1. A cooling system, for a combustion-powered tool, comprising:
a cylinder having a longitudinal axis;
a piston movably disposed within a piston chamber defined within said cylinder;
a combustion chamber, having a longitudinal axis, connected to said cylinder and within which forces and heat are cyclically generated for impacting upon said piston so as to move said piston within said cylinder;
a housing externally surrounding external wall portions of said combustion chamber and said cylinder of said combustion-powered tool so as to define an annular cooling air space between internal wall portions of said housing and said external wall portions of said combustion chamber and said cylinder whereby said annular cooling air space externally surrounds said combustion chamber and said cylinder;
a cooling air inlet defined upon said housing and fluidically connected to said annular cooling air space externally surrounding said combustion chamber and said cylinder for permitting cooling air to enter said annular cooling air space externally surrounding said combustion chamber and said cylinder; and
an air outlet, fluidically connected to both said annular cooling air space externally surrounding said combustion chamber and said cylinder, and said piston chamber, for inducing ambient cooling air to enter said cooling air inlet and to flow into and solely through said annular cooling air space externally surrounding said combustion chamber and said cylinder as air, disposed within said piston chamber and beneath said piston disposed within said piston chamber, is exhausted out from said piston chamber and out through said air outlet as said piston is moved within said piston chamber during a power stroke of said piston of said combustion-powered tool, such that said cooling air, flowing solely within said annular cooling air space, flows past said external wall portions of said combustion chamber and said cylinder and thereby cools said combustion chamber and said cylinder.
2. The cooling system as set forth in claim 1, wherein:
said air outlet comprises a jet pump assembly.
3. The cooling system as set forth in claim 2, wherein:
said jet pump assembly comprises a venturi section for creating a drop in pressure and an increase in velocity of exhaust gas from said cylinder through said venturi section of said jet pump assembly whereby ambient cooling air will be induced into said housing through said cooling air inlet.
4. The cooling system as set forth in claim 1, further comprising:
a fan operatively mounted within said air outlet;
a drive motor operatively connected to said fan for driving said fan when said drive motor is activated; and
a thermal switch mounted upon an external wall portion of one of the cylinder and chamber components of combustion-powered tool for sensing the temperature level of the one of said cylinder and chamber components of said combustion-powered tool and for activating said drive motor if said sensed temperature level of said one of said cylinder and chamber components of said combustion-powered tool exceeds a predetermined excessive temperature level.
5. The cooling system as set forth in claim 1, further comprising:
a nozzle member mounted upon said cylinder for exhausting air from said cylinder and entraining ambient cooling air into said space defined between said internal wall portions of said housing and said external wall portions of said combustion chamber and said cylinder.
6. The cooling system as set forth in claim 5, further comprising:
a storage plenum chamber fluidically connected to said nozzle member and adapted to store air exhausted from said cylinder; and
a control valve operatively associated with said storage plenum chamber for controlling the amount of air discharged from said storage plenum chamber and fluidically conducted to said nozzle member so as to control said entraining of said ambient cooling air into said space defined between said internal wall portions of said housing and said external wall portions of said combustion chamber and said cylinder.
7. The cooling system as set forth in claim 1, further comprising:
cooling structure mounted upon external wall portions of said combustion chamber and said cylinder for facilitating cooling of said combustion chamber and said cylinder.
8. The cooling system as set forth in claim 7, wherein:
said cooling structure mounted upon the external wall portions of said combustion chamber and said cylinder comprise cooling fins.
9. The cooling system as set forth in claim 8, wherein:
said cooling fins extend radially outwardly from said external wall portions of said combustion chamber and said cylinder so as to extend substantially perpendicular to said longitudinal axes of said combustion chamber and said cylinder.
10. The cooling system as set forth in claim 8, wherein:
said cooling fins are disposed within a circumferentially overlapped array so as to effectively reduce the radial and diametrical extent of said combustion-powered tool.
11. The cooling system as set forth in claim 7, wherein:
said air outlet is fluidically connected to said annular space, defined between said internal wall portions of said housing and said external wall portions of said combustion chamber and said cylinder, for inducing ambient cooling air to enter said cooling air inlet and said annular space, defined between said internal wall portions of said housing and said external wall portions of said combustion chamber and said cylinder, as said piston is moved within said cylinder during a return stroke of said piston of said combustion-powered tool, so as to pass by said cooling structure mounted upon said external wall portions of said combustion chamber and said cylinder and thereby cool said combustion chamber and said cylinder.
