All The Claims

1. A cleaning implement, comprising at least one head component that comprises at least two cleaning material support components and at least one cleaning surface component, wherein the cleaning material support components each comprise at least one cleaning material support component surface that at least partially defines at least one cleaning implement cartridge receiving area, wherein the cleaning material support components each comprise at least one opening such that the cleaning implement cartridge receiving areas communicate with the cleaning surface component, and wherein the cleaning implement cartridge receiving areas of the cleaning material support components are configured to receive at least a component of at least one cleaning implement cartridge comprising cleaning material such that at least a portion of the cleaning material is movable to andor from the cleaning implement cartridge receiving areas to extend over at least a portion of the cleaning surface component when the cleaning implement cartridge is at least partially disposed in the cleaning implement cartridge receiving areas.
2. The cleaning implement of claim 1, comprising an operably connected robot body structure.
3. The cleaning implement of claim 1, comprising at least one positioning mechanism component that is configured to selectively position the cleaning material at least relative to at least one of the cleaning material support components when at least the portion of the cleaning implement cartridge is at least partially disposed in the cleaning implement cartridge receiving areas.
4. The cleaning implement of claim 1, comprising at least one retaining component that is configured to substantially retain the cleaning implement cartridge at a selected position relative to at least one of the cleaning material support components when at least the portion of the cleaning implement cartridge is at least partially disposed in the cleaning implement cartridge receiving areas.
5. The cleaning implement of claim 1, comprising at least one retaining mechanism that is configured to substantially retain the cleaning material at a selected position relative to the cleaning surface component when at least the portion of the cleaning implement cartridge is at least partially disposed in the cleaning implement cartridge receiving areas and the cleaning material extends over at least the portion of the cleaning surface component.
6. The cleaning implement of claim 1, comprising at least the portion of the cleaning implement cartridge at least partially disposed in the cleaning implement cartridge receiving areas of the cleaning material support components.
7. The cleaning implement of claim 1, wherein the cleaning surface component comprises at least one elevational element.
8. The cleaning implement of claim 1, comprising at least one handle operably connected to the head component.
9. The cleaning implement of claim 8, wherein the handle is pivotally connected to the head component via at least one pivot mechanism.
10. The cleaning implement of claim 1, comprising at least one conveyance mechanism, or at least one component thereof, that is configured to convey at least the cleaning material over at least a portion of the cleaning surface component when at least the portion of the cleaning implement cartridge is at least partially disposed in the cleaning implement cartridge receiving areas.
11. The cleaning implement of claim 10, wherein the conveyance mechanism is manually operated via at least one manual conveyance component.
12. The cleaning implement of claim 10, wherein the conveyance mechanism or the component thereof is configured to operably engage the cleaning implement cartridge to effect conveyance of the cleaning material when at least the portion of the cleaning implement cartridge is at least partially disposed in the cleaning implement cartridge receiving areas.
13. The cleaning implement of claim 10, wherein the conveyance mechanism is configured to convey the cleaning material at least one selected incremental distance.
14. The cleaning implement of claim 10, wherein the conveyance mechanism comprises one or more gear components.
15. The cleaning implement of claim 10, wherein the conveyance mechanism comprises at least one motor component that is configured to effect conveyance of the cleaning material when at least the portion of the cleaning implement cartridge is at least partially disposed in the cleaning implement cartridge receiving areas.
16. The cleaning implement of claim 10, comprising at least one fluid handling mechanism or at least one component thereof that is configured to convey at least one fluid from at least one fluid source to at least one fluid outlet.
17. The cleaning implement of claim 16, wherein the fluid outlet communicates with the cleaning implement cartridge or a portion thereof when at least the portion of the cleaning implement cartridge is at least partially disposed in the cleaning implement cartridge receiving areas.
18. The cleaning implement of claim 16, wherein the fluid outlet is disposed proximal to at least one surface of the head component.
19. The cleaning implement of claim 16, wherein the fluid outlet comprises at least one nozzle.
20. The cleaning implement of claim 16, wherein the fluid handling mechanism comprises at least one pumping mechanism that is configured to pump the fluid from the fluid source to the fluid outlet.
