All The Claims

1. Mop cover for a cleaning device, comprising two layers, which are connected to each other in such a way that they configure a pouch-type mop cover having an introduction end, where the layers, on their faces facing away from each other, are configured as a wiping surface, the insertion end is closed in segments so as to be undetachable.
2. Mop cover according to claim 1, wherein the layers are configured to be quadrilateral, and in that the layers are connected to each other at three sides, and one side forms the insertion end.
3. Mop cover according to claim 1 wherein the insertion end, starting at its respective corners, a partial section is closed.
4. Mop cover according to claim 3, wherein one partial section is longer than the other partial section.
5. Mop cover according to claim 1, wherein a loop is arranged at one corner.
6. Mop cover according to claim 4, wherein a loop is arranged at the corner that is associated with the shorter partial section.
7. Mop cover according to claim 5, wherein the mop cover presents a color coding.
8. Mop cover according to claim 1, wherein the layers are configured to be trapezoid.
9. Mop cover according to claim 1, wherein at least one of the layers presents a cutout that is open towards the insertion end.
10. Mop cover according to claim 1, wherein the layers are different from each other.
11. Mop cover according to claim 1, wherein the mop cover is elastically expandable.
12. Mop system, comprising a mop cover according to claim 1 and a cleaning device, which comprises a mop plate that is connected by a joint to a handle, where the mop plate presents two main sides, which are attached in such a way that each main side can be pivoted, as desired, in the direction towards the floor to be cleaned.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A compound of formula (I):
wherein:
R1 is selected from the group consisting of halo, Ay, Het, \u2014NR7R8, \u2014NR7Ay, \u2014NHHet, \u2014NHR10Ay and \u2014NHR10Het;
each R7 and R8 are the same or different and are independently selected from the group consisting of H, alkyl, alkenyl, cycloalkyl, cycloalkenyl, \u2014OR9, \u2014C(O)R9, \u2014CO2R9, \u2014C(O)NR9R11, \u2014C(S)NR9R11, \u2014C(NH)NR9R11, \u2014SO2R10, \u2014SO2NR9R11, \u2014R10cycloalkyl, \u2014R10OR9, \u2014CH(R10OR9)2, \u2014R10C(O)R9, \u2014R10CO2R9, \u2014R10C(O)NR9R11, \u2014R10C(S)NR9R11, \u2014R10C(NH)NR9R11, \u2014R10SO2R10, \u2014R10SO2NR9R11, \u2014R10SO2NHCOR9, \u2014R10NR9R11, \u2014R10NHCOR9, \u2014R10NHSO2R9 and \u2014R10NHC(NH)NR9R11 and;
each R9 and R11 are the same or different and are independently selected from the group consisting of H, alkyl, cycloalkyl, \u2014R10cycloalkyl, \u2014R10OH, \u2014R10(OR10)w where w is 1-10, and \u2014R10NR10R10;
each R10 is the same or different and is independently selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl;
Ay is aryl;
Het is a 5- or 6-membered heterocyclic or heteroaryl group;
n is 0, 1 or 2;

R2 is selected from the group consisting of halo, alkyl, alkenyl, cycloalkyl, cycloalkenyl, Ay, Het, \u2014OR7, \u2014OAy, \u2014OHet, \u2014OR10Het, \u2014S(O)nR9, \u2014S(O)nAy, \u2014S(O)nHet, \u2014S(O)nNR7R8, \u2014NR7R8, \u2014NHHet, \u2014NHR10Ay, \u2014NHR10Het, \u2014R10NR7R8 and \u2014R10NR7Ay;
Y is N;
R3 and R4 are the same or different and are each independently selected from the group consisting of H, halo, alkyl, alkenyl, cycloalkyl, Ay, Het, \u2014OR7, \u2014OAy, \u2014C(O)R7, C(O)Ay, \u2014CO2R7, \u2014CO2Ay, \u2014SO2NHR9, \u2014NR7R8, \u2014NR7Ay, \u2014NHHet, \u2014NHR10Het \u2014R10OR7, \u2014R10OAy, \u2014R10NR7R8 and \u2014R10NR7Ay;

q is 0, 1, 2, 3, 4 or 5;
each R5 is the same or different and is independently selected from the group consisting of halo, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, Ay, Het, \u2014OR7, \u2014OAy, \u2014OHet, \u2014C(O)R9, \u2014C(O)Ay, \u2014C(O)Het, \u2014CO2R9, \u2014C(O)NR7R8, \u2014C(O)NR7Ay, \u2014C(O)NHR10Het, \u2014C(S)NR9R11, \u2014C(NH)NR7R8, \u2014C(NH)NR7Ay, \u2014S(O)nR9, \u2014S(O)2NR7R8, \u2014S(O)2NR7Ay, \u2014NR7R8, \u2014NR7Ay, \u2014NHHet, \u2014NHR10Ay, \u2014NHR10Het, \u2014R10cycloalkyl, \u2014R10OR9, \u2014R10C(O)R9, \u2014R10CO2R9, \u2014R10C(O)NR9R11, \u2014R10C(S)NR9R11, \u2014R10C(NH)NR9R11, \u2014R10SO2R9, \u2014R10SO2NR9R11, \u2014R10SO2NHCOR9, \u2014R10NR7R8, \u2014R10NR7Ay, \u2014R10NHC(NH)NR9R11, cyano, nitro and azido; or
