All The Claims

1. An information handling system, in which hardware is partitioned through the IO system, comprising:
a CPU system having a number of hardware partitions;
a memory system having the same number of hardware partitions;
a IO system having the same number of hardware partitions, and having at least one IO device;
wherein each IO device has a hardware context, comprising one or more memory storage elements, in each partition;
wherein the IO system is connected to the CPU system by means of a PCI Express bus; and
wherein partitioning of the IO system is performed by using at least part of the requester ID portion of a PCI Express packet header to map an IO device to the context of a desired partition.
2. The system of claim 1, wherein each hardware context comprises at least one register.
3. The system of claim 1, wherein the CPU system comprises a single partitioned CPU.
4. The system of claim 1, wherein the CPU system comprises multiple CPUs.
5. The system of claim 1, wherein the CPU system comprises multiple server CPUs.
6. The system of claim 1, wherein the CPU system has a northbridge for handling communications via the PCI Express bus.
7. The system of claim 1, wherein the CPU is programmed to define a control structure for partition selection.
8. The system of claim 7, wherein the control structure is implemented with a hypervisor function of the CPU.
9. A method of partitioning an information handling system having at least a CPU system, memory system, and IO system, such that hardware is partitioned through the IO system, comprising:
partitioning a CPU system into hardware partitions;
partitioning the memory system into hardware partitions;
partitioning the IO system into hardware partitions;
wherein the IO system has at least one IO device;
wherein each IO device has a hardware context, comprising one or more memory storage elements, in each partition;
wherein the IO system is connected to the CPU system by means of a PCI Express bus; and
wherein partitioning of the IO system is performed by using at least part of the requester ID portion of a PCI Express packet header to map an IO device to the context of a desired partition.
10. The method of claim 9, wherein each hardware context comprises at least one control register.
11. The method of claim 9, wherein the CPU system comprises a single partitioned CPU.
12. The method of claim 9, wherein the CPU system comprises multiple CPUs.
13. The method of claim 9, wherein the CPU system comprises multiple server CPUs.
14. The method of claim 9, wherein the CPU system has a northbridge for handling communications via the PCI Express bus.
15. The method of claim 9, further comprising programming the CPU to define a control structure for partition selection.
16. The method of claim 15, wherein the control structure is implemented with a hypervisor function of the CPU.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A medical device for treating body tissue of a patient comprising:
(a) an elongated member having a proximal end and a distal end;
(b) an expandable assembly disposed at the distal end of the elongated member, wherein the expandable assembly is capable of changing from a retracted position to an expanded position and the expandable assembly comprises a plurality of wire elements and wherein each wire element has a first end and a second end; and
(c) a patch having two opposing surfaces; wherein one of the opposing surfaces comprises an adhesive material and a biologically active material; wherein the other opposing surface is disposed upon at least one of the wire elements, and wherein the wire elements are arranged in a basket-like configuration when the expandable assembly is in the expanded position and wherein both ends of at least one wire element is connected to the distal end of the elongated member.
2. The medical device of claim 1 wherein at least two wire elements have midpoints between the ends of the wire elements and wherein the medical device further comprises a hub which connects the midpoints.
3. The medical device of claim 1 which further comprises a sheath being sized to slidably receive the elongated member and expandable assembly in its retracted position.
4. The medical device of claim 1 which further comprises an expansion mechanism for expanding the expandable assembly.
5. The medical device of claim 1 wherein the expandable assembly comprises about three or more wire elements.
6. The medical device of claim 5 wherein the expandable assembly comprises up to about twenty wire elements.
7. The medical device of claim 1 wherein each of the wire elements are of approximately equal lengths.
8. The medical device of claim 1 wherein each of the wire elements are approximately evenly spaced.
9. The medical device of claim 1 wherein the patch comprises a material selected from the group consisting of natural polymers, synthetic polymers, metals and biological fabric.
