1. An adhesive composition for use in an immunosensor, comprising:
an adhesive;
water;
a poloxamer; and
an anticoagulant.
2. The adhesive composition of claim 1, wherein the anticoagulant is selected from the group consisting of: heparin, citrate, ethylenediaminetetraacetic acid, and oxalate.
3. The adhesive composition of claim 1, wherein the poloxamer comprises units derived from ethylene oxide and propylene oxide.
4. The adhesive composition of claim 3, wherein ethylene oxide and propylene oxide serve as the monomers in block copolymers.
5. The adhesive composition of claim 1, wherein the adhesive is pressure-sensitive.
6. The adhesive composition of claim 1, wherein the adhesive is heat-activated.
7. The adhesive composition of claim 1, wherein the adhesive is water soluble.
8. The adhesive composition of claim 1, wherein the adhesive is a sulfopolyester.
9. The adhesive composition of claim 1, wherein a concentration of the poloxamer with respect to the adhesive is approximately in the range of about 0.05 to about 0.5 percent.
10. The adhesive composition of claim 2, wherein a concentration of the heparin with respect to the adhesive is approximately in the range of about 0.1 to about 10 milligrams per milliliter.
11. The adhesive composition of claim 1, wherein the adhesive and the water are combined to form a mixture prior to being included with the poloxamer and the anticoagulant.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A control solution for use in testing an electrochemical system for measuring the amount of an analyte in a sample, the control solution comprising:
(a) a predetermined amount of said analyte; and
(b) a predetermined amount of an internal reference compound, said internal reference compound having a higher oxidation potential than said analyte, said predetermined amount of said internal reference compound being dependent upon said predetermined amount of analyte, the control solution being configured to be distinguished from the sample based on a Differential Index (DI), the predetermined amount of the internal reference compound being such that the control solution has a DI of at least 1.5, the DI being defined as DI=ihigh voltilow volt
where: ihigh volt is an electrical current resulting from the application of a first potential sufficient to oxidize said internal reference compound and said analyte, and ilow volt is an electrical current resulting from the application of a second potential sufficient to oxidize said analyte and insufficient to oxidize said internal reference compound,
the second potential being applied before the first potential during the same period.
2. The control solution of claim 1, further comprising a buffer, the internal reference compound being different from the buffer, the internal reference compound and the buffer being configured to serve different functions.
3. The control solution of claim 1, wherein the second potential and the first potential are applied without a waiting period therebetween.
4. The control solution of claim 1, wherein said analyte is glucose and said sample is whole blood.
5. The control solution of claim 4, wherein the glucose is configured to be oxidized by glucose oxidase, the control solution further comprising a buffer to maintain pH between 5 and 7.
6. The control solution of claim 4, wherein the glucose is configured to be oxidized by glucose dehydrogenase, the control solution further comprising a buffer to maintain pH between 6 and 8.
7. The control solution of claim 4, wherein said internal reference compound is an oxidizable organo-metallic compound, coordination compound, or organic amine compound.
8. The control solution of claim 7, wherein said internal reference compound is said oxidizable organo-metallic compound, said oxidizable organo-metallic compound being ferrocene or ferrocene derivatives.
9. The control solution of claim 7, wherein said internal reference compound is said coordination compound, said coordination compound being potassium ferrocyanide.
10. The control solution of claim 7, wherein said internal reference compound is said organic amine compound, said organic amine compound being 3-(N-morpholino) propane sulfonic acid, N-(2-hydroxyethyl) piperazine-N1-(2-ethane sulfonic acid), 2-(2-Hydroxy-1,1-bis(hydroxy methyl)ethylaminoethane sulfonic acid, 2-Morpholino ethane sulfonic acid, and Bis(2-hydroxyethyl)amino-tris(hydroxymethyl) methane Bis-Tris, 4-aminobenzonitrile, 4-aminobenzoic acid, or 4-iodoaniline.
11. The control solution of claim 10, wherein said internal reference is Bis-Tris.