All The Claims

1. An adapter for releasably attaching a syringe to an injector, wherein the syringe comprises a body, a cone region attached to a forward end of the body and a plunger slideably positioned within the body, and wherein the injector comprises a front wall, an opening formed in the front wall, and a drive member reciprocally mounted in the injector, the adapter comprising:
a mounting mechanism positioned at a rear of the adapter to mount the adapter in a desired position relative to the front wall of the injector; and
a syringe carrier section associated with the mounting mechanism and adapted to seat at least a portion of the syringe, the syringe carrier section defining an opening along a top length thereof to allow placement of the syringe therein from the top, a forward portion of the syringe carrier section comprising two substantially opposed, linear shoulder portions each having first and second ends, the first ends of the shoulder portions being connected by a substantially arcuate member and the second ends of the shoulder portions cooperating to define an opening therebetween, the opposed shoulder portions abutting the cone region of the syringe so that the force exerted by the syringe on the adapter during an injection is generally symmetrical about an axis of the adapter, thereby reducing any bending moment about the mounting mechanism, the syringe carrier section further comprising a rear section defining an opening therein to allow the drive member of the injector to provide forward force to the plunger.
2. The adapter of claim 1 wherein the two substantially opposed shoulder portions are positioned on a first lateral side and a second lateral side, respectively, of the syringe carrier section.
3. The adapter of claim 1 wherein the forward portion of the syringe carrier section further comprises a rib member to strengthen the syringe carrier section.
4. The adapter of claim 1, further comprising an intermediate section operably connected to and disposed between the syringe carrier section and the mounting mechanism.
5. The adapter of claim 4 wherein the syringe carrier section is removably or movably connected to the intermediate section.
6. The adapter of claim 5 wherein the syringe carrier section and the intermediate section are movably connected via pin joints.
7. The adapter of claim 5, further comprising a locking member adapted to lock the syringe carrier section in a closed position.
8. The adapter of claim 4, further comprising a push rod at least partially disposed within the intermediate section for engaging the plunger of the syringe.
9. The adapter of claim 1 wherein the syringe carrier section further comprises a retaining member for retaining the syringe within the syringe carrier section.
10. The adapter of claim 1, further comprising a biasing retaining section operably associated with the syringe carrier section, the biasing retaining section comprising at least one flexible retaining member adapted to engage the syringe body to secure the syringe within the adapter.
11. The adapter of claim 10 wherein the at least one flexible retaining member comprises two retaining members.
12. The adapter of claim 10 wherein the biasing retaining section is removably connected to the syringe carrier section.
13. The adapter of claim 1 wherein the syringe carrier section further comprises at least one flexible retaining member adapted to engage the syringe body to secure the syringe within the adapter.
14. The adapter of claim 13 wherein the at least one flexible retaining member comprises two retaining members.
15. An adapter for releasably attaching a syringe to an injector, wherein the syringe comprises a body, a cone region attached to a forward end of the body and a plunger slideably positioned within the body, and wherein the injector comprises a front wall, an opening formed in the front wall, and a drive member reciprocally mounted in the injector, the adapter comprising:
an intermediate section defining a passage within which a push rod can move to communicate force from the injector drive member to the plunger,
a mounting mechanism positioned at a rear end of the intermediate section to mount the adapter in a desired position relative to the front wall of the injector; and
a syringe carrier section hingedly connected to a front end of the intermediate section and being adapted to seat at least a portion of the syringe, the syringe carrier section defining a first opening in a rear section thereof to allow the drive member of the injector to communicate forward force to the plunger via the push rod, the syringe carrier section defining a second opening on a top thereof, a forward portion of the syringe carrier section abutting the cone region of the syringe during injection, the syringe carrier section being rotatable relative to the intermediate section to move the forward portion of the syringe carrier section out of contact with the cone region of the syringe to enable removal of the syringe from the adapter without retraction of the drive member.
16. The adapter of claim 15 wherein the forward portion of the syringe carrier section comprises two substantially opposed shoulder portions, the opposed shoulder portions abutting the cone region of the syringe so that the force exerted by the syringe on the adapter during an injection is generally symmetrical about an axis of the adapter, thereby reducing any bending moment about the mounting mechanism.
17. The adapter of claim 16 wherein the two substantially opposed shoulder portions are positioned on a first lateral side and a second lateral side, respectively, of the syringe carrier section.
18. The adapter of claim 15 wherein the forward portion of the syringe carrier section further comprises a rib member to strengthen the syringe carrier section.
19. The adapter of claim 15, further comprising a locking member adapted to lock the syringe carrier section in a closed position.