21. The cleaning implement of claim 16, wherein the fluid handling mechanism comprises at least one vaporization component that is configured to vaporize the fluid at least proximal to the fluid outlet.
22. The cleaning implement of claim 16, wherein the fluid source and fluid outlet communicate via at least one fluid conduit.
23. The cleaning implement of claim 16, wherein the fluid source comprises at least one fluid container.
24. The cleaning implement of claim 23, wherein the fluid container is removable.
25. A cleaning implement cartridge, comprising at least two housings and at least one cleaning material, wherein each housing comprises at least one housing surface that at least partially defines a cavity, wherein each housing comprises at least one orifice that communicates with the cavity, wherein the cleaning material is at least partially disposed in the cavity of each housing such that the cleaning material is movable to andor from each housing, wherein at least a portion of each housing is configured to be received in a cleaning implement cartridge receiving area of a cleaning implement, and wherein the cleaning material is configured to extend over at least a portion of a cleaning surface component of the cleaning implement when each housing is at least partially disposed in the cleaning implement cartridge receiving area of the cleaning implement.
26. The cleaning implement cartridge of claim 25, comprising at east one conveyance mechanism or at least one component thereof.
27. The cleaning implement cartridge of claim 25, wherein the cleaning material is moistened with at least one fluid.
28. The cleaning implement cartridge of claim 25, comprising at least one positioning mechanism component that is configured to selectively position the cleaning material relative to the housings andor the cleaning implement.
29. The cleaning implement cartridge of claim 25, wherein the housings andor the cleaning material comprises at least one alignment component that is configured to align the cleaning material relative to the housings.
30. The cleaning implement cartridge of claim 25, wherein each housing comprises at least one alignment feature that is structured to align the housing and the cleaning implement relative to one another when the housing is at least partially disposed in the cleaning implement cartridge receiving area of the cleaning implement.
31. The cleaning implement cartridge of claim 25, wherein the cleaning material comprises at least one absorbent material.
32. The cleaning implement cartridge of claim 25, wherein the cleaning material comprises at least one cleaning material sheet.
33. The cleaning implement cartridge of claim 32, wherein the cleaning material sheet is at least partially segmented.
34. The cleaning implement cartridge of claim 32, wherein the cleaning material sheet is substantially continuous.
35. The cleaning implement cartridge of claim 25, wherein the cleaning material comprises at least one cleaning material roll.
36. The cleaning implement cartridge of claim 35, wherein the cleaning material roll is at least partially segmented.
37. The cleaning implement cartridge of claim 35, wherein the cleaning material roll is substantially continuous.
38. The cleaning implement cartridge of claim 35, wherein the housings andor cleaning material roll comprises at least one alignment component that is configured to align the cleaning material roll relative to the housings.
39. The cleaning implement cartridge of claim 38, wherein the alignment component comprises a rod that extends at least partially within the cavity.
40. The cleaning implement cartridge of claim 39, wherein the rod andor the cleaning material roll comprises at least one positioning component that is configured to position the rod and the cleaning material roll relative to one another.
41. The cleaning implement cartridge of claim 39, wherein the rod extends through at least a portion of at least one of the housings and operably connects, or is operably connectable, to at least one conveyance mechanism or at least one component thereof.
42. The cleaning implement cartridge of claim 39, wherein the cleaning material roll is configured to rotate in a substantially fixed position relative to the rod.
43. A cleaning implement, comprising at least one head component that comprises at least one cleaning material support component and at least one cleaning surface component, wherein the cleaning material support component comprises at least one cleaning material support component surface that at least partially defines at least one cleaning implement cartridge receiving area, wherein the cleaning material support component comprises at least one opening such that the cleaning implement cartridge receiving area communicates with the cleaning surface component, and wherein the cleaning implement cartridge receiving area is configured to receive at least one cleaning implement cartridge comprising cleaning material such that at least a portion of the cleaning material is movable to andor from the cleaning implement cartridge receiving area to extend over at least a portion of the cleaning surface component when the cleaning implement cartridge is at least partially disposed in the cleaning implement cartridge receiving area, and wherein the cleaning implement comprises at least one conveyance mechanism, or at least one component thereof, that is configured to convey at least the cleaning material over at least the portion of the cleaning surface component when the cleaning implement cartridge is at least partially disposed in the cleaning implement cartridge receiving area.
