1. An apparatus comprising:
an ambulatory medical device, including a ischemia detector circuit configured to detect an indication of a myocardial ischemia event; and
a processor circuit, configured to be communicatively coupled to the ischemia detector and to:
receive the indication of the myocardial ischemia event;
determine a confidence level of the myocardial ischemia event having occurred; and
respond using the confidence level, the responding including at least one of initiating, selecting, or adjusting a response.
2. The apparatus of claim 1, wherein the processor circuit is configured to determine a severity indicator value of the indication of the myocardial ischemia event.
3. The apparatus of claim 2, wherein the processor circuit is configured such that the responding comprises responding using both the severity indicator value and the confidence level.
4. The apparatus of claim 3, wherein the processor circuit is configured such that the severity indicator is multi-valued and the confidence level is multi-valued.
5. The apparatus of claim 1, wherein the processor circuit is configured such that the determining the confidence level comprises using a regression model.
6. The apparatus of claim 5, wherein the processor circuit is configured such that:
the detecting the indication of the myocardial ischemia event comprises using one or more sensor measurements from the ischemia detector circuit to detect the indication of the myocardial ischemia event; and
the determining the confidence level comprises computing a probability according to:
P
=
1
1
+
\uf74d
–
z
,
wherein z=b0+b1X1+b2X2+ . . . +bmXm, P is a probability of a myocardial ischemia event occurring, z is a measure of a total contribution of all of the one or more sensor measurements used, b0 is a logistic regression intercept, and b1, b2, . . . bm are the logistic regression coefficients of the one or more sensor measurements X1, X2, . . . Xm respectively.
7. The apparatus of claim 1, wherein the ambulatory medical device comprises an implantable medical device; and wherein the implantable medical device includes the processor circuit.
8. The apparatus of claim 1, wherein the processor circuit is configured such that the confidence level is determined using a time-wise sequence of multiple indications of the myocardial ischemia event.
9. A device-readable medium including instructions that, when performed by the device, comprise:
detecting an indication of a myocardial ischemia event;
determining a confidence level of the myocardial ischemia event having occurred; and
responding using the confidence level, the responding including at least one of initiating, selecting, or adjusting a response.
10. The device-readable medium of claim 9, wherein the instructions that, when performed by the device, comprise determining a severity indicator value of the indication of the myocardial ischemia event.
11. The device-readable medium of claim 10, wherein the responding comprises responding using both the severity indicator value and the confidence level.
12. The device-readable medium of claim 11, wherein the severity indicator is multi-valued and the confidence level is multi-valued.
13. The device-readable medium of claim 9, wherein the determining the confidence level comprises using a regression model.
14. The device-readable medium of claim 13, wherein:
the detecting the indication of the myocardial ischemia event comprises using one or more sensor measurements to detect the indication of the myocardial ischemia event; and
the determining the confidence level comprises computing a probability according to:
P
=
1
1
+
\uf74d
–
z
,
wherein z=b0+b1X1+b2X2+ . . . +bmXm, P is a probability of a myocardial ischemia event occurring, z is a measure of a total contribution of all of the one or more sensor measurements used, b0 is a logistic regression intercept, and b1, b2, . . . bm are the logistic regression coefficients of the one or more sensor measurements X1, X2, . . . Xm respectively.
15. The device-readable medium of claim 9, wherein the responding comprises providing a local alert.
16. The device-readable medium of claim 9, wherein the determining the confidence level comprises using a time-wise sequence of multiple indications of the myocardial ischemia event.
17. A method comprising:
detecting an indication of a myocardial ischemia event using an ambulatory medical device;
determining a confidence level of the myocardial ischemia event having occurred; and
responding using the confidence level, the responding including at least one of initiating, selecting, or adjusting a response.
18. The method of claim 17, comprising determining a severity indicator value of the indication of the myocardial ischemia event.
19. The method of claim 18, wherein the responding comprises responding using both the severity indicator value and the confidence level.
20. The method of claim 19, wherein the severity indicator is multi-valued and the confidence level is multi-valued.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. Device for regulating a volumetric flow comprising:
a hose segment through which fluid can flow and a hose clamp, wherein the hose clamp comprises a basic housing with an accommodating region for the hose segment and a clamping element that can be moved between at least two regulation positions, and in interaction with sections of the accommodating region as pressing points, the clamping element acts on the hose segment and its lumen in at least one regulation position;
the clamping element is arranged in a rotating manner and the clamping element extends radially around the center of rotation;
in the region of at least one regulation position a spacer is arranged in the lumen of the hose segment; and
the device can be set to at least the regulation positions open, closed or perfused, wherein in the closed position the lumen of the hose segment is completely closed and in the perfused position the lumen of the hose segment is kept at least partially open by the spacer in the interior of the hose segment.
2. Device according to claim 1 wherein in the perfused position the lumen of the hose segment is kept slightly open by the spacer in the interior of the hose segment.
3. Device according to claim 1 wherein the pressing points are formed by at least one counter-pressure element for the clamping element.
4. Device according to claim 1 wherein the section of the clamping element closest to the center of rotation interacts with at least one pressing point.
5. Device according to claim 1 wherein the clamping element is moved by a motor between the regulation positions and held in each of the regulation positions.
6. Device according to claim 1 wherein the device, the hose clampthe hose segment or parts thereof are at least in sections made of a material that is selected from a group that includes duroplastic or thermoplastic synthetic materials.
7. Device according to claim 1 wherein the fluid is selected from a group which includes water, aqueous solutions, solutions for injection, solutions for infusion, nutritional solutions, electrolyte solutions, blood, plasma, gas, air, and combinations thereof.
8. Device according to claim 1 wherein the hose segment is made of a flexible material and is squeezable in sections.
9. Device according to claim 1 wherein the hose segment has a lumen with an inner diameter of between 0.2 mm and 10 mm.
10. Device according to claim 1 wherein at least one of (i) the spacer is an integral component of the hose segment and in segment reduces the lumen of the hose and (ii) the spacer is formed by an elongated element that reduces the lumen of the hose which at least in sections is connected to the hose segment.
11. Device according to claim 1 wherein the reduction in the lumen by the spacer is between 0.01% to 5%, and through this the lumen of the hose segment in the perfused setting is kept slightly open so that a volumetric flow of between 0.1 mlmm and 8 mlmm is provided.
12. Hose segment for use in a device for regulating a volumetric flow, comprising a hose segment defining a lumen and including at least one spacer arranged for irregular reduction of the lumen, wherein the reduction in the lumen by the spacer is between 0.01% to 5%, and through this the lumen of the hose segment in the perfused setting is kept slightly open.
13. Hose segment according to claim 12 wherein the hose segment is made of a flexible material and is squeezable in sections.
14. Hose segment according to claim 12 wherein the hose segment has a clear inner diameter of between 0.2 mm and 10 mm.
15. Hose segment according to claim 12 wherein at least one of (i) the spacer is an integral component of the hose segment and (ii) the spacer is formed by an elongated element that is connected to the hose segment.
16. Hose segment according to claim 12 wherein the lumen of the hose segment in the perfused setting is kept slightly open so that a volumetric flow of between 0.1 mlmm and 8 mlmin is provided.
17. Hose segment according to claim 15 wherein the spacer element is at least partially made of a material selected from a group that includes plastic, wool, cotton, cellulose, metal, and combinations thereof.
18. Hose segment according to claim 12 wherein the spacer has a cross-sectional shape that is quadratic, rectangular, oval, circular, square or suchlike.
19. A method of using a hose segment comprising:
selecting a hose segment according to claim 12; and
utilizing the hose segment in a device according to claim 1.