1. A compound of the formula:
30
wherein R1 and R2, which are the same or different, are
a) H, halogen, OCH3, OH; or
31
where X is 0, NH or S; and n is an integer from 1 to 4; and
R4 and R5, which are the same or different, are a 1 to 4 carbon alkyl, H, CH2CCH or CH2CH2OH; or
R4 and R5 form an N-containing five- or six-membered ring or heteroaromatic ring; or
c) Y(CH2)nCH2OR6
where Y is O, NH or S and n is an integer from 1 to 4; and
R6 is H, CH2CH2OH, or CH2CH2Cl ; or
d) 2,3-dihydroxypropoxy, 2-methylsulfamylethoxy, 2-chloroethoxy, 1-ethyl-2-hydroxyethoxy, 2,2-diethyl-2-hydroxyethoxy or carboxymethoxy; and
R3 is H, halogen, OH or OCH3;
or a stereoisomer; or a non-toxic pharmaceutically acceptable salt or ester thereof or mixtures thereof,
provided that
a) when R2 is
32
in the 4-position of the phenyl
where R4 and R5
i) are the same, either methyl or ethyl; or
ii) form an N-containing five-membered ring;
then R1 and R3 cannot simultaneously be H; and
b) when R is
33
in the 4-position of the phenyl
where R4 and R5, which are the same or different, are methyl or H; or
when R2 is OCH2CH42OH or OCH2COOH in the 4position of the phenyl, then R1 and R3, cannot simultaneously be H, or OH in the 4-position of the phenyl; and
if R1 is OH in the 4-position of the phenyl, R3 cannot be H.
2. A triphenylethylene according to claim 1, wherein R1 and R2, which are the same or different are
a) H, halogen, OCH3, OH; or
34
where X is O, NH or S; and n is an integer from 1 to 4; and R4 and R5, which are the same or different, are a 1 to 4 carbon alkyl, H,
CH2CCH or CH2CH2OH; or R4 and R5 form an N- containing five- or six-membered ring or heteroaromatic ring.
3. A triphenylethylene according to claim 2 where X is O.
4. A triphenylethylene according to claim 3 where n is 1, and
R4 and R5 are methyl or form a piperidine or imidazole ring.
5. A triphenylethylene according to claim 2 where X is S.
6. A triphenylethylene according to claim 2 where X is NH.
7. A compound according to claim 4, which is selected from the group consisting of
(2-4-4-chloro-1-(4-fluorophenyl)-2-phenylbut-1-enylphenoxyethyl)-dimethylamine,
(2-4-4-chloro-1-(4-chlorophenyl)-2-phenylbut-1-enylphenoxyethyl)-dimethylamine,
(2-4-4-chloro-1,2-bis(4-chlorophenyl)but-1-enylphenoxyethyl)-dimethylamine,
(2-4-4-chloro-2-(4-fluorophenyl)-1-phenylbut-1-enylphenoxyethyl)-dimethylamine,
(2-4-4-chloro-2-(4-chlorophenyl)-1-phenylbut1-enylphenoxyethyl)-dimethylamine,
(2-4-4-chloro-2-(4-chlorophenyl)1-(4-methoxyphenyl)but-1-enylpheny-oxyethyl)dimethylamine,
2-3-(4-chloro-1,2-diphenylbut1-enyl)phenoxyethyldimethylamine,
1-2-4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxyethyl-1H-imidazole,
2-4-(4-chloro-1,2-diphenylbut-1-enyl)phenoxyethyl methylprop-2-ynylamine,
2-2-4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxyethylmethylamino)-ethanol,
3-4-chloro-1-4-(2-imidazol1-yl-ethoxy)phenyl-2-phenyl-but1-enyl-phenol,
1-(2-4-4-chloro-2-(2-chlorophenyl)-1-phenylbut-1-enylphenoxyethyl)-piperidine,
1-(2-4-4-chloro-2-(3-methoxyphenyl)-1-phenylbut-1-enylphenoxyethyl)-piperidine,
1-(2-4-4-chloro-2-(2-methoxyphenyl)-1-phenylbut-1-enylphenoxyethyl)piper or a stereoisomer; or a non-toxic pharmaceutically acceptable salt thereof.
8. A compound according to claim 5, which is
1-4-(2-Dimethylaminoethylsulfanyl)phenyl-1,2-diphenyl-4-chloro-but-1-ene; or a stereoisomer; or a non-toxic pharmaceutically acceptable salt thereof
9. A compound according to claim 6, which is
N-4-(4-chloro-1,2-diphenylbut-1-enyl)phenyl-N,N-dimethylethane-1,2-diamine; or a stereoisomer; or a non-toxic pharmaceutically acceptable salt thereof.
10. A triphenylethylene according to claim 1, wherein R1 and R2, which are the same or different are
a) H, halogen, OCH3, OH; or
b) Y(CH2)nCH2OR6
where Y is O, NH or S and n is an integer from 1 to 4; and R6 is H CH2CH2OH, or CH2CH2Cl.
