All The Claims

1. A locking swivel apparatus comprising:
an upper body portion having a counter bore about a cylindrical axis;
a mandrel receivable in the counter bore;
a lower cap member threadably engaged with the upper body portion;
an internal locking arrangement configured to selectively couple and decouple the upper body portion and the mandrel, said selective coupling and decoupling disposed to correspondingly constrain and allow relative rotation of the upper body portion and the mandrel about the cylindrical axis; and
a supplemental internal locking mechanism configured, upon engagement, to selectively constrain the upper body portion and the mandrel from reciprocating relative to one another along the cylindrical axis, said engagement of the supplemental locking mechanism operable to secure the upper body portion and the mandrel in a coupled position.
2. The locking swivel apparatus of claim 1, wherein the upper body portion has a lower face confronting a flange portion provided on the mandrel, the supplemental locking mechanism including at least one substantially rigid member selectively interposable between the lower face and the flange portion, said interposing operable to secure the upper body portion and the mandrel in a coupled position.
3. The locking swivel apparatus of claim 2, wherein the at least one rigid member includes at least one corresponding selectively extendable and retractable sleeve, extension of the at least one sleeve operable to secure the upper body portion and the mandrel in a coupled position, retraction of the at least one sleeve operable to allow the upper body portion and the mandrel to reciprocate along the cylindrical axis.
4. The locking swivel apparatus of claim 3, wherein the lower cap member comprises at least one internal recess into which the at least one sleeve may be retracted.
5. The locking swivel apparatus of claim 3, further comprising at least one pin member extending through the lower cap member and threaded to a corresponding one of the at least one extendable and retractable sleeves, the at least one pin member operable to extend or retract a corresponding one of the sleeves from outside the lower cap member.
6. The locking swivel apparatus of claim 3, further comprising manual actuation of said extension and retraction of the at least one sleeve.
7. The locking swivel apparatus of claim 3, further comprising power-assisted actuation of said extension and retraction of the at least one sleeve.
8. The locking swivel apparatus of claim 7, wherein said power-assisted actuation includes actuation selected from the group consisting of:
(a) hydraulic actuation; and
(b) pneumatic actuation.
9. The locking swivel apparatus of claim 1, wherein the locking arrangement further comprises a mechanism selected from the group consisting of:
(a) at least one pin member extendable through the upper body portion and engageable with a plurality of teeth disposed on an outer surface of the mandrel;
(b) a plurality of teeth disposed on the outer surface of the mandrel engageable with a plurality of teeth disposed in the counter bore;
(c) a plurality of mandrel teeth disposed on mandrel, the locking swivel apparatus further including a supplemental component receivable in the counter bore, the supplemental component further providing a second bore for receiving the mandrel, the supplemental component selected from the group consisting of a swivel mandrel and a lower body portion;
(d) at least one replaceable gear engageable between a plurality of teeth disposed on the outer surface of the mandrel and a plurality of teeth disposed in the counter bore; and
(e) first and second replaceable gear members engageable with one another, the first gear member engaged with a plurality of teeth disposed on the mandrel and the second gear member engaged with a plurality of teeth disposed in the counter bore.
10. The locking swivel apparatus of claim 1, wherein the supplemental internal locking mechanism has been retrofitted into the locking swivel apparatus.
11. The locking swivel apparatus of claim 1, wherein:
the upper body portion includes a plurality of spaced apart teeth extending radially inward into the counter bore;
the mandrel includes a plurality of spaced apart teeth extending radially outward from an outer surface thereof; and
the locking swivel apparatus includes first and second replaceable gear members engageable with one another, the first gear member engaged with the plurality of teeth disposed on the mandrel and the second gear member engaged with the plurality of teeth disposed in the counter bore.
12. The locking swivel apparatus of claim 11, wherein the first gear member comprises a plurality of teeth disposed on an inner surface thereof engaged with the plurality of teeth extending outward from the outer surface of the mandrel.
