrogen.
24. The compound of claim 23, wherein R10a and R10b taken together represent a substituted or unsubstituted cycloaliphatic, cycloheteroaliphatic, aryl or heteroaryl moiety and comprises one of the following groups:
wherein r is 0\u20134 and R12 is hydrogen, -halo, \u2014N(R7)2, \u2014C1-3 alkyl, \u2014C1-3 haloalkyl, \u2014NO2, \u2014O(C1-3 alkyl), \u2014CO2(C1-3 alkyl), \u2014CN, \u2014SO2(C1-3 alkyl), \u2014SO2NH2, \u2014OC(O)NH2, \u2014NH2SO2(C1-3 alkyl), \u2014NHC(O)(C1-3 alkyl), \u2014C(O)NH2, and \u2014CO(C1-3 alkyl), wherein the (C1-3 alkyl) is most preferably methyl, wherein each occurrence of R7 is independently hydrogen, an optionally substituted group selected from aliphatic, heteroaliphatic, aryl or heteroaryl, or two occurrences of R7 on the same nitrogen atom are taken together with the nitrogen atom to form an optionally substituted group selected from a 5\u20138 membered heterocyclic or 5\u20138 membered heteroaryl ring.
25. The compound of claim 2, wherein when R3 is \u2014Q1\u2014A\u2014Q2\u2014Y, R4 is hydrogen, C1-3aliphatic, hydroxy, hydroxyalkyl, alkoxy, amino, aminoalkyl, mono- or di-alkylamino, mono- or di-alkylaminoalkyl, or optionally substituted phenyl.
26. The compound of claim 25, wherein R4 is hydrogen, methyl, ethyl, cyclopropyl, hydroxy, phenyl or \u2014CH2NH2.
27. The compound of claim 2, wherein when R4 is \u2014Q1\u2014A\u2014Q2\u2014Y, R3 is hydrogen, C1-3aliphatic, hydroxy, hydroxyalkyl, alkoxy, amino, aminoalkyl, mono- or di-alkylamino, mono- or di-alkylaminoalkyl, or optionally substituted phenyl.
28. The compound of claim 27, wherein R3 is hydrogen, methyl, ethyl, cyclopropyl, hydroxy, phenyl or \u2014CH2NH2.
29. The compound of claim 2, wherein R5 is hydrogen, halogen, \u2014NO2, \u2014CN, hydroxy, optionally substituted C1-3alkyl, optionally substituted alkoxy, \u2014SO2NH2, or \u2014C(O)alkyl.
30. The compound of claim 29 wherein R5 is Cl, CF3, OCF3, CH3, \u2014CN, \u2014SO2NH2 or \u2014C(O)Me.
31. The compound of claim 2, wherein Q1 is NH and Q2 is NH, and compounds are defined by the general formula IIa(i) or IIb(i):
32. The compound of claim 2, wherein Q1 is S and Q2 is NH, and compounds are defined by the general formula IIa(ii) or IIb(ii):
33. The compound of claim 2, wherein Q1 is O and Q2 is NH, and compounds are defined by the general formula IIa(iii) or IIb(iii):
34. The compound of claim 2, wherein Q2 is NH, and compounds are defined by the general formula IIa(iv) or IIb(iv):
wherein Q1 is \u2014C(RA)2.
35. The compound of claim 2, wherein Q2 is NH and Y is an optionally substituted heteroaryl moiety, and compounds are defined by the general formula IIa(v) or IIb(v):
wherein Q1 is a direct bond.
36. The compound of any one of claims 31, 32, 33, 34 or 35, wherein:
(i) R1, R2, R4 and R5 are each hydrogen and wherein Z is CR6 and R6 is hydrogen; or R1, R2, R3 and R5 are each hydrogen and wherein Z is CR6 and R6 is hydrogen;
(ii) ring A is defined according to one of the following groups:
(a) a ring A is one of formulas
(b) ring A is one of formulas
(c) ring A is one of formulas II-A, II-B, II-C, II-D, II-E, II-F, II-H, II-I, II-J, II-K, II-L, II-N, II-O, or II-DD;
(d) ring A is one of the formulas II-A, II-B, II-C, II-D, II-E, II-H, or II-K;
(e) ring A is one of formulas II-A or II-B;
(f) ring A is II-A and Z1 is CRV and Z2 is CRW;
(g) ring A is II-A and Z1 is N and Z2 is N;
(h) ring A is II-A and Z1 is N and Z2 is CRW;
(i) ring A is II-A and Z1 is CRV and Z2 is N;
(j) ring A is an optionally substituted aryl or heteroaryl moiety of formula i, ii, i or x;
(k) ring A is a monocyclic ring system and RV and RW, when present, are hydrogen or amino; RX groups, when present, is hydrogen, alkyl- or dialkylamino, acetamido, or a C1-4 aliphatic group such as methyl, ethyl, cyclopropyl, or isopropyl; RY groups, when present, is hydrogen, an optionally substituted group selected from hydrogen, C1-6 aliphatic, C1-6 heteroaliphatic, aryl, or heteroaryl, \u2014Q(n)N(R7)2, \u2014Q(n)OR7, \u2014Q(n)SR7, \u2014Q(n)(C\u2550O)O(R7), \u2014Q(n)C(O)N(R7)2, \u2014Q(n)NHC(O)R7, \u2014Q(n)NHSO2R7, or \u2014Q(n)SO2N(R7)2, wherein n is 0 or 1, and wherein Q is preferably \u2014(C(R\u2033)2)\u2014, wherein R\u2033 is hydrogen or C1-3alkyl, and wherein each occurrence of R7 is independently hydrogen, an optionally substituted group selected from aliphatic, heteroaliphatic, aryl or heteroaryl, or two occurrences of R7 on the same nitrogen atom are taken together with the nitrogen atom to form an optionally substituted group selected from a 5\u20138 membered heterocyclic or 5\u20138 membered heteroaryl ring;
(l) ring A is a monocyclic ring system and RV, RW and RX groups, when present, are hydrogen or amino; RY groups include groups selected from optionally substituted 5\u20136 membered heteroaryl or heterocyclyl rings, such as 2-pyridyl, 4-pyridyl, pyrrolidinyl, piperidinyl, morpholinyl, or piperazinyl; optionally substituted aryl or cycloalkyl rings such as phenyl, halogen substituted phenyl, alkoxy substituted phenyl, trifluoromethyl substituted phenyl, nitro substituted phenyl, methyl substituted phenyl; optionally substituted C1-6 aliphatic, such as methyl, ethyl, cyclopropyl, cyclopentyl, cyclohexyl, amino substituted cycloalkyl, acetamido substituted cycloalkyl, isopropyl, or t-butyl; alkoxyalkylamino such as methoxyethylamino; alkoxyalkyl such as methoxymethyl or methoxyethyl; aminoalkyl such as aminoethyl, dimethylaminoethyl; alkyl- or dialkylamino such as ethylamino or dimethylamino; alkyl- or dialkylaminoalkoxy such as dimethylaminopropyloxy; alkyl- or dialkylaminoalkoxyalkyl such as dimethylaminoethoxymethyl; and acetamido;
(m) ring A system is a bicyclic ring system and the ring formed when Rx and Ry are taken together may be substituted or unsubstituted;
(n) ring A system is a bicyclic ring system formed by RX and RY taken together and substituted by one or more occurrences of R8 or R9, wherein each occurrence of R8 is independently \u2014R7, halo, \u2014O(CH2)2-4\u2014N(R7)2, \u2014O(CH2)2-4\u2014R7, \u2014OR7, \u2014N(R7)\u2014(CH2)2-4\u2014N(R7)2, \u2014N(R7)\u2014(CH2)2-4\u2014R7, \u2014C(\u2550O)R7, \u2014CO2R7, COCOR7, \u2014NO2, \u2014CN, \u2014S(O)R7, \u2014SO2R7, \u2014SR7, \u2014N(R7)2, \u2014CON(R7)2, \u2014SO2N(R7)2, \u2014OC(\u2550O)R7, \u2014N(R7)COR7, \u2014N(R7)CO2(optionally substituted C1-6 aliphatic), \u2014N(R7)N(R7)2, \u2014C\u2550NN(R7)2, \u2014C\u2550N\u2014OR, \u2014NHOR7, \u2014N(R7)CON(R7)2, \u2014N(R7)SO2N(R7)2, \u2014N(R7)SO2R7, or \u2014OC(\u2550O)N(R7)2, wherein each occurrence of R7 is independently hydrogen, an optionally substituted group selected from aliphatic, heteroaliphatic, aryl or heteroaryl, or two occurrences of R7 on the same nitrogen atom are taken together with the nitrogen atom to form an optionally substituted group selected from a 5\u20138 membered heterocyclic or 5\u20138 membered heteroaryl ring; and each occurrence of R9 is independently hydrogen, \u2014R\u2032, \u2014COR\u2032, \u2014CO2(R\u2032), \u2014CON(R\u2032)2, or \u2014SO2R\u2032, wherein each occurrence of R\u2032 is independently hydrogen, an optionally substituted group selected from aliphatic, heteroaliphatic, aryl or heteroaryl, or two occurrences of R\u2032 on the same nitrogen atom are taken together with the nitrogen to form an optionally substituted group selected from a 5\u20138 membered heterocyclic or 5\u20138 membered heteroaryl ring,