\u2003two adjacent R5 groups together with the atoms to which they are bonded form a C5-6 cycloalkyl or aryl;
p is 1, 2 or 3; and
each R6 is the same or different and is independently selected from the group consisting of halo, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, Ay, Het, \u2014OR7, \u2014OAy, \u2014OHet, \u2014OR10Ay, \u2014OR10Het, \u2014C(O)R9, \u2014C(O)Ay, \u2014C(O)Het, \u2014CO2R9, \u2014C(O)NR7R8, \u2014C(O)NR7Ay, \u2014C(O)NHR10Ay, \u2014C(O)NHR10Het, \u2014C(S)NR9R11, \u2014C(NH)NR7R8, \u2014C(NH)NR7Ay, \u2014S(O)nR9, \u2014S(O)nAy, \u2014S(O)nHet, \u2014S(O)2NR7R8, \u2014S(O)2NR7Ay, \u2014NR7R8, \u2014NR7Ay, \u2014NHHet, \u2014NHR10Ay, \u2014NHR10Het, \u2014R10cycloalkyl, \u2014R10Ay, \u2014R10Het, \u2014R10OR9, \u2014R10\u2014O\u2014C(O)R9, \u2014R10\u2014O\u2014C(O)Ay, \u2014R10\u2014O\u2014C(O) Het, \u2014R10\u2014O\u2014S(O)nR9, \u2014R10C(O)R9, \u2014R10CO2R9, \u2014R10C(O)NR9R11, \u2014R10C(S)NR9R11, \u2014R10C(NH)NR9R11, \u2014R10SO2R9, \u2014R10SO2NR9R11, \u2014R10SO2NHCOR9, \u2014R10NR7R8, \u2014R10NR7Ay, \u2014R10NHC(NH)NR9R11, cyano, nitro and azido; or
\u2003two adjacent R6 groups together with the atoms to which they are bonded form a C5-6 cycloalkyl or a 5- or 6-membered heterocyclic group containing 1 or 2 heteroatoms; or
\u2003R6 is in the 6 position and R6 and R7 together with the atoms to which they are bonded form a C5-6 cycloalkyl or a 5- or 6-membered heterocyclic group containing 1 or 2 heteroatoms;
or a pharmaceutically acceptable salt or solvate thereof.
2. The compound according to claim 1 wherein R1 is selected from the group consisting of halo, Ay, Het, \u2014NR7R8, \u2014NHHet, \u2014NHR10Ay and \u2014NHR10Het.
3. The compound according to any of claim 1 wherein R1 is selected from the group consisting of Het and \u2014NR7R8.
4. The compound according to any of claim 1 wherein R2 is selected from the group consisting of R2 is selected from the group consisting of Het, \u2014OR7, \u2014OAy, \u2014OHet, \u2014OR10Het, \u2014S(O)nR9, \u2014S(O)nAy, \u2014NR7R8, \u2014NHHet and \u2014NHR10Het.
5. The compound according to claim 1 wherein R2 is selected from the group consisting of Het, \u2014NR7R8 and \u2014NHHet.
6. The compound according to claim 1 wherein R3 and R4 are the same or different and are each independently selected from the group consisting of H, halo, alkyl, Ay, \u2014OR7, \u2014CO2R7, \u2014NR7R8, \u2014R10OR7 and \u2014R10NR7R8.
7. The compound according to claim 1 wherein R3 and R4 are each H.
8. The compound according to claim 1 wherein q is 0, 1 or 2.
9. The compound according to claim 1 wherein each R5 is the same or different and is independently selected from the group consisting of halo, alkyl, alkenyl, Ay, Het, \u2014OR7, \u2014OAy, \u2014CO2R9, \u2014C(O)NR7R8, \u2014C(O)NR7Ay, \u2014S(O)2NR7R8, \u2014NR7R8, \u2014NR7Ay, \u2014NHR10Ay, cyano, nitro and azido.
10. The compound according to claim 1, wherein each R5 is the same or different and is independently selected from the group consisting of halo, alkyl, \u2014OR7, \u2014NR7R8 and cyano.
11. The compound according to claim 1 wherein p is 1 or 2.
12. The compound according to claim 1 wherein p is 1.
13. The compound according to claim 1 wherein each R6 is the same or different and is independently selected from the group consisting of halo, alkyl, Ay, Het, \u2014OR7, \u2014OAy, \u2014OHet, \u2014C(O)Het, \u2014CO2R9, \u2014C(O)NR7R8, \u2014C(O)NR7Ay, \u2014C(O)NHR10Het, \u2014NR7R8, \u2014NR7Ay, \u2014NHHet, \u2014NHR10Ay, \u2014NHR10Het, \u2014R10OR9 and cyano.
14. The compound according to claim 1, wherein each R6 is the same or different and is independently selected from the group consisting of halo, alkyl, \u2014C(O)NR7R8, \u2014NR7R8, \u2014NR7Ay, \u2014NHHet, \u2014NHR10Ay, and \u2014NHR10Het.