13. The locking swivel apparatus of claim 12, further comprising a threaded ring, the first gear member secured in said engagement with the plurality of teeth extending outward from the outer surface of the mandrel by the threaded ring.
14. The locking swivel apparatus of claim 11, wherein the second gear member comprises a plurality of teeth disposed on an outer surface thereof engaged with the plurality of teeth extending into the counter bore of the upper body portion.
15. The locking swivel apparatus of claim 14, further comprising a threaded ring, the second gear member secured in said engagement with the plurality of teeth extending into the counter bore of the upper body portion by the threaded ring.
16. The locking swivel apparatus of claim 11, wherein the first gear member comprises a plurality of teeth disposed on an outer surface thereof and selectively engageable and disengageable with a plurality of teeth disposed on an inner surface of the second gear member.
17. The locking swivel apparatus of claim 11, wherein at least one of the first and second gear members have been retrofitted into the locking arrangement.
18. The locking swivel apparatus of claim 1, wherein said decoupling of the upper body portion and the mandrel is enabled by urging the mandrel deeper into the counter bore in a direction substantially parallel to the cylindrical axis.
19. The locking swivel apparatus of claim 1, wherein said coupling of the upper body portion and the mandrel is enabled by urging the mandrel out of the counter bore in a direction substantially parallel to the cylindrical axis.
20. The locking swivel apparatus of claim 1, being coupleable to a drill string.
21. The locking swivel apparatus of claim 20, wherein the mandrel includes a threaded end distal from the counter bore for coupling with the drill string.
22. The locking swivel apparatus of claim 20, wherein the upper body portion includes a threaded end distal from the counter bore for coupling with the drill string.
23. The locking swivel apparatus of claim 1, wherein the lower cap member includes a left-hand thread.
24. The locking swivel apparatus of claim 1, wherein the lower cap member further comprises at least one blow hole extending therethrough for equalizing pressure in the counter bore during said coupling and decoupling of the upper body portion and the mandrel.
25. The locking swivel apparatus of claim 1, further comprising an indicator for providing visual indication of whether the upper body portion and the mandrel are in a coupled or decoupled position.
26. The locking swivel apparatus of claim 1, wherein the mandrel further comprises a flange extending outward from an outer surface thereof.
27. The locking swivel apparatus of claim 26, wherein the flange contacts a lower face of the upper body portion when the upper body portion and the mandrel are in a decoupled position.
28. The locking swivel apparatus of claim 26, wherein the flange contacts a shoulder portion of the cap member when the upper body portion and the mandrel are in a coupled position.
29. The locking swivel apparatus of claim 1, in which the supplemental internal locking mechanism has been retrofitted onto the locking swivel apparatus.
30. A locking swivel apparatus comprising:
an upper body portion having a counter bore about a cylindrical axis;
a mandrel receivable in the counter bore, the mandrel having a flange confronting a lower face of the upper body portion;
a lower cap member threadably engaged with the upper body portion;
an internal locking arrangement configured to selectively couple and decouple the upper body portion and the mandrel, said selective coupling and decoupling disposed to correspondingly constrain and allow relative rotation of the upper body portion and the mandrel about the cylindrical axis, the locking arrangement including at least one replaceable gear member; and
a supplemental internal locking mechanism including at least one selectively extendable and retractable sleeve, extension of the at least one sleeve operable to interpose the sleeve between the lower face and the flange, retraction of the at least one sleeve operable to withdraw the sleeve from between the flange and the lower face;
the supplemental locking mechanism further configured, upon interposing of the at least one sleeve between the lower face and the flange, to secure the upper body portion and the mandrel in a coupled position, the supplemental locking mechanism further configured, upon withdrawal of the at least one sleeve from between the lower face and the flange, to allow reciprocation of the upper body and the mandrel along the cylindrical axis.