(iii) Y is defined according to one of the following groups:
(a) Y is an optionally substituted heteroaryl moiety;
(b) Y is selected from one of the heteroaryl moieties a\u2013y;
(c) Y is selected from one of the following heteroaryl moieties:
wherein q is 0\u20134, R10 is \u2014R, wherein \u2014R is defined generally above and in classes and subclasses herein, and wherein each occurrence of R11 is independently hydrogen, \u2014R\u2032, \u2014COR\u2032, \u2014CO2(R\u2032), \u2014CON(R\u2032)2, or \u2014SO2R\u2032, wherein each occurrence of R\u2032 is independently hydrogen, an optionally substituted group selected from aliphatic, heteroaliphatic, aryl or heteroaryl, or two occurrences of R\u2032 on the same nitrogen atom are taken together with the nitrogen to form an optionally substituted group selected from a 5\u20138 membered heterocyclic or 5\u20138 membered heteroaryl ring;

(d) Y is a pyrazole moiety, h;
(e) Y is one of a, b, f, h or o, optionally substituted with one or more R10 groups, wherein each occurrence of R10 is independently hydrogen, C1-4aliphatic, alkoxycarbonyl, optionally substituted phenyl, hydroxyalkyl, alkoxyalkyl, aminocarbonyl, mono- or dialkylaminocarbonyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, phenylaminocarbonyl, and (N-heterocycle)carbonyl;
(f) Y is one of a, b, f, h or o, optionally substituted with one or more R10 groups, wherein each occurrence of R10 is independently hydrogen, methyl, cyclopropyl, ethyl, isopropyl, propyl, t-butyl, cyclopentyl, phenyl, CO2H, CO2CH3, CH2OH, CH2OCH3, CH2CH2CH2OH, CH2CH2CH2OCH3, CH2CH2CH2OCH2Ph, CH2CH2CH2NH2, CH2CH2CH2NHCOOC(CH3)3, CONHCH(CH3)2, CONHCH2CH\u2550CH2, CONHCH2CH2OCH3, CONHCH2Ph, CONH(cyclohexyl), CON(Et)2, CON(CH3)CH2Ph, CONH(n-C3H7), CON(Et)CH2CH2CH3, CONHCH2CH(CH3)2, CON(n-C3H7)2, CO(3-methoxymethylpyrrolidin-1-yl), CONH(3-tolyl), CONH(4-tolyl), CONHCH3, CO(morpholin-1-yl), CO(4-methylpiperazin-1-yl), CONHCH2CH2OH, CONH2, and CO(piperidin-1-yl).
(g) Y is a pyrazole moiety, h\u2032, wherein the pyrazole is substituted with R10a and R10b,
wherein each occurrence of R10a is hydrogen, C1-4aliphatic, alkoxycarbonyl, optionally substituted phenyl, hydroxyalkyl, alkoxyalkyl, aminocarbonyl, mono- or dialkylaminocarbonyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, phenylaminocarbonyl, and (N-heterocycle)carbonyl, and R10b is hydrogen;

(h) Y is a pyrazole moiety, h\u2032, wherein the pyrazole is substituted with R10a and R10b,
wherein each occurrence of R10a is hydrogen, methyl, cyclopropyl, ethyl, isopropyl, propyl, t-butyl, cyclopentyl, phenyl, CO2H, CO2CH3, CH2OH, CH2OCH3, CH2CH2CH2OH, CH2CH2CH2OCH3, CH2CH2CH2OCH2Ph, CH2CH2CH2NH2, CH2CH2CH2NHCOOC(CH3)3, CONHCH(CH3)2, CONHCH2CH\u2550CH2, CONHCH2CH2OCH3, CONHCH2Ph, CONH(cyclohexyl), CON(Et)2, CON(CH3)CH2Ph, CONH(n-C3H7), CON(Et)CH2CH2CH3, CONHCH2CH(CH3)2, CON(n-C3H7)2, CO(3-methoxymethylpyrrolidin-1-yl), CONH(3-tolyl), CONH(4-tolyl), CONHCH3, CO(morpholin-1-yl), CO(4-methylpiperazin-1-yl), CONHCH2CH2OH, CONH2, and CO(piperidin-1-yl, and R10b is hydrogen;