10. The medical device of claim 1 wherein the patch is circular in shape.
11. The medical device of claim 1 wherein the thickness of the patch is about 10 micron to about 1 mm.
12. The medical device of claim 1 wherein one side of the patch is substantially impermeable.
13. The medical device of claim 1 wherein the biologically active material comprises at least one of cells, genetic materials or drugs.
14. The medical device of claim 13 wherein the cells comprise at least one of endothelial progenitor cells, stem cells, cardiomyocytes, skeletal myoblasts or transformed cells.
15. The medical device of claim 13 wherein the genetic materials are nucleic acid molecules encoding proteins comprising at least one of FGF, FGF-1, FGF-2, EMGF or VEGF.
16. The medical device of claim 13 wherein the drugs comprise at least one of estrogen, estradiol, estriol, dioxin, captopril or enalopril.
17. The medical device of claim 1 wherein the opposing surface of the patch which comprises an adhesive material further comprises carbowax.
18. The medical device of claim 1 wherein the adhesive material is a bioadhesive material comprising at least one of hydrogels, fibrin glue, cyanoacrylates, gelatin-resorcinol formaldehyde-glutaraldehyde, synthetic gums or natural gums.
19. A medical device for treating body tissue of a patient comprising:
(a) an elongated member having a proximal end and a distal end:
(b) an expandable assembly disposed at and connected to the distal end of the elongated member, wherein the expandable assembly is capable of changing from a retracted position to an expanded position and the expandable assembly comprises a plurality of wire elements and wherein each wire element has a first end and a second end; and
(c) a patch having two opposing surfaces; wherein one of the opposing surfaces comprises an adhesive material and a biologically active material; wherein the other opposing surface is disposed upon at least one of the wire elements; and wherein the wire elements are arranged in a basket-like configuration when the expandable assembly is in the expanded position and the first end of the wire element is connected to the distal end of the elongated member and the second end of the wire is connected to the elongated member at a point more proximal than the first end of the wire element.
20. A medical device for treating body tissue of a patient comprising:
(a) an elongated member having a proximal end and a distal end;
(b) an expandable assembly disposed at and connected to the distal end of the elongated member, wherein the expandable assembly is capable of changing from a retracted position to an expanded position and the expandable assembly comprises a plurality of wire elements and wherein each wire element has a first end and a second end; and
(c) a patch having two opposing surfaces; wherein one of the opposing surfaces comprises an adhesive material and a biologically active material; wherein the other opposing surface is disposed upon at least one of the wire elements, and wherein a penetrating element is disposed at the distal end of the elongated member.
21. The medical device of claim 20 wherein the wire elements are arranged in a basket-like configuration when the expandable assembly is in the expanded position and at least one end of at least one wire element is connected to the distal end of the elongated member.

1. A compound of Formula A:
or a pharmaceutically acceptable salt thereof wherein:
R1 is \u2014CD3;
each of R2a and R2b is independently selected from \u2014CH3, and \u2014CD3;
R3 is selected from \u2014CH2 and \u2014CD2-;
R4 is \u2014C(R5)2\u2014CR5OH\u2014C(R5)2\u2014, wherein each R5 is independently selected from D and H; and
each Y is independently selected from H and D.
2. The compound of claim 1, wherein each Y is the same.
3. The compound of claim 2, wherein each Y is deuterium.
4. The compound of claim 2 wherein: each Y is hydrogen.
5. The compound according to claim 1, wherein the compound is selected from any one of the compounds in the table below or a pharmaceutically acceptable salt thereof:
Compound
each Y
R1
R2a
R2b
R3
R4
100
H
CD3
CH3
CH3
CD2
CH2CH(OH)CH2
102
H
CD3
CH3
CH3
CH2
CD2CD(OH)CD2
105
H
CD3
CH3
CH3
CD2
CD2CD(OH)CD2
107
H
CD3
CD3
CD3
CD2
CD2CD(OH)CD2.
