1. A method of treating a disorder or condition selected from the group consisting of attention deficit disorder, attention deficit hyperactivity disorder (ADHD), Alzheimer’s disease (AD), mild cognitive impairment, senile dementia, AIDS dementia, Pick’s Disease and, dementia associated with Lewy bodies, , in a patient in need of such treatment, comprising administering a therapeutically effective amount of a compound of formula (IIA):
or a pharmaceutically acceptable salt, ester or amide thereof, wherein
n is 1 or 2;
R1, is hydrogen, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein the alkyl group, alkenyl, alkynyl, aryl, and heteroaryl groups are each substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of alkoxy, alkoxycarbonyl, carboxy, cyano, haloalkoxy, halo, hydroxyl, nitro, and RaRbN\u2014;
L is C(O), C(S), S(O), or S(O)2;
X is O or S;
Z is aryl, cycloalkyl, heteroaryl, heterocycle, ReRfN\u2014, \u2014R3 or \u2014OR3;
Ra and Rb are each independently hydrogen, alkyl, alkylcarbonyl, arylalkyl, and heteroaryl;
Rc and Rd are each independently hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycle, and heterocyclealkyl;
Re and Rf are each independently hydrogen, alkyl, alkylcarbonyl, alkenyl, alkynyl, aryl, arylalkyl, aryl(hydroxyl)alkyl, cycloalkyl, cycloalkylalkyl, heterocycle, heterocyclealkyl, heteroaryl, heteroaryl(hydroxyl)alkyl, heteroarylalkyl, or hydroxyalkyl, wherein the alkyl group and the alkyl of alkylcarbonyl is substituted with 0, 1, 2 , or 3 substituents selected from alkoxy, cyano, or halo;
R3 is alkyl, alkenyl, alkynyl, arylalkyl, haloalkyl, haloalkenyl, or haloalkynyl;
and R6 is alkyl, alkenyl, formyl, cyano, heteroaryl(hydroxyl)alkyl, or CH\u2550N\u2014(CH2)b\u2014ORg, wherein the alkyl group and the alkenyl group is substituted with 0, 1, 2 , or 3 substituents independently selected from the group consisting of alkoxy, alkoxycarbonyl, aryloxy, alkylcarbonyloxy, aryl, arylalkoxy, carboxy, cycloalkyl, cyano, halo, haloalkoxy, heteroaryl, heterocycle, hydroxyl, nitro, and RCRdN\u2014;
h is 0, 2, or 3; and
Rg is hydrogen or alkyl.
2. The method of claim 1, wherein
R1 is hydrogen;
L is C(O); and
X is S.
3. The method of claim 2 wherein
R6 is alkyl, wherein the alkyl group is substituted with 1, 2, or 3 hydroxyl groups.
4. The method of claim 3,
wherein Z is a heterocycle represented by the formula RkR1N\u2014, wherein Rk and R1 taken together with the nitrogen atom to which each is attached form a monocyclic heterocycle, a bicyclic heterocycle, a monocyclic heteroaryl, or a bicyclic heteroaryl, wherein each group is substituted with 0, 1, 2, or 3 substituents selected from halo, hydroxyl, aryl, and heteroaryl.
5. The method of claim 4, wherein
Z is unsubstituted pyrrolidine or pyrrolidine substituted with fluoro.
6. The method of claim 2, wherein
Z is \u2014NReRf; and
Re and Rf are each independently selected from hydrogen, alkyl, arylalkyl, aryl(hydroxyl)alkyl, heteroaryl, heteroaryl(hydroxyl)alkyl, heterocyclealkyl, and heteroarylalkyl.
7. The method of claim 6, wherein
Re is hydrogen or alkyl; and
Rf is arylalkyl, heterocyclealkyl, or heteroarylalkyl.