(i) Y is heteroaryl moiety substituted by at least two occurrences of R10 and where two occurrences of R10 taken together may represent an optionally substituted group selected from cycloaliphatic, cycloheteroaliphatic, aryl or heteroaryl;
(j) Y represents one of the following heteroaryl moieties:
wherein r is 0\u20134 and R12 is hydrogen, -halo, \u2014N(R7)2, \u2014C1-3 alkyl, \u2014C1-3 haloalkyl, NO2, \u2014O(C1-3 alkyl), \u2014CO2(C1-3 alkyl), \u2014CN, \u2014SO2(C1-3 alkyl), \u2014SO2NH2, \u2014OC(O)NH2, \u2014NH2SO2(C1-3 alkyl), \u2014NHC(O)(C1-3 alkyl), \u2014C(O)NH2, and \u2014CO(C1-3 alkyl), wherein the (C1-3 alkyl) is most preferably methyl;
(iv) for compounds of formula IIa(i), R4 is defined according to one of the following groups:
(a) R4 is hydrogen, C1-3aliphatic, hydroxy, hydroxyalkyl, alkoxy, amino, aminoalkyl, mono- or di-alkylamino, mono- or di-alkylaminoalkyl, or optionally substituted phenyl, or
(b) R4 is hydrogen, methyl, ethyl, cyclopropyl, hydroxy, phenyl or \u2014CH2NH2;

(v) for compounds of formula IIb(i), R3 is defined according to one of the following groups:
(a) R3 is hydrogen, C1-3aliphatic, hydroxy, hydroxyalkyl, alkoxy, amino, aminoalkyl, mono- or di-alkylamino, mono- or di-alkylaminoalkyl, or optionally substituted phenyl, or
(b) R3 is hydrogen, methyl, ethyl, cyclopropyl, hydroxy, phenyl or \u2014CH2NH2; and

(vi) R5 is defined according to one of the following groups:
(a) hydrogen, halogen, \u2014NO2, \u2014CN, hydroxy, optionally substituted C1-3alkyl, optionally substituted alkoxy, \u2014SO2NH2, or \u2014C(O)alkyl, or
(b) R5 is hydrogen, Cl, CF3, OCF3, CH3, \u2014CN, \u2014SO2NH2 or \u2014C(O)Me.
37. The compound of claim 1, wherein either of R3 or R4 is \u2014Q1\u2014A\u2014Q2\u2014Y, wherein A is an optionally substituted cycloaliphatic or heterocycloaliphatic moiety and compounds have the general formula IIIa or IIIb:
wherein U is NR13, C(R14)2, or O; V is NR13, C(R14)2, or O; W is NR13, C(R14)2, or O, and X is NR13, C(R14)2, or O, and t is 0, 1 or 2, wherein each occurrence of R13 is independently hydrogen, \u2014R\u2032, \u2014COR\u2032, \u2014CO2(R\u2032), \u2014CON(R\u2032)2, or \u2014SO2R\u2032, wherein each occurrence of R\u2032 is independently hydrogen, optionally substituted group selected from C1-6 aliphatic, C1-6heteroaliphatic, aryl or heteroaryl, or two occurrences of R\u2032 on the same nitrogen atom are taken together with the nitrogen to form an optionally substituted group selected from a 5\u20138 membered heterocyclic or 5\u20138 membered heteroaryl ring; and wherein each occurrence of R14 is independently \u2014R, with the proviso that when any one of U, V, W, or X is O or NR13, an adjacent group U, V, W or X is C(R14)2.
38. The compound of claim 37, wherein ring A is selected from the following group:
wherein R13 is hydrogen, \u2014R\u2032, \u2014COR\u2032, \u2014CO2(R\u2032), \u2014CON(R\u2032)2, or \u2014SO2R\u2032, wherein each occurrence of R\u2032 is independently hydrogen, optionally substituted group selected from aliphatic, heteroaliphatic, aryl or heteroaryl, or two occurrences of R\u2032 on the same nitrogen atom are taken together with the nitrogen to form an optionally substituted group selected from a 5\u20138 membered heterocyclic or heteroaryl ring; R14 is oxo or \u2014R; and x is 0\u20134.
39. The compound of claim 38, wherein x is 0 or 1 and R14 is -halo, \u2014N(R7)2, \u2014C1-3 alkyl, \u2014haloalkyl, \u2014NO2, \u2014O(C1-3 alkyl), \u2014CO2(C1-3 alkyl), \u2014CN, \u2014SO2(C1-3 alkyl), \u2014SO2NH2, \u2014OC(O)NH2, \u2014NH2SO2(C1-3 alkyl), \u2014NHC(O)(C1-3 alkyl), \u2014C(O)NH2, and \u2014CO(C1-3 alkyl), wherein the (C1-3 alkyl) is most preferably methyl.
40. The compound of claim 38, wherein R13 is hydrogen or C1-4alkyl.
41. The compound of claim 38, wherein ring A is selected from one of xi, xii or xvi and x is 0.
42. The compound of claim 37, wherein Y is an optionally substituted heteroaryl moiety.
43. The compound of claim 37, wherein Y is selected from one of the following heteroaryl moieties a\u2013y:
wherein q is 0\u20134, R10 is \u2014R, and wherein each occurrence of R11 is independently hydrogen, \u2014R\u2032, \u2014COR\u2032, \u2014CO2(R\u2032), \u2014CON(R\u2032)2, or \u2014SO2R\u2032, wherein each occurrence of R\u2032 is independently hydrogen, an optionally substituted group selected from aliphatic, heteroaliphatic, aryl or heteroaryl, or two occurrences of R\u2032 on the same nitrogen atom are taken together with the nitrogen to form an optionally substituted group selected from a 5\u20138 membered heterocyclic or 5\u20138 membered heteroaryl ring.
44. The compound of claim 43, wherein Y is one of the following heteroaryl moieties:
wherein q is 0\u20134, R10 is \u2014R, and wherein each occurrence of R11 is independently hydrogen, \u2014R\u2032, \u2014COR\u2032, \u2014CO2(R\u2032), \u2014CON(R\u2032)2, or \u2014SO2R\u2032, wherein each occurrence of R\u2032 is independently hydrogen, optionally substituted group selected from aliphatic, heteroaliphatic, aryl or heteroaryl, or two occurrences of R\u2032 on the same nitrogen atom are taken together with the nitrogen to form an optionally substituted group selected from a 5\u20138 membered heterocyclic or 5\u20138 membered heteroaryl ring.
