All The Claims

1. A folded box gluing machine for making folded boxes from blanks comprising:
an orienting station arranged to orient and guide the blanks;
a pre-breaker station arranged adjacent to the orienting station with a gap therebetween and arranged to fold flaps of the blanks back and forth;
a conveying mechanism arranged to deliver the blanks through the orienting station and the pre-breaker station; and
an embossing mechanism including embossing dies arranged in the gap between the orienting station and the pre-breaker station so as to emboss the blanks; wherein
one of the embossing dies includes a product-specific male mold and another die includes a product-neutral female mold; and
the product-specific male mold and the product-neutral female mold define dots of Braille script.
2. The folded box gluing machine according to claim 1, wherein the embossing mechanism is a rotational embossing mechanism including rotating embossing dies.
3. The folded box gluing machine according to claim 2, wherein the embossing dies have a common rotation drive.
4. The folded box gluing machine according to claim 2, wherein a lower embossing die is coupled to a drive of the conveying mechanism and an upper embossing die includes a rotation drive.
5. The folded box gluing machine according to claim 1, wherein the product-neutral female mold is interchangeable.
6. The folded box gluing machine according to claim 1, wherein the embossing dies are mounted in the machine and can be positioned in a crosswise direction.
7. The folded box gluing machine according to claim 1, wherein the product-specific male mold is interchangeable.
8. The folded box gluing machine according to claim 1, wherein positions of the embossing dies are adjustable relative to each other.
9. The folded box gluing machine according to claim 1, wherein the embossing mechanism is arranged in front of a first folding station.
10. The folded box gluing machine according to claim 1, wherein the embossing mechanism is arranged to be removed from the machine.
11. The folded box gluing machine according to claim 10, wherein the embossing mechanism is arranged to swivel in the machine from an active position to an inactive position.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A process transmitter for measuring a process variable, the process transmitter comprising:
a process sensor for sensing the process variable of a process fluid;
transmitter circuitry for processing a signal from the process sensor;
a transmitter housing for receiving the process sensor and transmitter circuitry;
at least one transmitter mounting component for isolating the sensor or the transmitter circuitry from the process fluid or external environment; and
a mechanical integrity sensor for validating assembly of the transmitter housing and transmitter mounting component.
2. The process transmitter of claim 1 wherein:
the transmitter housing includes at least one access opening for the process sensor or the transmitter circuitry;
the transmitter access opening is mechanically sealed with a transmitter mounting component; and
the mechanical integrity sensor comprises a proximity sensor for sensing proximity of the transmitter mounting component to the housing.
3. The process transmitter of claim 2 wherein the transmitter circuitry verifies that the transmitter mounting component is fully seated with the access opening such that the transmitter mounting component prevents contaminants from entering the housing.
4. The process transmitter of claim 2 wherein the transmitter circuitry verifies that the transmitter mounting component is properly threaded with the housing such that the component provides an adequate flame quenching channel.
5. The process transmitter of claim 2 wherein the transmitter circuitry includes predetermined values for comparison to a signal generated by the mechanical integrity sensor.
6. The process transmitter of claim 1 wherein:
the transmitter mounting component comprises a process flange for joining the transmitter housing with the process fluid; and
the mechanical integrity sensor comprises a material verification sensor for sensing material properties of the process flange.
7. The process transmitter of claim 6 wherein the transmitter circuitry validates the sensed material property of the process flange with material property data stored in the transmitter circuitry.
8. The process transmitter of claim 6 wherein the material verification sensor comprises an inductive permeability sensor.
9. The process transmitter of claim 6 and further comprising a second material verification sensor for sensing material properties of a process diaphragm positioned within the process transmitter.
10. The process transmitter of claim 1 wherein the transmitter circuitry includes electronics that annunciate to a user output of the mechanical integrity sensor.
11. The process transmitter of claim 1 wherein the transmitter circuitry operates the mechanical integrity sensor as a continuous background operation.
12. The process transmitter of claim 1 wherein the transmitter circuitry includes a user control such that a user is able to manually initiate operation of the mechanical integrity sensor.