15. A compound selected from the group consisting of:
N-Cyclopentyl-2-(4-fluorophenyl)-3-2-(1-pyrrolidinyl)-4-pyrimidinyl-6-(trifluoromethyl)pyrazolo1,5-apyridin-7-amine;
N-Cyclopentyl-3-2-(cyclopentylamino)-4-pyrimidinyl-2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo1,5-apyridin-7-amine;
Ethyl 7-(cyclopentylamino)-3-2-(cyclopentylamino)-4-pyrimidinyl-2-(4-fluorophenyl)pyrazolo1,5-apyridine-6-carboxylate;
7-(Cyclopentylamino)-3-2-(cyclopentylamino)-4-pyrimidinyl-2-(4-fluorophenyl)pyrazolo1,5-apyridine-6-carboxylic acid;
N-Cyclopentyl-3-2-(cyclopentylamino)-4-pyrimidinyl-2-(4-fluorophenyl)-6-(1-pyrrolidinylcarbonyl)pyrazolo1,5-apyridin-7-amine;
7-(Cyclopentylamino)-3-2-(cyclopentylamino)-4-pyrimidinyl-2-(4-fluorophenyl)-N,N -dimethylpyrazolo1,5-apyridine-6-carboxamide;
7-(Cyclopentylamino)-3-2-(cyclopentylamino)-4-pyrimidinyl-2-(4-fluorophenyl) -N-hydroxypyrazolo1,5-apyridine-6-carboxamide;
7-(Cyclopentylamino)-3-2-(cyclopentylamino)-4-pyrimidinyl-2-(4-fluorophenyl)-N-2-(4-morpholinyl)ethylpyrazolo1,5-apyridine-6-carboxamide;
7-(Cyclopentylamino)-3-2-(cyclopentylamino)-4-pyrimidinyl-2-(4-fluorophenyl)-N-3-(1H-imidazol-1-yl)propylpyrazolo1,5-apyridine-6-carboxamide;
7-(Cyclopentylamino)-3-2-(cyclopentylamino)-4-pyrimidinyl-2-(4-fluorophenyl)-N-2-hydroxy-1-(hydroxymethyl)ethylpyrazolo1,5-apyridine-6-carboxamide;
7-(Cyclopentylamino)-3-2-(cyclopentylamino)-4-pyrimidinyl-2-(4-fluorophenyl)pyrazolo1,5-apyridin-6-ylmethanol;
N-Cyclopentyl-4-5,7-dichloro-2-(4-fluorophenyl)pyrazolo1,5-apyridin-3-yl-2-pyrimidinamine;
N-{4-5-Chloro-7-(cyclopentylamino)-2-(4-fluorophenyl)pyrazolo1,5-apyridin-3-yl-2-pyrimidinyl}-N-cyclopentylamine;
N5, N7-Dicyclopentyl-3-2-(cyclopentylamino)-4-pyrimidinyl-2-(4-fluorophenyl) -pyrazolo1,5-apyridine-5,7-diamine;
5-Chloro-3-2-(cyclopentylamino)-4-pyrimidinyl-2-(4-fluorophenyl)-N-isopropylpyrazolo1,5-apyridin-7-amine;
3-2-(Cyclopentylamino)-4-pyrimidinyl-2-(4-fluorophenyl)-N5,N7-diisopropyl-pyrazolo1,5-apyridine-5,7-diamine;
N-Cyclopentyl-4-5,7-dichloro-2-(4-methoxyphenyl)pyrazolo1,5-apyridin-3-yl-2-pyrimidinamine;
N-{4-5-Chloro-7-(cyclopentylamino)-2-(4-methoxyphenyl)pyrazolo1,5-apyridin-3-yl-2-pyrimidinyl}-N-cyclopentylamine;
5-Chloro-N-cyclopentyl-3-2-(cyclopentylamino)pyrimidin-4-yl-2-(3-methylphenyl)pyrazolo1,5-apyridin-7-amine;
5-Chloro-3-2-(cyclopentylamino)pyrimidin-4-yl-N-cyclopropyl-2-(3-methylphenyl)pyrazolo1,5-apyridin-7-amine;
5-Chloro-N-cyclopentyl-3-2-(cyclopropylamino)pyrimidin-4-yl-2-(3-methylphenyl)pyrazolo1,5-apyridin-7-amine;
5-Chloro-3-2-(cyclopentylamino)-4-pyrimidinyl-N-cyclopropyl-2-(4-fluorophenyl)pyrazolo1,5-apyridin-7-amine;
4-5-Chloro-2-(4-fluorophenyl)-7-(4-methyl-1-piperazinyl)pyrazolo1,5-apyridin-3-yl-N-cyclopentyl-2-pyrimidinamine;
4 5-Chloro-2-(4-fluorophenyl)-7-(1-piperidinyl)pyrazolo1,5-apyridin-3-yl-N-cyclopentyl-2-pyrimidinamine;