45. The compound of claim 43, wherein each R10 is independently hydrogen, C1-4aliphatic, alkoxycarbonyl, optionally substituted phenyl, hydroxyalkyl, alkoxyalkyl, aminocarbonyl, mono- or dialkylaminocarbonyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, phenylaminocarbonyl, or (N-heterocycle)carbonyl.
46. The compound of claim 43, wherein each occurrence of R10 is independently methyl, cyclopropyl, ethyl, isopropyl, propyl, t-butyl, cyclopentyl, phenyl, CO2H, CO2CH3, CH2OH, CH2OCH3, CH2CH2CH2OH, CH2CH2CH2OCH3, CH2CH2CH2OCH2Ph, CH2Ch2Ch2NH2, CH2CH2CH2NHCOOC(CH3)3, CONHCH(CH3)2, CONHCH2CH\u2550CH2, CONHCH2CH2OCH3, CONHCH2Ph, CONH(cyclohexyl), CON(Et)2, CON(CH3)CH2Ph, CONH(n-C3H7), CON(Et)CH2CH2CH3, CONHCH2CH(CH3)2, CON(n-C3H7)2, CO(3-methoxymethylpyrrolidin-1-yl), CONH(3-tolyl), CONH(4-tolyl), CONHCH3, CO(morpholin-1-yl), CO(4-methylpiperazin-1-yl), CONHCH2CH2OH, CONH2, or CO(piperidin-1-yl).
47. The compound of claim 43, wherein, Y is a pyrazole moiety, h\u2032, wherein the pyrazole is substituted with of R10a and R10b,
wherein R10a is hydrogen, C1-4aliphatic, alkoxycarbonyl, optionally substituted phenyl, hydroxyalkyl, alkoxyalkyl, aminocarbonyl, mono- or dialkylaminocarbonyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, phenylaminocarbonyl, and (N-heterocycle)carbonyl; and R10b is hydrogen.
48. The compound of claim 47, wherein R10a and R10b taken together represent a substituted or unsubstituted cycloaliphatic, cycloheteroaliphatic, aryl or heteroaryl moiety and comprises one of the following groups:
wherein r is 0\u20134 and R12 is hydrogen, -halo, \u2014N(R7)2, \u2014C1-3 alkyl, \u2014C1-3 haloalkyl, \u2014NO2, \u2014O(C1-3 alkyl), \u2014CO2(C1-3 alkyl), \u2014CN, \u2014SO2(C1-3 alkyl), \u2014SO2NH2, \u2014OC(O)NH2, \u2014NH2SO2(C1-3 alkyl), \u2014NHC(O)(C1-3 alkyl), \u2014C(O)NH2, and \u2014CO(C1-3 alkyl), wherein each occurrence of R7 is independently hydrogen, an optionally substituted group selected from aliphatic, heteroaliphatic, aryl or heteroaryl, or two occurrences of R7 on the same nitrogen atom are taken together with the nitrogen atom to form an optionally substituted group selected from a 5\u20138 membered heterocyclic or 5\u20138 membered heteroaryl ring.
49. The compound of claim 37, wherein when R3 is \u2014Q1\u2014A\u2014Q2\u2014Y, R4 is hydrogen, C1-3aliphatic, hydroxy, hydroxyalkyl, alkoxy, amino, aminoalkyl, mono- or di-alkylamino, mono- or di-alkylaminoalkyl, or optionally substituted phenyl.
50. The compound of claim 49, wherein R4 is hydrogen, methyl, ethyl, cyclopropyl, hydroxy, phenyl or \u2014CH2NH2.
51. The compound of claim 37, wherein when R4 is \u2014Q1\u2014A\u2014Q2\u2014Y, R3 is preferably hydrogen, C1-3aliphatic, hydroxy, hydroxyalkyl, alkoxy, amino, aminoalkyl, mono- or di-alkylamino, mono- or di-alkylaminoalkyl, or optionally substituted phenyl.
52. The compound of claim 51, wherein R3 is hydrogen, methyl, ethyl, cyclopropyl, hydroxy, phenyl or \u2014CH2NH2.
53. The compound of claim 37, wherein R5 is hydrogen, halogen, \u2014NO2, \u2014CN, hydroxy, optionally substituted C1-3alkyl, optionally substituted alkoxy, \u2014SO2NH2, or \u2014C(O)alkyl.
54. The compound of claim 53, wherein R5 is Cl, CF3, OCF3, CH3, \u2014CN, \u2014SO2NH2 or \u2014C(O)Me.
55. The compound of claim 37, wherein Q1 is NH and Q2 is NH, and compounds are defined by the general formula IIIa(i) or IIIb(i):
56. The compound of claim 37 wherein Q1 is S, and Q2 is NH, and compounds are defined by the general formula IIIa(ii) or IIIb(ii):
57. The compound of claim 37 wherein Q1 is O and Q2 is NH, and compounds are defined by the general formula IIIa(iii) or IIIb(iii):
58. The compound of claim 37, wherein Q2 is NH, and compounds are defined by the general formula IIIa(iv) or IIIb(iv):
wherein Q1 is \u2014C(RA)2\u2014.
59. The compound of claim 37, wherein Q2 is NH, and compounds are defined by the general formula IIIa(v) or IIIb(v):
wherein Q1 is a direct bond.
60. The compound of any one of claims 55, 56, 57, 58, or 59 wherein:
(i) R1, R2, R4 and R5 are each hydrogen and wherein Z is CR6 and R6 is hydrogen; or R1, R2, R3 and R5 are each hydrogen and wherein Z is CR6 and R6 is hydrogen;
(ii) ring A is defined according to one of the following groups:
(a) ring A is selected from one of the groups:
wherein R13 is hydrogen, \u2014R\u2032, \u2014COR\u2032, \u2014CO2(R\u2032), \u2014CON(R\u2032)2, or \u2014SO2R\u2032, wherein each occurrence of R\u2032 is independently hydrogen, an optionally substituted group selected from aliphatic, heteroaliphatic, aryl or heteroaryl, or two occurrences of R\u2032 on the same nitrogen atom are taken together with the nitrogen to form an optionally substituted group selected from a 5\u20138 membered heterocyclic or 5\u20138 membered heteroaryl ring; R14 is oxo or \u2014R; and x is 0\u20134; or

