1. A solid pharmaceutical composition suitable for the oral delivery of a pharmacologically active agent comprising
a. a therapeutically-effective amount of a pharmacologically active agent;
b. pharmaceutically acceptable inactive excipients, and
c. a delivery agent for said pharmacologically active agent, wherein said delivery agent is in micronized form.
2. A composition according to claim 1 wherein the active agent is a peptide.
3. A composition according to claim 2 wherein the peptide is a calcitonin.
4. A composition according to claim 3 wherein the calcitonin is salmon calcitonin.
5. A composition according to claim 1 wherein said inactive excipients are selected from the group consisting of crospovidone and povidone.
6. A composition according to claim 1 wherein the delivery agent is selected from the group consisting of 5-CNAC, SNAD, and SNAC.
7. A composition according to claim 1 wherein the delivery agent is selected from the group consisting of a disodium salt of 5-CNAC, a disodium salt of SNAD, and a disodium salt of SNAC.
8. A composition according to claim 1 which additionally includes a diluent.
9. A composition according to claim 8 wherein the diluent is microcrystalline cellulose.
10. A composition according to claim 1 which additionally includes a lubricant.
11. A composition according to claim 10 wherein the lubricant is magnesium stearate.
12. A method for enhancing the oral bioavailability of a pharmacologically active agent, said method comprising administering to a patient in need of a pharmacologically active agent, an effective amount of a pharmaceutical composition according to claim 1.
13. A method of treatment of bone related diseases and calcium disorders comprising administering to a patient in need of such treatment a therapeutically effective amount of a composition according to claim 1, wherein said pharmacologically active agent is a bone active agent.
14. A method according to claim 13, wherein said pharmacologically active agent is calcitonin.
15. A method according to claim 14 wherein said calcitonin is salmon calcitonin.
16. (canceled)
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A wheel cover attachment device, comprising:
a wheel cover having a flange and a tubular body, the tubular body having an interior surface, a distal end positioned distal from the flange, and a proximate end positioned proximate to the flange; and
an arm attached substantially parallel to the interior surface of the tubular body, the arm having a body between a first end and a second end, the body being separated from the interior surface and compressible toward the interior surface between the first and second ends.
2. The device of claim 1, wherein the first end is attached to the interior surface of the tubular body.
3. The device of claim 2, wherein the second end of the arm contacts the proximate end of the tubular body.
4. The device of claim 3, wherein the body of the arm is separated from the interior surface of the tubular body by from about 5 mm to about 20 mm.
5. An apparatus for attaching a wheel cover to a rear hub axle plate of a wheel of a vehicle, comprising:
a wheel cover having a flange portion and a tubular body having a length, the tubular body having a cylindrical interior surface;
a plurality of arms attached to the cylindrical interior surface of the tubular body along the length of the tubular body, wherein the plurality of arms having a body separated from the cylindrical interior surface for frictionally engaging the rear hub axle plate; and
an attachment cylinder attached to the flange portion of the wheel cover.
6. The apparatus of claim 5, wherein each of the plurality of arms has a first end, a second end and a body located therebetween; the body separated from the interior surface, wherein the body is capable of flexing in a direction of the interior surface of the tubular body.
7. The apparatus of claim 6, wherein the attachment cylinder has a rib for engaging a nut.
8. The apparatus of claim 7, wherein the attachment cylinder has an engagement end, wherein the engagement end has a plurality of notches for the nut.
9. The apparatus of claim 8, wherein the rib is a line of engagement for engagement with the nut.
10. An apparatus for attaching a wheel cover to a rear hub axle plate of a wheel of a vehicle, comprising:
a wheel cover having a tubular body having a cylindrical interior surface having an axis;
an arm attached to the cylindrical interior surface of the tubular body, wherein the arm includes a body positioned substantially parallel to the axis and separated from the cylindrical interior surface for frictionally engaging the rear hub axle plate.
11. The apparatus of claim 10 further comprising a plurality of arms attached to the cylindrical interior surface of the tubular body, wherein the arms each have a body separated from the cylindrical interior surface for frictionally engaging the rear hub axle plate.
12. The apparatus of claim 10 further comprising the arm having a first end attached to the interior surface.
13. A wheel cover attachment device, comprising:
a wheel cover having a flange and a tubular body, the tubular body having an interior surface, a distal end positioned distal from the flange, and a proximate end positioned proximate to the flange; and
an arm attached to the interior surface of the tubular body at a first end and contacting the proximate end of the tubular body at a second end, the arm having a body between the first end and the second end, the body being separated from the interior surface by from about 5 mm to about 20 mm and compressible toward the interior surface between the first and second ends.
14. An apparatus for attaching a wheel cover to a rear hub axle plate of a wheel of a vehicle, comprising:
a wheel cover having a flange portion and a tubular body having a length, the tubular body having a cylindrical interior surface;
a plurality of arms attached to the cylindrical interior surface of the tubular body along the length of the tubular body, wherein the plurality of arms have a body separated from the cylindrical interior surface for frictionally engaging the rear hub axle plate, wherein each of the plurality of arms has a first end, a second end and a body located therebetween, the body separated from the interior surface and capable of flexing in a direction of the interior surface of the tubular body; and
an attachment cylinder attached to the flange portion of the wheel cover, the attachment cylinder having a rib for engaging a nut.
15. The apparatus of claim 14, wherein the attachment cylinder has an engagement end, wherein the engagement end has a plurality of notches for the nut.
16. The apparatus of claim 14, wherein the rib is a line of engagement for engagement with the nut.