31. A method for securing a locking swivel apparatus in a locked arrangement, the method comprising:
(a) providing a locking swivel apparatus including:
an upper body portion having a counter bore about a cylindrical axis;
a mandrel receivable in the counter bore, the mandrel having a flange confronting a lower face of the upper body portion;
a lower cap member threadably engaged with the upper body portion;
an internal locking arrangement configured to selectively couple and decouple the upper body portion and the mandrel, said selective coupling and decoupling disposed to correspondingly constrain and allow relative rotation of the upper body portion and the mandrel about the cylindrical axis; and
a supplemental internal locking mechanism including at least one selectively extendable and retractable sleeve, extension of the at least one sleeve operable to interpose the at least one sleeve between the lower face and the flange, retraction of the at least one sleeve operable to withdraw the sleeve from between the lower face and the flange;
the supplemental locking mechanism further configured, upon interposing of the at least one sleeve between the lower face and the flange, to secure the upper body portion and the mandrel in a coupled position, the supplemental locking mechanism further configured, upon withdrawal of the at least one sleeve from between the lower face and the flange, to allow reciprocation of the upper body and the mandrel along the cylindrical axis;

(b) operating the locking arrangement to engage the upper body portion and the mandrel in a coupled position; and
(c) extending the at least one sleeve between the lower face and the flange to secure the upper body portion and the mandrel in a coupled position.
32. The method of claim 31, further comprising:
(d) retracting the at least one sleeve, allowing the upper body portion and the mandrel to reciprocate along the cylindrical axis.
33. The method of claim 31, wherein
(c) includes manual actuation of said extension of the at least one sleeve.
34. The method of claim 31, wherein
(c) includes power-assisted actuation of said extension of the at least one sleeve.
35. The method of claim 34, wherein said power-assisted actuation includes actuation selected from the group consisting of:
(1) hydraulic actuation; and
(2) pneumatic actuation.
36. The method of claim 31, wherein:
(b) includes urging the mandrel out of the counter bore in a direction substantially parallel to the cylindrical axis to enable said coupling of the upper body portion and the mandrel.
37. The method of claim 36, wherein the mandrel is said urged out of the counter bore until a flange portion of the mandrel contacts a shoulder portion of the lower cap member.
38. The method of claim 31, wherein:
the upper body portion is coupled to an upper section of a drill string;
the mandrel is coupled to a lower section of the drill string; and
said securing the locking swivel apparatus in the locked arrangement secures said upper and lower sections of the drill string in a coupled position, thereby constraining relative rotation about the cylindrical axis.
39. A method for fabricating a locking swivel apparatus having a supplemental internal locking mechanism, the method comprising:
(a) forming a cylindrical counter bore about a cylindrical axis in an upper body portion;
(b) forming a mandrel receivable in the counter bore;
(c) providing an internal locking arrangement disposed to couple the mandrel to the upper portion when the mandrel is slid into the counter bore of the upper body portion;
(d) positioning the mandrel in the counter bore such that selective reciprocation of the mandrel and the upper body portion along the cylindrical axis causes corresponding coupling and decoupling of the upper body portion and the mandrel via the internal locking arrangement, said coupling and decoupling of the upper body portion and the mandrel correspondingly constraining and allowing relative rotation of the upper body portion and the mandrel about the cylindrical axis;
(e) providing a supplemental internal locking mechanism including at least one extendable and retractable sleeve;
(f) positioning the at least one sleeve in the counter bore such that selective extension and retraction of the at least one sleeve correspondingly interposes and withdraws the at least one sleeve from between a lower face of the upper body portion and a flange portion of the mandrel.
40. The method of claim 39, further comprising:
(g) providing a lower cap member sized and shaped to threadably engage with the upper body portion, the lower cap member, when threadably engaged with the upper body portion, retaining the mandrel within the counter bore.
41. The method of claim 40, wherein the lower cap member includes at least one internal recess into which the at least one sleeve may be retracted.