6. The compound according to claim 1, wherein the compound is selected from any one of the compounds in the table below or a pharmaceutically acceptable salt thereof:
Compound
each Y
R1
R2a
R2b
R3
R4
108
H
CD3
CD3
CD3
CH2
CH2CH(OH)CH2
109
H
CD3
CH3
CH3
CH2
CH2CH(OH)CH2
110
D
CD3
CD3
CD3
CD2
CD2CD(OH)CD2.
7. The compound according to any one of claims 1 to 4 and 5 to 6, wherein any atom not designated as deuterium is present at its natural isotopic abundance.
8. A pyrogen-free composition comprising an effective amount of a compound of Formula A:
or a pharmaceutically acceptable salt thereof wherein:
R1 is \u2014CD3;
each of R2a and R2b is independently selected from \u2014CH3 and \u2014CD3;
R3 is selected from \u2014CH2 and \u2014CD2-;
R4 is \u2014C(R5)2\u2014CR5OH\u2014C(R5)2\u2014, wherein each R5 is independently selected from D and H; and
each Y is independently selected from H and D;
and an acceptable carrier.
9. The composition according to claim 8, wherein the composition is formulated for pharmaceutical use; and the carrier is a pharmaceutically acceptable carrier.
10. The composition according to claim 9, further comprising a second therapeutic agent useful in treating a subject suffering from or susceptible to a disease or condition selected from ischemia; angina; left ventricular remodeling after heart failure; arrhythmias; congestive heart failure; myocardial infarction; diabetes; obesity; high serum cholesterol; viral infections; endothelial dysfunction; pathological effects of acute increases in free fatty acid flux; inflammatory diseases; proliferative diseases; and wounds.
11. The composition according to claim 10, wherein the second therapeutic agent is selected from a calcium channel blocker; a beta-blocker; a nitrate; a remodeling agent; a sterol absorption inhibitor; a sodium-hydrogen exchanger type-1 inhibitor; an HMG CoA reductase inhibitor; a UCP inhibitor; a Fas inhibitor; an adenosine A-3 receptor agonist; an aldosterone antagonist; and a quinoline or a derivative or an intermediate thereof.
12. The composition according to claim 11, wherein the second therapeutic agent is selected from a beta blocker, a calcium channel blocker or a nitrate.
13. The composition according to claim 12, wherein the second therapeutic agent is amlodipine, atenolol, or nitroglycerine.
14. The compound of claim 1, wherein R2a and R2b are simultaneously \u2014CD3 or \u2014CH3.
15. The compound of claim 14, wherein R2a and R2b are simultaneously \u2014CD3.
16. The compound of claim 15, wherein R3 is \u2014CD2-.
17. The compound of claim 16, wherein R4 is \u2014CD2-CR5OH\u2014C(R5)2\u2014 or \u2014C(R5)2\u2014CR5OH\u2014CD2-.
18. The compound of claim 17, wherein R4 is \u2014CD2-CR5OH\u2014CD2-.
19. The compound of claim 18, wherein R4 is \u2014CD2-CDOH\u2014CD2-.
20. The compound of claim 4, wherein R2a and R2b are simultaneously \u2014CD3 or \u2014CH3.
21. The compound of claim 20, wherein R2a and R2b are simultaneously \u2014CD3.
22. The compound of claim 21, wherein R3 is \u2014CD2-.
23. The compound of claim 22, wherein R4 is \u2014CD2-CR5OH\u2014C(R5)2\u2014 or \u2014C(R5)2\u2014CR5OH\u2014CD2-.
24. The compound of claim 23, wherein R4 is \u2014CD2-CR5OH\u2014CD2-.
25. The compound of claim 24, wherein R4 is \u2014CD2-CDOH\u2014CD2-.
26. A pyrogen-free composition comprising an effective amount of a compound of claim 4
or a pharmaceutically acceptable salt thereof,
and an acceptable carrier.
27. The composition according to claim 26, wherein the composition is formulated for pharmaceutical use; and the carrier is a pharmaceutically acceptable carrier.