44. The cleaning implement of claim 43, comprising an operably connected robot body structure.
45. The cleaning of claim 43, comprising at least one positioning mechanism component that is configured to selectively position the cleaning material at least relative to the cleaning material support component when the cleaning implement cartridge is at least partially disposed in the cleaning implement cartridge receiving area.
46. The cleaning implement of claim 43, comprising at least two cleaning material support components that are each configured to receive at least a component of the cleaning implement cartridge.
47. The cleaning implement of claim 43, comprising at least one retaining component that is configured to substantially retain the cleaning implement cartridge at a selected position relative to the cleaning material support component when the cleaning implement cartridge is at least partially disposed in the cleaning implement cartridge receiving area.
48. The cleaning implement of claim 43, comprising at least one retaining mechanism that is configured to substantially retain the cleaning material at a selected position relative to the cleaning surface component when the cleaning implement cartridge is at least partially disposed in the cleaning implement cartridge receiving area and the cleaning material extends over at least the portion of the cleaning surface component.
49. The cleaning implement of claim 43, comprising the cleaning implement cartridge at least partially disposed in the cleaning implement cartridge receiving area of the cleaning material support component.
50. The cleaning implement of claim 43, wherein the cleaning surface component comprises at least one elevational element.
51. The cleaning implement of claim 43, comprising at least one handle operably connected to the head component.
52. The cleaning implement of claim 51, wherein the handle is pivotally connected to the head component via at least one pivot mechanism.
53. The cleaning implement of claim 43, wherein the conveyance mechanism is manually operated via at least one manual conveyance component.
54. The cleaning implement of claim 43, wherein the conveyance mechanism or the component thereof is configured to operably engage the cleaning implement cartridge to effect conveyance of the cleaning material when the cleaning implement cartridge is at least partially disposed in the cleaning implement cartridge receiving area.
55. The cleaning implement of claim 43, wherein the conveyance mechanism is configured to convey the cleaning material at least one selected incremental distance.
56. The cleaning implement of claim 43, wherein the conveyance mechanism comprises one or more gear components.
57. The cleaning implement of claim 43, wherein the conveyance mechanism comprises at least one motor component that is configured to effect conveyance of the cleaning material when the cleaning implement cartridge is at least partially disposed in the cleaning implement cartridge receiving area.
58. The cleaning implement of claim 43, comprising at least one fluid handling mechanism or at least one component thereof that is configure to convey at least one fluid from at least one fluid source to at least one fluid outlet.
59. The cleaning implement of claim 58, wherein the fluid outlet communicates with the cleaning implement cartridge or a portion thereof when the cleaning implement cartridge is at least partially disposed in the cleaning implement cartridge receiving area.
60. The cleaning implement of claim 58, wherein the fluid outlet is disposed proximal to at least one surface of the head component.
61. The cleaning of claim 58, wherein the fluid outlet comprises at least one nozzle.
62. The cleaning implement of claim 58, wherein the fluid handling mechanism comprises at least one pumping mechanism that is configured to the pump fluid from the fluid source to the fluid outlet.
63. The cleaning implement of claim 58, wherein the fluid handling mechanism comprises at least one vaporization component that is configured to vaporize the fluid at least proximal to the fluid outlet.
64. The cleaning implement of claim 58, wherein the fluid source and fluid outlet communicate via at least one fluid conduit.