(b) ring A is selected from one of xi, xii or xvi and x is 0 or 1; R14 is -halo, \u2014N(R7)2, \u2014C1-3 alkyl, \u2014C1-3 haloalkyl, \u2014NO2, \u2014O(C1-3 alkyl), \u2014CO2(C1-3 alkyl), \u2014CN, \u2014SO2(C1-3 alkyl), \u2014SO2NH2, \u2014OC(O)NH2, \u2014NH2SO2(C1-3 alkyl), \u2014NHC(O)(C1-3 alkyl), \u2014C(O)NH2, and \u2014CO(C1-3 alkyl), wherein the (C1-3 alkyl) is most preferably methyl; and R13 is hydrogen or C1-4alkyl;

(iii) Y is defined according to one of the following groups:
(a) Y is an optionally substituted heteroaryl moiety;
(b) Y is selected from one of the heteroaryl moieties a\u2013y;
(c) Y is selected from one of the following heteroaryl moieties:
wherein q is 0\u20134, R10 is \u2014R, wherein \u2014R is defined generally above and in classes and subclasses herein, and wherein each occurrence of R11 is independently hydrogen, \u2014R\u2032, \u2014COR\u2032, \u2014CO2(R\u2032), \u2014CON(R\u2032)2, or \u2014SO2R, wherein each occurrence of R\u2032 is independently hydrogen, an optionally substituted group selected from aliphatic, heteroaliphatic, aryl or heteroaryl, or two occurrences of R\u2032 on the same nitrogen atom are taken together with the nitrogen to form an optionally substituted group selected from a 5\u20138 membered heterocyclic or 5\u20138 membered heteroaryl ring;