4-5-Chloro-2-(4-fluorophenyl)-7-(4-morpholinyl)pyrazolo1,5-apyridin-3-yl-N-cyclopentyl-2-pyrimidinamine;
N-5-Chloro-3-2-(cyclopentylamino)pyrimidin-4-yl-2-(4-fluorophenyl)pyrazolo1,5-apyridin-7-yl-N\u2032-cyclopentylguanidine hydrochloride;
5-Chloro-N-cyclopropyl-3-2-(cyclopropylamino)pyrimidin-4-yl-2-(4-fluorophenyl)pyrazolo1,5-apyridin-7-amine;
N-cyclopentyl-4-5,7-dichloro-2-(3-chlorophenyl)pyrazolo1,5-apyridin-3-yl-2-pyrimidinamine;
N-{4-5-chloro-2-(3-chlorophenyl)-7-(cyclopentylamino)pyrazolo1,5-apyridin-3-yl-2-pyrimidinyl}-N-cyclopentylamine;
N-{4-5-Chloro-7-(cyclopropylamino)-2-(4-methoxyphenyl)pyrazolo1,5-apyridin-3-yl-2-pyrimidinyl}-N-cyclopentylamine;
4-5-Chloro-3-2-(cyclopentylamino)-4-pyrimidinyl-7-(cyclopropylamino)pyrazolo1,5-apyridin-2-ylphenol;
5-Chloro-3-2-(cyclopentylamino)-4-pyrimidinyl-N-cyclopropyl-2-4-(cyclopropylmethoxy)phenylpyrazolo1,5-apyridin-7-amine;
4-5-Chloro-3-2-(cyclopentylamino)-4-pyrimidinyl-7-(cyclopentylamino)pyrazolo1,5-apyridin-2-ylphenol;
5-Chloro-3-2-(cyclopentylamino)-4-pyrimidinyl-N-cyclopentyl-2-4-(cyclopropylmethoxy)phenylpyrazolo1,5-apyridin-7-amine;
5,7-dichloro-2-(4-methoxyphenyl)-3-2-(methylthio)pyrimidin-4-ylpyrazolo1,5-apyridine;
N-{5-Chloro-2-(4-methoxyphenyl)-3-2-(methylsulfanyl)-4-pyrimidinylpyrazolo1,5-apyridin-7-yl}-N-cyclopentylamine;
N-{5-Chloro-2-(4-methoxyphenyl)-3-2-(methylsulfinyl)-4-pyrimidinylpyrazolo1,5-apyridin-7-yl}-N-cyclopentylamine;
N-{4-5-Chloro-7-(cyclopentylamino)-2-(4-methoxyphenyl)pyrazolo1,5-apyridin-3-yl-2-pyrimidinyl}-N-cyclopropylamine;
4-{5-Chloro-7-(cyclopentylamino)-3-2-(cyclopropylamino)-4-pyrimidinylpyrazolo1,5-apyridin-2-yl}phenol;
N-(4-{5-Chloro-7-(cyclopentylamino)-2-4-(cyclopropylmethoxy)phenylpyrazolo-1,5-apyridin-3-yl}-2-pyrimidinyl)-N -cyclopropylamine;
7-Chloro-N-cyclopentyl-3-2-(cyclopentylamino)pyrimidin-4-yl-2-(4-fluorophenyl)pyrazolo1,5-apyridin-5-amine;
4,6-Dibromo-N-cyclopentyl-3-2-(cyclopentylamino)pyrimidin-4-yl-2-(4-fluorophenyl)pyrazolo1,5-apyridin-7-amine;
4,6-Dibromo-3-5-bromo-2-(cyclopentylamino)pyrimidin-4-yl-N-cyclopentyl-2-(4-fluorophenyl)pyrazolo1,5-apyridin-7-amine;
6-Chloro-N-cyclopentyl-3-2-(cyclopentylamino)pyrimidin-4-yl-2-(4-fluorophenyl)pyrazolo1,5-apyridin-7-amine;
N-Cyclopentyl-3-2-(cyclopentylamino)-4-pyrimidinyl-2-(4-fluorophenyl)-5-methoxypyrazolo1,5-apyridin-7-amine; and
N-Cyclopentyl-3-2-(cyclopentylamino)-4-pyrimidinyl-2-(4-fluorophenyl)-5-(2-methoxyethoxy)pyrazolo1,5-apyridin-7-amine,
and pharmaceutically acceptable salts, and solvates thereof.
16. A pharmaceutical composition comprising a compound according to claim 1.
17. The pharmaceutical composition according to claim 16 further comprising a pharmaceutically acceptable carrier or diluent.
18. The pharmaceutical composition according to claim 16 further comprising an antiviral agent selected from the group consisting of aciclovir and valaciclovir.
