We claim:
1. An apparatus, comprising:
an application server component that communicates to one or more mobile stations, of a plurality of mobile stations, one or more updates of one or more statuses of respective one or more mobile stations of the plurality of mobile stations;
wherein the plurality of mobile stations comprise a first mobile station and a second mobile station, wherein the one or more updates of the one or more statuses of the respective one or more mobile stations comprise an update of a status of the first mobile station;
wherein the application server component communicates the update of the status of the first mobile station to the second mobile station to indicate to the second mobile station whether the first mobile station is available for participation in a call with the second mobile station.
2. The apparatus of claim 1, wherein the update of the status of the first mobile station comprises a first update of the status of the first mobile station;
wherein the first mobile station comprises a status-change component, wherein a user of the first mobile station employs the status-change component to communicate a change in the status of the first mobile station to the application server component;
wherein based on the change in the status of the first mobile station, the application server component communicates a second update of the status of the first mobile station to the second mobile station.
3. The apparatus of claim 1, wherein the update of the status of the first mobile station indicates to the second mobile station that the first mobile station is available for participation in the call with the second mobile station, the apparatus further comprising:
a telecommunications network component;
wherein upon an involvement by the first mobile station in a call with a third mobile station of the plurality of mobile stations, the telecommunications network component communicates to the application server component the involvement of the first mobile station in the call with the third mobile station.
4. The apparatus of claim 3, wherein the update of the status of the first mobile station comprises a first update of the status of the first mobile station, wherein the second mobile station comprises a buddy list that is administered by a user of the second mobile station, wherein the buddy list comprises an indication of the first mobile station;
wherein the one or more updates of the one or more statuses of the respective one or more mobile stations comprise a second update of the status of the first mobile station;
wherein based on the involvement of the first mobile station in the call with the third mobile station the application server component communicates to the second mobile station the second update of the status of the first mobile station;
wherein the second update of the status of the first mobile station indicates to the second mobile station that the first mobile station is unavailable for participation in a call with the second mobile station.
5. The apparatus of claim 4, wherein upon completion of the call with the third mobile station, the telecommunications network component communicates to the application server component the completion of the call with the third mobile station;
wherein the one or more updates of the one or more statuses of the respective one or more mobile stations comprise a third update of the status of the first mobile station;
wherein based on the completion of the call with the third mobile station the application server component communicates to the second mobile station the third update of the status of the first mobile station;
wherein the third update of the status of the first mobile station indicates to the second mobile station that the first mobile station is available for participation in a call with the second mobile station.
6. The apparatus of claim 1, wherein the second mobile station comprises a buddy list that is administered by a user of the second mobile station, wherein the buddy list comprises an indication of the first mobile station;
wherein the application server component employs the buddy list to monitor the status of the first mobile station;
wherein the application server component employs the buddy list to generate the update of the status of the first mobile station.
7. The apparatus of claim 1, wherein the first mobile station notifies the application server component upon a change in the status of the first mobile station.
8. The apparatus of claim 1, further comprising:
a telecommunications network component, wherein the application server component communicates the update of the status of the first mobile station to the second mobile station through the telecommunications network component.
9. The apparatus of claim 8, wherein the telecommunications network component notifies the application server component upon a change in the status of the first mobile station.
10. The apparatus of claim 8, wherein the telecommunications network component comprises a user profile database, wherein the user profile database comprises a buddy list that is administered by a user of the second mobile station, wherein the buddy list comprises an indication of the first mobile station;
wherein the application server component employs the buddy list to monitor the status of the first mobile station;
wherein the application server component employs the buddy list to generate the update of the status of the first mobile station.
11. The apparatus of claim 10, wherein the buddy list comprises an indication of the first mobile station and one or more additional mobile stations of the plurality of mobile stations, wherein the one or more updates of the one or more statuses of the respective one or more mobile stations comprise one or more updates of one or more statuses of the one or more additional mobile stations, respectively;
wherein the application server component employs the buddy list to monitor the one or more statuses of the one or more additional mobile stations, respectively;
wherein the application server component employs the buddy list to generate the one or more updates of the one or more statuses of the one or more additional mobile stations, respectively.