20. The adapter of claim 15 wherein the syringe carrier section further comprises a retaining member for retaining the syringe within the syringe carrier section.
21. The adapter of claim 15, further comprising a biasing retaining section operably associated with the syringe carrier section, the biasing retaining section comprising at least one flexible retaining member adapted to engage the syringe body to secure the syringe within the adapter.
22. The adapter of claim 21 wherein the at least one flexible retaining member comprises two retaining members.
23. The adapter of claim 21 wherein the biasing retaining section is removably connected to the syringe carrier section.
24. The adapter of claim 15 wherein the syringe carrier section further comprises at least one flexible retaining member adapted to engage the syringe body to secure the syringe within the adapter.
25. The adapter of claim 24 wherein the at least one flexible retaining member comprises two retaining members.
26. An adapter for releasably attaching a syringe to an injector, wherein the syringe comprises a body, a cone region attached to a forward end of the body and a plunger slideably positioned within the body, and wherein the injector comprises a front wall, an opening formed in the front wall, and a drive member reciprocally mounted in the injector, the adapter comprising:
a mounting mechanism positioned at a rear of the adapter to mount the adapter in a desired position relative to the front wall of the injector; and
a syringe carrier section adapted to seat at least a portion of the syringe, the syringe carrier section defining an opening on a top thereof to allow placement of the syringe therein from the top, the syringe carrier section comprising an outer wall and at least one flexing retaining member disposed inward from the outer wall, the flexing retaining member adapted to place pressure on at least one side of the syringe to retain the syringe within the syringe carrier section, the syringe carrier section further comprising an opening in a rear section thereof to allow the drive member of the injector to communicate forward force to the plunger.
27. The adapter of claim 26 wherein a forward portion of the syringe carrier section comprises two substantially opposed shoulder portions, the opposed shoulder portions abutting the cone region of the syringe so that the force exerted by the syringe on the adapter during an injection is generally symmetrical about an axis of the adapter, thereby reducing any bending moment about the mounting mechanism.
28. The adapter of claim 27 wherein the two substantially opposed shoulder portions are positioned on a first lateral side and a second lateral side, respectively, of the syringe carrier section.
29. The adapter of claim 27 wherein the forward portion of the syringe carrier section further comprises a rib member to strengthen the syringe carrier section.
30. The adapter of claim 26, further comprising an intermediate section operably connected to and disposed between the syringe carrier section and the mounting mechanism.
31. The adapter of claim 30, further comprising a push rod at least partially disposed within the intermediate section for engaging the plunger of the syringe.
32. The adapter of claim 30, wherein the syringe carrier section is removably or movably connected to the intermediate section.
33. The adapter of claim 32, wherein the syringe carrier section and the intermediate section are movably connected via pin joints.
34. The adapter of claim 32 further comprising a locking member adapted to lock the syringe carrier section in a closed position.
35. The adapter of claim 26 wherein the at least one flexing retaining member comprises two retaining members.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1-21. (canceled)
22. A system comprising:
a power management member;
a power domain for supplying power to the power management member;
a first power manager for computing a power state for the power management member;
a first power-controlling driver for receiving instructions from the first power manager to change a power state of the power management member based on the computed power state of the power management member;
a second power manager for receiving the computed power state of the power management member from the first power manager and (ii) computing a power state for the power domain based on the computed power state of the power management member received from the first power manager; and
a second power-controlling driver for receiving instructions from the second power manager to change a power state of the power domain based on the computed power state of the power domain.
23. The system of claim 22, wherein the power management member comprises one of a device and a power domain.
24. The system of claim 22, wherein the first power-controlling driver changes the power state of the power management member based on instructions from the first power manager.
25. The system of claim 22, wherein the first and second power managers communicate with each other based on a hierarchical relationship.
26. The system of claim 22, wherein after computing the power state for the power management member, the first power manager selects a power state from at least three different power states.
27. The system of claim 26, wherein the instructions received at the first power-controlling driver comprise instructions for changing the power state of the power management member to the selected power state.
28. The system of claim 22, wherein the instructions received at the second power-controlling driver comprise instructions to adjust an output power characteristic of the power domain.
29. A method comprising:
at a child power manager, selecting a power state for a power management member, said power state selected from at least three different power states;
at a parent power manager, receiving from the child power manager a notification of the selected power state; and
at the parent power manager, defining a power state of a parent power domain when an output power characteristic of the parent power domain is insufficient to satisfy the selected power state of the power management member.
30. A method for distributing management of power of a computer system, the method comprising:
at a parent power manager, receiving a higher input power requirement from a child power manager that is operating at a particular input power state; and
at the parent power manager, defining a power state for a parent power domain based on said received higher input power requirement, said child power manager being a power manager for a member of said parent power domain.