13. The process transmitter of claim 1 wherein the
the transmitter mounting component comprises a sensor module for joining the transmitter housing with a process fluid flange; and
the mechanical integrity sensor comprises a proximity sensor for sensing orientation of the transmitter housing on the sensor module.
14. A process transmitter for measuring a process variable, the process transmitter comprising:
a process sensor module for sensing the process variable of a process fluid;
a transmitter housing for receiving the process sensor;
at least one housing cover for sealing the sensor within the housing; and
a mechanical integrity sensor for sensing assembly of the housing cover or sensor module with the transmitter housing.
15. The process transmitter of claim 14 wherein the mechanical integrity sensor comprises a proximity sensor.
16. The process transmitter of claim 15 wherein the proximity sensor is selected from the group consisting of an inductive proximity sensor, a capacitive proximity sensor, a magnetometer, an ultrasonic proximity sensor, an optical proximity sensor or a mechanical limit switch.
17. The process transmitter of claim 14 and further comprising electronic circuitry that annunciates when a housing cover or sensor module is improperly positioned or missing.
18. The process transmitter of claim 14 further comprising transmitter circuitry which includes predetermined proximity values for comparison to a signal generated by the mechanical integrity sensor.
19. The process transmitter of claim 14 wherein the mechanical integrity sensor is comprised of a capacitive proximity sensor.
20. The process transmitter of claim 19 wherein the capacitive proximity sensor comprises:
a first capacitor comprising a first terminal screw and a second terminal screw;
a second capacitor comprising the first terminal screw and a housing cover; and
a third capacitor comprising the second terminal screw and the housing cover;
wherein the capacitance of the circuit formed by the first, second and third capacitors changes as the housing cover is assembled with the transmitter housing.
21. The process transmitter of claim 14 wherein the mechanical integrity sensor comprises an inductive proximity sensor.
22. The process transmitter of claim 21 wherein the inductive proximity sensor comprises:
an inductance coil for generating an electrostatic field positioned within the sensor housing adjacent a housing cover;
a core material positioned within the inductance coil;
an oscillator for generating an eddy current in the core; and
a signal level detector for sensing a change in an amplitude of oscillation of the eddy current when a housing cover is positioned near the core.
23. A process transmitter for measuring a process variable, the process transmitter comprising:
a process sensor for sensing the process variable of a process fluid;
a transmitter housing for receiving the process sensor;
a process flange for joining the transmitter housing with a process fluid source; and
a mechanical integrity sensor for verifying material properties of the process flange.
24. The process transmitter of claim 23 wherein the mechanical integrity sensor comprises an inductive permeability sensor.
25. The process transmitter of claim 24 wherein the inductive permeability sensor comprises:
an inductance coil for generating an electrostatic field positioned within the sensor housing adjacent a housing cover;
a core material positioned within the inductance coil;
an oscillator for generating an eddy current in the core; and
a signal level detector for sensing a change in an amplitude of oscillation of the eddy current when the process flange is positioned near the core.
26. The process transmitter of claim 23 and further comprising a second material verification sensor for sensing material properties of a process diaphragm positioned within the process transmitter.
27. The process transmitter of claim 23 and further comprising transmitter circuitry including predetermined material property values for comparison to a signal generated by the mechanical integrity sensor.
28. The process transmitter of claim 27 and further comprising electronic circuitry that annunciates when the signal generated by the mechanical integrity sensor differs from a predetermined material property value.