65. The cleaning implement of claim 58, wherein the fluid source comprises at least one fluid container.
66. The cleaning implement of claim 58, wherein the fluid container is removable.
67. A cleaning implement cartridge, comprising at least one housing and at least one cleaning material, wherein the housing comprises at least one housing surface that at least partially defines a cavity, wherein the housing comprises at least one orifice that communicates with the cavity, wherein the cleaning material is at least partially disposed in the cavity such that the cleaning material is movable to andor from the housing, wherein at least a portion of the housing is configured to be received in a cleaning implement cartridge receiving area of a cleaning implement, wherein the cleaning material is configured to extend over at least a portion of a cleaning surface component of the cleaning implement when the housing is at least partially disposed in the cleaning implement cartridge receiving area of the cleaning implement, wherein the cleaning material comprises at least one cleaning material roll, wherein the housing andor cleaning material roll comprises at least one alignment component that is configured to align the cleaning material roll relative to the housing, wherein the alignment component comprises a rod that extends at least partially within the cavity, and wherein the rod extends through at least a portion of the housing and operably connects, or is operably connectable, to at least one conveyance mechanism at least one component thereof.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

We claim:

1. A heterogeneous catalyst immobilized on an inorganic support, comprising at least one active rhenium containing at least one carbene group and, if desired, further functional groups, wherein the rhenium is bonded to the material used as support by a covalent bond.
2. A catalyst as claimed in claim 1, which conforms to the general formula (II)
SRe(CR1)a(CR2R3)b(CR4R5R6)c(X)d(II)
in which R1 to R6, independently of one another, are selected from the group consisting of hydrogen, cyclic and acyclic, linear and branched, substituted and unsubstituted C1-C40-alkyl groups, C2-C40-alkenyl and alkynyl groups, C5-C9-aromatic groups and silyl groups, preferably from linear and branched C1-C10-alkyl groups, C2-C10-alkenyl and alkynyl groups and C6-C7-aromatic groups, which may carry halogens, ester groups or silyl groups as substituents, in particular from the group consisting of methyl, ethyl, propyl, i-propyl, n-butyl, i-butyl, tert-butyl, cyclohexyl, phenyl, trialkylsilyl and vinyl groups,
X is selected from the group consisting of hydrogen, halogens, oxo groups, imido groups, alkoxy groups and nitride groups, and
the indices a, b, c and d, independently of one another, are integers from 0 to 4, preferably from 0 to 2, where the values of the individual numbers depend on the stoichiometrically necessary amounts.
3. A catalyst as claimed in claim 1 or 2, wherein the support is selected from the group consisting of SiO2, Al2O3, SiO2Al2O3, B2O3Al2O3, B2O3Al2O3SiO2, NbO2 TiO2, ZrO2 and zeolites and clays of natural and synthetic origin, which may have been modified by Lewis or Bronsted acids, in particular sulfate ions, BF3 or organoboron species, preferably SiO2, which may be porous or nonporous.
4. A catalyst as claimed in one of claims 1 to 3, wherein the active rhenium compound is covalently bonded to an oxygen atom present in the support.
5. A catalyst as claimed in one of claims 1 to 4, which conforms to the formula (III)
SRe(CR1)(CHR2)(CH2R3)(III)
in which S is a suitable support, preferably SiO2, and R1, R2 and R3, independently of one another, are a linear or branched C1-C5-alkyl group, preferably a tert-butyl group.
6. A process for the preparation of a catalyst containing a rhenium compound with at least one carbene group as claimed in one of claims 1 to 5, which comprises reacting a suitable precursor compound of the active rhenium compound with an inorganic support, where the precursor compounds and the support each contain at least one reactive group which react with one another to form a covalent bond between the support and the rhenium, and introducing, if appropriate, a carbene function into the compound thus obtained.
7. A process as claimed in claim 6, wherein the precursor compound contains at least one carbene group or at least one precursor function of a carbene group from which the latter is formed during the reaction with the support.
8. A process as claimed in claim 6 or 7, wherein the precursor compound contains at least one carbene, carbyne or alkyl unit.
9. A process as claimed in one of claims 6 to 8, wherein the precursor compound conforms to the general formula (I)
Re(CR1)a(CR2R3)b(CR4R5R6)c(X)d(I)
in which R5 to R6, X and a, b, c and d are as defined in claim 1, and where the respective numerical values for a, b, c and d depend on the stoichiometry necessary.