12. The apparatus of claim 8, wherein the call comprises a first call, wherein the telecommunications network component comprises a user profile database, wherein the user profile database comprises a reverse-buddy list of the second mobile station;
wherein the reverse-buddy list comprises a list of one or more mobile stations of the plurality of mobile stations that administer a buddy list that comprises an indication of the second mobile station;
wherein the one or more updates of the one or more statuses of the respective one or more mobile stations comprise an update of a status of the second mobile station;
wherein the application server component communicates the update of the status of the second mobile station to the one or more mobile stations, that administer the buddy list that comprises the indication of the second mobile station, to indicate whether the first mobile station is available for participation in a second call.
13. The apparatus of claim 8, wherein the telecommunications network component comprises a user profile database, wherein the user profile database comprises a buddy list that is administered by a user of the second mobile station, wherein the buddy list comprises an indication of the first mobile station;
wherein upon receipt by the application server component of a call request from the second mobile station to the first mobile station the application server component translates the call request from the indication of the first mobile station to a termination address of the first mobile station.
14. The apparatus of claim 8, wherein the telecommunications network component comprises a session control component and a user profile database, wherein upon a change in the status of the first mobile station, the session control component retrieves a profile of the first mobile station from the user profile database;
wherein the session control component employs the profile to determine permissions for the first mobile station.
15. The apparatus of claim 1, wherein the plurality of mobile stations comprises a plurality of mobile telephones, wherein the first mobile station comprises a first mobile telephone of the plurality of mobile telephones, wherein the second mobile station comprises a second mobile telephone of the plurality of mobile telephones.
16. The apparatus of claim 1, wherein the call comprises any one or more of voice communication, data communication, and messaging.
17. A method, comprising the steps of:
monitoring one or more statuses of respective one or more mobile telephones of a plurality of mobile telephones, wherein the plurality of mobile telephones comprise a first mobile telephone and a second mobile telephone; and
communicating to the first mobile telephone an update of a status, of the one or more statuses, of the second mobile telephone.
18. The method of claim 17, wherein the step of monitoring the one or more statuses of the respective one or more mobile telephones of the plurality of mobile telephones comprises the steps of:
detecting by a telecommunications network component the one or more statuses of the respective one or more mobile telephones; and
storing the one or more statuses of the respective one or more mobile telephones in a user profile database.
19. The method of claim 17, wherein the step of communicating to the first mobile telephone the update of the status of the second mobile telephone comprises the steps of:
accessing a buddy list of the first mobile telephone that comprises an indication of the one or more mobile telephones;
retrieving the one or more statuses of the respective one or more mobile telephones; and
communicating to the first mobile telephone an update of the one or more statuses of the respective one or more mobile telephones.
20. The method of claim 17, wherein the step of communicating to the first mobile telephone the update of the status of the second mobile telephone comprises the steps of:
receiving from the second mobile telephone an indication of a change in the status of the second mobile telephone; and
sending the indication to the first mobile telephone.
21. The method of claim 20, further comprising the step of:
sending the indication to one or more mobile telephones of the plurality of mobile telephones that administer a buddy list that comprises an indication of the second mobile telephone.
22. The method of claim 17, further comprising the steps of:
translating a call request made by the first mobile telephone to initiate a call with a third mobile telephone of the plurality of mobile telephones from an indication of the third mobile telephone to a termination address that corresponds to the third mobile telephone; and
connecting the first mobile telephone with the termination address for mobile communication with the third mobile telephone.
23. The method of claim 17, wherein the step of communicating to the first mobile telephone the update of the status of the second mobile telephone comprises the step of:
notifying a telecommunications network component of a busy status of the second mobile telephone to alert one or more mobile telephones of the plurality of mobile telephones that the second mobile telephone is unavailable for mobile communication.
24. An article, comprising:
one or more computer-readable signal-bearing media;
means in the one or more media for monitoring one or more statuses of respective one or more mobile telephones of a plurality of mobile telephones, wherein the plurality of mobile telephones comprise a first mobile telephone and a second mobile telephone; and
means in the one or more media for communicating to the first mobile telephone an update of a status, of the one or more statuses, of the second mobile telephone.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
What is claimed is:
1. A method for inhibiting the growth or proliferation of a colon neoplasia in a subject, the method comprising administering to the subject an agent that decreases the amount of a polypeptide present in or produced by the colon neoplasia, said polypeptide selected from among: ColoUp1, ColoUp2, ColoUp3, ColoUp4, ColoUp5, ColoUp6, ColoUp7 and ColoUp8.
