All The Claims

1. A device comprising a porous polymeric structure composition, a disease-associated antigen, and a toll-like receptor (TLR) agonist, wherein said TLR agonist preferentially binds to TLR3.
2. The device of claim 1, wherein said disease-associated antigen comprises a tumor antigen.
3. The device of claim 1, wherein said polymeric structure composition comprises poly-lactide-co-glycolide (PLG).
4. The device of claim 1, wherein said TLR agonist comprises a TLR3 agonist.
5. The device of claim 1, wherein said TLR3 agonist comprises polyinosine-polycytidylic acid (poly I:C) or PEI-poly (I:C).
6. The device of claim 1, wherein said TLR agonist further comprises pathogen associated molecular patterns (PAMPs).
7. The device of claim 1, wherein said TLR agonist comprises a nucleic acid.
8. The device of claim 1, wherein said TLR agonist further comprises a TLR9 agonist.
9. The device of claim 8, wherein said TLR9 agonist comprises a cytosine-guanosine oligonucleotide (CpG-ODN) or a PEI-CpG-ODN.
10. The device of claim 1, wherein said device further comprises a recruitment composition.
11. The device of claim 11, wherein said recruitment composition comprises granulocyte macrophage colony stimulating factor (GM-CSF), Flt3L, or CCL20.
12. The device of claim 10, wherein said recruitment composition comprises encapsulated GM-CSF.
13. The device of claim 2, wherein said tumor antigen comprises a tumor lysate, purified protein tumor antigen, or synthesized tumor antigen.
14. The device of claim 6, wherein said PAMPs comprises a monophosphoryl lipid A (MPLA).
15. The device of claim 1, wherein said device comprises a combination of TLR agonists, said combination comprising a TLR3 agonist and a TLR9 agonist.
16. The device of claim 15, wherein said TLR3 agonist comprises poly (I:C) and said TLR9 agonist comprises CpG-ODN.
17. The device of claim 1, wherein said device comprises a combination of TLR agonists, said combination comprising a TLR3 agonist and a TLR4 agonist.
18. The device of claim 17, wherein said TLR3 agonist comprises poly (I:C) and said TLR4 agonist comprises MPLA.
19. The device of claim 1, wherein said TLR3 agonist is present in an amount to preferentially stimulate CD8+ dendritic cells or CD141+ dendritic cells.
20. A device comprising a polymeric structure composition, a tumor antigen, and a combination of TLR agonists, wherein said TLR agonist is selected from the group consisting of TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13.
21. A method for eliciting an anti-tumor immune response, comprising contacting or implanting into a subject device comprising a polymeric structure composition, a tumor antigen, and a TLR agonist, wherein said TLR agonist preferentially binds to TLR3.
22. The method of claim 21, wherein said TLR agonist comprises a TLR3 agonist.
23. The method of claim 21, wherein said TLR agonist comprises a TLR3 agonist and a TLR9 agonist.
24. The method of claim 21, wherein said anti-tumor immune response comprises activation of a CD8+ dendritic cell or a CD141+ dendritic cell.
25. The method of claim 23, wherein said anti-tumor immune response comprises activation of a plasmacytoid dendritic cell or a CD141+ dendritic cell.
26. The method of claim 23, wherein said anti-tumor immune response comprises a reduction in tumor burden.
27. The method of claim 21, wherein said TLR agonist is present at a concentration effective to induce production of interleukin-12 (IL-12) by dendritic cells.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A manufacturing method of a multilayer wiring board which includes a plurality of insulating layers, a plurality of conductive layers, a conductive non-through hole for electrically connecting the plurality of conductive layers to each other, and a capacitor produced by forming electrodes on upper and lower surfaces of at least one insulating layer containing a high-dielectric material, comprising at least:
the step of forming conductive patterns including one of the electrodes of the capacitor, the conductive patterns having a recessed portion between the conductive patterns;
the step of filling and hardening an insulating material different from the high-dielectric material in the recessed portion between the conductive patterns;
the step of planarizing the surfaces of the conductive patterns and the surface of the insulating material filled and hardened in the recessed portion between the conductive patterns by polishing, so as to form planarized surfaces of both the conductive patterns and the insulating material filled and hardened in the recessed portion between the conductive patterns;
the step of providing a high-dielectric material sheet in a semi-hardened state, said high-dielectric material sheet having the at least one insulating layer containing the high-dielectric material and a metal foil laminated thereto, and
the step of heating and laminating the high-dielectric material sheet in the semi-hardened state on the planarized surfaces of both the conductive patterns and the insulating material filled and hardened in the recessed portion, so that the at least one insulating layer of the high-dielectric material sheet is between (a) the conductive patterns and the insulating material filled and hardened in the recessed portion, and (b) the metal foil.