10. A process as claimed in claim 6, wherein the precursor compound contains a precursor function of a carbene function, this precursor function being converted into a carbene function using a suitable reagent after the reaction between the precursor compound and the support.
11. A process as claimed in one of claims 6 to 10, wherein the support is selected from the group consisting of SiO2, Al2O3, SiO2Al2O3, B2O3Al2O3, B2O3Al2O3SiO2, NbO2, TiO2, ZrO2 and zeolites and clays of natural and synthetic origin, which may have been modified by Lewis or Brnsted acids, in particular sulfate ions, BF3 or organoboron species, preferably SiO2, which may be porous or nonporous.
12. The use of a catalyst as claimed in one of claims 1 to 5 as catalyst in olefin metathesis.
13. The use as claimed in claim 12, wherein the metathesis reaction is carried out using olefins which are selected from the group consisting of acyclic and cyclic, terminal and internal, linear and branched, unsubstituted and mono-, di-, tri- and tetrasubstituted olefins, and where the substituents may be selected from the group consisting of double and triple bonds, aromatic functions, ester, aldehyde, keto, nitrile, amide, alcohol and amine functions, and sulfur and phosphorus units.
14. The use as claimed in claim 12 or 13, wherein the olefin metathesis is selected from the group consisting of self-metathesis, cross-metathesis, ethanolysis, and the metathesis reactions known under the abbreviations ROMP, RCM and ADMET.
15. The use as claimed in one of claims 12 to 14, wherein the olefin metathesis is carried out at temperatures of from 50 to 400 C., preferably from 0 to 150 C., in particular from 15 to 100 C., and the olefincatalyst molar ratio has values of from 1 to 10,000,000, preferably from 2 to 100,000, in particular from 4 to 1000.

1. A compound having a structure represented by a formula:
wherein m is an integer selected from 2, 3, and 4;
wherein n is an integer selected from 0 and 1;
wherein p is an integer selected 0, 1, 2, 3, and 4;
wherein Q is selected from NR6, O, and S;
wherein R6 is selected from hydrogen and C1-C4 alkyl;

wherein R1 is selected from hydrogen and C1-C4 alkyl;
wherein each of R2 and R3 is independently selected from hydrogen and C1-C4 alkyl;
wherein each occurrence of R4a and R4b is independently selected from hydrogen, halogen, \u2014OH, \u2014CN, \u2014N3, \u2014NH2, and C1-C4 alkyl, or wherein each of R4a and R4b are optionally covalently bonded and, together with the intermediate atoms, comprise a 3- to 5-membered cycle;
wherein R5 is selected from Cy2 and Ar2;
wherein Cy2, when present, is selected from cycloalkyl and heterocycloalkyl, and Cy2 is substituted with 0, 1, 2, or 3 groups independently selected from halogen, \u2014OH, \u2014CN, \u2014N3, \u2014NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkylamino, and C1-C4 dialkylamino, provided that when m is 2 then Cy2 is not cycloalkyl;
wherein Ar2, when present, is selected from aryl and heteroaryl, and Ar2 is substituted with 0, 1, 2, or 3 substituents independently selected from halogen, \u2014OH, \u2014CN, \u2014N3, \u2014NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkylamino, C1-C4 dialkylamino, Cy3, Ar3, and \u2014NH(C\u2550O)(C1-C4 alkyl)Cy3, provided that when m is 2 then Ar2 is not substituted or unsubstituted phenyl, substituted or unsubstituted furanyl, or substituted or unsubstituted pyridinyl;
wherein Cy3, when present, is selected from cycloalkyl and heterocycloalkyl, and Cy3 is substituted with 0, 1, 2, or 3 groups independently selected from halogen, \u2014OH, \u2014CN, \u2014N3, \u2014NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkylamino, and C1-C4 dialkylamino;
wherein Ar3, when present, is selected from aryl and heteroaryl, and Ar3 is substituted with 0, 1, 2, or 3 groups independently selected from halogen, \u2014OH, \u2014CN, \u2014N3, \u2014NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkylamino, and C1-C4 dialkylamino;

provided that when m is 3, n is 0, and p is 0, that Ar2, when present, is not a structure represented by a formula:
and
wherein Ar1 is selected from aryl and heteroaryl, and Ar1 is substituted with 0, 1, 2, or 3 groups independently selected from halogen, \u2014OH, \u2014CN, \u2014N3, \u2014NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkylamino, and C1-C4 dialkylamino,
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1, wherein Ar2 is aryl, and Ar2 is substituted with 0, 1, 2, or 3 substituents independently selected from halogen, \u2014OH, \u2014CN, \u2014N3, \u2014NH2, C1-C3 alkyl, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkylamino, C1-C4 dialkylamino, Cy3, and Ar3.