19. A process for preparing the compound according to claim 1 wherein Y is N, R2 is selected from the group consisting of alkyl, alkenyl, cycloalkyl, cycloalkenyl, Ay, Het, \u2014OR7, \u2014OAy, \u2014OHet, \u2014OR10Het, \u2014S(O)nR9, \u2014S(O)nAy, \u2014S(O)nHet, \u2014S(O)nNR7R8, \u2014NR7R8, \u2014NHHet, \u2014NHR10Ay, \u2014NHR10Het, \u2014R10NR7R8 and \u2014R10NR7Ay; and R3 and R4 are H, said process comprising the steps of:
a) reacting a compound of formula (VIII):
\u2003with a compound of formula (X):
\u2003to prepare a compound of formula (IX):
b) halogenating the compound of formula (IX) to prepare a compound of formula (I-A):
\u2003where Hal is halo; and
c) optionally either:
1) replacing the C-7 halogen of the compound of formula (I-A) with an amine nucleophile selected from the group consisting of \u2014NR7R8, \u2014NR7Ay, \u2014NHHet, \u2014NHR10Ay and \u2014NHR10Het; or
2) coupling the compound of formula (I-A) with a metal compound selected from the group consisting of Ay-M3 and Het-M3 wherein M3 is \u2014B(OH)2, \u2014B(ORa)2, \u2014B(Ra)2, \u2014Sn(Ra)3, Zn-halide, Zn\u2014Ra or Mg-halide where Ra is alkyl or cycloalkyl and halide is halo, to prepare a compound of formula (I-B):
\u2003wherein R1 is selected from the group consisting of Ay, Het, \u2014NR7R8, \u2014NR7Ay, \u2014NHHet, \u2014NHR10Ay, and \u2014NHR10Het.
20. A process for preparing the compound according to claim 1 wherein Y is N; R2 is selected from the group consisting of alkyl, alkenyl, cycloalkyl, cycloalkenyl, Ay, Het, \u2014OR7, \u2014OAy, \u2014OHet, \u2014OR10Het, \u2014S(O)nR9, \u2014S(O)nAy, \u2014S(O)nHet, \u2014S(O)nNR7R8, \u2014NR7R8, \u2014NHHet, \u2014NHR10Ay, \u2014NHR10Het, \u2014R10NR7R8 and \u2014R10NR7Ay; R3 is selected from the group consisting of H, halo, alkyl, alkenyl, cycloalkyl, Het, \u2014C(O)R7, C(O)Ay, \u2014CO2R7, \u2014CO2Ay, \u2014SO2NHR9, \u2014NR7R8 where neither R7 nor R8 is H, \u2014NR7Ay where R7 is not H, \u2014R10OR7, \u2014R10OAy, \u2014R10NR7R8 and \u2014R10NR7Ay; and R4 is H, said process comprising the steps of:
a) reacting a compound of formula (XVI):
\u2003with a compound of formula (X):
\u2003to prepare a compound of formula (IX):
b) halogenating the compound of formula (IX) to prepare a compound of formula (I-A):
\u2003where Hal is halo; and
c) optionally either:
1) replacing the C-7 halogen of the compound of formula (I-A) with an amine nucleophile selected from the group consisting of \u2014NR7R8, \u2014NR7Ay, \u2014NHHet, \u2014NHR10Ay and \u2014NHR10Het; or
2) coupling the compound of formula (I-A) with a metal compound selected from the group consisting of Ay-M3 and Het-M3 wherein M3 is \u2014B(OH)2, \u2014B(ORa)2, \u2014B(Ra)2, \u2014Sn(Ra)3, Zn-halide, Zn\u2014Ra or Mg-halide where Ra is alkyl or cycloalkyl and halide is halo; to prepare a compound of formula (I-B):
\u2003wherein R1 is selected from the group consisting of Ay, Het, \u2014NR7R8, \u2014NR7Ay, \u2014NHHet, \u2014NHR10Ay and \u2014NHR10Het.
21. A process for preparing the compound according to claim 1 wherein Y is N and R2 is selected from the group consisting of alkyl, alkenyl, cycloalkyl, cycloalkenyl, Ay, Het, \u2014OR7, \u2014OAy, \u2014OHet, \u2014OR10Het, \u2014S(O)nR9, \u2014S(O)nAy, \u2014S(O)nHet, \u2014S(O)nNR7R8, \u2014NR7R8, \u2014NHHet, \u2014NHR10Ay, \u2014NHR10Het, \u2014R10NR7R8 and \u2014R10NR7Ay, said process comprising the steps of:
a) reacting a compound of formula (XX):
\u2003with a compound of formula (X):
\u2003to prepare an intermediate compound;
b) oxidizing the intermediate compound to prepare a compound of formula (IX):
c) halogenating the compound of formula (IX) to prepare a compound of formula (I-A):
\u2003where Hal is halo; and
d) optionally either:
1) replacing the C-7 halogen of the compound of formula (I-A) with an amine nucleophile selected from the group consisting of \u2014NR7R8, \u2014NR7Ay, \u2014NHHet, \u2014NHR10Ay and \u2014NHR10Het; or
2) coupling the compound of formula (I-A) with a metal compound selected from the group consisting of Ay-M3 and Het-M3 wherein M3 is \u2014B(OH)2, \u2014B(ORa)2, \u2014B(Ra)2, \u2014Sn(Ra)3, Zn-halide, Zn\u2014Ra or Mg-halide where Ra is alkyl or cycloalkyl and halide is halo, to prepare a compound of formula (I-B):
\u2003wherein R1 is selected from the group consisting of Ay, Het, \u2014NR7R8, \u2014NR7Ay, \u2014NHHet, \u2014NHR10Ay and \u2014NHR10Het.