8. The method according to claim 1, wherein the compound of formula (IIA) is selected from the group consisting of:
ethyl (2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidenecarbamate;
methyl (2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidenecarbamate;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylideneacetamide;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N,N-dimethylurea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N,N-diethylurea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N,N-diisopropylurea;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidenepiperidine-1-carboxamide;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidenecyclobutanecarboxamide;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-2,2-dimethylpropanamide;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidenebenzamide;
4-chloro-N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidenebenzamide;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-oxazol-2(3H)-ylidene-N,N-dimethylurea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-oxazol-2(3H)-ylidene-N,N-dimethylthiourea;
N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(pyrrolidin-1-ylmethyl)-1,3-thiazol-2(3H)-ylideneacetamide;
N-(2Z)-5-(hydroxymethyl)-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenepiperidine-1-carboxamide;
N,N-diethyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene-N-phenylurea;
N,N-dimethyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenecyclobutanecarboxamide;
N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenecyclopropanecarboxamide;
N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenemethanesulfonamide;
N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneethanesulfonamide;
N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenepropane-1-sulfonamide;
N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenebenzenesulfonamide;
N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenethiophene-2-sulfonamide;
3-cyano-N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenebenzenesulfonamide;
3-methoxy-N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenebenzenesulfonamide;
3-chloro-N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenebenzenesulfonamide;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N\u2032-isopropylurea;
N-(sec-butyl)-N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylideneurea;
N-(tert-butyl)-N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylideneurea;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N\u2032-(1-methylbutyl)urea;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N\u2032-(1,1-dimethylpropyl)urea;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N\u2032-(1,2-dimethylpropyl)urea;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N\u2032-(1-ethylpropyl)urea;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N\u2032-(2-methoxy-1-methylethyl) urea;
N-cyclopentyl-N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylideneurea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-ethyl-N-methylurea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-isopropyl-N-methylurea;
N-butyl-N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-methylurea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-is obutyl-N-methylurea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-(1,3-dioxolan-2-ylmethyl)-N-methylurea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-methyl-N-(3-methylbutyl) urea;
N-butyl-N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-ethylurea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N,N-dipropylurea;
N,N-dibutyl-N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylideneurea;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-2,5-dimethylpyrrolidine-1-carboxamide;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-2-methylpiperidine-1-carboxamide;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-(2-methoxyethyl)-N-methylurea;
N-benzyl-N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiaz ol-2(3H)-ylidene-N-ethylurea;
N-benzyl-N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-isopropylurea;
N-benzyl-N-butul-N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylideneurea;
N-benzyl-N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-(2-hydroxyethyl)urea;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N\u2032-(1,1,3,3-tetramethylbutyl) urea;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N\u2032-(1R)-2-hydroxy-1-phenylethylurea;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N\u2032-(1S)-2-hydroxy-1-phenylethylurea;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N\u2032-(1S)-1-phenylethylurea;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N\u2032-(1R)-1-phenylethylurea;
N-benzyl-N-(tert-butyl)-N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylideneurea;
N-benzyl-N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-methylurea;
N-benzyl-N-(2-cyanoethyl)-N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylideneurea;
N-(3-chlorobenzyl)-N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-methylurea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-(2-methoxybenzyl)-N-methylurea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-(3-methoxybenzyl)-N-methylurea;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-1,3-dihydro-2H-isoindole-2-carboxamide;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-3,4-dihydroisoquinoline-2(1H)-carboxamide;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-ethyl-N-(pyridin-4-ylmethyl)urea;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N\u2032-(1-phenylpropyl)urea;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N\u2032-2,3-dihydro-1H-inden-1-ylurea;