12. The cooling system as set forth in claim 1, further comprising:
cooling structure mounted upon external wall portions of said combustion chamber and said cylinder for facilitating cooling of said combustion chamber and said cylinder.
13. The fastener-driving tool as set forth in claim 12, wherein:
said cooling structure mounted upon said external wall portions of said chamber and said cylinder comprise cooling fins.
14. The fastener-driving tool as set forth in claim 13, wherein:
said cooling fins extend radially outwardly from said external wall portions of said chamber and said cylinder so as to extend substantially perpendicular to said longitudinal axes of said chamber and said cylinder.
15. The fastener-driving tool as set forth in claim 13, wherein:
said cooling fins are disposed within a circumferentially overlapped array so as to effectively reduce the radial and diametrical extent of said fastener-driving tool.
16. The fastener-driving tool as set forth in claim 12, wherein:
said air outlet is fluidically connected to said space, defined between said internal wall portions of said housing and said external wall portions of said combustion chamber and said cylinder, for inducing ambient cooling air to enter said cooling air inlet and said space, defined between said internal wall portions of said housing and said external wall portions of said combustion chamber and said cylinder, and to pass by said cooling structure mounted upon said external wall portions of said chamber and said cylinder so as to cool said chamber and said cylinder as said piston is moved within said cylinder during a return stroke of said piston of said fastener-driving tool.
17. A fastener-driving tool, comprising:
a cylinder having a longitudinal axis;
a piston movably disposed within a piston chamber defined within said cylinder;
a driver blade fixedly attached to said piston for driving a fastener our from said fastener-driving tool;
a combustion chamber, having a longitudinal axis, connected to said cylinder and within which forces and heat are cyclically generated for impacting upon said piston so as to move said piston within said cylinder whereby said driver blade can drive a fastener out from said fastener-driving tool;
a housing externally surrounding external wall portions of said combustion chamber and said cylinder of said fastener-driving tool so as to define an annular cooling air space between internal wall portions of said housing and said external wall portions of said combustion chamber and said cylinder whereby said annular cooling air space externally surrounds said combustion chamber and said cylinder;
a cooling air inlet defined upon said housing and fluidically connected to said annular cooling air space externally surrounding said combustion chamber and said cylinder for permitting cooling air to enter said annular cooling air space externally surrounding said combustion chamber and said cylinder; and
an air outlet, fluidically connected to both said annular cooling air space externally surrounding said combustion chamber and said cylinder, and said piston chamber, for inducing ambient cooling air to enter said cooling air inlet and to flow into and solely through said annular cooling air space externally surrounding said combustion chamber and said cylinder as air, disposed within said piston chamber and beneath said piston disposed within said piston chamber, is exhausted out from said piston chamber and out through said air outlet as said piston is moved within said piston chamber of said cylinder during a power stroke of said piston of said fastener-driving tool, such that said cooling air, flowing solely within said annular cooling air space, flows past said external wall portions of said combustion chamber and said cylinder and thereby cools said combustion chamber and said cylinder.
18. The fastener-driving tool as set forth in claim 17, wherein:
said air outlet comprises a jet pump assembly.
19. The fastener-driving tool as set forth in claim 18, wherein:
said jet pump assembly comprises a venturi section for creating a drop in pressure and an increase in velocity of exhaust gas from said cylinder through said venturi section of said jet pump assembly whereby ambient cooling air will be induced into said housing through said cooling air inlet.
20. The fastener-driving tool as set forth in claim 17, further comprising:
a fan operatively mounted within said air outlet;
a drive motor operatively connected to said fan for driving said fan when said drive motor is activated; and
a thermal switch mounted upon an external wall portion of one of said cylinder and chamber components of said fastener-driving tool for sensing the temperature level of said one of said cylinder and chamber components of said fastener-driving tool and for activating said drive motor if said sensed temperature level of said one of said cylinder and chamber components of said fastener-driving tool exceeds a predetermined excessive temperature level.