3. The compound of claim 1, wherein Ar2 is heteroaryl, and Ar2 is substituted with 0, 1, 2, or 3 substituents independently selected from halogen, \u2014OH, \u2014CN, \u2014N3, \u2014NH2, C1-C3 alkyl, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkylamino, C1-C4 dialkylamino, Cy3, and Ar3.
4. The compound of claim 1, wherein Ar1 is aryl, and Ar1 is substituted with 0, 1, 2, or 3 groups independently selected from halogen, \u2014OH, \u2014CN, \u2014N3, \u2014NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkylamino, and C1-C4 dialkylamino.
5. The compound of claim 1, wherein Ar1 is phenyl, and Ar1 is substituted with 0, 1, 2, or 3 groups independently selected from halogen, \u2014OH, \u2014CN, \u2014N3, \u2014NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkylamino, and C1-C4 dialkylamino.
6. The compound of claim 1, wherein Ar1 is heteroaryl, and Ar1 is substituted with 0, 1, 2, or 3 groups independently selected from halogen, \u2014OH, \u2014CN, \u2014N3, \u2014NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkylamino, and C1-C4 dialkylamino.
7. The compound of claim 1, wherein Ar1 is thiophenyl, and Ar1 is substituted with 0, 1, 2, or 3 groups independently selected from halogen, \u2014OH, \u2014CN, \u2014N3, \u2014NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkylamino, and C1-C4 dialkylamino.
8. The compound of claim 1, wherein the compound has a structure represented by a formula:
9. The compound of claim 1, wherein the compound has a structure represented by a formula:
10. The compound of claim 1, wherein the compound has a structure represented by a formula:
wherein each of R20a, R20b, R20c, R20d, and R20e are independently selected from hydrogen, halogen, \u2014OH, \u2014CN, \u2014N3, \u2014NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkylamino, and C1-C4 dialkylamino, provided that at least two of R20a, R20b, R20c, R20d, and R20e are hydrogen.
11. The compound of claim 1, wherein the compound has a structure represented by a formula:
wherein each of R20b, R20c, and R20d are hydrogen and each of R20a and R20e are independently selected from hydrogen, halogen, \u2014OH, \u2014CN, \u2014N3, \u2014NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkylamino, and C1-C4 dialkylamino.
12. The compound of claim 1, wherein the compound has a structure represented by a formula:
13. The compound of claim 1, wherein the compound has a structure represented by a formula:
wherein each of R30a, R30b, and R30c are independently selected from hydrogen, halogen, \u2014OH, \u2014CN, \u2014N3, \u2014NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkylamino, and C1-C4 dialkylamino.
14. The compound of claim 1, wherein the compound has a structure represented by a formula:
15. A compound having a structure selected from:
or a pharmaceutically acceptable salt thereof.
