1-10. (canceled)
11. A process for preparing a compound of formula III:
or a salt thereof; where R1 is \u2014C1-6alkyl; R2 is \u2014O\u2014C1-5alkyl; R3 is \u2014C1-6alkyl, \u2014C0-3alkylenearyl, \u2014C0-3alkyleneheteroaryl, or \u2014C0-3alkylene-C3-7cycloalkyl; and R4 is \u2014C1-6alkyl, \u2014C0-6alkylene-C3-7cycloalkyl, \u2014C0-6alkylenearyl, or \u2014C0-6alkylenemorpholine; the process comprising the steps of:
(a) reacting a compound of formula I:
with a potassium-C1-6alkyl-trifluoroborate reagent in the presence of a palladium-phosphine catalyst to form a compound of formula 3:
where P is a carboxylic acid protecting group;
(b) reacting the compound of formula 3 with hydroxylamine or a salt thereof to form a compound of formula 4:
(c) reacting the compound of formula 4 with a reducing agent to form a compound of formula II:
or a salt thereof;
(d) reacting the compound of formula II or a salt thereof with a compound of formula 5:
or a salt thereof, in the presence of an amine-carboxylic acid coupling reagent to form a compound of formula 6:
or a salt thereof; and
(e) removing the carboxylic acid protecting group, P, from the compound of formula 6 or a salt thereof, to form a compound of formula III or a salt thereof.
12. The process of claim 11, where the palladium-phosphine catalyst in step (a) is a combination of a palladium catalyst and a source of phosphine.
13. The process of claim 12, where the palladium catalyst is palladium(II)acetate and the source of phosphine is di(1-adamantyl)-n-butylphosphine.
14. The process of claim 11, where the reducing agent in step (c) is hydrogenRaney nickel.
15. The process of claim 11, further comprising the step of preparing a crystalline form of the compound of formula III.
16-29. (canceled)
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1-5. (canceled)
6. A rotary impact tool comprising:
a hammer configured to rotate by receiving a rotational force of a motor;
an anvil configured to rotate by receiving a rotational force of the hammer;
an end tool attached to the anvil;
wherein when a torque of a value not less than a predetermined value is applied to the anvil from the outside, the hammer is disengaged from the anvil to rotate idle and applies an impact to the anvil in a rotational direction after rotating idle by a predetermined angle;
an impact detection device configured to detect impacts; and
a speed switching device configured to switch the rotational speed of the motor,
wherein when the impact detection device detects start of impact during rotation of the anvil in a tightening direction, the speed switching device switches the rotational speed of the motor from a normal speed to a low speed.
7. The rotary impact tool according to claim 6, further comprising a speed adjusting mechanism capable of adjusting between 0 and a predetermined value a difference between the normal speed and the low speed.
8. The rotary impact tool according to claim 6, further comprising a main switch configured to adjust the rotating speed of the motor according to a pulling amount of a trigger, wherein:
both in the case that the motor is switched to the normal speed and in the case that the motor is switched to the low speed, the rotational speed of the motor can be adjusted according to the pulling amount of the trigger.
9. The rotary impact tool according to claim 6, wherein the impact detection device comprises one of a piezoelectric sensor and an acceleration sensor.
10. The rotary impact tool according to claim 6, wherein during the rotation of the anvil in a direction opposite to the tightening direction, the speed switching device does not switch the rotational speed of the motor even in the case that the impact detection device detects an impact.