22. A process for preparing the compound according to claim 1, said process comprising the steps of:
a) reacting a compound of formula (XXII):
\u2003wherein X1 is selected from the group consisting of chloro, bromo and iodo;
with a compound of formula (XXIV):
\u2003wherein M2 is selected from the group consisting of \u2014B(OH)2, \u2014B(ORa)2, \u2014B(Ra)2, \u2014Sn(Ra)3, Zn-halide, ZnRa, and Mg-halide where Ra is alkyl or cycloalkyl and halide is halo; to prepare a compound of formula (IX):
b) halogenating the compound of formula (IX) to prepare a compound of formula (I-A):
\u2003where Hal is halo; and
c) optionally either:
1) replacing the C-7 halogen of the compound of formula (I-A) with an amine nucleophile selected from the group consisting of \u2014NR7R8, \u2014NR7Ay, \u2014NHHet, \u2014NHR10Ay and \u2014NHR10Het; or
2) coupling the compound of formula (I-A) with a metal compound selected from the group consisting of Ay-M3 and Het-M3 wherein M3 is \u2014B(OH)2, \u2014B(ORa)2, \u2014B(Ra)2, \u2014Sn(Ra)3, Zn-halide, Zn\u2014Ra or Mg-halide where Ra is alkyl or cycloalkyl and halide is halo, to prepare a compound of formula (I-B):
\u2003wherein R1 is selected from the group consisting of Ay, Het, \u2014NR7R8, \u2014NR7Ay, \u2014NHHet, \u2014NHR10Ay and \u2014NHR10Het.
23. The process according to claim 19 further comprising the step of converting the compound of formula (I) to a pharmaceutically acceptable salt or solvate thereof.
24. The process according to claim 19 further comprising the step of converting a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof to another compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof.

1. A method of facilitating multi-media communications between a first communicator and a second communicator, the method comprising:
initiating a communication event over a network between the first communicator, operating a first communications device, and the second communicator, operating a second communications device, via a first communications medium; the network being operatively, electrically coupled with an intermediary computing device;
transmitting information between said first communications device and said second communications device only on the first communications medium;
determining that said communications event should transition from the first communications medium to the second communications medium;
terminating the transmission of information between said first communications device and said second communications device on the first communications medium;
transitioning said communications event from said first communications medium to a second communications medium, different from said first communications medium, using the intermediary computing device; at least one of the first communications medium or second communications medium being, on its own, a stateless medium; and
transmitting information between said first communications device and said second communications device only on the second communications medium;
wherein said intermediary computing device maintains said communications event as a continuous, stateful event over: (i) delays between the transmission of information between the first communications device and the second device; and (ii) the transition between the first communications medium and the second communications medium.
2. The method of claim 1 wherein said first communications medium is a SMS text messaging service.
3. The method of claim 2 wherein said second communications medium is a voice call, e-mail, or facsimile transmission.
4. The method of claim 2, further comprising:
providing the second communicator with an option to transition said communications event from said first communications media to said second communications medium, prior to the step of transitioning said communications event.
5. The method of claim 2 wherein said information, communicated from said first communicator, is comprised of a request for a voice call at a future time.
6. The method of claim 5 wherein said future time relates to a time that affords a desired rate when using said second communications medium.
7. The method of claim 5 wherein said information, communicated from said first communicator, is comprised of communications contact information for a third communicator to whom said communications event is to be bridged.
8. The method of claim 1 wherein the first communicator is a customer and the second communicator is a merchant, said first communications medium is a voice call and said second communications medium is a text messaging service.
9. The method of claim 8, further comprising:
transmitting financial data from the first communicator to the second communicator via said second communications medium.
10. The method of claim 9, further comprising:
bridging said communications event from said second communications medium to said first communications medium after said financial data is transmitted.
11. The method of claim 1 wherein said first communications medium is a voice call and said second communications medium is a voice call, e-mail, or facsimile transmission.
12. The method of claim 11, further comprising:
determining that a delay in said communications event will be necessary;
terminating said communications event during said delay;
reestablishing said communications event via a text messaging service, e-mail, or facsimile transmission to the second communicator at the expiration of said delay;
providing the second communicator with an option to bridge said communications event from said text messaging service, e-mail, or facsimile transmission to said second communications medium, prior to the step of bridging said communications event.
13. The method of claim 12, further comprising:
determining when said delay is no greater than a precalculated amount of time, prior to the step of reestablishing said communications event;
reestablishing said communications event when said delay is less than or equal to said predetermined amount of time.
14. The method of claim 2, further comprising:
transmitting survey questions to the second communicator, during said communications event, using said first communications medium;
receiving responses to said survey questions from the second communicator prior to the step of bridging said communications event from said first communications medium to said second communications medium; and
bridging said communications event from said first communications medium to a service agent, via said second communications medium, only when said responses at least approximate one or more predetermined model responses.
15. The method of claim 1, further comprising:
transmitting emergency information to the second communicator, during said communications event, using said first communications medium;
providing the second communicator with an option to bridge said communications event from said first communications medium to said second communications medium, prior to the step of bridging said communications event; and
bridging said communications event from said first communications medium to said second communications medium, in response to the second communicator accepting the option to bridge said communications event from said first communications medium to said second communications medium.
