1. A system for reducing noise in an integrated circuit (IC) comprising:
a primary circuit including a first header communicating with a first power supply voltage for powering-up a voltage island circuit on the IC and functional circuitry on the IC;
a secondary circuit including a secondary header communicating with a second power supply voltage for powering-up the voltage island;
a programmed device for directing the primary and secondary circuits for powering the voltage island circuit and functional circuitry, the programmed device directing the secondary circuit to initially enable powering-up of the voltage island circuit to a pre-charged state, and subsequently disabling the secondary circuit while directing the primary circuit to enable powering of the functional circuitry during operation and the voltage island circuit, wherein a step response is avoided at the voltage island,
wherein said primary circuit is sized to provide required load currents for functional operation of the IC at low voltage droop,
wherein said programmed device controls said first and second headers for managing the state of the first and secondary headers of the at least one voltage island, and wherein said programmed device operates as a header control for prioritizing initial power requests for multiple voltage islands.
2. The system according to claim 1 wherein the primary circuit and the secondary circuit include primary and secondary switches, respectively.
3. The system according to claim 2, wherein the primary switch includes a primary transistor and the secondary switch includes a secondary transistor.
4. The system according to claim 1 wherein the primary circuit communicates with the first power supply via a first power path on the IC chip; and the secondary circuit communicates with the second power supply via a secondary power path on the IC chip.
5. The system according to claim 4 wherein the second power supply connects to a plurality of secondary circuits.
6. A device for eliminating step response power supply perturbation during voltage island power-uppower-down on an integrated circuit, which comprises:
an IC chip including a primary power supply and a secondary power supply, and the IC chip includes at least one voltage island;
a primary header on the voltage island of the IC chip, the primary header communicating with the primary power supply;
a secondary header on the voltage island of the IC chip, the secondary header communicating with the secondary power supply;
a control decoder communicating with the IC chip and the voltage island for regulating the state of the primary and secondary headers, and
said device further including a header control system for managing the primary and secondary header of the at least one voltage island, wherein the header control system prioritizes initial power requests for multiple voltage islands.
7. The device of claim 6 wherein the control decoder sequentially enables the secondary header on the voltage island while the primary header on the voltage island is disabled, and the control decoder disables the secondary header on the voltage island and near simultaneously enables the primary header on the voltage island.
8. The device according to claim 7 wherein the control decoder prevents disabling the secondary header on the voltage island and near simultaneously enabling the primary header on the voltage island during a period when noise is on the secondary header or the secondary voltage is not substantially equal to the primary voltage.
9. The device according to claim 6 wherein the secondary header power supply connects to a plurality of secondary headers.
10. The device according to claim 6 wherein the secondary header power supply connects to a plurality of secondary headers on a plurality of IC chips.
11. A device for eliminating step response power supply perturbation during voltage island power-uppower-down on an integrated circuit, which comprises:
an IC chip including a primary power supply and a secondary power supply, and the IC chip includes at least one voltage island;
a primary header on the voltage island of the IC chip, the primary header communicating with the primary power supply;
a secondary header on the voltage island of the IC chip, the secondary header communicating with the secondary power supply; and
a control decoder communicating with the IC chip and the voltage island for regulating the state of the primary and secondary headers, wherein the primary header on the voltage island of the IC chip communicates with the primary power supply via a primary header power path on the IC chip; and the secondary header on the voltage island of the IC chip communicates with the secondary power supply via a secondary header power path on the IC chip, said device further including a header control system for managing a plurality of voltage islands which each include the primary and secondary headers, and the plurality of voltage islands sharing the secondary power supply via the secondary header power path such that the header control system limits loading of the secondary power supply.
12. The device according to claim 11 wherein the voltages on the primary header and the secondary header are substantially the same.
13. A method for eliminating step response power supply perturbation during voltage island power-uppower-down on an integrated circuit, comprising:
providing an IC chip communicating with a primary power supply, and the IC chip including at least one voltage island;
providing a primary header on the voltage island of the chip, the primary header communicating with the primary power supply via a primary header power path;
providing a secondary header on the voltage island of the chip, the secondary header communicating with a secondary power supply via a secondary header power path;
providing a control decoder communicating with the IC chip and the at least one voltage island;
requesting an initial power-up of the voltage island;
enabling the secondary header using the control decoder;
disabling the secondary header using the control decoder;
enabling the primary header using the control decoders,
wherein a primary circuit is sized to provide required load currents for functional operation of the IC at low voltage droop,
providing a header control system for managing the primary and secondary headers of the at least one voltage island, wherein said header control system prioritizes initial power requests for multiple voltage islands.
14. The method of claim 13 wherein the secondary header is disabled and the primary header is enabled near simultaneously.