42. The method of claim 40, further comprising:
(h) providing threaded pin members, each sized and shaped for extending through openings in the lower cap member and threadably engaging a corresponding one of the at least one sleeve; and
(i) extending each pin member through the lower cap member to threadably engage its corresponding sleeve.
43. The method of claim 39, further comprising:
(g) forming a threaded end on the upper body portion distal from the counter bore, the threaded end being sized and shaped to couple with a drill string.
44. The method of claim 39, further comprising:
(g) forming a threaded end on the mandrel distal from the counter bore, the threaded end being sized and shaped to couple with a drill string.
45. The method of claim 39, wherein
(b) further includes forming a flange extending outward from an outer surface of the mandrel.
46. The method of claim 39, wherein
(a) further includes forming a plurality of spaced apart teeth on the upper body portion to extend radially into the counter bore.
47. The method of claim 39, wherein
(b) further includes forming a plurality of spaced apart teeth extending radially outward from an outer surface of the mandrel.
48. The method of claim 39, wherein the locking arrangement comprises a mechanism selected from the group consisting of:
(1) at least one pin member extendable through the upper body portion and engageable with a plurality of teeth disposed on an outer surface of the mandrel;
(2) a plurality of teeth disposed on the outer surface of the mandrel engageable with a plurality of teeth disposed in the counter bore;
(3) a plurality of mandrel teeth disposed on mandrel, the locking swivel apparatus further including a supplemental component receivable in the counter bore, the supplemental component further providing a second bore for receiving the mandrel, the supplemental component selected from the group consisting of a swivel mandrel and a lower body portion;
(4) at least one replaceable gear engageable between a plurality of teeth disposed on the outer surface of the mandrel and a plurality of teeth disposed in the counter bore; and
(5) first and second replaceable gear members engageable with one another, the first gear member engaged with a plurality of teeth disposed on the mandrel and the second gear member engaged with a plurality of teeth disposed in the counter bore.
49. The method of claim 39, wherein the locking arrangement includes at least one replaceable gear member.
50. The method of claim 39, wherein:
(a) further includes forming a plurality of spaced apart teeth on the upper body portion to extend radially into the counter bore;
(b) further includes forming a plurality of spaced apart teeth extending radially outward from an outer surface of the mandrel; and
the locking arrangement includes first and second replaceable gear members each having internal and external spaced apart teeth, the internal teeth of the first replaceable gear member being shaped and sized to engage with said teeth on the mandrel, the external teeth of the second replaceable gear member being shaped and sized to engage with said teeth on the upper body portion, the external teeth of the first replaceable gear member being shaped and sized to engage with the internal teeth of the second replaceable gear member.
51. The method of claim 50, further comprising:
(f) periodically replacing at least one of the first and second replaceable gear members.
52. A method for retrofitting a lockable swivel apparatus with a supplemental internal locking mechanism configured to secure the swivel apparatus in a locked position, the swivel apparatus including:
an upper body portion having a counter bore about a cylindrical axis;
a mandrel receivable in the counter bore; and
an internal locking arrangement disposed to selectively couple and decouple the upper body portion and the mandrel when the mandrel is slid into the counter bore, said coupling and decoupling disposed to correspondingly constrain and allow relative rotation of the upper body portion and the mandrel about the cylindrical axis;
the method comprising:
(a) disassembling the swivel apparatus;
(b) providing a supplemental internal locking mechanism including at least one extendable and retractable sleeve, each sleeve selectively interposable between a flange on the mandrel confronting a lower face on the upper body portion;
(c) reassembling the swivel apparatus, said reassembly including disposing each sleeve to be remotely manipulable from outside the swivel apparatus, wherein selective interposing of the at least one sleeve between the flange and the lower face from outside the swivel apparatus is operable to retain the upper body portion and the mandrel in a coupled position.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. Unsolvated crystalline 1-{(\u03b1-isobutanoyloxyethoxy)carbonylaminomethyl}-1-cyclohexane acetic acid.