21. The fastener-driving tool as set forth in claim 17, further comprising:
a nozzle member mounted upon said cylinder for exhausting air from said cylinder and entraining ambient cooling air into said space defined between said internal wall portions of said housing and said external wall portions of said combustion chamber and said cylinder.
22. The fastener-driving tool as set forth in claim 21, further comprising:
a storage plenum chamber fluidically connected to said nozzle member and adapted to store air exhausted from said cylinder; and
a control valve operatively associated with said storage plenum chamber for controlling the amount of air discharged from said storage plenum chamber and fluidically conducted to said nozzle member so as to control said entraining of said ambient cooling air into said space defined between said internal wall portions of said housing and said said external wall portions of said combustion chamber and said cylinder.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of general formula (I), or a pharmaceutical acceptable salt thereof, or a solvate thereof including a hydrate, or any stereoisomer or mixture of stereoisomers:
wherein:
R1 is a radical derived from one of the known ring systems selected from the group consisting of:
one aromatic ring having 5-6 carbon atoms, being optionally one of said carbon atoms replaced by one N, O, or S atom; and
a two fused ring system, wherein
one of the rings is aromatic and the other is aromatic or partially insaturated,
each ring has 5-6 carbon atoms, being optionally 1-3 of said carbon atoms replaced by N, O, or S;
wherein each ring, forming the known ring system, is optionally substituted by at least one radical selected from the group consisting of: (C1-C8)alkyl, \u2014OH, halogen, (C1-C8)alkoxy, \u2014CN, (C1-C8)fluoralkyl, (C1-C8)fluoroalkoxy, \u2014CH2\u2014R5, \u2014R10, -Qn-OR5, -Qn-NR4C(O)R5, -Qn-C(O)NR4R5, -Qn-NH2, -Qn-NR4R5, -Qn-S\u2014R5, -Qn-S(O2)\u2014R5, -Qn-NR4S(O2)R5, -Qn-S(O2)NR4R5, -Qn-NR4\u2014CO, \u2014NR4R5, -Qn-NR4\u2014CO\u2014OR5, and -Qn-O\u2014CO\u2014NR4R5; where Qn is \u2014(CH2)n\u2014, being n=0, 1, 2 or 3;
R2 is a phenyl radical optionally substituted by at least one radical selected from the group consisting of: halogen, \u2014OH, \u2014Pn\u2014OR5, \u2014NR4C(O)R6, \u2014C(O)NR4R6, \u2014NH2, \u2014NR4R5, \u2014R10, \u2014R6, \u2014CN, (C1-C4)fluoralkyl, (C1-C4)fluoroalkoxy, (C1-C4)alkoxy, and (C1-C4)alkyl; where Pn is \u2014(CH2)n\u2014 being n=0 or 1
Xn represents a birradical selected from the group consisting of: \u2014(CH2)1-4\u2014, (C2-C4)-alkenyl, (C2-C4)alkynyl, \u2014S\u2014(CH2)1-3\u2014#, and \u2014(CH2)1-3\u2014O\u2014#; wherein the symbol # indicates the position at which Xn is attached to R1;
Yn is a birradical selected from the group consisting of: \u2014(CH2)2-4\u2014, \u2014S\u2014(CH2)1-3#, and \u2014O\u2014(CH2)1-3\u2014#; wherein the symbol # indicates the position at which Yn is attached to R2;
R3 is a radical selected from the group consisting of: \u2014OR4, \u2014O\u2014CR4R4\u2014O\u2014C(O)\u2014R4;
R4 is a radical selected from: hydrogen and (C1-C4)alkyl optionally substituted by at least one radical selected from the group consisting of: \u2014NH2 and \u2014OH;
R5 is a radical selected from: hydrogen, and -Ln-R7, where