28. The composition according to claim 27, further comprising a second therapeutic agent useful in treating a subject suffering from or susceptible to a disease or condition selected from ischemia; angina; left ventricular remodeling after heart failure; arrhythmias; congestive heart failure; myocardial infarction; diabetes; obesity; high serum cholesterol; viral infections; endothelial dysfunction; pathological effects of acute increases in free fatty acid flux; inflammatory diseases; proliferative diseases; and wounds.
29. The composition according to claim 28, wherein the second therapeutic agent is selected from a calcium channel blocker; a beta-blocker; a nitrate; a remodeling agent; a sterol absorption inhibitor; a sodium-hydrogen exchanger type-1 inhibitor; an HMG CoA reductase inhibitor; a UCP inhibitor; a Fas inhibitor; an adenosine A-3 receptor agonist; an aldosterone antagonist; and a quinoline or a derivative or an intermediate thereof.
30. The composition according to claim 29, wherein the second therapeutic agent is selected from a beta blocker, a calcium channel blacker or a nitrate.
31. The composition according to claim 30, wherein the second therapeutic agent is amlodipine, atenolol, or nitroglycerine.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A fastening device comprising:
a support having a screw hole;
an object to be fixed having a through hole which is aligned with the screw hole, and
a fastener which detachably fixes the object to be fixed to the support by being screwed into the screw hole from the through hole, the fastener including:
(i) a male screw portion which is screwed into the screw hole;
(ii) a gripper coaxially provided with respect to the male screw portion, the gripper being capable of protruding outside the object to be fixed from the through hole and getting into the through hole, and having an end surface on which a concave portion, in which a tool can be engaged, is formed on an opposite side of the male screw portion; and
(iii) a stopper positioned between the male screw portion and the gripper, the stopper being radially outward of the male screw portion and the gripper,

the object to be fixed being fixed to the support via the fastener and the end surface of the gripper being positioned inside the through hole, in a state in which the male screw portion of the fastener is screwed into the screw hole, and
the gripper protruding outside of the object to be fixed from the through hole and the stopper being caught in the object to be fixed and holding the fastener to the object to be fixed, in a state in which the fastener is loosened and the male screw portion is removed from the screw hole.
2. The fastening device of claim 1, wherein the end surface of the gripper is flush with an outer surface of the object to be fixed in a state in which the male screw portion of the fastener is screwed into the screw hole.
3. The fastening device of claim 2, wherein the stopper is shaped like a flange which is continuous in a circumferential direction of the gripper, the object to be fixed has a guide portion which an outer circumferential surface of the stopper slidably contacts, and the guide portion extends in an axial direction of the gripper.
4. (canceled)
5. The fastening device of claim 3, wherein the object to be fixed has a receiving portion, the receiving portion receiving the stopper and abutting against the support when the male screw portion is screwed into the screw hole.
6. The fastening device of claim 1, further comprising an elastic member which elastically urges the fastener toward the through hole.
7. A module mounting mechanism comprising:
a receptacle having an opening and a screw hole facing the opening;
a module detachably inserted into the receptacle from the opening and having a through hole which is aligned with the screw hole; and
a fastener which detachably fixes the module to the receptacle by being screwed into the screw hole from the through hole when the module is inserted into the receptacle, the fastener including:
(i) a male screw portion which is screwed into the screw hole;
(ii) a gripper coaxially provided with respect to the male screw portion, the gripper being capable of protruding outside the module from the through hole and getting into the through hole, and having an end surface on which a concave portion, in which a tool can be engaged, is formed on an opposite side of the male screw portion; and
(iii) a stopper positioned between the male screw portion and the gripper, the stopper being radially outward of the male screw portion and the gripper,

the module being fixed to the receptacle via the fastener and the end surface of the gripper being positioned inside the through hole, in a state in which the male screw portion of the fastener is screwed into the screw hole, and
the gripper protruding outside of the module from the through hole and the stopper being caught in the module and holding the fastener to the module, in a state in which the fastener is loosened and the male screw portion is removed from the screw hole.