1. A compound of formula (1) or a pharmaceutically acceptable salt thereof:
49
in which
Ar is phenyl, naphthyl, a monocyclic heteroaromatic group or a bicyclic heteroaromatic group, said Ar group being optionally substituted by 1-4 substituents, which may be the same or different, and which are selected from the group consisting of:
halogen, hydroxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, C1-6alkyl, trifluoromethanesulfonyloxy, pentafluoroethyl, C1-6alkoxy, arylC1-6alkoxy, C1-6alkylthio, C1-6alkoxyC1-6alkyl, C3-7cycloalkylC1-6alkoxy, C1-6alkanoyl, C1-6alkoxycarbonyl, C1-6alkylsulfonyl, C1-6alkylsulfinyl, C1-6alkylsulfonyloxy, C1-6alkylsulfonylC1-6alkyl, arylsulfonyl, arylsulfonyloxy, arylsulfonylC1-6alkyl, C1-6alkylsulfonamido, C1-6alkylamido, C1-6alkylsulfonamidoC1-6alkyl, C1-6alkylamidoC1-6alkyl, arylsulfonamido, arylcarboxamido, arylsulfonamidoC1-6alkyl, arylcarboxamidoC1-6alkyl, aroyl, aroylC1-6alkyl, arylC1-6alkanoyl, a group R3OCO(CH2)s, R3CON(R4)(CH2)), R3R4NCO(CH2), or R3R4NSO2(CH2)s where each of R3 and R4 independently represents a hydrogen atom or C1-4alkali or R3 and R4 form part of a C3-6azacyloalkane or C3-6(2-oxo)azacycloalkane ring and s represents zero or an integer from 1 to 4, and a group Ar1-Z, wherein Z represents a single bond, O, S or CH2 and Ar1 represents a phenyl or a monocyclic heteroaromatic group, said Ar1 group being optionally substituted by 1-3 substituents, which may be the same or different, and which are selected from the group consisting of: a halogen, hydroxy, cyano, trifluormethyl, C1-6alkyl. C1-6alkoxy or C1-6alkanoyl:

when Ar is a phenyl or a monocyclic heteroaromatic group, substituents positioned ortho to one another may be linked to form a 5- or 6-membered ring;
R1 is hydrogen. C1-6alkyl. C1-6alkenyl. C3-6alkynyl or arylC1-6alkyl;
R2 is halogen. C1-6alkyl, cyano, CF3, C1-6alkanoyl. C1-6alkoxy or hydroxy;
X is CH or N:
Y is a single bond, O, or CO;
p is 0, 1 or 2;
r is 0, 1, 2 or 3;
m is 2, 3 or 4;
n and q are independently 1 or 2.
2. A compound according to claim 1 in which Ar is phenyl, naphthyl, indolyl, quinolinyl, quinazolinyl, indazolyl, isoquinolinyl, cinnolinyl or benzofuranyl, said groups being optionally substituted as defined in claim 1.
3. A compound according to claim 1 or 2, in which Ar is substituted by halogen (particularly fluoro or chloro), C1-6alkyl (particularly methyl, ethyl and propyl), cyano, CF3, C1-6alkoxy (particularly methoxy, ethoxy or isopropoxy), C1-6alkanoyl or a group Ar1-Z as defined in claim 1.
4. A compound according to claim 3, in which Ar1 is a monocyclic heteroaromatic group (particularly isoxazolyl), optionally substituted as defined in claim 1 and Z is a single bond.
5. A compound according to claim 1 in which Ar is 4-indolyl 4-indolyl(2-CN), 5-quinolinyl, 5-quinolinyl(2-Me), 8-quinolinyl, 1-isoquinolinyl, naphthyl, phenyl(2-CN), phenyl(2,3-dichloro), phenyl(3-Br), phenyl(3-Me), phenyl(3-CF3), phenyl(2-propyl), phenyl(2-CN, 4-F), phenyl(2-(5-isoxazolyl), phenyl(3-ethyl-4-Cl), 2,2-dimethyl-2,3-dihydrobenzobfuran-7-yl, (5-F)-2,2,2-dimethyl-2,3-dihydrobenzobfuran-7-yl, (6-F)-3,4-dihydro-2H-benzobpyranyl. (2,2-dimethyl)3,4-dihydro-2H-benzobpyranyl, 5-oxo-5,6,7,8-tetrahydronaphthyl 7-(2,3-dihydrobenzofuranyl), 7-(2-methyl)benzobfuranyl, 7-benzobfuranyl, 5-quinolinyl(2-Me, 8-Cl), 5-quinolinyl(2Me, 8-F), 5-quinolinyl(2-Me, 7-Cl), 5-quinolinyl(2Me, 7-F) or 5-quinazolinyl(2Me).