Ln is \u2014(CH2)n\u2014 with n=0, 1, 2, 3 or 4; and
R7 is a known ring systems with 1 ring or 2 fused rings, each one of the rings forming said ring system being partially unsaturated or aromatic, have 5-6 members, each member being independently selected from C, N, O, S, CH, CH2, and NH; and being each ring forming said ring system optionally substituted by at least one radical selected from the group consisting of: (C1-C4)-alkyl, \u2014CN, (C1-C4)fluoralkyl, (C1-C4)fluoroalkoxy, halogen, (C1-C4)alkoxy, \u2014NH2, \u2014OH, dialkyl(C1-C4)amino, and a known aromatic ring of 5-6 members independently selected from N, O, S, CH, and NH which is linked to R7 via a (C1-C4)alkyl birradical;
R6 is a radical selected from the group consisting of: (C1-C4)alkyl optionally substituted by at least one radical selected from the group consisting of: halogen, cyano, amino, and an aromatic known ring having 5-6 members independently selected from N, O, S, CH, and NH;
R10 is an aromatic known ring having 5-6 members independently selected from N, O, S, CH, and NH;
with the proviso that when R1 is phenyl:
R2 is a phenyl radical substituted by at least one radical selected from the group consisting of: (C1-C4)alkoxy, (C1-C4)alkyl, \u2014NHC(O)CH3, halogen, \u2014O\u2014CH2\u2014R8, \u2014OH, \u2014NH2, \u2014OR11, \u2014R8, \u2014NHR11, and \u2014NH\u2014CH2-phenyl;
R8 is a aromatic known ring having 5-6 members independently selected from N, O, S, CH, and NH;
R11 is a phenyl ring optionally substituted with \u2014F, \u2014CF3, \u2014OCH3 and \u2014CN;
R3 is selected from the group consisting of: \u2014OH, (C1-C4)alkoxy and \u2014O\u2014CH2\u2014O\u2014C(O)\u2014CH3;
Xn is selected from the group consisting of: \u2014(CH2)3\u2014; and
Yn is selected from the group consisting of: \u2014(CH2)2;
and with the proviso that R1 and R2 are not simultaneously a phenyl substituted by one \u2014OMe radical.
2. A compound according to claim 1, wherein:
R1 is a radical derived from one of the known ring systems selected from the group consisting of:
one aromatic ring having 5-6 carbon atoms, being optionally one of said carbon atoms replaced by one N, O or S; and
a two fused ring system, wherein
one of the rings is aromatic and the other is aromatic or partially insaturated,
each ring has 5-6 carbon atoms, being optionally 1-3 carbon atoms replaced by N, O, or S;
being each ring, forming said ring system, optionally substituted by at least one radical selected from the group consisting of: (C1-C8)alkyl, \u2014OH, halogen, (C1-C8)alkoxy, \u2014CN, \u2014(C1-C4)fluoralkyl, \u2014(C1-C4)fluoroalkoxy, \u2014CH2\u2014R5, \u2014R10, -Qn-OR5, -Qn-NR4C(O)R5, -Qn-C(O)NR4R5, -Qn-NH2, -Qn-NR4R5, -Qn-NR4S(O2)R5, -Qn-S(O2)NR4R5 and -Qn-NR4\u2014CO\u2014OR5;
where Qn is \u2014(CH2)n\u2014, being n=0 or 1;
R4 is a radical selected from: hydrogen and (C1-C4)alkyl;
R5 is a radical selected from: hydrogen, and -Ln-R7 where
Ln is \u2014(CH2)n\u2014 with n=0 or 1; and
R7 is an aromatic ring with 5-6 members, each member being independently selected from N, O, S, CH, and NH; and being optionally substituted by at least one radical selected from the group consisting of: \u2014(C1-C4)-alkyl, \u2014CN, \u2014(C1-C4)fluoralkyl, \u2014(C1-C4)fluoroalkoxy, halogen, \u2014(C1-C4)alkoxy, \u2014NH2, \u2014OH and dialkyl(C1-C4)amino.