N-(5-fluoro-2-phenoxybenzyl)-N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(2-chloro-6-fluorobenzyl)-N-ethyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-benzyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene-N-prop-2-ynylurea;
N-4-(allyloxy)benzyl-N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-formyl-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(Z)-(hydroxyimino)methyl-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(hydroxymethyl)-1,3-thiazol-2(3H)-ylidene-N,N-dimethylurea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(fluoromethyl)-1,3-thiazol-2(3H)-ylidene-N,N-dimethylurea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-formyl-1,3-thiazol-2(3H)-ylidene-N,N-dimethylurea;
(3R)-3-fluoro-N-(2Z)-5-(hydroxymethyl)-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
(3S)-3-fluoro-N-(2Z)-5-(hydroxymethyl)-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
N-4-(difluoromethoxy)benzyl-N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-1-(4-ethoxyphenyl)ethyl-N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-methyl-N-(6-methylpyridin-2-yl)methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-benzyl-N-but-2-ynyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(1-methyl-1-phenylethyl)-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(2-chlorobenzyl)-N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene-N-(thien-2-ylmethyl)urea;
N-(4-chlorobenzyl)-N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(3-chlorobenzyl)-N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-1-(methoxymethyl)propyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-cyclopentyl-N-(4-fluorobenzyl)-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(1S)-2-hydroxy-1-phenylethyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene-N\u2032-(1R)-1-phenylethylurea;
N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene-N\u2032-(1S)-1-phenylethylurea;
(3R)-3-hydroxy-N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
N-methyl-N-(1-methyl-1H-pyrazol-4-yl)methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene-N-(pyrazin-2-ylmethyl)urea;
N-(2Z)-5-(methoxymethyl)-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
N-(2Z)-5-(ethoxymethyl)-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(hydroxymethyl)-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(ethoxymethyl)-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-{(4-fluorophenyl) aminomethyl}-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5- {(4-fluorophenyl) (methyl) aminomethyl}-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N\u2032-2,3-dihydro-1H-inden-2-ylurea;
N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene-1H-imidazole-1-carboxamide;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N\u2032-1-(methoxymethyhpropyurea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-isobutyl-N-prop-2-ynylurea;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylideneazetidine-1-carboxamide;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N\u2032-(1-methyl-1-phenylethyl)urea;
N-cyclopropyl-N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-(2-fluorobenzyl) urea;
N-(2-chlorobenzyl)-N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-methylurea;
N-(4-chlorobenzyl)-N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-methylurea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-(4-methoxybenzyl)-N-methylurea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-methyl-N-(pyridin-2-ylmethyl)urea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-methyl-N-(pyridin-3-ylmethyl)urea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-ethyl-N-(pyridin-3-ylmethyl) urea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-methyl-N-(pyridin-4-ylmethyl)urea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene-N-methyl-N-(pyrazin-2-ylmethyl)urea;
N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene-N-(pyridin-3-ylmethyl)urea;
N-(2Z)-5-(hydroxymethyl)-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl-1,3-thiazol-2(3H)-ylideneacetamide;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxo1-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carb othioamide;
2-methyl-N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl-1,3-thiazol-2(3H)-ylideneindoline-1-carboxamide;
5-bromo-N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneindoline-1-carboxamide;
N-methyl-N-(1-methyl-1H-indo1-5-yl)-methyl-N\u2032-(2Z)-5-methyl-3-2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene-N-(4-pyridin-4-ylbenzyl)urea;
N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene-N-(1R)-1-phenylethylurea;
2-(4-fluorophenyl)-N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneindoline-1-carboxamide;
N-but-2-ynyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl-1,3-thiazol-2(3H)-ylidene-N-phenylurea;
N-isobutyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benz odioxin-6-yl)-1,3-thiazol-2(3H)-ylidene-N-prop-2-ynylurea;
N,N-dibut-2-ynyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-ethyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene-N-(thien-2-ylmethyl)urea;