8. The module mounting mechanism of claim 7, wherein the module has an outer surface exposed to an outside of the receptacle, and the end surface of the gripper is flush with the outer surface of the module in a state in which the male screw portion of the fastener is screwed into the screw hole.
9. The module mounting mechanism of claim 8, wherein the stopper is shaped like a flange which is continuous in a circumferential direction of the gripper, the module has a guide portion which an outer peripheral surface of the stopper slidably contacts, and the guide portion extends in an axial direction of the gripper.
10. The module mounting mechanism of claim 9, wherein the module has a receiving portion which receives the stopper when the male screw portion is screwed into the screw hole.
11. The module mounting mechanism of claim 10, wherein the receptacle has a wall which guides an insertion direction of the module and a fixing bracket held at an end portion facing the opening of the wall, the screw hole is formed in the fixing bracket, and the receiving portion of the module abuts against the fixing bracket when the male screw portion of the fastener is screwed into the screw hole.
12. The module mounting mechanism of claim 11, wherein the stopper of the fastener and the fixing bracket sandwich the receiving portion of the module when the male screw portion is screwed into the screw hole.
13. The module mounting mechanism of claim 7, further comprising an elastic member which elastically urges the fastener toward the through hole.
14. An information processing apparatus comprising:
a housing including a receptacle, an opening which is continuous with the receptacle, and a screw hole facing the opening;
a circuit module having a circuit board detachably inserted into the receptacle of the housing, and a front panel provided at one end of the circuit board, the front panel having a through hole which is aligned with the screw hole and closing the opening when the circuit board is inserted into the receptacle; and
a fastener which detachably fixes the circuit module to the housing by being screwed into the screw hole from the through hole when the circuit board is inserted into the receptacle, the fastener including:
(i) a male screw portion which is screwed into the screw hole;
(ii) a gripper coaxially provided with respect to the male screw portion, the gripper being capable of protruding outside the front panel from the through hole and getting into the through hole, and having an end surface on which a concave portion, in which a tool can be engaged, is formed on an opposite side of the male screw portion; and
(iii) a stopper positioned between the male screw portion and the gripper, the stopper being radially outward of the male screw portion and the gripper,

the circuit module being fixed to the housing via the fastener and the end surface of the gripper being positioned inside the through hole of the front panel, in a state in which the male screw portion of the fastener is screwed into the screw hole, and
the gripper protruding outside of the front panel from the through hole and the stopper being caught in the front panel and holding the fastener to the front panel, in a state in which the fastener is loosened and the male screw portion is removed from the screw hole.
15. The information processing apparatus of claim 14, wherein the front panel has an outer surface exposed to an outside of the housing, and the end surface of the gripper is flush with the outer surface of the front panel in a state in which the male screw portion of the fastener is screwed into the screw hole.
16. The information processing apparatus of claim 15, wherein the stopper is shaped like a flange which is continuous in a circumferential direction of the gripper, the front panel has a guide portion which an outer circumferential surface of the stopper slidably contacts, and the guide portion extends in an axial direction of the gripper.
17. The information processing apparatus of claim 15, wherein each of the housing and the front panel of the circuit module has conductivity, the front panel including a metal receiving portion which receives the stopper when the male screw portion is screwed into the screw hole, and the receiving portion being electrically connected to the front panel, and
the receptacle of the housing includes a wall which guides an insertion direction of the circuit board and a fixing bracket held at an end portion facing the opening of the wall, and the fixing bracket being electrically connected to the housing, the screw hole being formed in the fixing bracket, and the receiving portion of the front panel abutting against the fixing bracket when the male screw portion of the fastener is screwed into the screw hole.
18. The information processing apparatus of claim 17, wherein the stopper of the fastener and the fixing bracket sandwich the receiving portion when the male screw portion is screwed into the screw hole.
19. The information processing apparatus of claim 14, wherein the front panel has a connector used to connect a cable.
20. The information processing apparatus of claim 14, further comprising an elastic member which elastically urges the fastener toward the through hole.