15. The method of claim 13 further comprising a power down sequence including a series of stepped reductions in current demand from the voltage island when the primary header is switched from enabled to a disabled mode using the control decoder.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A labeling reagent for use in mass spectrometry, represented by formula I;
including a salt form andor hydrate form thereof; wherein,
Y is a 5, 6 or 7 membered heterocyclic ring that may be substituted or unsubstituted and that may optionally be cleavably linked to a support, wherein the heterocyclic ring comprises at least one ring nitrogen atom that is linked through a covalent bond to the group J;
J is a group represented by formula \u2014CJ\u20322-, wherein each J\u2032 is, independently of the other, hydrogen, deuterium, fluorine, chlorine, bromine, iodine, \u2014R3, \u2014OR3, \u2014SR3, \u2014R3\u2032OR3 or \u2014R3\u2032SR3;
K is a group represented by formula \u2014(CK\u20322)n\u2014 or \u2014((CK\u20322)m\u2014X2\u2014(CK\u20322)m)p, wherein n is 0 or an integer from 2 to 10, each in is, independently of the other, an integer from 1 to 5, p is an integer from 1 to 4 and each K\u2032 is, independently of the other, hydrogen, deuterium, fluorine, chlorine, bromine, iodine, \u2014R4, \u2014OR4, \u2014SR4, \u2014R4\u2032OR4 or \u2014R4\u2032SR4;
either
1) R1 is hydrogen, deuterium or R6 and R2 is hydrogen, deuterium or R7;
or
2) R1 and R2 taken together is a group represented by formula \u2014(CR\u20322)q\u2014 or \u2014((CR\u20322)m\u2014X2\u2014(CR\u20322)m)p\u2014 that forms a ring that bridges the two nitrogen atoms, wherein q is an integer from 1 to 10, each in is, independently of the other, an integer from 1 to 5, p is an integer from 1 to 4 and each R\u2032 is, independently of the other, hydrogen, deuterium, fluorine, chlorine, bromine, iodine, \u2014R5, \u2014OR5, \u2014SR5, \u2014R5\u2032OR5 or \u2014R5\u2032SR5;
X1 is \u2550O, \u2550S, \u2550NH or \u2550NR7;
each X2 is, independently of the other, \u2014O\u2014 or \u2014S\u2014; and
Z is hydrogen or a covalently linked analyte;
wherein,
each R3, R4, R5, R6, andor R7 is, independently of the other, alkyl, alkenyl, alkynyl, aryl, heteroaryl or arylalkyl;
each R3\u2032, R4\u2032, andor R5\u2032 is, independently of the other, alkylene, alkenylene, alkynylene, arylene or alkylarylene; and
the labeling reagent comprises at least one isotopically enriched site.
2. The labeling reagent of claim 1, wherein the group Y-J comprises at least one isotopically enriched site.
3. The labeling reagent of claim 1, wherein the group represented by formula I#;
comprises at least one isotopically enriched site;
wherein,
K is a group represented by formula \u2014(CK\u20322)n\u2014 or \u2014((CK\u20322)m\u2014X2\u2014(CK\u20322)m)p, wherein n is 0 or an integer from 2 to 10, each m is, independently of the other, an integer from 1 to 5, p is an integer from 1 to 4 and each K\u2032 is, independently of the other, hydrogen, deuterium, fluorine, chlorine, bromine, iodine, \u2014R4, \u2014OR4, \u2014SR4, \u2014R4\u2032OR4 or \u2014R4\u2032SR4;
either
1) R1 is hydrogen, deuterium or R6 and R2 is hydrogen, deuterium or R7;
or
2) R1 and R2 taken together is a group represented by formula \u2014(CR\u20322)q\u2014 or \u2014((CR\u20322)m\u2014X2\u2014(CR\u20322)m)p\u2014 that forms a ring that bridges the two nitrogen atoms, wherein q is an integer from 1 to 10, each m is, independently of the other, an integer from 1 to 5, p is an integer from 1 to 4 and each R\u2032 is, independently of the other, hydrogen, deuterium, fluorine, chlorine, bromine, iodine, \u2014R5, \u2014OR5, \u2014SR5, \u2014R5\u2032OR5 or \u2014R5\u2032SR5;
X1 is \u2550O, \u2550S, \u2550NH or \u2550NR7; and
each X2 is, independently of the other, \u2014O\u2014 or \u2014S\u2014;
wherein,
each R4, R5, R6, andor R7 is, independently of the other, alkyl, alkenyl, alkynyl, aryl, heteroaryl or arylalkyl; and
each R4\u2032, andor R5\u2032 is, independently of the other, alkylene, alkenylene, alkynylene, arylene or alkylarylene.