(d) Y is a pyrazole moiety, h;
(e) Y is one of a, b, f, h or o, optionally substituted with one or more R10 groups, wherein each occurrence of R10 is independently hydrogen, C1-4aliphatic, alkoxycarbonyl, optionally substituted phenyl, hydroxyalkyl, alkoxyalkyl, aminocarbonyl, mono- or dialkylaminocarbonyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, phenylaminocarbonyl, and (N-heterocycle)carbonyl;
(f) Y is one of a, b, f, h or o, optionally substituted with one or more R10 groups, wherein each occurrence of R10 is independently hydrogen, methyl, cyclopropyl, ethyl, isopropyl, propyl, t-butyl, cyclopentyl, phenyl, CO2H, CO2CH3, CH2OH, CH2OCH3, CH2CH2CH2OH, CH2CH2CH2OCH3, CH2CH2CH2OCH2Ph, CH2CH2CH2NH2, CH2CH2CH2NHCOOC(CH3)3, CONHCH(CH3)2, CONHCH2CH\u2550CH2, CONHCH2CH2OCH3, CONHCH2Ph, CONH(cyclohexyl), CON(Et)2, CON(CH3)CH2Ph, CONH(n-C3H7), CON(Et)CH2CH2CH3, CONHCH2CH(CH3)2, CON(n-C3H7)2, CO(3-methoxymethylpyrrolidin-1-yl), CONH(3-tolyl), CONH(4-tolyl), CONHCH3, CO(morpholin-1-yl), CO(4-methylpiperazin-1-yl), CONHCH2CH2OH, CONH2, and CO(piperidin-1-yl);
(g) Y is a pyrazole moiety, h\u2032, wherein the pyrazole is substituted with R10a and R10b ,
wherein each occurrence of R10a is hydrogen, C1-4aliphatic, alkoxycarbonyl, optionally substituted phenyl, hydroxyalkyl, alkoxyalkyl, aminocarbonyl, mono- or dialkylaminocarbonyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, phenylaminocarbonyl, and (N-heterocycle)carbonyl, and R10b is hydrogen;

(h) Y is a pyrazole moiety, h\u2032, wherein the pyrazole is substituted with two occurrences of R10 (R10a and R10b as depicted),
wherein each occurrence of R10a is hydrogen, methyl, cyclopropyl, ethyl, isopropyl, propyl, t-butyl, cyclopentyl, phenyl, CO2H, CO2CH3, CH2OH, CH2OCH3, CH2CH2CH2OH, CH2CH2CH2OCH3, CH2CH2CH2OCH2Ph, CH2CH2CH2NH2, CH2CH2CH2NHCOOC(CH3)3, CONHCH(CH3)2, CONHCH2CH\u2550CH2, CONHCH2CH2OCH3, CONHCH2Ph, CONH(cyclohexyl), CON(Et)2, CON(CH3)CH2Ph, CONH(n-C3H7), CON(Et)CH2CH2CH3, CONHCH2CH(CH3)2, CON(n-C3H7)2, CO(2-methoxymethylpyrrolidin-1-yl), CONH(3-tolyl), CONH(4-tolyl), CONHCH3, CO(morpholin-1-yl), CO(4-methylpiperazin-1-yl), CONHCH2CH2OH, CONH2, and CO(piperidin-1-yl, and R10b is hydrogen;

(i) Y is heteroaryl moiety substituted by at least two occurrences of R10 and where two occurrences of R10 taken together may represent an optionally substituted group selected from cycloaliphatic, cycloheteroaliphatic, aryl or heteroaryl;
(j) Y represents one of the following heteroaryl moieties:
wherein r is 0\u20134 and R12 is hydrogen, -halo, \u2014N(R7)2, \u2014C1-3 alkyl, \u2014C1-3 haloalkyl, \u2014NO2, \u2014O(C1-3 alkyl), \u2014CO2(C1-3 alkyl), \u2014CN, \u2014SO2(C1-3 alkyl), \u2014SO2NH2, \u2014OC(O)NH2, \u2014NH2SO2(C1-3 alkyl), \u2014NHC(O)(C1-3 alkyl), \u2014C(O)NH2, and \u2014CO(C1-3 alkyl), wherein the (C1-3 alkyl) is most preferably methyl;
(iv) R4 is defined according to one of the following groups:
(a) R4 is hydrogen, C1-3aliphatic, hydroxy, hydroxyalkyl, alkoxy, amino, aminoalkyl, mono- or di-alkylamino, mono- or di-alkylaminoalkyl, or optionally substituted phenyl, or
(b) R4 is hydrogen, methyl, ethyl, cyclopropyl, hydroxy, phenyl or \u2014CH2NH2;

(v) R3 is defined according to one of the following groups:
(a) R3 is hydrogen, C1-3aliphatic, hydroxy, hydroxyalkyl, alkoxy, amino, aminoalkyl, mono- or di-alkylamino, mono- or di-alkylaminoalkyl, or optionally substituted phenyl, or
(b) R3 is hydrogen, methyl, ethyl, cyclopropyl, hydroxy, phenyl or \u2014CH2NH2; and

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

The invention claimed is:

1. A media release mechanism comprising:
a spindle having a fixed end, a free end, and an exterior surface,
a ramp on the exterior surface of said spindle, wherein said ramp slopes from said free end to said fixed end, and
a fin for engagement with said ramp, said fin having an outer surface and an inner surface.
2. A media release mechanism as defined in claim 1, wherein said inner surface of said fin is angled relative to said outer surface of said fin.
3. A media release mechanism as defined in claim 1, further including a back plate, and wherein said fixed end of said spindle is mounted to said back plate.
4. A media release mechanism as defined in claim 3, further including arms extending from said back plate and said spindle is mounted to said back plate by engaging said arms with said spindle.
5. A media release mechanism as defined in claim 4, wherein said arms further include ears extending from said arms, wherein said spindle includes apertures through a wall of said spindle, and wherein said ears engage with said apertures.
6. A media release mechanism as defined in claim 3, further comprising a spring having a first end and a second end, wherein said first end of said spring is attached to said fin and a second end of said spring is attached to said back plate.
7. A media release mechanism as defined in claim 1, further comprising a protrusion extending from said inner surface of said fin.
8. A media release mechanism as defined in claim 7, wherein said ramp includes a slot and said protrusion of said fin is positioned within said slot.
9. A media release mechanism as defined in claim 7, wherein said protrusion is T-shaped.
10. A media release mechanism as defined in claim 1, wherein said spindle further includes fingers extending from said exterior surface of said spindle on either side of said ramp.
11. A media release mechanism as defined in claim 1, wherein said spindle includes a rib extending from the exterior surface of said spindle.
12. A media release mechanism as defined in claim 1, wherein said fin further includes a finger grip.
13. A media release mechanism as defined in claim 1, wherein said fin further includes a body and a tab extending outwardly from said body proximate said fixed end of said spindle.
14. A media release mechanism as defined in claim 2, wherein a ramp angle is formed by said ramp and said exterior surface of said spindle, wherein a fin angle is formed by said inner surface of said fin and said outer surface of said fin, and said ramp angle corresponds to said fin angle.
15. A media release mechanism as defined in claim 1, further including a slot in said spindle through which a media can be positioned and retained.
16. A printer comprising:
a housing;
printhead means mounted in said housing;
media delivery means mounted in said housing for delivering a media to said printhead;
a media take-up and release mechanism mounted in said housing; and
wherein said media take-up and release mechanism includes;
a spindle having a fixed end, a free end, and an exterior surface,
a ramp on the exterior surface of said spindle, wherein said ramp slopes from said free end to said fixed end, and
a fin for engagement with said ramp, said fin having an outer surface and an inner surface.
17. A printer as defined in claim 16, wherein, said inner surface of said fin is angled relative to said outer surface of said fin.
18. A printer as defined in claim 16, further including a back plate mounted in said housing and said media release mechanism is mounted to said back plate.
19. A printer as defined in claim 16, wherein said media release mechanism further includes a protrusion extending from said inner surface of said fin, said ramp includes a slot, and said protrusion of said fin is positioned with in said slot.
20. A printer as defined in claim 16, wherein said media release mechanism further includes fingers extending from said exterior surface of said spindle on either side of said ramp.
21. A method of collecting and releasing media from a spindle assembly including the steps of:
providing a spindle having a fixed end, a free end, and an exterior surface,
providing a ramp on the exterior surface of said spindle, wherein said ramp slopes outward from said free end to said fixed end,
providing a fin for engagement with said ramp, said fin having an outer surface and an inner surface,
winding said media around said spindle and said fin,
sliding said fin toward said free end of said spindle, and
removing said media from said spindle and said fin.
22. A method of collecting and releasing media from a spindle as defined in claim 21, wherein said inner surface of said fin is angled relative to said outer surface of said fin.
23. A method as defined in claim 21, further including the steps of:
providing a slot in said spindle;
threading said media through said slot prior to winding said media around said spindle and said fin.
24. A spindle having an exterior surface and a slot provided in said exterior surface, and wherein said slot receives a media to be wound around said exterior surface.
25. A spindle as defined in claim 21, wherein said slot includes a first portion, a second portion and a third portion, said first portion being angled relative to said exterior surface, said second portion being angled relative to said first portion, and said third portion parallel to said exterior surface.