2. The crystal of claim 1 corresponding to the representative X-ray powder diffraction pattern of FIG. 1 in an X-ray powder diffractogram using Cu K\u03b1 radiation.
3. The crystal of claim 1 having an X-ray powder diffraction pattern comprising peaks at 7.0, 16.4 and 17.9\xb10.3 degrees 2\u03b8 in an X-ray powder diffractogram using Cu K\u03b1 radiation.
4. The crystal of claim 3 further comprising peaks at 8.2, 10.5, 18.9, 20.9 and 23.3\xb10.3 degrees 2\u03b8 in an X-ray powder diffractogram using Cu K\u03b1 radiation.
5. The crystal of claim 1 corresponding to the representative thermogravimetric analysis thermogram of FIG. 2.
6. The crystal of claim 1 having a differential scanning calorimetry thermogram comprising an exotherm with a maximum at 63\xb12\xb0 C., as determined by a differential scanning calorimetry at a scan rate of 5\xb0 C.minute.
7. A method of treating restless legs syndrome comprising administering unsolvated crystalline 1-{(\u03b1-isobutanoyloxyethoxy)carbonyl aminomethyl}-1-cyclohexane acetic acid.
8. A method of treating post herpetic neuralgia comprising administering unsolvated crystalline 1-{(\u03b1-isobutanoyloxyethoxy)carbonyl aminomethyl}-1-cyclohexane acetic acid.
9. A pharmaceutical composition comprising the unsolvated crystalline 1-{(\u03b1-isobutanoyloxyethoxy)carbonyl aminomethyl}-1-cyclohexane acetic acid.

1. A shock absorber leash comprising in combination,
at its proximal end,
means for grasping used for holding said shock absorber leash when dealing with an animal;

and at its distal end,
means for attaching for fastening to the animal;

an elongated strap subassembly including
means for strapping comprising a strap of non elastic, continuous structure for connecting said means for grasping with said means for attaching;
means for length adjusting including an elastic strip having its ends attached to a means for buckling used for adjusting a length of said elastic strip, said means for length adjusting being interposed laterally between the ends of a segment of said strap, said segment of said strap being provided adjacent to its ends with a first and second rings and forming a loop when said means for length adjusting is not completely stretched; said means for length adjusting being detachable, when required, from a remaining of said shock absorber leash by using said means for buckling and a free passage of said elastic strip through said first and second ring.
2. The shock absorber leash, as defined in claim 1, wherein
said means for grasping includes a tubular handle incorporating
a tubular element made to resist deformation and breaking;
a sleeve in which said tubular element is inserted; and
a pair of grommets, press fitted into extremities of said tubular element, so that a translation of said sleeve along said tubular element is prevented;

said means for attaching comprising a clasp that incorporates
a bracket pivotally joined to said means for strapping;
a hook pivotally joined to said bracket; and
a spring operated element for closing said hook;

said means for strapping having an end of said strap, which after leaving said means of grasping, passes through the first ring and is folded back upon itself and, then, superposed and permanently joined by stitching to a remaining of the strap, thus forming a first stitch; another end of the strap, after leaving said means for grasping and participating, as a superposed component, in said first secured connection, extends into said segment, respectively said loop, then is doubled back upon itself and, after passing through said second ring, returns and is superposed on and permanently joined by said conventional means for securing to said remaining of said strap, thus forming a second secured connection; subsequently, said strap first passes through an adjustable buckle for adjusting an effective length of said strap, second, passes through said bracket of said clasp, third, passes again through said adjustable buckle and, finally, through a first pull ring; after passing through the latter, said strap is doubled back and permanently joined by said conventional means for securing to said remaining of said strap, thus forming a third secured connection;
said means for length adjusting including said elastic strip and said means for buckling, the latter being a cam-buckle of double bar type, one end of said elastic strip entering from one side of a bar and exiting from another side of said bar to form together a pair of said elastic strips, superposed, the latter traversing said first and second rings, then returning to said cam-buckle for passing adjacently another bar of said cam-buckle for exiting from the latter; said elastic strip, impliedly said pair of said elastic strips, superimposed, being so dimensioned in length as to bias said ends of said segment toward each other,
whereby upon application of a sharp, corrective pull on said shock absorber leash by an animal trainer, said elastic strip elongates, while upon relaxation of said shock absorber leash, said elastic strip shortens and once again places said ends of said segment in their normal spaced relation relative each other.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

We claim:

1. A scaffold for promoting restoration of a tissue when implanted at an anatomical site in a patient, comprising:
at least a portion of a devitalized mammalian parenchymatous tissue combined with a target mammalian cell population, wherein the combined tissue and cell population is sized and shaped for implantation at the anatomical site in the patient remote from the tissue requiring restoration.