31. The method of claim 30, wherein the member is one of a device or a power domain.
32. The method of claim 30, wherein the child power manager is a first child power manager and the member is a first member of the parent power domain, the method further comprising:
at the parent power manager, retrieving an input power requirement of a second member of the parent power domain;
at the parent power manager, combining the input power requirements of the first and second members of the parent power domain; and
at the parent power manager, defining a power state for the parent power domain based on the combined input requirements.
33. The method of claim 30, wherein the higher input power requirement is selected based on an activity state of the member.
34. The method of claim 30 further comprising, at the parent power manager, changing a power state of the parent power domain to the defined power state when the parent power domain has sufficient power for the defined power state.
35. The method of claim 30 further comprising, at the parent power manager, notifying a grandparent power manager of the defined power state of the parent power domain, the grandparent power manager associated with a grandparent power domain that supplies power to the parent power domain.
36. The method of claim 29 further comprising, at the parent power manager, changing a power state of the parent power domain to the defined power state upon the parent power domain having sufficient power for the defined power state.
37. The method of claim 36 further comprising, at the child power manager, receiving a notification from the parent power manager of the changed power state of the parent power domain.
38. The method of claim 36 further comprising, at the parent power manager, notifying a grandparent power manager of the change in the power state of the parent power domain, the grandparent power manager associated with a grandparent power domain that supplies power to the parent power domain.
39. The method of claim 29, wherein the parent power domain supplies power to the power management member.
40. The method of claim 29, wherein the power management member is one of a device or a power domain.

What is claimed is:

1. An isolated polynucleotide comprising a nucleotide sequence that has at least 80% identity over its entire length to a nucleotide sequence encoding the ASP2 polypeptide of SEQ ID NO:2; or a nucleotide sequence complementary to said isolated polynucleotide.
2. The polynucleotide of claim 1 wherein said polynucleotide comprises the nucleotide sequence contained in SEQ ID NO:1 encoding the ASP2 polypeptide of SEQ ID NO02.
3. The polynucleotide of claim 1 wherein said polynucleotide comprises a nucleotide sequence that is at least 80% identical to that of SEQ ID NO:1 over its entire length.
4. The polynucleotide of claim 3 which is polynucleotide of SEQ ID NO: 1.
5. The polynucleotide of claim 1 which is DNA or RNA.
6. A DNA or RNA molecule comprising an expression system, wherein said expression system is capable of producing a ASP2 polypeptide comprising an amino acid sequence, which has at least 80% identity with the polypeptide of SEQ ID NO:2 when said expression system is present in a compatible host cell.
7. A host cell comprising the expression system of claim 6.
8. A process for producing a ASP2 polypeptide comprising culturing a host of claim 7 under conditions sufficient for the production of said polypeptide and recovering the polypeptide from the culture.
9. A process for producing a cell which produces a ASP2 polypeptide thereof comprising transforming or transfecting a host cell with the expression system of claim 6 such that the host cell, under appropriate culture conditions, produces a ASP2 polypeptide.
10. A ASP2 polypeptide comprising an amino acid sequence which is at least 80% identical to the amino acid sequence of SEQ ID NO:2 over its entire length.
11. The polypeptide of claim 10 which comprises the amino acid sequence of SEQ ID NO:2.
12. An antibody immunospecific for the ASP2 polypeptide of claim 10.
13. A method for the treatment of a subject in need of enhanced activity or expression of ASP2 polypeptide of claim 10 comprising:
(a) administering to the subject a therapeutically effective amount of an agonist to said polypeptide; andor
(b) providing to the subject an isolated polynucleotide comprising a nucleotide sequence that has at least 80% identity to a nucleotide sequence encoding the ASP2 polypeptide of SEQ ID NO:2 over its entire length; or a nucleotide sequence complementary to said nucleotide sequence in a form so as to effect production of said polypeptide activity in vivo.
14. A method for the treatment of a subject having need to inhibit activity or expression of ASP2 polypeptide of claim 10 comprising:
(a) administering to the subject a therapeutically effective amount of an antagonist to said polypeptide; andor
(b) administering to the subject a nucleic acid molecule that inhibits the expression of the nucleotide sequence encoding said polypeptide; andor
(c) administering to the subject a therapeutically effective amount of a polypeptide that competes with said polypeptide for its ligand, substrate, or receptor.