16. A method for treating a disorder associated with E-cadherin activity in a subject, the method comprising administering to the subject an effective amount of at least one compound having a structure represented by a formula:
wherein m is an integer selected from 2, 3, and 4;
wherein n is an integer selected from 0 and 1;
wherein p is an integer selected 0, 1, 2, 3, and 4;
wherein Q is selected from NR6, O, and S;
wherein R6 is selected from hydrogen and C1-C4 alkyl;

wherein R1 is selected from hydrogen and C1-C4 alkyl;
wherein each of R2 and R3 is independently selected from hydrogen and C1-C4 alkyl;
wherein each occurrence of R4a and R4b is independently selected from hydrogen, halogen, \u2014OH, \u2014CN, \u2014N3, \u2014NH2, and C1-C4 alkyl, or wherein each of R4a and R4b are optionally covalently bonded and, together with the intermediate atoms, comprise a 3- to 5-membered cycle;
wherein R5 is selected from Cy2 and Ar2;
wherein Cy2, when present, is selected from cycloalkyl and heterocycloalkyl, and Cy2 is substituted with 0, 1, 2, or 3 groups independently selected from halogen, \u2014OH, \u2014CN, \u2014N3, \u2014NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkylamino, and C1-C4 dialkylamino;
wherein Ar2, when present, is selected from aryl and heteroaryl, and Ar2 is substituted with 0, 1, 2, or 3 substituents independently selected from halogen, \u2014OH, \u2014CN, \u2014N3, \u2014NH2, C1-C3 alkyl, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkylamino, C1-C4 dialkylamino, Cy3, Ar3, and \u2014NH(C\u2550O)(C1-C4 alkyl)Cy3;
wherein Cy3, when present, is selected from cycloalkyl and heterocycloalkyl, and Cy3 is substituted with 0, 1, 2, or 3 groups independently selected from halogen, \u2014OH, \u2014CN, \u2014N3, \u2014NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkylamino, and C1-C4 dialkylamino;
wherein Ar3, when present, is selected from aryl and heteroaryl, and Ar3 is substituted with 0, 1, 2, or 3 groups independently selected from halogen, \u2014OH, \u2014CN, \u2014N3, \u2014NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkylamino, and C1-C4 dialkylamino; and
wherein Ar1, when present, is selected from aryl and heteroaryl, and Ar1 is substituted with 0, 1, 2, or 3 groups independently selected from halogen, \u2014OH, \u2014CN, \u2014N3, \u2014NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 monohaloalkyl, C1-C4 polyhaloalkyl, C1-C4 alkylamino, and C1-C4 dialkylamino,
or a pharmaceutically acceptable salt thereof, thereby treating the disorder in the subject.
17. The method of claim 16, wherein the disorder associated with E-cadherin activity is a disorder of uncontrolled cellular proliferation.
18. The method of claim 17, wherein the disorder of uncontrolled cellular proliferation is cancer.
19. The method of claim 17, wherein the disorder of uncontrolled cellular proliferation is selected from breast cancer, renal cancer, gastric cancer, and colorectal cancer.
20. The method of claim 17, wherein the disorder of uncontrolled cellular proliferation is selected from lymphoma, cancers of the brain, genitourinary tract cancer, lymphatic system cancer, stomach cancer, larynx cancer, lung, pancreatic cancer, breast cancer, and malignant melanoma.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method for uphilllow pressure casting a liquid melt in a device which comprises a casting furnace lying below a casting table, the casting furnace having a riser pipe with a mouth opening, a mould having an underlying pouring-in hole, and a displaceable slide valve closure having a displaceable overlying opening section and a displaceable underlying opening section, said slide valve closure, when inserted between said casting furnace and said casting table, forming a flow-through channel comprising a substantially straight, longitudinal course during casting of the liquid melt, the flow-through channel being formed from the overlying opening section and the underlying opening section which are directly adjacent to one another, said method comprising:
casting the liquid melt in the pouring-in hole of the mould;
shutting off the slide valve closure;
displacing the overlying and underlying opening sections of the flow through channel with respect to one another and transversely to the longitudinal course of the flow-through channel directly after casting the liquid melt in the pouring-in hole of the mould, so that the overlying opening section remains in open communication with the pouring-in hole of the mould and the underlying opening section remains in open communication with the mouth opening of the riser, and the overlying and underlying sections are completely offset with respect to one another; and
actively cooling the liquid melt located inside the overlying opening section of the flow-through channel beginning at the latest from the time the two opening sections of the flow-through channel are displaced with respect to one another.
