1. A method of obtaining a corn plant with improved tar spot complex (TARSC) resistance comprising:
a) providing a population of corn plants;
b) detecting in said population a plant comprising a TARSC resistance allele at a polymorphic locus in, or genetically linked to, a chromosomal segment between 0 cM (0 IcM) and 17.8 cM (approximately 74.5 IcM) on chromosome 10; and
c) selecting said plant from said population based on the presence of said allele.
2. The method of claim 1, wherein said segment is flanked by loci SEQ ID NO: 1 and SEQ ID NO: 7 on chromosome 10.
3. The method of claim 2, wherein said segment is flanked by loci SEQ ID NO: 4 and SEQ ID NO: 6 on chromosome 10.
4. The method of claim 1, wherein said segment is located between 3.99 cM (approximately 8 IcM) and 17.7 cM (approximately 74.1 IcM), between 9.4 cM (approximately 35.8 IcM) and 13.7 cM (approximately 57.5 IcM), or between 8.3 cM (approximately 31.9 IcM) and 11.9 cM (approximately 50.2 IcM) on chromosome 10.
5. The method of claim 1, wherein said polymorphic locus comprises a sequence selected from the group consisting of SEQ ID NOs: 1, 2, 3, 4, 5, 6, 7, and 36.
6. The method of claim 1, wherein said plant exhibits increased yield relative to a control plant not comprising said TARSC resistance allele.
7. The method of claim 1, wherein step (a) of providing comprises crossing a first corn plant comprising a TARSC resistance allele with a second corn plant to produce a population of corn plants.
8. The method of claim 7, wherein producing the population of corn plants comprises backcrossing.
9. The method of claim 1, wherein step (b) of detecting comprises the use of an oligonucleotide probe.
10. A method of producing a corn plant with improved tar spot complex (TARSC) resistance comprising:
a) crossing a first corn plant comprising a TARSC resistance allele with a second corn plant of a different genotype to produce one or more progeny plants; and
b) selecting a progeny plant based on the presence of said allele at a polymorphic locus in, or genetically linked to, a chromosomal segment between 0 cM (0 IcM) and 17.8 cM (approximately 74.5 IcM) on chromosome 10;
wherein said allele confers improved TARSC resistance compared to a plant lacking said allele.
11. The method of claim 10, wherein said segment is flanked by loci SEQ ID NO: 1 and SEQ ID NO: 7 on chromosome 10.
12. The method of claim 11, wherein said segment is flanked by loci SEQ ID NO: 4 and SEQ ID NO: 6 on chromosome 10.
13. The method of claim 10, wherein said segment is located between 3.99 cM (approximately 8 IcM) and 17.7 cM (approximately 74.1 IcM), between 9.4 cM (approximately 35.8 IcM) and 13.7 cM (approximately 57.5 IcM), or between 8.3 cM (approximately 31.9 IcM) and 11.9 cM (approximately 50.2 IcM) on chromosome 10.
14. The method of claim 10, wherein said polymorphic locus comprises a polynucleotide comprising a sequence selected from the group consisting of SEQ ID NOs: 1, 2, 3, 4, 5, 6, 7, and 36.
15. The method of claim 10, wherein said plant exhibits increased yield relative to a control plant not comprising said TARSC resistance allele.
16. The method of claim 10, further comprising:
c) crossing said progeny plant with itself or a second plant to produce one or more further progeny plants; and
d) selecting a further progeny plant comprising said allele.
17. The method of claim 16, wherein step (d) of selecting comprises marker-assisted selection.
18. The method of claim 17, wherein said marker-assisted selection comprises selecting a progeny plant based on the presence of said allele in at least one polymorphic sequence selected from the group consisting of SEQ ID NOs: 1, 2, 3, 4, 5, 6, 7, and 36.
19. The method of claim 16, wherein said further progeny plant is an F2-F7 progeny plant.
20. The method of claim 19, wherein producing the progeny plant comprises backcrossing.
21. The method of claim 20, wherein backcrossing comprises from 2-7 generations of backcrosses.
22. The method of claim 20, wherein backcrossing comprises marker-assisted selection.
23. The method of claim 22, wherein backcrossing comprises marker-assisted selection in at least two generations.
24. The method of claim 23, wherein backcrossing comprises marker-assisted selection in all generations.
25. The method of claim 22, wherein said marker-assisted selection comprises selecting a progeny plant based on the presence of said allele in at least one polymorphic locus selected from the group consisting of: SEQ ID NOs: 1, 2, 3, 4, 5, 6, 7, and 36.