3. A compound according to claim 2, wherein:
R1 is a radical derived from naphtyl; phenyl and thiophene, being the phenyl and thiophene radical optionally substituted by at least one radical selected from the group consisting of: (C1-C4)alkyl, \u2014OH, halogen, (C1-C4)alkoxy, \u2014CN, \u2014CF3, \u2014CHF2, \u2014OCF3, \u2014OCHF2, \u2014NH2, \u2014R10, \u2014NR4C(O)R5, \u2014C(O)NR4R5, \u2014NR4S(O2)R5, and \u2014S(O2)NR4R5;
R2 is a phenyl radical optionally substituted by at least one radical selected from the group consisting of: halogen; \u2014OH, \u2014OR5, \u2014NHC(O)R6, \u2014C(O)NHR6, \u2014NH2, \u2014NHR5, \u2014R10, \u2014R6, \u2014CN, \u2014CF3, \u2014CHF2, \u2014OCF3, \u2014OCHF2, (C1-C4)alkoxy and (C1-C4)alkyl;
Xn represents a birradical selected from the group consisting of: \u2014(CH2)2-4\u2014, (C2-C4)-alkenyl, (C2-C4)alkynyl, and \u2014S\u2014(CH2)1-3\u2014#, wherein the symbol # indicates the position at which Xn is attached to R1;
Yn is a birradical selected from the group consisting of: \u2014(CH2)2-3\u2014, \u2014S\u2014(CH2)1-2#, and \u2014(CH2)1-2\u2014#; wherein the symbol # indicates the position at which Yn is attached to R2;
R5 is a radical selected from: hydrogen and -Ln-R7,
where Ln is \u2014(CH2)n\u2014 being n=0 or 1; and
R7 is an aromatic known ring system with 5-6 members, each member being independently selected from N, O, S, CH, and NH; and being optionally substituted by at least one radical selected from the group consisting of: (C1-C4)-alkyl, \u2014CN, \u2014CF3, \u2014CHF2, \u2014OCF3, \u2014OCHF2, halogen, (C1-C4)alkoxy, \u2014NH2, \u2014OH and dialkyl(C1-C4)amino.
4. The compound according to claim 3, wherein
R1 is selected from the group consisting:
wherein the symbol # indicates the position at which R1 is attached to Xn;
wherein R9 is \u2014CH3, \u2014Rx or \u2014CH2\u2014Rx;
R2 is
wherein
the symbol # indicates the position at which R2 is attached to Yn;
R\u20332 is selected from the group consisting of: hydrogen, \u2014OCH3, \u2014OH; and
R\u20322 is selected from the group consisting of: hydrogen, \u2014NH2, (C1-C4)alkyl, \u2014OH, \u2014OCH3, \u2014CN, halogen, \u2014NH\u2014CO\u2014CH3, \u2014O\u2014R5, \u2014O\u2014CH2-phenyl, \u2014O\u2014CH2-pyridine, \u2014NH\u2014CH2-phenyl, and an aromatic known ring having 5-6 members selected from CH, N, NH, O and S;
R5 is phenyl optionally substituted by one radical selected from: \u2014CN, \u2014F, \u2014OCH3, \u2014CF3;
Rx is phenyl optionally substituted by one radical selected from the group consisting of: (C1-C4)alkyl, (C1-C4)alkoxy, and dialkyl(C1-C4)amino;
Xn represents a birradical selected from the group consisting of: \u2014(CH2)2-4\u2014, C3-alkenyl, \u2014C3-alkynyl, and \u2014S\u2014(CH2)2-#; wherein the symbol # indicates the position at which Xn is attached to R1;
Yn is a birradical selected from the group consisting of: \u2014(CH2)2-3\u2014, \u2014SCH2\u2014#, and \u2014OCH2-#; wherein the symbol # indicates the position at which Xn is attached to R2; and
R3 is hydroxyl, methoxy, ethoxy or \u2014O\u2014CH2\u2014O\u2014C(O)\u2014CH3.
5. The compound according to claim 1, wherein
R1 is selected from the group consisting of:
wherein the symbol # indicates the position at which R1 is attached to Xn;
R2 is selected from the group consisting of:
wherein R\u20322 and R\u20332 are selected from the group consisting of: hydrogen, \u2014NH2, \u2014OH, \u2014OCH3, \u2014Br, \u2014CONH2, and phenyl; and the symbol # indicates the position at which R2 is attached to Yn;
Xn is selected from the group consisting of: \u2014(CH2)\u2014, \u2014(CH2)2\u2014, \u2014(CH2)3\u2014, wherein the symbol # indicates the position at which Xn is attached to R1;
Yn is selected from the group consisting of: \u2014(CH2)2\u2014 and \u2014S\u2014CH2\u2014#; wherein the symbol # indicates the position at which Yn is attached to R2; and
R3 is hydroxyl, methoxy, ethoxy, and \u2014O\u2014CH2\u2014O\u2014C(O)\u2014CH3.