6. A compound according to any of claims 1 to 5, wherein r is 0, 1 or 2.
7. A compound according to any of claims 1 to 6, wherein R2 is halogen, particularly fluoro.
8. A compound according to any of claims 1 to 7, in which R1 is hydrogen or methyl.
9. A compound according to any of claims 1 to 8, in which m is 2.
10. A compound according to claim 1 which is a compound selected from Example E1-E 167 or a pharmaceutically acceptable salt thereof.
11. A compound according to claim 1 which is:
6-(4-(1-(2-(4-1H-Indolyloxy)ethyl)piperidinyl)oxy)-4H-benzo1,4oxazin-3-one;
6-(4-(1-(2-(4-(2-Cyano)-1H-indolyloxy)ethyl)piperidinyl)oxy)-4H-benzo1,4oxazin-3-one;
6-(4-(1-(3-(2-(5-Isoxazolyl)phenoxy)propyl)piperidinyl)oxy)-4H-benzo1,4oxazin-3-one;
6-(4-(1-(2-(5-Quinolinyloxy)ethyl)piperidinyl)methyl)-4H-benzo1,4oxazin-3-one;
6-(4-(1-(3-(2-Cyanophenoxy)propyl)piperidinyl)oxy)-4H-benxo1,4oxazin-3-one;
6-(4-(1-(3-(7-(2,2-Dimethyl-2,3-dihydro)benzobfuranyloxy)propyl)piperidinyl)-oxy)-4H-benzo1,4oxazin-3-one;
6-(4-(1-(2-(7-(2,2-Dimethyl-2,3-dihydro)benzobfuranyloxy)ethyl)piperidinyl)oxy)-4-methyl-4H-benzo1,4oxazin-3-one;
6-(4-(1-(2-(1-naphthyloxy)ethyl)piperidinyl)oxy)-4-methyl-4H-benzo1,4oxazin-3-one;
()-6-(3-(1 (3-(2-Cyanophenoxy)propyl)piperidinyl)methoxy)-4H-benzo1,4oxazin-3-10 one;
()-6-(3-(1-(3-(2-Cyanophenoxy)propyl)pyrrolidinyl)methoxy)-4H-benzo 1,4oxazin-3-one;
6-(4-(1-(3-(2-(5-Isoxazolyl)phenoxy)propyl)piperazinyl)methyl)-4H-benzo0.4oxazin-3-one;
6-(4-(1-(2-(5-(2-Methyl)quinolinyloxy)ethyl)piperidinyl)methyl)-4H-benzo1,4oxazin-1-one;
6-(4-(1-(2-(5-(3-Methyl)quinolinyloxy)ethyl)piperidinyl)methyl)-4H-benzo1,4oxazin-3-one;
6-(4-(1-(2-(5-quinolinyloxy)ethyl)piperidinyl)methyl)-4H-benzo1,4oxazin-3-one;
6-(4-(1-(2-(4-(1,2-Dihydro)benzobfuranyloxy)ethyl)piperidinyl)methyl)-4H-benzo1,4oxazin-3-one;
6-(4-(1-(2-(4-(1H)-Indazolyloxy)ethyl)piperidinyl)methyl)-4H-benzo1,4oxazin-3-one;
6-(4-(1-(2-(5-(2-Methyl)quinolinyloxy)ethyl)piperidinyl)oxy)-4H-benzo1,4oxazin-3-one;
4-Methyl-6-(4-(1-(2-(5-(2-methyl)quinolinyloxy)ethyl)piperidinyl)oxy)-4H-benzo1,4oxazin-3-one;
6-(4-(1-(2-(5-(2-Methyl)quinolinyloxy)ethyl)piperazinyl)methyl)-4H-benzo1,4oxazin-3-one;
6-(4-(1-(3-(S-(2-methyl)quinolinyloxy)propyl)piperidinyl)methyl)-4H-benzo1,4oxazin-3-one;
6-(4-(1-(2-(5-(2-Methyl)quinolinyloxy)propyl)piperazinyl)methyl)-4-benzo1,4oxazin-3-one;
6-(4-(1-(3-(5-(2-Methyl)quinolinyloxy)propyl)piperidinyl)oxy)-4H-benzo1,4oxazin-3-one;