26. The method of claim 10, wherein said first corn plant is an inbred or a hybrid.
27. The method of claim 10, wherein said second corn plant is an agronomically elite corn plant.
28. The method of claim 27, wherein said agronomically elite corn plant is an inbred or a hybrid.
29. A corn plant produced by the method of claim 1.
30. A plant part of the corn plant of claim 29.
31. A seed that produces the plant of claim 29.
32. A corn plant produced by the method of claim 10.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method of evaluating a vessel of a patient, comprising:
introducing at least one instrument into the vessel of the patient;
obtaining from the at least one instrument proximal pressure measurements from within the vessel at a position proximal of a stenosis of the vessel;
obtaining from the at least one instrument distal pressure measurements within the vessel at a position distal of the stenosis of the vessel;
calculating a pressure ratio for each cardiac cycle based on the average distal pressure measurement and the average proximal pressure measurement in the vessel of the patient during each cardiac cycle of the patient;
applying a correlation factor to the calculated pressure ratio to produce a predicted diagnostic pressure ratio, and
displaying the predicted diagnostic pressure ratio to a user.
2. The method of claim 1, wherein the predicted diagnostic pressure ratio correlates to an accepted diagnostic pressure ratio.
3. The method of claim 2, wherein the accepted diagnostic pressure ratio is at least one of fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR).
4. The method of claim 3, wherein the correlation factor has a fixed value.
5. The method of claim 3, wherein the correlation factor is variable.
6. The method of claim 5, wherein the correlation factor has a first correlation value for calculated pressure ratios below a first threshold, a second correlation value for calculated pressure ratios between the first threshold and a second threshold, and a third correlation value for calculated pressure ratios above the second threshold.
7. The method of claim 3, wherein the correlation factor is defined based on a relationship of a slope of a plot of calculated pressure ratios relative to accepted diagnostic pressure ratios.
8. The method of claim 3, wherein the correlation factor is defined based on a relationship of a measure of curvature of a plot of calculated pressure ratios relative to accepted diagnostic pressure ratios.
9. The method of claim 3, wherein the correlation factor is defined based on a relationship of an approximated polynomial function of a plot of calculated pressure ratios relative to accepted diagnostic pressure ratios.
10. The method of claim 3, wherein the correlation factor is defined based on a relationship of an area below the curve of a plot of calculated pressure ratios to accepted diagnostic pressure ratios.
11. A system for evaluating a vessel of a patient, comprising:
one or more instruments sized and shaped for introduction into the vessel of the patient;
a processing system in communication with the one or more instruments, the processing unit configured to:
obtain, from the one or more instruments, proximal pressure measurements measured within the vessel at a position proximal of a stenosis of the vessel;
obtain, from the one or more instruments, distal pressure measurements measured within the vessel at a position distal of the stenosis of the vessel;
calculate a pressure ratio based on the obtained proximal and distal pressure measurements;
apply a correlation factor to the calculated pressure ratio to produce a predicted diagnostic pressure ratio; and
output the predicted diagnostic pressure ratio to a display.
12. The system of claim 11, wherein the predicted diagnostic pressure ratio correlates to an accepted diagnostic pressure ratio.
13. The system of claim 12, wherein the accepted diagnostic pressure ratio is at least one of fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR).
14. The system of claim 13, wherein the correlation factor has a fixed value.
15. The system of claim 13, wherein the correlation factor is variable.
16. The system of claim 15, wherein the correlation factor has a first correlation value for calculated pressure ratios below a first threshold, a second correlation value for calculated pressure ratios between the first threshold and a second threshold, and a third correlation value for calculated pressure ratios above the second threshold.
17. The system of claim 13, wherein the correlation factor is defined based on a relationship of a slope of a plot of calculated pressure ratios relative to accepted diagnostic pressure ratios.
18. The system of claim 13, wherein the correlation factor is defined based on a relationship of a measure of curvature of a plot of calculated pressure ratios relative to accepted diagnostic pressure ratios.
19. The system of claim 13, wherein the correlation factor is defined based on a relationship of an approximated polynomial function of a plot of calculated pressure ratios relative to accepted diagnostic pressure ratios.
20. The system of claim 13, wherein the correlation factor is defined based on a relationship of an area below the curve of a plot of calculated pressure ratios to accepted diagnostic pressure ratios.