6. The compound according to claim 1, wherein
R1 is phenyl;
R2 is a phenyl radical substituted by at least one radical selected from the group consisting of: (C1-C4)alkoxy, (C3-C4)alkyl, \u2014NHC(O)CH3, halogen, \u2014O\u2014CH2\u2014R8, \u2014OH, \u2014NH2, \u2014OR11, \u2014R8, \u2014NHR11, and \u2014NH\u2014CH2-phenyl;
R8 is a aromatic known ring having 5-6 members independently selected from N, O, S, CH, and NH;
R11 is a phenyl ring optionally substituted with \u2014F, \u2014CF3, \u2014OCH3 and \u2014CN;
R3 is selected from the group consisting of: \u2014OH, (C1-C4)alkoxy and \u2014O\u2014CH2\u2014O\u2014C(O)\u2014CH3;
Xn is selected from the group consisting of: \u2014(CH2)3\u2014; and
Yn is selected from the group consisting of: \u2014(CH2)2.
7. The compound according to claim 1, wherein
R1 is phenyl substituted by at least one radical selected from \u2014S(O2)NR4R5, \u2014NR4S(O2)R5 and \u2014NR4C(O)R5;
R2 is phenyl optionally substituted by one (C1-C4)alkyl radical;
R3 is selected from the group consisting of: \u2014OH, methoxy, and \u2014O\u2014CH2\u2014O\u2014C(O)\u2014CH3;
R4 is hydrogen; and
R5 is -Ln-R7, where
Ln is \u2014(CH2)n\u2014 being n=0 or 1; and
R7 is phenyl optionally substituted by at least one radical selected from the group consisting of: (C1-C4)-alkyl, (C1-C4)alkoxy, and dialkyl(C1-C4)amino;
Xn is
\u2003wherein the symbol # indicates the position at which Xn is attached to R1; and
Yn is \u2014(CH2)2\u2014.
8. The compound according to claim 1, wherein
R1 is naphtyl;
R2 is phenyl optionally substituted by one radical selected from the group consisting of: (C1-C4)alkyl radical, thiophene and pyridine;
R3 is \u2014OH;
Xn is \u2014(CH2)3\u2014; and
Yn is \u2014(CH2)2\u2014.
9. The compound according to claim 1, wherein
R1 is thiophene substituted by one \u2014S(O2)NR4R5 radical;
R2 is phenyl;
R3 is \u2014OH;
R4 is hydrogen;
R5 is a (C1-C4)alkyl radical;
Xn is \u2014(CH2)3\u2014; and
Yn is \u2014(CH2)2\u2014.
10. The compound according to claim 1, which is selected from the group consisting of:
2-{4-(Methylamino)sulfonylbenzyl}-4-phenylbutanoic acid;
5-(4-(Methylamino)sulfonylphenyl)-2-(2-phenylethyl)pentanoic acid;
(Acetyloxy)methyl 5-(3-{(3,4-dimethoxyphenyl)aminosulfonyl}phenyl)-2-(2-phenylethyl)pentanoate;
(Acetyloxy)methyl 5-(3-(4-methylanilinosulfonylphenyl)-2-(2-phenylethyl)pentanoate;
(Acetyloxy)methyl 5-(3-(methylamino)sulfonylphenyl)-2-(2-phenylethyl)pentanoate;
Sodium 5-phenyl-2-(2-phenylethyl)pentanoate;
5-(2-Naphthyl)-2-(2-phenylethyl)pentanoic acid;
5-(1-Naphthyl)-2-(2-phenylethyl)pentanoic acid;
5-3-{4-(Dimethylamino)benzoylamino}phenyl-2-(2-phenylethyl)pentanoic acid;
5-3-{4-(Dimethylamino)benzoylamino}phenyl-2-(2-phenylethyl)pentanoic acid hydrochloride;
5-(3\u2032-{(4-Methylphenyl)sulfonylamino}phenyl)-2-(2-phenylethyl)pentanoic acid;
5-{5-(Methylamino)sulfonylthien-2-yl}-2-(2-phenylethyl)pentanoic acid;
5-(3-(Benzylamino)sulfonylphenyl)-2-(2-phenylethyl)pentanoic acid;
5-Phenyl-2-(2-pyridin-2-ylethyl)pentanoic acid;