2. The method of claim 1, wherein the agent is an siRNA probe that hybridizes to an MRNA encoding a polypeptide selected from among: ColoUp 1, ColoUp2, ColoUp3, ColoUp4, ColoUp5, ColoUp6, ColoUp7 and ColoUp8.
3. The method of claim 2, wherein the siRNA probe hybridizes to a nucleic acid selected from among: SEQ ID Nos. 4, 5 and 7-12.
4. The method of claim 1, wherein the agent is an antisense probe that hybridizes to a nucleic acid encoding a polypeptide selected from among: ColoUp1, ColoUp2, ColoUp3, ColoUp4, ColoUp5, ColoUp6, ColoUp7 and ColoUp8.
5. The method of claim 4, wherein the antisense probe hybridizes to a nucleic acid selected from among: SEQ ID Nos. 4, 5 and 7-12.
6. The method of claim 1, wherein the agent is a nucleic acid vector that causes the production of a siRNA or an antisense probe that hybridizes to a nucleic acid encoding a polypeptide selected from among: ColoUp1, ColoUp2, ColoUp3, ColoUp4, ColoUp5, ColoUp6, ColoUp7 and ColoUp8.
7. The method of claim 6, wherein the siRNA or antisense probe hybridizes to a nucleic acid selected from among: SEQ ID Nos. 4, 5 and 7-12.
8. A method for inhibiting the growth or proliferation of a cell of a colon neoplasia in a subject, the method comprising administering to the subject an agent that binds to and antagonizes a polypeptide selected from among: ColoUp1, ColoUp2, ColoUp3, ColoUp4, ColoUp5, ColoUp6, ColoUp7 and ColoUp8.
9. The method of claim 8, wherein the agent is an antibody that binds to a polypeptide selected from among ColoUp1, ColoUp2, ColoUp3, ColoUp4, ColoUp5, ColoUp6, ColoUp7 and ColoUp8.
10. The method of claim 9, wherein the polypeptide is selected from among: SEQ ID Nos. 1-3, 13, 14 and 16-21.
11. The method of claim 9, wherein the antibody comprises a monoclonal antibody.
12. The method of claim 9, wherein the antibody comprises a polyclonal antibody.
13. The method of claim 9, wherein the antibody comprises a single chain antibody.
14. The method of claim 9, wherein the antibody comprises a humanized antibody.
15. The method of claim 8, wherein the agent is a small molecule that binds to a polypeptide selected from among: SEQ ID Nos. 1-3, 13, 14 and 16-21.
16. A therapeutic agent that is targeted to a colon neoplasia, the agent comprising a targeting moiety and an active moiety, wherein the targeting moiety binds to a polypeptide selected from among ColoUp1, ColoUp2, ColoUp3, ColoUp4, ColoUp5, ColoUp6, ColoUp7 and ColoUp8 and wherein the active moiety facilitates the killing or growth inhibition of a cell of a colon neoplasia.
17. The therapeutic agent of claim 16, wherein the targeting moiety comprises an antibody.
18. The therapeutic agent of claim 17, wherein the antibody binds to a polypeptide selected from among SEQ ID Nos. 1-3, 13, 14 and 16-21.
19. The therapeutic agent of claim 18, wherein the antibody is selected from among: a monoclonal antibody, a polyclonal antibody, a single chain antibody.
20. The therapeutic agent of claim 18, wherein the antibody is a humanized antibody.
21. The therapeutic agent of claim 16, wherein the active moiety sensitizes the cell to a chemotherapeutic agent or radiation.
22. A method of identifying a candidate agent for treating colon cancer, the method comprising: identifying a candidate agent that binds to andor inhibits an activity of a polypeptide selected from among: ColoUp1, ColoUp2, ColoUp3, ColoUp4, ColoUp5, ColoUp6, ColoUp7 and ColoUp8.
23. The method of claim 22, further comprising testing the candidate agent for antineoplastic effects on a cell of a colon neoplasia or a cell of a cell line derived from a colon neoplasia.
24. The method of claim 22, further comprising testing the candidate agent for antineoplastic effects on a mouse xenograft comprising cells of a human colon cancer or cells of a cell line derived from a colon cancer cell line.
25. The method of claim 22, wherein the candidate agent is a siRNA probe or an antisense probe.
26. The method of claim 22, wherein the candidate agent is an antibody.
27. The method of claim 22, wherein the candidate agent is a small molecule.