2. The method of claim 1, further comprising lowering the liquid melt in the riser pipe after the slide valve closure is shut-off until at least the underlying opening section of the flow-through channel is emptied of liquid melt.
3. The method of claim 2, further comprising lowering the liquid melt in the riser pipe as far as slightly below the mouth opening of the riser pipe after the slide valve closure is shut off.
4. The method of claim 2, further comprising introducing a protective gas at the mouth opening of the riser pipe during the lowering of the liquid melt.
5. The method of claim 1, further comprising displacing the overlying opening section of the flow-through channel jointly with the pouring-in hole of the mould with respect to the underlying opening section of the flow-through channel, said underlying opening section being held in a fixed position at the mouth opening of the riser pipe.
6. The method of claim 5, further comprising displacing the mould together with the overlying opening section of the flow-through channel.
7. The method of claim 1, further comprising actively cooling the liquid melt inside the pouring-in hole of the mould at the latest from the time the two opening sections of the flow-through channel are displaced with respect to each other.
8. The method of claim 1, further comprising removing the mould from the slide valve closure immediately after solidification of the liquid melt in the overlying opening section of the flow-through channel and in the pouring-in hole of the mould.
9. The method of claim 1, wherein said liquid melt comprises light metal alloys.
10. An apparatus for uphilllow-pressure casting a liquid melt, said apparatus comprising:
a casting furnace lying below a casting table, the casting furnace having a riser pipe with a mouth opening;
a mould having an underlying pouring-in hole; and
a displaceable slide valve closure constituting a flow-through channel comprising a substantially straight, longitudinal course during casting of the liquid melt, when said slide valve closure is slide valve closure is inserted between said casting furnace and said casting table, wherein the slide valve closure comprises two individually displaceable plates, an upper plate and a lower plate, each of said plates having a flow-through opening, wherein the two plates overlap with their flow-through openings during the casting of the liquid melt and are displaceable towards each other for shut-off directly after casting so that the flow-through opening in the upper plate is in open communication with the pouring-in hole free from undercut and the flow-through opening in the lower plate is in open communication with the mouth opening of the riser pipe while the flow-through openings are completely offset with respect to each other, and wherein a connecting-piece projection of a displaceable holder is surrounded by a coolant ring in the holder, said holder being connected to a coolant line.
11. The apparatus of claim 10, wherein the plates are held in a cassette secured to the casting table, and wherein the upper plate is held in the displaceable holder in the cassette on which the mould is placed.
12. The apparatus of claim 10, wherein the mould comprises a lower cylindrical sprue connecting piece, said sprue connecting piece forming the pouring-in hole which fits into a connecting-piece projection of the displaceable holder, said connecting piece projection being aligned towards the flow-through opening in the upper plate.
13. The apparatus of claim 12, wherein the front face of the cylindrical sprue connecting piece is placed on the upper plate.
14. The apparatus of claim 10, further comprising a coolant chamber below or inside the lower plate, said coolant chamber being connected to a coolant line.
15. The apparatus of claim 10, further comprising an actuating device for the holder, wherein said actuating device is arranged on the cassette.
16. The apparatus of claim 10, further comprising spring means acting on the holder, said spring means being supported in the cassette, and holding the upper plate and the lower plate braced against each other.
17. The apparatus of claim 10, wherein the riser pipe is suspended elastically flexibly in the casting furnace being adjustable in height with respect to the casting table.
18. The apparatus of claim 10, wherein the flow-through opening in the upper plate and the pouring-in hole continuously expand upwards, said flow-through opening and said pouring-in hole exhibiting an upwardly expanding conicity.
19. The apparatus of claim 10, wherein the flow-through opening in the lower plate and parts adjacent thereto in the downward direction as far as the mouth of the riser pipe, forming the flow-through channel, continuously expand downwards, exhibiting a downwardly expanding conicity.
20. The apparatus of claim 10, wherein the liquid melt further comprises light metal alloys.
21. The apparatus of claim 13, wherein the front face of the cylindrical sprue is braceable against the upper plate.