4-methyl-6-(4-(1-(3-(5-(2-Methyl)quinolinyloxy)propyl)piperidinyl)oxy)-4H-benzo0.4oxazin-3-one:
4-Methyl-6-(4-(1-(2-(5-(2-methyl)quinolinyloxy)ethyl)piperidinyl)methyl)-4H-benzo1,4oxazin-3-one;
6-(4-(1-(2-(5-(8-Chloro-2-methyl)quinolinyloxy)ethyl)piperidinyl)methyl)-4H-benzo1,4oxazin-3-one;
4-Methyl-6-(4-(1-(3-(5-(2-methyl)quinolinyloxy)propyl)piperidinyl)-methyl)-4H-benzo1,4oxazin-3-one;
6-(4-(1-(2-(5-(8-Chloro-2-methyl)quinolinyloxy)ethyl)piperidinyl)methyl)-4-methyl-4H-benzo1,4oxazin-3-one;
6-(4-(1-(2-(5-(8-Fluoro-2-methyl)quinolinyloxy)ethyl)piperidinyl)methyl)-4H-benzo1,4oxazin-3-one;
6-(4-(1-(2-(5-(8-Fluoro-2-methyl)quinolinyloxy)ethyl)piperidinyl)methyl)-4-methyl-4H-benzo1,4oxazin-3-one;
6-(4-(1-(2-(5-(8-Fluoro-2-methyl)quinolinyloxy)ethyl)piperidinyl)oxy)-4H-benzo1,4oxazin-3-one,
6-(4-(1-(2-(5-(8-Fluoro-2-methyl)quinolinyloxy)ethyl)piperidinyl)oxy)-4-methyl-4H-benzo1,4oxazin-3-one-
6-(4-(1-(2-(5-(7-Chloro-2-methyl)quinolinyloxy)ethyl)piperidinyl)methyl)-4H-benzo 1,4oxazin-3-one;
6-(4-(1-(2-(5-(7-Chloro-2-methyl)quinolinyloxy)ethyl)piperidinyl)methyl)-4-methyl-4H-benzo1,4oxazin-3-one;
6-(4-(1-(5-(7-Chloro-2-methyl)quinolinyloxy)ethyl)piperidinyl)oxy)-4H-benzo1,4oxazin-3-one;
6-(4-(2-(5-(7-Chloro-2-methyl)quinolinyloxy)ethyl)piperidinyl)oxyl)-4-methyl-4H-benzo1,4oxazin-3-one;
6-(4-(1-(2-(5-(7-Chloro-2-methyl)quinolinyloxy)ethyl)piperazinyl)methyl)-4H-benzo1,4oxazin-3-one;
6-(4-(1-(3-(5-(7-Chloro-2-methyl)quinolinyloxy)propyl)piperidinyl)oxy)-4H-benzo1,4oxazin-3-one;
6-(4-(1-(2-(5-(7-Chloro-2-methyl)quinolinyloxy)propyl)piperidinyl)oxy)-4-methyl-4H-benzo1,4oxazine-3-one;
6-(4-(1-(3-(5-(2-Methyl)quinolinyloxy)ethyl)piperidinyl)methyl)-4-(2-propyl)-4H-benzo1,4oxazin-3-one:
6-(4-(1-(2-(5-(2-methyl)quinolinyloxy)ethyl)piperidinyl)methyl)-4H-benzo1,4-10 oxazin-3-one:
6-(4-(1-(2)-(5-(7-Fluoro-2-methyl)quinolinyloxy)ethyl)piperidinyl)methyl)-4H-benzo1,4oxazin-3-one:
7-Fluoro-6-(4-(1-(2-(5-(2-methyl)quinolinyloxy)ethyl)piperidinyl)methyl)-4H-benzo1,4oxazin-3-one;
8-Fluoro-4-methyl-6-(4-(1-(2-(5-(2-methyl)quinolinyloxy)ethyl)piperidinyl) methyl)-4H-benzo1,4oxazin-3-one;
8-Fluoro-6-(4-(1-(2-(5-(2-methyl)quinolinyloxy)ethyl)piperidinyl)methyl)-4H-benzo1,4oxazin-3-one;
7,8-Difluoro-6-(4-(1-(2-(5-(2-methyl)quinolinyloxy)ethyl)piperazinyl)methyl)-4H-benzo1,4oxazin-3-one,
4-Ethyl-6-1-2-)-(2-methyl-quinolin-5-yloxy)-ethyl-piperidin-4-ylmethyl-4H-benzo1,4oxazin-3-one
or a pharmaceutically acceptable salt thereof.