4. The labeling reagent of claim 1, wherein the group represented by formula Y-J comprises at least one isotopically enriched site and the group represented by formula I#;
comprises at least one isotopically enriched site;
wherein,
Y is a 5, 6 or 7 membered heterocyclic ring that may be substituted or unsubstituted and that may optionally be cleavably linked to a support, wherein the heterocyclic ring comprises at least one ring nitrogen atom that is linked through a covalent bond to the group J;
J is a group represented by formula \u2014CJ\u20322-, wherein each J\u2032 is, independently of the other, hydrogen, deuterium, fluorine, chlorine, bromine, iodine, \u2014R3, \u2014OR3, \u2014SR3, \u2014R3\u2032OR3 or \u2014R3\u2032SR3;
K is a group represented by formula \u2014(CK\u20322)n\u2014 or \u2014((CK\u20322)m\u2014X2\u2014(CK\u20322)m)p, wherein n is 0 or an integer from 2 to 10, each m is, independently of the other, an integer from 1 to 5, p is an integer from 1 to 4 and each K\u2032 is, independently of the other, hydrogen, deuterium, fluorine, chlorine, bromine, iodine, \u2014R4, \u2014OR4, \u2014SR4, \u2014R4\u2032OR4 or \u2014R4\u2032SR4;
either
1) R1 is hydrogen, deuterium or R6, and R2 is hydrogen, deuterium or R7;
or
2) R1 and R2 taken together is a group represented by formula \u2014(CR\u20322)q\u2014 or \u2014((CR\u20322)m\u2014X2\u2014(CR\u20322)m)p\u2014 that forms a ring that bridges the two nitrogen atoms, wherein q is an integer from 1 to 10, each in is, independently of the other, an integer from 1 to 5, p is an integer from 1 to 4 and each R\u2032 is, independently of the other, hydrogen, deuterium, fluorine, chlorine, bromine, iodine, \u2014R5, \u2014OR5, \u2014SR5, \u2014R5\u2032OR5 or \u2014R5\u2032SR5;
X1 is \u2550O, \u2550S, \u2550NH or \u2550NR7; and
each X2 is, independently of the other, \u2014O\u2014 or \u2014S\u2014;
wherein,
each R3, R4, R5, R6, andor R7 is, independently of the other, alkyl, alkenyl, alkynyl, aryl, heteroaryl or arylalkyl; and
each R3\u2032, R4\u2032, andor R5\u2032 is, independently of the other, alkylene, alkenylene, alkynylene, arylene or alkylarylene.
5. The labeling reagent of claim 1, represented by formula III*;
including a salt form andor hydrate form thereof;
wherein,
R11 is hydrogen, deuterium, methyl, \u2014C(H)2D, \u2014C(H)D2, \u2014CD3 or \u2014R\u2032\u2033,
Z is hydrogen or a covalently linked analyte;
wherein,
R\u2032\u2033 is H2N\u2014R9\u2032\u2014, H(R10)N\u2014R9\u2032\u2014, (R10)2N\u2014R9\u2032\u2014, HO\u2014R9\u2032\u2014, HS\u2014R9\u2032\u2014 or a cleavable linker that cleavably links the compound to a support; and
wherein,
each R9\u2032 is, independently of the other, alkylene, alkenylene, alkynylene, arylene or alkylarylene; and
each R10 is, independently of the other, alkyl, alkenyl, alkynyl, aryl, heteroaryl or arylalkyl.
6. The labeling reagent of claim 5, wherein the labeling reagent is, represented by formula M, MI, MII, MIII, MIV or MV;
including a salt form andor hydrate form thereof;
wherein,
* indicates an isotopically enriched site comprising a 13C substituted for 12C, 15N substituted for 14N or 18O substituted for 16O, as appropriate; and
Z is hydrogen or a covalently linked analyte.
7. The labeling reagent of claim 5, wherein the labeling reagent is represented by formula MVI, MVII, MVIII, MIX, MX, MXI, MXII or MXIII:
including a salt form andor hydrate form thereof;
wherein,
* indicates an isotopically enriched site comprising a 13C substituted for 12C or 15N substituted for 14N, as appropriate; and
Z is hydrogen or a covalently linked analyte.
8. A labeling reagent for use in mass spectrometry represented by formula B:
wherein the labeling reagent comprises at least one isotopically enriched site.
9. A set of isobaric labeling reagents, comprising the reagents represented by formula BI, BII, BIII and BIV:
wherein * indicates an isotopically enriched site comprising a 13C substituted for 12C, 15N substituted for 14N or 18O substituted for 16O, as appropriate.
10. A set of structurally similar labeling reagents of different gross mass, comprising the reagents represented by formula BI and BV:
wherein * indicates an isotopically enriched site comprising a 13C substituted for 12C or 15N substituted, as appropriate.
11. The labeling reagent of claim 1, wherein Z is a covalently linked analyte and a reactive group of the analyte is a carboxylic acid.
12. The labeling reagent of claim 11, wherein said covalently linked analyte is selected from the group consisting of prostaglandins, fatty acids, carnitines, and salts thereof.