2-2-(3-methoxyphenyl)ethyl-5-phenylpentanoic acid;
2-2-(3-Hydroxyphenyl)ethyl-5-phenylpentanoic acid;
2-{2-4-(Acetylamino)phenylethyl}-5-phenylpentanoic acid;
2-2-(4-Aminophenyl)ethyl-5-phenylpentanoic acid;
2-2-(4-(Benzylamino)phenyl)ethyl-5-phenylpentanoic acid;
5-(3-(4-Methylanilinosulfonylphenyl)-2-(2-phenylethyl)pentanoic acid;
Sodium 5-(3-(4-methylanilinosulfonylphenyl)-2-(2-phenylethyl)pentanoate;
5-3-(4-Methylanilinosulfonyl)phenyl-2-(2-phenylethyl)pent-4-ynoic acid;
5-(3-(Anilinosulfonylphenyl)-2-(2-phenylethyl)pentanoic acid;
5-(4-Anilinosulfonylphenyl)-2-(2-phenylethyl)pentanoic acid;
5-(3-(Methylamino)sulfonylphenyl)-2-(2-phenylethyl)pentanoic acid;
Methyl 5-(3-(methylamino)sulfonylphenyl)-2-(2-phenylethyl)pentanoate;
5-(3-{(3,4-dimethoxyphenyl)aminosulfonyl}phenyl)-2-(2-phenylethyl)pentanoic acid;
5-3-(4-methylanilinosulfonyl)phenyl-2-(3-phenylpropyl)pentanoic acid;
2-2-(4-Ethylphenyl)ethyl-5-phenylpentanoic acid;
5-4-(Anilinosulfonyl)phenyl-2-2-(4-ethylphenyl)ethylpentanoic acid;
Methyl 5-4-(anilinosulfonyl)phenyl-2-2-(4-ethylphenyl)ethylpentanoate;
2-2-(4-Ethylphenyl)ethyl-6-phenylhexanoic acid;
5-(3-{4-(Dimethylamino)benzoylamino}phenyl)-2-2-(4-ethylphenyl)ethylpentanoic acid;
5-(1-Naphthyl)-2-2-(4-ethylphenyl)ethyl-pentanoic acid;
2-2-(4-hydroxyphenyl)ethyl-5-phenylpentanoic acid;
2-2-(4-Benzyloxyphenyl)ethyl-5-phenylpentanoic acid;
(Acetyloxy)methyl 2-2-(4-benzyloxyphenyl)ethyl-5-phenylpentanoate;
2-2-(4-Methoxyphenyl)ethyl-5-phenylpentanoic acid;
2-{2-4-(Pyridin-2-ylmethoxy)phenylethyl}-5-phenylpentanoic acid;
2-{2-4-(Pyridin-4-ylmethoxy)phenylethyl}-5-phenylpentanoic acid;
2-{2-4-(2-Cyanophenoxy)phenylethyl}-5-phenylpentanoic acid;
2-{2-4-(3-cyanophenoxy)phenylethyl}-5-phenylpentanoic acid;
2-{2-4-(4-cyanophenoxy)phenylethyl}-5-phenylpentanoic acid;
2-{2-4\u2032-(2-Furyl)phenylethyl}-5-phenylpentanoic acid;
2-{2-4\u2032-(3-Furyl)phenylethyl}-5-phenylpentanoic acid;
2-{2-4\u2032-(3-Thienyl)phenylethyl}-5-phenylpentanoic acid;
2-{2-(4\u2032-Pyridinyl)phenyl-4-ylethyl}-5-phenylpentanoic acid;
2-{2-(4\u2032-Pyridinyl)phenyl-4-ylethyl}-5-phenylpentanoic acid hydrochloride;
2-2-(4-Pyridin-3\u2032-ylphenyl)ethyl-5-phenylpentanoic acid;
5-Phenyl-2-2-(4\u2032-thien-2-ylphenyl)ethylpentanoic acid;
2-2-(1,1\u2032-Biphenyl-4-yl)ethyl-5-phenylpentanoic acid;
5-(1-Naphthyl)-2-2-(4\u2032-thien-2-ylphenyl)ethyl-pentanoic acid;
5-(1-Naphthyl)-2-2-(4\u2032-pyridin-3-ylphenyl)ethyl-pentanoic acid;
2-{2-4-(Pyridin-3-ylmethoxy)phenylethyl}-5-phenylpentanoic acid;
2-{2-4-(4-Fluorophenoxy)phenylethyl}-5-phenylpentanoic acid;
2-{2-4-Phenoxyphenylethyl}-5-phenylpentanoic acid;
2-{2-4-(4-Trifluoromethylphenoxy)phenylethyl}-5-phenylpentanoic acid;
2-2-(4-Bromophenyl)ethyl-5-phenylpentanoic acid;
2-{2-4-(4-Methoxyphenoxy)phenylethyl}-5-phenylpentanoic acid;
2-2-(2,3-Dihydro-1H-indol-3-yl)ethyl-5-phenylpentanoic acid;
5-(1-Naphthyl)-2-2-(4\u2032-pyridin-3-ylphenyl)ethyl-pentanoic acid; and
2-2-(4-Anilinophenyl)ethyl-5-phenylpentanoic acid.