2. The scaffold of claim 1 wherein the devitalized mammalian tissue further comprises a basement membrane.
3. The scaffold of claim 1 wherein the devitalized tissue is spleen.
4. The scaffold of claim 1 wherein the devitalized tissue comprises kidney.
5. The scaffold of claim 1 wherein the devitalized tissue comprises lymph node.
6. The scaffold of claim 1 wherein the devitalized tissue comprises an allogeneic tissue source.
7. The scaffold of claim 1 wherein the devitalized tissue comprises an autogeneic tissue source.
8. The scaffold of claim 1 wherein the devitalized tissue comprises an xenogeneic tissue source.
9. The scaffold of claim I wherein the stem cell population is introduced into the tissue.
10. The scaffold of claim 1 wherein the stem cells comprise autogeneic stem cells.
11. The scaffold of claim 1 wherein the stem cells comprise allogeneic stem cells.
12. The scaffold of claim 1 wherein the stem cells comprise xenogeneic stem cells.
13. The scaffold according to claim 1 wherein the tissue undergoing restoration comprises an endocrine tissue.
14. The scaffold of claim 13 wherein the devitalized parenchymatous tissue comprises spleen.
15. The scaffold of claim 13 wherein the devitalized parenchymatous tissue comprises kidney.
16. The scaffold of claim 13 wherein the devitalized parenchymatous tissue comprises pancreas.
17. The scaffold of claim 13 wherein the target cell population comprises mammalian endocrine cells.
18. The scaffold of claim 17 wherein the mammalian endocrine cells comprise pancreatic islet cells.
19. The scaffold of claim 17 wherein the mammalian endocrine cells comprise pituitary cells.
20. The scaffold of claim 17 wherein the mammalian endocrine cells comprise thyroid cells.
21. The scaffold of claim 17 wherein the mammalian endocrine cells comprise cells from the adrenal gland.
22. The scaffold of claim 13 wherein the devitalized parenchymatous mammalian tissue is autogeneic.
23. The scaffold of claim 13 wherein the devitalized parenchymatous mammalian tissue is allogeneic.
24. The scaffold of claim 13 wherein the devitalized parenchymatous mammalian tissue is xenogeneic.
25. The scaffold of claim 13 wherein the mammalian endocrine cells are autogeneic.
26. The scaffold of claim 13 wherein the mammalian endocrine cells are allogeneic.
27. The scaffold of claim 13 wherein the mammalian endocrine cells are xenogeneic.
28. A method for promoting restoration of a tissue when implanted at an anatomical site in a patient, comprising:
at least a portion of a devitalized mammalian parenchymatous tissue combined with a target mammalian cell population, wherein the combined tissue and cell population is sized and shaped for implantation at the anatomical site in the patient remote from the tissue requiring restoration.
29. The method of claim 28, wherein the scaffold is implanted subcutaneously.
30. The method of claim 28, wherein the scaffold is implanted into the abdominal cavity.
31. The method of claim 28, wherein the scaffold is implanted into the thoracic cavity.
32. The method of claim 28, wherein the scaffold is implanted subcutaneously.