1461104660-182e1243-ad15-46c6-be01-d28417e409ee

1. A notification system comprising:
a message server having a processor configured to send and receive electronic messages, each of the electronic messages having a message header; and
an application program interface configured to communicate with the message server, with a message interface, and with a notification interface,
wherein the application program interface is configured to provide functions allowing a user to, via the message interface, read, draft, and send the electronic messages,
wherein the application program interface is configured to apply first and second filters to the message header of at least a portion of the electronic messages received by the message server thereby resulting in respective first and second filtered messages and to cause the notification interface to display first and second graphical indicators having different shapes and colors for the respective first and second filtered messages based on the application of the respective first and second filters,
wherein the notification interface is part of a toolbar that is different from the message interface and is configured to display the first and second graphical indicators in response to the first and second filtered messages, regardless of whether the message interface is activated,
wherein the notification interface is configured to change the shape or color of the at least one of the first and second graphical indicators based on at least one newly filtered message from one of the first and second filtered messages,
wherein the application program interface is configured to provide functions allowing the user to concurrently select, via the notification interface as part of the toolbar, a different type for each of the first and second graphical indicators from first and second graphical indicator types for each of the respective first and second filters, and
wherein the first graphical indicator type is displayed as part of the toolbar in response to filtered messages associated with the first filter and the second graphical indicator type is displayed concurrently as part of the toolbar in response to filtered messages associated with the second filter.
2. The notification system of claim 1,
wherein the toolbar is included in the display of a general-purpose web browser such that at least one of the first and second graphical indicators is displayable regardless of a webpage being currently displayed by the web browser.
3. The notification system of claim 1,
wherein the application program interface is configured to provide functions allowing the user to select, via the notification interface, at least one of the first and second filters from among a plurality of filter options.
4. The notification system of claim 3,
wherein each of the filter options includes a filter parameter corresponding to at least a portion of the message header, and
the application program interface is configured to cause the notification interface to display at least one of the first and second graphical indicators for those of the first and second filtered messages whose message header matches the filter parameter of at least one of the first and second filters and to cause the notification interface to not display the at least one of the first and second graphical indicators for those of the first and second filtered messages whose message header does not match the filter parameter of the at least one of the first and second filters.
5. The notification system of claim 4, wherein the application program interface is configured to, via the message interface, update a previously displayed graphical indicator in response to the newly filtered message whose message header matches the filter parameter of the at least one filter.
6. The notification system of claim 4, wherein, when a portion of the message header of at least one of the received messages being filtered matches the filter parameter of at least one of the first and second filters and at least one of the first and second graphical indicators displayed by the notification interface includes information contained in the portion of the message header.
7. The notification system of claim 1, further comprising:
a database configured to communicate with the application program interface and to store at least one of the first and second filters.
8. The notification system of claim 1,
wherein the message server is an email server and the electronic messages are email messages.
9. The notification system of claim 1, wherein the application program interface is configured to provide functions allowing the user to select, via the notification interface, a type of at least one of the first and second graphical indicators from among more than one graphical indicator type options.
10. A method comprising:
causing a message server to receive electronic messages, each of the electronic messages having a message header;
causing a processor to apply first and second filters to the message headers of the received messages thereby resulting in first and second filtered messages; and
causing the processor to display, via a notification interface, first and second graphical indicators having different shapes and colors for the respective first and second filtered messages based on the application of the respective first and second filters, at least one of the first and second graphical indicators being for displaying at least one of a priority, size, and message content from the filtered message only when at least one portion of the message header matches a filter parameter of at least one of the applied first and second filters,
wherein the notification interface is part of a toolbar that is different from a message interface that is used by the processor to provide functions allowing a user to read, draft, and send at least one of the electronic messages,
wherein the first and second graphical indicators are displayed by the notification interface in response to the first and second filtered messages, regardless of whether the message interface is activated,
wherein the shape or color of at least one of the first and second graphical indicators is changed by the notification interface based on at least one newly filtered message from one of the first and second filtered messages,
wherein the notification interface, as part of the toolbar, provides functions allowing the user to concurrently select a different type for each of the first and second graphical indicators from first and second graphical indicator types for each of the respective first and second filters, and
wherein the first graphical indicator type is displayed as part of the toolbar in response to filtered messages associated with the first filter and the second graphical indicator type is displayed concurrently as part of the toolbar in response to filtered messages associated with the second filter.
11. The method of claim 10, wherein the toolbar is included in the display of a general-purpose web browser such that at least one of the first and second graphical indicators is displayable regardless of a webpage being currently displayed by the web browser.
12. The method of claim 10, further comprising:
allowing the user to select, via the notification interface, at least one of the first and second filters from among a plurality of filter options.
13. The method of claim 10, further comprising:
causing the processor to update, via the message interface, a previously displayed graphical indicator in response to the newly filtered message whose message header matches the filter parameter of at least one of the first and second filters.
14. The method of claim 13,
wherein, when a portion of the message header of at least one of the received messages matches the filter parameter of at least one of the first and second filters and at least one of the first and second graphical indicators being displayed by the notification interface includes information contained in the portion of the message header.
15. The method of claim 10, further comprising:
causing the processor to provide functions allowing the user to select, via the notification interface, a type of at least one of the first and second graphical indicators from among a plurality of graphical indicator type options.
16. A non-transitory computer readable medium tangibly embodying computer-executable instructions, the instructions being executable by a processor to cause the processor to:
apply first and second filters to message headers of electronic messages received by a message server thereby resulting in first and second filtered messages;
display, via a notification interface, first and second graphical indicators having different shapes and colors for the respective first and second filtered messages based on the applied respective first and second filters, at least one of the first and second graphical indictors being displayed for at least one of the first and second filtered messages only when at least one portion of the message header matches a filter parameter of at least one of the applied first and second filters associated with a specific sender;
change, via the notification interface, a shape or color of at least one of the first and second graphical indicators based on at least one newly filtered message from one of the first and second filtered messages,
wherein the notification interface is part of a toolbar that is different from a message interface that is used by the processor to provide functions allowing a user to read, draft, and send at least one of the electronic messages,
wherein the first and second graphical indicators are displayed by the notification interface in response to the first and second filtered messages, regardless of whether the message interface is activated,
wherein the notification interface, as part of the toolbar, provides functions allowing the user to concurrently select a different type for each of the first and second graphical indicators from first and second graphical indicator types for each of the respective first and second filters, and
wherein the first graphical indicator type is displayed as part of the toolbar in response to filtered messages associated with the first filter and the second graphical indicator type is displayed concurrently as part of the toolbar in response to filtered messages associated with the second filter.
17. The non-transitory computer readable medium of claim 16,
wherein the toolbar is included in the display of a general-purpose web browser such that at least one of the first and second graphical indicators is displayable regardless of a webpage being currently displayed by the web browser.
18. The non-transitory computer readable medium of claim 16, wherein the instructions are executable by a processor to cause the processor to:
allow the user to select, via the notification interface, at least one of the first and second filters from among a plurality of filter options.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method for optimizing a cloud-computing environment, the method comprising:
a processor of a computer system receiving extrinsic data that describes a set of virtual resources of the cloud-computing environment;
the processor selecting a set of candidate resource configurations, wherein every virtual resource of the set of virtual resources is associated with a plurality of candidate resource configurations of the set of candidate resource configurations in a one-to-many relationship;
the processor further selecting a set of candidate environment configurations, wherein each candidate environment configuration of the set of candidate environment configurations comprises at least one candidate resource configuration of the set of candidate resource configurations;
the processor provisioning a virtual test environment, wherein the virtual test environment simulates the cloud-computing environment, and wherein the virtual test environment comprises a virtual representation of each virtual resource of the set of virtual resources of the cloud-computing environment;
the processor configuring the virtual test environment by successively loading the virtual test environment with combinations of a configuration of at least two candidate environment configurations of the set of candidate environment configurations and a configuration of at least two candidate resource configurations of the set of candidate resource configurations, wherein the at least two candidate resource configurations are associated with a same tested resource of the set of virtual resources;
the processor evaluating a first resource-fitness characteristic of a first loaded resource configuration of the at least two candidate resource configurations, wherein the first loaded resource configuration is associated with the same tested resource of the set of virtual resources, and wherein the first resource-fitness characteristic is assigned a value as a function of an operation of the same tested resource within the virtual test environment while the virtual test environment is loaded with the first loaded resource configuration;
the processor deriving a value of an environment-fitness characteristic of a first loaded environment configuration of the at least two candidate environment configurations as a function of an operation of the virtual test environment while the virtual test environment is loaded with the first loaded environment configuration;
the processor ranking the at least two candidate resource configurations as a function of the evaluating and of the deriving;
the processor further ranking the at least two candidate environment configurations as a function of the evaluating and of the deriving;
the processor revising at least one candidate resource configuration of the set of candidate resource configurations and at least one candidate environment configuration of the set of candidate environment configurations as a function of the ranking and of the further ranking;
the processor repeating the configuring, the evaluating, the deriving, the ranking, the further ranking, and the revising until a termination condition is satisfied; and
the processor identifying an optimal environment configuration as a function of the further ranking.
2. The method of claim 1, wherein a first virtual resource of the set of virtual resources comprises a first set of functional blocks, wherein a first functional block of the first set of functional blocks comprises a first set of configurable parameters, and wherein a first configuration of the first virtual resource comprises a first set of values of the first set of configurable parameters.
3. The method of claim 2, further comprising:
the processor organizing the set of virtual resources, the functional blocks comprised by each virtual resource of the set of virtual resources, and the sets of configurable parameters associated with each virtual resource of the set of virtual resources into a hierarchical structure, wherein the organizing is performed as a function of the extrinsic data.
4. The method of claim 1, wherein the virtual test environment is provisioned as a function of resource constraints, projected loads, and user requirements further described by the extrinsic data.
5. The method of claim 1, further comprising:
the processor identifying a plurality of distinct subsets of a union of the at least two candidate environment configurations and the at least two candidate resource configurations; and
the processor performing multiple iterations of the loading, evaluating, and deriving, wherein each iteration of the multiple iterations comprises loading the virtual test environment with a different subset of the plurality of distinct subsets.
6. The method of claim 2, further comprising:
the processor organizing the set of all functional blocks comprised by all virtual resources of the set of virtual resources into a set of groups,
wherein a first group of the set of groups comprises all functional blocks that comprise one or more configurable parameters associated with a first resource of the set of virtual resources,
wherein a configuration of the set of first-resource configurations, of the set of candidate resource configurations, that identifies a configuration of the first resource and comprises the first group of the set of groups, and
wherein a distinct candidate configuration of the first resource is identified by a distinct set of one or more values of the one or more configurable parameters comprised by a resource configuration of the set of first-resource configurations.
7. The method of claim 2, wherein revising a first candidate resource configuration comprises revising one or more values of one or more configurable parameters comprised by the first candidate configuration, wherein the first candidate resource configuration is selected from the set of candidate resource configurations by an application of a first statistical function, wherein the one or more configurable parameters are selected from a set of all configurable parameters comprised by the first candidate resource configuration by an application of a second statistical function, and wherein the revised one or more values are selected by an application of a third statistical function.
8. The method of claim 7, wherein the first, second, or third statistical function comprises a random selection.
9. The method of claim 2, wherein the revising at least one candidate resource configuration comprises producing and adding two new configurations to the set of candidate resource configurations by crossing two existing configurations of the set of candidate resource configurations, wherein the two existing configurations each identify a distinct configuration of a same crossover resource of the set of virtual resources, and wherein crossing a first configuration of the two existing configurations with a second configuration of the two existing configurations comprises:
the processor selecting one or more configurable parameters common to both of the two existing configurations; and
the processor swapping a first set of values of the selected one or more configurable parameters comprised by the first configuration with a second set of values of the selected one or more configurable parameters comprised by the second configuration,
wherein the two existing configurations are selected from the set of candidate resource configurations by an application of a first statistical function, and wherein the selected one or more configurable parameters are selected from a set of all configurable parameters comprised by the two existing configurations by an application of a second statistical function.
10. The method of claim 9, wherein the first statistical function or the second statistical function comprises a random selection.
11. The method of claim 1, wherein the termination condition is satisfied when one repetition of the configuring, the evaluating, the deriving, the ranking, the further ranking, and the revising does not substantially alter the set of candidate resource configurations and the set of candidate environment configurations, wherein the substantially altering comprises producing a difference in one or more values of one or more configurable parameters comprised by the set of candidate resource configurations or by the set of set of candidate environment configurations, such that the produced difference exceeds a predetermined threshold level.
12. The method of claim 1, wherein the termination condition is selected from a group comprising: repeating the provisioning, the configuring, the evaluating, the deriving, the ranking, the further ranking, and the revising a predetermined number of times; consuming an amount or number of resources that exceeds a predetermined threshold level; and exceeding a time limit.
13. The method of claim 1, wherein the identifying an optimal environment configuration is a further function of the revising.
14. The method of claim 1, further comprising providing at least one support service for at least one of creating, integrating, hosting, maintaining, and deploying computer-readable program code in the computer system, wherein the computer-readable program code in combination with the computer system is configured to implement the receiving, selecting, further selecting, provisioning, configuring, evaluating, deriving, ranking, further ranking, revising, repeating, and identifying.
15. A computer program product, comprising a computer-readable hardware storage device having a computer-readable program code stored therein, said program code configured to be executed by a processor of a computer system to implement a method for optimizing a cloud-computing environment, the method comprising:
the processor receiving extrinsic data that describes a set of virtual resources of the cloud-computing environment;
the processor selecting a set of candidate resource configurations, wherein every virtual resource of the set of virtual resources is associated with a plurality of candidate resource configurations of the set of candidate resource configurations in a one-to-many relationship;
the processor further selecting a set of candidate environment configurations, wherein each candidate environment configuration of the set of candidate environment configurations comprises at least one candidate resource configuration of the set of candidate resource configurations;
the processor provisioning a virtual test environment, wherein the virtual test environment simulates the cloud-computing environment, and wherein the virtual test environment comprises a virtual representation of each virtual resource of the set of virtual resources of the cloud-computing environment;
the processor configuring the virtual test environment by successively loading the virtual test environment with combinations of a configuration of at least two candidate environment configurations of the set of candidate environment configurations and a configuration of at least two candidate resource configurations of the set of candidate resource configurations, wherein the at least two candidate resource configurations are associated with a same tested resource of the set of virtual resources;
the processor evaluating a first resource-fitness characteristic of a first loaded resource configuration of the at least two candidate resource configurations, wherein the first loaded resource configuration is associated with the same tested resource of the set of virtual resources, and wherein the first resource-fitness characteristic is assigned a value as a function of an operation of the same tested resource within the virtual test environment while the virtual test environment is loaded with the first loaded resource configuration;
the processor deriving a value of an environment-fitness characteristic of a first loaded environment configuration of the at least two candidate environment configurations as a function of an operation of the virtual test environment while the virtual test environment is loaded with the first loaded environment configuration;
the processor ranking the at least two candidate resource configurations as a function of the evaluating and of the deriving;
the processor further ranking the at least two candidate environment configurations as a function of the evaluating and of the deriving;
the processor revising at least one candidate resource configuration of the set of candidate resource configurations and at least one candidate environment configuration of the set of candidate environment configurations as a function of the ranking and of the further ranking;
the processor repeating the configuring, the evaluating, the deriving, the ranking, the further ranking, and the revising until a termination condition is satisfied; and
the processor identifying an optimal environment configuration as a function of the further ranking.
16. The computer program product of claim 15, wherein a first virtual resource of the set of virtual resources comprises a first set of functional blocks, wherein a first functional block of the first set of functional blocks comprises a first set of configurable parameters, and wherein a first configuration of the first virtual resource comprises a first set of values of the first set of configurable parameters.
17. The computer program product of claim 15, wherein the termination condition is satisfied when one repetition of the configuring, the evaluating, the deriving, the ranking, the further ranking, and the revising does not substantially alter the set of candidate resource configurations and the set of candidate environment configurations, wherein the substantially altering comprises producing a difference in one or more values of one or more configurable parameters comprised by the set of candidate resource configurations or by the set of set of candidate environment configurations, such that the produced difference exceeds a predetermined threshold level.
18. A computer system comprising a processor, a memory coupled to said processor, and a computer-readable hardware storage device coupled to said processor, said storage device containing program code configured to be run by said processor via the memory to implement a method for optimizing a cloud-computing environment, the method comprising:
the processor receiving extrinsic data that describes a set of virtual resources of the cloud-computing environment;
the processor selecting a set of candidate resource configurations, wherein every virtual resource of the set of virtual resources is associated with a plurality of candidate resource configurations of the set of candidate resource configurations in a one-to-many relationship;
the processor further selecting a set of candidate environment configurations, wherein each candidate environment configuration of the set of candidate environment configurations comprises at least one candidate resource configuration of the set of candidate resource configurations;
the processor provisioning a virtual test environment, wherein the virtual test environment simulates the cloud-computing environment, and wherein the virtual test environment comprises a virtual representation of each virtual resource of the set of virtual resources of the cloud-computing environment;
the processor configuring the virtual test environment by successively loading the virtual test environment with combinations of a configuration of at least two candidate environment configurations of the set of candidate environment configurations and a configuration of at least two candidate resource configurations of the set of candidate resource configurations, wherein the at least two candidate resource configurations are associated with a same tested resource of the set of virtual resources;
the processor evaluating a first resource-fitness characteristic of a first loaded resource configuration of the at least two candidate resource configurations, wherein the first loaded resource configuration is associated with the same tested resource of the set of virtual resources, and wherein the first resource-fitness characteristic is assigned a value as a function of an operation of the same tested resource within the virtual test environment while the virtual test environment is loaded with the first loaded resource configuration;
the processor deriving a value of an environment-fitness characteristic of a first loaded environment configuration of the at least two candidate environment configurations as a function of an operation of the virtual test environment while the virtual test environment is loaded with the first loaded environment configuration;
the processor ranking the at least two candidate resource configurations as a function of the evaluating and of the deriving;
the processor further ranking the at least two candidate environment configurations as a function of the evaluating and of the deriving;
the processor revising at least one candidate resource configuration of the set of candidate resource configurations and at least one candidate environment configuration of the set of candidate environment configurations as a function of the ranking and of the further ranking;
the processor repeating the configuring, the evaluating, the deriving, the ranking, the further ranking, and the revising until a termination condition is satisfied; and
the processor identifying an optimal environment configuration as a function of the further ranking.
19. The computer system of claim 18, wherein a first virtual resource of the set of virtual resources comprises a first set of functional blocks, wherein a first functional block of the first set of functional blocks comprises a first set of configurable parameters, and wherein a first configuration of the first virtual resource comprises a first set of values of the first set of configurable parameters.
20. The computer system of claim 18, wherein the termination condition is satisfied when one repetition of the configuring, the evaluating, the deriving, the ranking, the further ranking, and the revising does not substantially alter the set of candidate resource configurations and the set of candidate environment configurations, wherein the substantially altering comprises producing a difference in one or more values of one or more configurable parameters comprised by the set of candidate resource configurations or by the set of set of candidate environment configurations, such that the produced difference exceeds a predetermined threshold level.