2. The manufacturing method of a multilayer wiring board according to claim 1, further comprising a step of forming a conductive pattern including another of the electrodes of the capacitor by etching the metal foil.
3. The manufacturing method of a multilayer wiring board according to claim 1, further comprising the step of forming an inductor in at least one of the conductive layers.
4. A semiconductor device wherein a semiconductor chip is mounted on a multilayer wiring board manufactured by a manufacturing method according to claim 1.
5. A wireless electronic device wherein a semiconductor device according to claim 4 is mounted.
6. The manufacturing method of a multilayer wiring board according to claim 1, wherein said recessed portion exposes an insulating structure underlying the conductive patterns, said insulating material being provided on the insulating structure.
7. The manufacturing method of a multilayer wiring board according to claim 1, wherein said conductive patterns are formed on an underlying substrate; and, subsequent to forming the conductive patterns, the insulating material is filled and hardened in said recessed portions.
8. The manufacturing method of a multilayer wiring board according to claim 7, wherein said recessed portions expose the underlying substrate on which the conductive patterns are formed, and said insulating material is provided on the underlying substrate.

1. A jump rope, comprising:
a rope section having two ends;
a connector attached to one end of the rope section, the connector having a hook section, a middle section connected at one end to the hook section, and a flange section integral with the other end of the middle section;
an end cap attached to another end of the rope section;
a first handle having two open ends and a conical shape, one of the open ends having a smaller size fixedly connected to the end cap; and
a second handle having two open ends and a conical shape, one of the open ends having a smaller size configured to slide over the flange section of the connector and abut against the middle section of the connector allowing the connector to spin freely in the handle when the jump rope is in use and the connector is not connected to another jump rope, wherein when the jump rope is connected to another jump rope, the second handle can be locked to the first handle so as not to be sliding around on the jump rope when the jump rope is in use.
2. The jump rope according to claim 1, wherein the hook section comprises an open hook at one end form of a pliable plastic material that is hard enough to hold the connector to another connector on another jump rope, and soft enough to allow the open hook to flex when being connected to a hook section of another jump rope.
3. The jump rope according to claim 2, wherein the hook section is made of polyvinyl chloride.
4. The jump rope according to claim 1, wherein the handle is made of polyvinyl chloride, K-Resin or polyethylene.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A focus control apparatus to be provided to an image capturing apparatus to which an interchangeable lens is detachably attachable, the image capturing apparatus being configured to capture an object image formed by the interchangeable lens, the focus control apparatus comprising:
a focus detector configured to detect a focus state of the interchangeable lens; and
a controller configured to perform focus control of the interchangeable lens by using information obtained through the detection of the focus state and a correction value corresponding to the interchangeable lens,
wherein a first interchangeable lens and a second interchangeable lens, each of which is the interchangeable lens, are attachable to the image capturing apparatus, the first interchangeable lens holding correction value calculation data that is used to calculate the correction value and is unique to the first interchangeable lens, the second interchangeable lens not holding the correction value calculation data,
the focus control apparatus includes a first memory storing values for calculating the correction value corresponding to the second interchangeable lens, and
the controller is configured to:
perform, when the second interchangeable lens is attached to the image capturing apparatus, the focus control by using the correction value calculated based on the values read from the first memory; and

calculate, when the first interchangeable lens is attached to the image capturing apparatus, the correction value by using the correction value calculation data acquired from the first interchangeable lens and then perform the focus control by using the calculated correction value.
2. A focus control apparatus according to claim 1, further comprising a second memory configured to store the correction value calculated by using the correction value calculation data acquired from the first interchangeable lens,
wherein the controller is configured to perform, when the first interchangeable lens of which the correction value is stored in the second memory is again attached to the image capturing apparatus, the focus control by using the correction value stored in the second memory.
3. A focus control apparatus according to claim 1, wherein the correction value calculation data is data of an imaging position for each of at least one of a focal length of the first interchangeable lens, an object distance, and a spatial frequency and an image height of an object image formed by the first interchangeable lens.
4. A focus control apparatus according to claim 1, wherein the correction value and the correction value calculation data have data structures different from each other.
5. A focus control apparatus according to claim 1, wherein the correction value calculation data is data for calculating the correction value for a manufacturing error of the first interchangeable lens.