16. The method of claim 15 wherein said first communications medium is a voice call and said second communications medium is a text messaging service.
17. The method of claim 15 wherein said first communications medium is a text messaging service and said second communications medium is a voice call.
18. The method of claim 1, further comprising:
transmitting one or more data queries to the second communicator, during said communications event, using said first communications medium;
receiving data from the second communicator in response to said one or more data queries;
providing the first communicator with an option to transition said communications event from said first communications medium to said second communications medium, prior to the step of transitioning said communications event;
transitioning said communications event from said first communications medium to said second communications medium, in response to the first communicator accepting the option to transition said communications event from said first communications medium to said second communications medium; and
receiving secondary data from the second communicator via said second communications medium.
19. The method of claim 1 wherein said information communicated from the first communicator to the second communicator is comprised of a notice of a recent transaction relating to the second communicator.
20. The method of claim 19, further comprising:
querying the second communicator, during said communications event via said first communications medium, to determine if said transaction is valid;
receiving a response from the second communicator regarding said query;
transitioning said communications event from said first communications medium to said second communications medium, where said response from the second communicator indicates that said transaction is not valid.
21. The method of claim 20 wherein, if said response indicates that said transaction is valid, the second communicator is provided with an option to bridge said communications event from said first communications medium to said second communications medium.
22. The method of claim 20 wherein said communications event is bridged to a service agent via said second communications medium; said second communications medium being a voice call.
23. The method of claim 12 wherein said communications event is bridged to a service agent via said second communications medium; said second communications medium being a voice call.
24. The method of claim 23 wherein identification data is transferred to said service agent, relative to a purpose for said communications event.
25. The method of claim 1 wherein said information relates to a query as to an availability of the second communicator.
26. The method of claim 25, further comprising:
providing the second communicator with an option to transition said communications event from said first communications medium to said second communications medium, prior to the step of transitioning said communications event; and
transitioning said communications event from said first communications medium to said second communications medium, in response to the second communicator accepting the option to transition said communications event from said first communications medium to said second communications medium.
27. The method of claim 26 wherein said first communications medium is a text messaging service and said second communications medium is a voice call.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

In the claims:

1. A wheel end assembly for a motor vehicle comprising:
a knuckle having a plurality of apertures formed therein for attachment of said knuckle to the vehicle, said knuckle having a generally circular bore formed therein;
a bearing positioned in said generally circular bore, said bearing having an inner race and an outer race;
a wheel hub having a neck portion, in rotational communication with said bearing, and a flange portion attached to said neck portion;
said flange portion having a flange face with an outer portion, an inner portion, and a relief channel disposed between said outer portion and said inner portion;
a plurality of wheel bolt receiving apertures formed in said relief channel each for receipt of a wheel bolt therethrough;
said inner portion and said outer portion of said flange face lying generally in a single plane with said plane being generally parallel to a plane in which a pair of brake mounting structures are disposed; and
wherein run-out of said flange face with respect to an axis of rotation of said bearing.
2. The assembly as recited in claim 1, wherein said generally circular bore of said knuckle has an upper snap ring groove and a lower shoulder portion for receiving said bearing therebetween.
3. The assembly as recited in claim 2, wherein a snap ring is positioned in said snap ring groove and wherein said bearing is snap fit into said knuckle between said snap ring and said lower shoulder portion.
4. The assembly as recited in claim 1, wherein said neck portion of said wheel hub is press fit into communication with said bearing.
5. The assembly as recited in claim 1, wherein said bearing outer race is integrally formed with said knuckle.
6. The assembly as recited in claim 1, wherein said bearing inner race is integrally formed with said neck portion of said wheel hub.
7. The assembly as recited in claim 1, wherein parallelism between said inner portion of said flange face and said outer portion of said flange face and a pair of brake caliper ears can be accurately maintained.
8. The assembly as recited in claim 1, wherein said inner portion of said flange face and said outer portion of said flange face have a flatness of at least 20 m.
9. A knuckle hub assembly comprising:
a knuckle having a plurality of apertures formed therein for attachment to a supporting structure;
an attachment structure formed in said knuckle for communicating with a bearing;
a wheel hub having a neck portion and a flange portion, said neck portion being in rotatable communication with said bearing;
a flange face formed on said flange portion for mating with a brake rotor;
a relief channel formed in said flange face and dividing said flange face into an inner portion and an outer portion; and
whereby said flange face inner portion is parallel to a first brake caliper and said flange face outer portion is parallel to a second brake caliper and whereby lateral run-out of said flange face with respect to said brake rotor is minimized.
10. The assembly as recited in claim 9, wherein said inner portion and said outer portion of said flange face are generally co-planar to each other.
11. The assembly as recited in claim 10, wherein a plurality of wheel bolt receiving apertures are formed in said relief channel, each of said apertures receiving a wheel bolt therethrough.
12. The assembly as recited in claim 11, wherein said supporting structure is part of a motor vehicle.
13. The assembly as recited in claim 12, wherein said knuckle has a generally circular bore formed therein.
14. The assembly as recited in claim 13, wherein said generally circular bore receives said bearing therein and wherein said attachment structure that communicates with said bearing is an inner surface of said bore.