N-methyl-N-(3-methylpyridin-2-yl)methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-methyl-N-(3-methylpyridin-4-yl)methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene-2-pyridin-3-ylpyrrolidine-1-carboxamide;
N-(4-ethylbenzyl)-N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-ethyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene-N-(pyridin-4-ylmethyl)urea;
N-(4-ethoxybenzyl)-N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-methyl-N-(4-methylbenzyl)-\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1 ,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(4-bromobenzyl)-N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(4-tert-butylbenzyl)-N-methyl-N\u2032-(2E)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(4-isopropylbenzyl)-N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(3,4-dichlorobenzyl)-N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(2,4-dichlorobenzyl)-N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(4-fluorobenzyl)-N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(4-methoxybenzyl)-N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene-N-(quinolin-6-ylmethyl)urea;
N-(3-bromobenzyl)-N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(2-bromobenzyl)-N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(pyridin-3-ylamino)methyl-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(methoxymethyl)-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(isopropoxymethyl)-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
N-(2Z)-5-(benzyoloxy)menthyl-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene-2,5-dihydro-1H-pyrrole-1-carboxamide;
(2S)-2-methyl-N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
N-(1-cyclopropyl-1-methylethyl)-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl-1,3-thiazol-2(3H)-ylideneurea;
N-(1,3-dioxolan-2-ylmethyl)-N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(1,3-dimethyl-1H-pyrazol-4-yl)methyl-N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(2Z)-5-cyano-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(1-hydroxyethyl)-1,3-thiazol-2(3H)-ylidene-N,N-dimethylurea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(1-hydroxybutyl)-1,3-thiazol-2(3H)-ylidene-N,N-dimethylurea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(1-hydroxy-2-methylpropyl)-1,3-thiazol-2(3H)-ylidene-N,N-dimethylurea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5- {(E)-(2-hydroxyethyl)iminomethyl}-1,3-thiazol-2(3H)-ylidene-N,N-dimethylurea;
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(hydroxymethyl)-4-pyridin-2-yl-1,3-thiazol-2(3H)-ylidene-N,N-dimethylurea compound with N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-hydroxy (pyridin-2-yl) methyl-1,3-thiazol-2(3H)-ylidene-N,N-dimethylurea (1:1);
N\u2032-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(difluoromethyl)-1,3-thiazol-2(3H)-ylidene-N,N-dimethylurea;
N-(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(fluoromethyl)-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
(3S)-3-hydroxy-N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
2,2-dimethyl-N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenepropanamide;
3-methyl-N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenebutanamide;
N-(2Z)-5-(cyanomethyl)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
(3R)-3-fluoro-N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
(3S)-3-fluoro-N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenepyrrolidine-1-carboxamide;
N-(2Z)-5-(hydroxymethyl)-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene-2,2-dimethylpropanamide;
N-(2Z)-5-(hydroxymethyl)-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenebenzamide;
N-(2Z)-5-(hydroxymethyl)-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene-1H-imidazole-1-carboxamide;
N-benzyl-N-(2-hydroxyethyl)-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneindoline-1-carboxamide;
2-methyl-N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidenepiperidine-1-carboxamide;
N-(tert-butyl)-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(2-hydroxy-1,1-dimethylethyl)-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(1,1-dimethylprop-2-ynyl)-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene-N\u2032-(1,1,3,3-tetramethylbutyl)urea;
N-(1,1-dimethylpropyl)-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(1-ethyl-1-methylpropyl)-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene-N-(thieno2,3-bpyridin-2-ylmethyl)urea;
N-(1R)-2-hydroxy-1-phenylethyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(1,2-dimethylpropyl)-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-isopropyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(2-methoxy-1-methylethyl)-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(sec-butyl)-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(1-ethylpropyl)-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-(1-methylbutyl)-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-benzyl-N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene-N-prop-2-ynylurea;
N-benzyl-N-isopropyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-ethyl-N-methyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea;
N-benzyl-N-ethyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea; and
N-benzyl-N-butyl-N\u2032-(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylideneurea.