12. A process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof, which process comprises:
(a) the coupling of a compound of formula (II):
50
in which R1R2, Y, n, p, q and r are defined in formula (1),
with a compound of formula (III):
51
in which Ar and m are as defined for formula (I) and L is a leaving group: or
(b) reacting a compound of formula (11) as defined above with a compound of formula (IV)
52
in which Ar and m are defined in formula (l), in the presence of a reducing agent; or
(c) for a compound of formula (I) wherein X is N, reacting a compound of formula
(v):
53
in which p, R2, r and R1 are as defined in formula (1), with a compound of formula (VI):
54
in which Ar, m, q and n are as defined in formula (I), in the presence of a reducing agent;
and optionally thereafter for each of process (a). (b) or (c):
removing any protecting groups, andor
converting a compound of formula (I) into another compound of formula (I), andor
forming a pharmaceutically acceptable salt.
13. A pharmaceutical composition which comprises a compound according to any one of claims 1 to 11 and a pharmaceutically acceptable carrier or excipient.
14. A process for preparing a pharmaceutical composition according to claim 13, the process comprising mixing a compound according to any one of claims 1 to 11 and a pharmaceutically acceptable carrier or excipient.
15. A compound according to any one of claims 1 to 11 or a composition according, to claim 13 for use in therapy.
16. A compound according to any one of claims 1 to 11 or a composition according to claim 13 for use in the treatment or prophylaxis of CNS and other disorders.
17. A compound according to any one of claims 1 to 11 or a composition according to claim 13 for use in the treatment or prophylaxis of depression andor anxiety.
18. A method of treating CNS and other disorders which comprises administering a safe and therapeutically effective amount to a patient in need thereof of a compound according to any one of claims 1 to 11 or a pharmaceutically acceptable salt thereof, or a composition according to claim 13.
19. A method according to claim 18, wherein the disorder is depression andor anxiety.
20. The use of a compound according to any one of claims 1 to 11 or a pharmaceutically acceptable salt thereof, or a composition according to claim 13, in the manufacture of a medicament for the treatment or prophylaxis of CNS and other disorders.
21. The use as claimed in claim 20, wherein the medicament is for the treatment or prophylaxis of depression andor anxiety.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A cardiopulmonary resuscitator, comprising:
a panel for supporting a patient;
a first belt, disposed at a side of the panel, for wrapping around a chest of the patient;
a flexible body, disposed on one side of the panel opposite to the side for supporting the patient, functioning to tighten and loosen the first belt for compressing and releasing the chest of the patient through a inflating and deflating motion generated by a pneumatic power; and
a controlling module, connected to a pneumatic source, being capable of adjusting the airflow provided from the pneumatic source to pass in and out the flexible body.
2. The cardiopulmonary resuscitator according to claim 1, wherein the flexible body is a bladder.
3. The cardiopulmonary resuscitator according to claim 1, further comprises a second belt with two ends connecting to two ends of the first belt respectively and contacting with the flexible body.
4. The cardiopulmonary resuscitator according to claim 3, wherein there is a buckle disposed between the first belt and the second belt.
5. The cardiopulmonary resuscitator according to claim 3, further comprises a hook-and-loop fastener disposed between the second belt and the flexible body for attaching the flexible body to the second belt.
6. The cardiopulmonary resuscitator according to claim 1, wherein the pneumatic source is selected from a group consisting a high pressure bottle and a inflator, which generates air through a compression and inflation movement operated by a action force.
7. The cardiopulmonary resuscitator according to claim 1, further comprising a massage pad, made of a rubber material and disposed on side of the first belt toward the chest of the patient.
8. The cardiopulmonary resuscitator according to claim 1, wherein the panel further comprises a handle for carrying.
9. The cardiopulmonary resuscitator according to claim 1, wherein the first belt further comprises a fastener for adjusting the first belt according to size of the chest of the patient.