15. The assembly as recited in claim 14, wherein said knuckle bore has an upper snap ring groove and a lower shoulder portion between which said bearing is press-fit.
16. The assembly as recited in claim 13, wherein said bearing has an inner race and an outer race and said bearing outer race is integrally formed with said knuckle.
17. The assembly as recited in claim 13, wherein said bearing has an inner race and an outer race and said bearing inner race is integrally formed with said wheel hub neck portion.
18. The assembly as recited in claim 13, wherein said inner portion of said flange face and said outer portion of said flange face have a flatness of at least 20 m.
19. The assembly as recited in claim 13, wherein said run-out between said flange face and an axis of rotation of said bearing is minimized.
20. The assembly as recited in claim 19, wherein said run-out between said flange face and said bearing axis of rotation is 14 m or better.
21. The assembly as recited in claim 13, wherein said bearing is mounted to said attachment structure which is located on an upper portion of said knuckle.
22. A method for manufacturing a knucklehub assembly, comprising:
providing a wheel hub having a neck portion and a flange portion, said flange portion having a flange face with an inner portion, an outer portion, and a relief channel disposed between said inner portion and said outer portion;
forming a plurality of bolt receiving apertures in said relief channel;
locating a bearing into a generally circular bore formed in a knuckle;
journaling said neck portion of said wheel hub into said bearing to allow rotation of said wheel hub with respect to said knuckle;
final finishing said inner portion and said outer portion of said flange face whereby said inner portion and said outer portion are co-planar whereby lateral run-out of said flange face to a brake rotor is minimized.
23. The method as recited in claim 22, further comprising finishing said inner portion and said outer portion of said flange face prior to said final finishing step.
24. The method as recited in claim 22, further comprising locating said assembly in a clamping fixture.
25. The method as recited in claim 22, further comprising press-fitting a wheel bolt into each of said plurality of bolt receiving holes prior to said step of final finishing.
26. The method as recited in claim 22, further comprising forming said relief channel in said flange through machining.
27. The method as recited in claim 22, further comprising forming said relief channel in said flange face through forging.
28. The method as recited in claim 22, further comprising press-fitting said bearing into said knuckle bore.
29. The method as recited in claim 22, further comprising integrally forming an outer race of said bearing with said knuckle.
30. The method as recited in claim 22, further comprising integrally forming an inner race of said bearing with said neck portion of said wheel hub.
31. The method as recited in claim 22, wherein said final finishing step includes finishing said inner portion and said outer portion of said flange face such that they have a flatness of at least 20 m.
32. The method as recited in claim 22, wherein parallelism between said inner portion and said outer portion of said flange face and a plurality of brake caliper ears is maintained.
33. The method as recited in claim 22, wherein said final finishing step provides run-out between said flange face and said bearing axis of rotation of 14 m or better.
34. A method for manufacturing a wheel end assembly, comprising:
providing a wheel hub having a neck portion and a flange portion, said flange portion having a flange face;
forming a relief channel in said flange face such that said flange face has an inner portion and an outer portion;
forming a plurality of bolt receiving holes in said relief channel;
finishing said flange face in order to flatten said flange face inner portion and said flange face outer portion;
placing said wheel hub in rotational communication with a knuckle; and
final finishing said inner portion and said outer portion of said flange face whereby lateral run out of said flange face is minimized.
35. The method as recited in claim 34, wherein said step of final finishing includes forming said inner portion and said outer portion such that they are coplanar.
36. The method as recited in claim 34, wherein said step of final finishing includes forming said inner portion and said outer portion such that they are flat.
37. The method as recited in claim 36, wherein said inner portion and said outer portion each have a flatness of at least 20 m.
38. The method as recited in claim 34, wherein parallelism between said inner portion and said outer portion of said flange face and a plurality of brake caliper ears is maintained.
39. The method as recited in claim 34, further comprising:
locating the wheel end assembly into a fixture assembly prior to said step of final finishing.
40. The method as recited in claim 34, further comprising:
providing a knuckle having a bearing retention structure formed therein.
41. The method as recited in claim 40, wherein said bearing retention structure is a generally circular bore formed in said knuckle.
42. The method as recited in claim 41, further comprising:
snap-fitting a bearing having an inner race and an outer race into said bore.
43. The method as recited in claim 42, wherein said bearing is located in said bore between a lower shoulder portion and an upper snap ring.
44. The method as recited in claim 41, wherein said bearing is only partially disposed in said bore.
45. The method as recited in claim 40 wherein said bearing retention structure is disposed on an upper surface of said knuckle.
46. The method as recite in claim 34, wherein said relief channel is formed in said flange face through machining.
47. The method as recited in claim 34, wherein said relief channel is formed in said flange face through forging.
48. The method as recited in claim 34, further comprising:
integrally forming an outer race of said bearing with said knuckle.
49. The method as recited in claim 34, further comprising:
integrally forming an inner race of said bearing with said neck portion of said wheel hub.
50. The method as recited in claim 34, further comprising:
press-fitting a wheel bolt into each of said plurality of bolt receiving holes prior to said step of final finishing.
51. The method as recited in claim 34, wherein wheel bolts are passed through each of said plurality of bolt receiving holes when a wheel is attached to said wheel hub.