6. An image capturing apparatus to which an interchangeable lens is detachably attachable, the image capturing apparatus comprising:
a focus control apparatus; and
an image sensor configured to capture an object image formed by the interchangeable lens and convert the object image into an electric signal,
wherein the focus control apparatus comprises:
a focus detector configured to detect a focus state of the interchangeable lens; and
a controller configured to perform focus control of the interchangeable lens by using information obtained through the detection of the focus state and a correction value corresponding to the interchangeable lens,
wherein a first interchangeable lens and a second interchangeable lens, each of which is the interchangeable lens, are attachable to the image capturing apparatus, the first interchangeable lens holding correction value calculation data that is used to calculate the correction value and is unique to the first interchangeable lens, the second interchangeable lens not holding the correction value calculation data,
the focus control apparatus includes a first memory storing values for calculating the correction value corresponding to the second interchangeable lens, and
the controller is configured to:
perform, when the second interchangeable lens is attached to the image capturing apparatus, the focus control by using the correction value calculated based on the values read from the first memory; and
calculate, when the first interchangeable lens is attached to the image capturing apparatus, the correction value by using the correction value calculation data acquired from the first interchangeable lens and then perform the focus control by using the calculated correction value.
7. An interchangeable lens detachably attachable to an image capturing apparatus,
the image capturing apparatus comprising:
a focus control apparatus; and
an image sensor configured to capture an object image formed by the interchangeable lens and convert the object image into an electric signal,
wherein the focus control apparatus comprises:
a focus detector configured to detect a focus state of the interchangeable lens; and
a controller configured to perform focus control of the interchangeable lens by using information obtained through the detection of the focus state and a correction value corresponding to the interchangeable lens,
wherein a first interchangeable lens and a second interchangeable lens, each of which is the interchangeable lens, are attachable to the image capturing apparatus, the first interchangeable lens holding correction value calculation data that is used to calculate the correction value and is unique to the first interchangeable lens, the second interchangeable lens not holding the correction value calculation data,
the focus control apparatus includes a first memory storing values for calculating the correction value corresponding to the second interchangeable lens, and
the controller is configured to:
perform, when the second interchangeable lens is attached to the image capturing apparatus, the focus control by using the correction value calculated based on the values read from the first memory; and
calculate, when the first interchangeable lens is attached to the image capturing apparatus, the correction value by using the correction value calculation data acquired from the first interchangeable lens and then perform the focus control by using the calculated correction value,
the interchangeable lens comprising:
a lens memory storing correction value calculation data that is used to calculate the correction value and is unique to the interchangeable lens; and
a communicator configured to send the correction value calculation data to the image capturing apparatus.
8. A focus control method to be used for an image capturing apparatus to which an interchangeable lens is detachably attachable and which is configured to capture an object image formed by the interchangeable lens, the method comprising:
a detection step of detecting a focus state of the interchangeable lens; and
a control step of performing focus control of the interchangeable lens by using information obtained through the detection of the focus state and a correction value corresponding to the interchangeable lens,
wherein a first interchangeable lens and a second interchangeable lens, each of which is the interchangeable lens, are attachable to the image capturing apparatus, the first interchangeable lens holding correction value calculation data that is used to calculate the correction value and is unique to the first interchangeable lens, the second interchangeable lens not holding the correction value calculation data, and
in the controlling step,
the method performs, when the second interchangeable lens is attached to the image capturing apparatus, the focus control by using the correction value calculated based on values read from a first memory included in the image capturing apparatus; and
the method calculates, when the first interchangeable lens is attached to the image capturing apparatus, the correction value by using the correction value calculation data acquired from the first interchangeable lens and then performs the focus control by using the calculated correction value.
9. A non-transitory computer-readable storage medium that stores a focus control program as a computer program for causing a computer of an image capturing apparatus to which an interchangeable lens is detachably attachable and which is configured to capture an object image formed by the interchangeable lens, to perform an operation,
the operation comprising:
a detection step of detecting a focus state of the interchangeable lens; and
a control step of performing focus control of the interchangeable lens by using information obtained through the detection of the focus state and a correction value corresponding to the interchangeable lens,
wherein a first interchangeable lens and a second interchangeable lens, each of which is the interchangeable lens, are attachable to the image capturing apparatus, the first interchangeable lens holding correction value calculation data that is used to calculate the correction value and is unique to the first interchangeable lens, the second interchangeable lens not holding the correction value calculation data, and
in the controlling step,
the operation performs, when the second interchangeable lens is attached to the image capturing apparatus, the focus control by using the correction value calculated based on values read from a first memory included in the image capturing apparatus; and
the operation calculates, when the first interchangeable lens is attached to the image capturing apparatus, the correction value by using the correction value calculation data acquired from the first interchangeable lens and then performs the focus control by using the calculated correction value.