9. The method of claim 1, wherein the disorder or condition is attention deficit hyperactivity disorders, comprising administering a compound of formula (IIA) in combination with a medication used in the treatment of attention deficit hyperactivity disorders.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A semiconductor device comprising:
a first conductive type semiconductor substrate;
a first semiconductor region provided on an upper surface of the semiconductor substrate and including a region in which first conductive type first pillar regions and second conductive type second pillar regions, each having a long side in a first direction parallel to the upper surface of the semiconductor substrate, which are alternately arranged in a second direction which is parallel to the upper surface of the semiconductor substrate and which is orthogonal to the first direction;
second conductive type second semiconductor regions provided on surfaces of second pillar regions in an element region in which a semiconductor element is formed so as to be in contact with first pillar regions in the element region;
gate electrodes each provided on parts of adjacent second semiconductor regions and on one of the first pillar regions interposed therebetween with a gate insulating film provided under the gate electrodes;
third semiconductor regions each functioning as a first conductive type source region provided in parts of surfaces of the second semiconductor regions located under side portions of the gate electrodes; and
a second conductive type resurf region which is a part of a terminal region surrounding the element region and which is provided on first pillar regions and second pillar regions in the part of the terminal region,
wherein the widths of the second pillar regions provided from the element region to the terminal region are each set as a first width, and the widths of the first pillar regions provided in the element region and the widths of the first pillar regions connected to the resurf region in the terminal region are each set as a second width,
in first pillar regions which are provided in the terminal region and which are not connected to the resurf region, a first pillar region having a third width smaller than the second width and a first pillar region having a fourth width are alternately arranged in this order in a direction apart from the element region along the second direction, and
in second pillar regions which are provided in the terminal region and which are not connected to the resurf region, adjacent second pillar regions with the first pillar region having a fourth width interposed therebetween are connected to each other with a connection portion composed of a second conductive type semiconductor or a conductor.
2. The semiconductor device according to claim 1,
wherein the fourth width is larger than the second width.
3. The semiconductor device according to claim 1 or 2,
wherein the connection portion includes a second conductive type semiconductor having a concentration higher than that of the resurf region.
4. The semiconductor device according to claim 1 or 2,
wherein the connection portion includes a metal wire.
5. The semiconductor device according to one of claims 1 to 4,
wherein the length of the connection portion and the length of the resurf region are equal to each other in the first direction,
further comprising second conductive type semiconductor regions having an impurity concentration equal to that of the resurf region and provided at two ends of the connection portion in the first direction.
6. The semiconductor device according to one of claims 1 to 5,
wherein the first semiconductor region is a region formed by a process including the steps of forming a plurality of trench grooves in a first conductive type semiconductor layer provided on the upper surface of the semiconductor substrate to form the first pillar regions between the trench grooves and filling a second conductive type semiconductor in the trench grooves by an epitaxial growth to form the second pillar regions.
7. A method for manufacturing a semiconductor device comprising the steps of:
forming a first conductive type semiconductor layer on a first conductive type semiconductor substrate;
forming trench grooves in the first conductive type semiconductor layer to form first conductive type first pillar regions between the trench grooves, the grooves each having a long side in a first direction parallel to an upper surface of the semiconductor substrate and being arranged in a second direction which is parallel to the upper surface of the semiconductor substrate and which is orthogonal to the first direction;
filling a second conductive type semiconductor in the trench grooves by an epitaxial growth to form second conductive type second pillar regions;
forming second conductive type second semiconductor regions on surfaces of second pillar regions in an element region in which a semiconductor element is formed so as to be in contact with first pillar regions in the element region;
forming gate electrodes each provided on parts of adjacent second semiconductor regions and on one of the first pillar region interposed therebetween with a gate insulating film provided under the gate electrodes;
forming third semiconductor regions each functioning as a first conductive type source region in parts of the second semiconductor regions located under side portions of the gate electrodes; and
forming a second conductive type resurf region which is a part of a terminal region surrounding the element region on first pillar regions and second pillar regions in the part of the terminal region,
wherein in the step of forming trench grooves, the trench grooves are formed so that the widths of the second pillar regions formed from the element region to the terminal region are each set as a first width, the widths of the first pillar regions formed in the element region and the widths of the first pillar regions connected to the resurf region in the terminal region are each set as a second width, and in first pillar regions which are provided in the terminal region and which are not provided with the resurf region thereon, a first pillar region having a third width smaller than the second width and a first pillar region having a fourth width are alternately arranged in that order in a direction apart from the element region along the second direction, and
in second pillar regions which are formed in the terminal region and which are not connected to the resurf region, adjacent second pillar regions with the first pillar region having a fourth width interposed therebetween are connected to each other by forming a connection portion including a second conductive type semiconductor or a conductor.