15. A process for diagnosing a disease or a susceptibility to a disease in a subject related to expression or activity of ASP2 polypeptide of claim 10 in a subject comprising:
(a) determining the presence or absence of a mutation in the nucleotide sequence encoding said ASP2 polypeptide in the genome of said subject; andor
(b) analyzing for the presence or amount of the ASP2 polypeptide expression in a sample derived from said subject.
16. A method for identifying compounds which inhibit (antagonize) or agonize the ASP2 polypeptide of claim 10 which comprises:
(a) contacting a candidate compound with cells which express the ASP2 polypeptide (or cell membrane expressing ASP2 polypeptide) or respond to ASP2 polypeptide; and
(b) observing the binding, or stimulation or inhibition of a functional response; or comparing the ability of the cells (or cell membrane) which were contacted with the candidate compounds with the same cells which were not contacted for ASP2 polypeptide activity.
17. An agonist identified by the method of claim 16.
18. An antagonist identified by the method of claim 16.
19. A recombinant host cell produced by a method of claim 9 or a membrane thereof expressing a ASP2 polypeptide.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. An intraocular lens configured for implantation in a capsular sac following extraction of a natural lens, the intraocular lens accommodating in response to movement of the capsular sac, the intraocular lens comprising:
an optic portion including a lens element, an intermediate layer and an actuator, the actuator disposed in contact with the lens element;
a haptic having an interior volume coupled in fluid communication with the actuator;
a fluid disposed in the actuator and the interior volume of the haptic; and
a secondary deflection mechanism coupled to the lens element,
wherein the lens element is configured to be deformed by movement of the actuator in response to movement of the first fluid between the haptic and the actuator, and
wherein the secondary deflection mechanism is configured to further deform the lens element in response to deformation of the lens element by the actuator.
2. The intraocular lens of claim 1 wherein the secondary deflection mechanism is a portion of the lens element having a reduced thickness.
3. The intraocular lens of claim 1 wherein the secondary deflection mechanism is a flexible coupling between the lens element and the intermediate layer.
4. The intraocular lens of claim 1 wherein the secondary deflection mechanism is a fluid-mediated actuator comprising a sealed cavity between the lens element and the intermediate later that is filled with a second fluid, and
wherein deformation of the lens element and movement of the actuator redistributes the second fluid within the sealed cavity which further deforms the lens element.
5. The intraocular lens of claim 4 wherein the first fluid and the second fluid have approximately the same refractive index.
6. The intraocular lens of claim 4 wherein the lens element and the actuator are configured such that the volume of a peripheral portion of the sealed cavity decreases and the volume of a central portion of the sealed cavity increases when the first fluid is transferred from the haptic to the actuator.
7. The intraocular lens of claim 1 further comprising a backstop coupled to at least a portion of the haptic.
8. The intraocular lens of claim 1 further comprising a support member that extends further radially outward than the haptic.
9. The intraocular lens of claim 1 wherein the actuator includes a rolling undulation.
10. The intraocular lens of claim 1 wherein the actuator includes a bellows.
11. The intraocular lens of claim 1 wherein the intermediate layer and the actuator are monolithic.
12. The intraocular lens of claim 1 wherein the intermediate layer and the actuator are separate components coupled together.
13. The intraocular lens of claim 4 wherein the lens element and the intermediate layer are sealed such that relative motion adjacent the seal is permitted.
14. The intraocular lens of claim 1 wherein the lens element is deformed to an aspheric configuration by the actuator and secondary deflection mechanism.
15. An intraocular lens configured for implantation in a capsule following extraction of a natural lens, the intraocular lens accommodating in response to shape changes of the patient’s lens capsule, the intraocular lens comprising:
an optic portion including a lens element, an actuator and a sealed fluid cavity adjacent at least a portion of the lens element;
a haptic having an interior volume coupled in fluid communication with the actuator, and a capsule wall contacting portion;
a first fluid disposed in the actuator and the interior volume of the haptic; and
a second fluid disposed in the sealed fluid cavity,
wherein the actuator is coupled with the lens element such that shape changes of the patient’s lens capsule displaces fluid between the interior volume of the haptic and the actuator to change a deflection of the lens element, and
wherein deflection of the lens element causes the second fluid to redistribute within the sealed fluid cavity to alter the deflection of the lens element.
16. The intraocular lens of claim 15 further comprising a backstop coupled to at least a portion of the haptic.
17. The intraocular lens of claim 15 further comprising a support member that extends further radially outward than the haptic.
18. The intraocular lens of claim 17 wherein the support member is a wire that circumscribes and is radially spaced from the haptic.
19. The intraocular lens of claim 17 wherein the support member is a tab that extends radially outward from a portion of the haptic.
20. The intraocular lens of claim 15 wherein the support member is integrated into the haptic.