11. A pharmaceutical composition comprising:
a therapeutically effective amount of the compound of formula (I) of claim 1, together with appropriate amounts of pharmaceutical excipients or carriers.
12. A medicament comprising a compound selected from the group consisting of:
2-Methyl-4-phenylbutanoic acid;
2-Ethyl-4-phenylbutanoic acid;
2-(2-Phenylethyl)pentanoic acid;
2-Benzyl-4-phenylbutanoic acid;
5-Phenyl-2-(2-phenylethyl)pentanoic acid;
Methyl 2-methyl-4-phenylbutanoate;
Methyl 2-ethyl-4-phenylbutanoate;
(Acetyloxy)methyl 2-benzyl-4-phenylbutanoate;
(Acetyloxy)methyl 5-phenyl-2-(2-phenylethyl)pentanoate;
Sodium 2-(Benzylthio)-5-phenylpentanoate;
2-(Benzyloxy)-5-phenylpentanoic acid;
5-Phenyl-2-propylpentanoic acid;
(4E)-5-Phenyl-2-(2-phenylethyl)pent-4-enoic acid; and
6-Phenyl-2-(2-phenylethyl)hexanoic acid.
13. A method of treating cancer in a subject, wherein the improvement comprises:
utilizing a compound selected from the group consisting of:
2-Methyl-4-phenylbutanoic acid;
2-Ethyl-4-phenylbutanoic acid;
2-(2-Phenylethyl)pentanoic acid;
2-Benzyl-4-phenylbutanoic acid;
5-Phenyl-2-(2-phenylethyl)pentanoic acid;
Methyl 2-methyl-4-phenylbutanoate;
Methyl 2-ethyl-4-phenylbutanoate;
(Acetyloxy)methyl 2-benzyl-4-phenylbutanoate;
(Acetyloxy)methyl 5-phenyl-2-(2-phenylethyl)pentanoate;
Sodium 2-(Benzylthio)-5-phenylpentanoate;
2-(Benzyloxy)-5-phenylpentanoic acid;
5-Phenyl-2-propylpentanoic acid;
(4E)-5-Phenyl-2-(2-phenylethyl)pent-4-enoic acid; and
6-Phenyl-2-(2-phenylethyl)hexanoic acid;
so as to treat the cancer in the subject.
14. A method of treating cancer in a subject, wherein the improvement comprises:
utilizing the compound of claim 1 so as to treat the cancer in the subject.
15. A method of treating cancer in a subject, wherein the improvement comprises:
utilizing the compound of claim 2, to treat the cancer.
16. A method of treating cancer in a subject, wherein the improvement comprises:
utilizing the compound of claim 2 to treat the cancer.
17. A method of treating cancer in a subject, wherein the improvement comprises:
utilizing the compound of claim 3 to treat the cancer.
18. A method of treating cancer in a subject, wherein the improvement comprises:
utilizing the compound of claim 4 to treat the cancer.
19. A method of treating cancer in a subject, wherein the improvement comprises:
utilizing the compound of claim 5 to treat the cancer.
20. A method of treating cancer in a subject, wherein the improvement comprises:
utilizing the compound of claim 6 to treat the cancer.