11. A triphenylethylene according to claim 10 where Y is O.
12. A triphenylethylene according to claim 10 where Y is S.
13. A triphenylethylene according to claim 10 where Y is NH.
14. A compound according to claim 11, which is selected from the group consisting of
2-4-4-chloro-2-phenyl-1-(4-fluorophenyl)but1-enylphenoxyethanol,
2-4-4-chloro-2-phenyl-1-(4-chlorophenyl)but-1-enylphenoxyethanol,
3-4-chloro-1-4-(2-hydroxyethoxy)phenyl-2-phenyl-but-1-enyl-phenol,
4-1-(2-chloroethyl)-2-4-(2-hydroxyethoxy)phenyl-2-phenylvinyl phenol,
2-4-4-chloro-1,2-bis(4-chlorophenyl)but-1-enylphenoxyethanol,
2-4-4-chloro-2-(4-chlorophenyl)-1-(4-methoxyphenyl)but1-enylphenoxyetlanol,
2-(4-4-chloro-1-4-(2-hydroxyethoxy)phenyl-2-phenyl-but1-enylphenoxy)-1-ethanol,
2-3-(4-chloro-1,2-diphenyl-but1-enyl)phenoxyethanol,
3-4-(4-chloro-1,2-diphenylbut-1-enyl)phenoxypropan1-ol,
2-2-4-(4-chloro-1,2-diphenylbut-1-enyl)phenoxyethoxyethanol,
3-4-(4-chloro-1,2-diphenylbut1-enyl)phenoxymethylpentan-3-ol,
1-(4-2-(2-chloroethoxyethoxyphenyl)-4-chloro-1-(4-chlorophenyl)-2-phenyl-but-1-ene and
1-(4-2-(2-chloroethoxyethoxyphenyl)-4-chloro-1-(4-fluorophenyl)-2-phenyl-but1-ene; or a stereoisomer; or a non-toxic pharmaceutically acceptable salt thereof.
15. A compound according to claim 12, which is
2-4-(4-chloro-1,2-diphenyl-but-1-enyl)-phenylsulfanylethanol; or a stereoisomer; or a non-toxic pharmaceutically acceptable salt thereof.
16. A compound according to claim 13, which is
2-4-(4-chloro-1,2-diphenyl-but-1-enyl)phenylaminoethanol; or a stereoisomer; or a non-toxic pharmaceutically acceptable salt thereof.
17. A compound according to claim 1, which is selected from the group consisting of
3-4-(4-chloro-1,2-diphenylbut-1-enyl)phenoxymethylpentan-3-ol,
2-4-(4-chloro-1,2-diphenylbut-1-enyl)phenoxybutan-1-ol,
3-4-(4-chloro-1,2-diphenyl-but-1enyl)phenoxypropane-1,2-diol,
3-4-4-chloro-1-(4-chlorophenyl)-2-phenyl-but-1-enylphenoxy propane 1,2 diol,
4-chloro-1-4-(2-methylsulfanyl-ethoxy)phenyl-1,2-diphenyl-but-1-ene,
4-chloro-1-4-(2-chloroethoxy)phenyl-1,2-bis(4-chlorophenyl)-but-1-ene, and
4-4-chloro-1-(4-chlorophenyl)-2-phenylbut-1-enylphenoxyacetic acid; or a stereoisomer; or a non-toxic pharmaceutically acceptable salt or ester thereof.
18. A compound according to claim 1, which is 3-(4-chloro-1-4-2-(2-hydroxyethoxy)ethoxy4phenyl -2-phenylbut-1-enyl)phenol; or a stereoisomer; or a non-toxic pharmaceutically acceptable salt thereof.
19. A pharmaceutical composition comprising an amount effective to produce a tissue specific estrogen andor antiestrogenic effect of said novel selective estrogen receptor modulator compound according to claim 1, or a stereoisomer, or a non-toxic pharmaceutically acceptable salt or ester thereof, and a pharmaceutically compatible acceptable carrier therefor.
20. A method of producing a tissue specific estrogenic andor antiestrogenic effect in a subject in which such an effect is desired which comprises administering to said subject said novel selective estrogen receptor modulator compound according to claim 1, a stereoisomer, or a non-toxic pharmaceutically acceptable salt or ester thereof in an amount sufficient to produce the desired effect.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A display device, comprising:
a reflective cover, having an opening confined by a top inner surface, at least one side inner surface, and a bottom inner surface of the reflective cover;
a light guide plate, having a top surface, a bottom surface, and a side face connected to the top surface and the bottom surface, a part of the top surface being covered by the top inner surface of the reflective cover; and
a display device, placed under the light guide plate and a partial surface of the display device being covered by the bottom inner surface of the reflective cover;
wherein the reflective cover bonds the light guide plate and the display device together.
2. The display device as claim 1, wherein the reflective cover has a light source inside to provide an incident light through the opening of the reflective cover, the side face of the light guide plate neighbors the light source to receive the incident light.
3. The display device as claim 1, wherein the part of the top surface of the light guide plate covered by the top inner surface of the reflective cover is in contact with the top inner surface of the reflective cover, and the partial surface of the display device covered by the bottom inner surface of the reflective cover is in contact with the bottom inner surface of the reflective cover.
4. The display device as claim 1, wherein the at least one side inner surface comprises two side inner surfaces
5. The display device as claim 1, further including a plurality of pillar structures placed under the bottom surface of the light guide plate.
6. The display device as claim 5, wherein the display device is adhered to the pillar structures by a glue material.
7. The display device as claim 5, wherein the opening of the reflective cover has a vertical width smaller than a total thickness of the light guide plate, the pillar structures, and the display device to provide a clamping force to expel air between the light guide plate and the pillar structures, and air between the pillar structures and the display device.
8. The display device as claim 5, wherein the light guide plate has a first refractive index and the pillar structures have a second refractive index larger than the first refractive index.
9. The display device as claim 5, wherein each the pillar structure has a top face and a bottom face opposite to the top face, the top face has a first area and the bottom face has a second area, the first area being larger than or equal to the second area.
10. The display device as claim 5, wherein each the pillar structure has a top face and a bottom face opposite to the top face, the top face has a first area and the bottom face has a second area, the first area being smaller than the second area.
11. The display device as claim 5, wherein each the pillar structure is located a first distance from a light source inside the reflective cover, each the pillar structure has a top face area varying with the first distance, and the top face area becomes larger as the first distance increases.
12. The display device as claim 11, wherein a gap is formed between two neighboring ones of the pillar structures and located a second distance from the light source, the gap varies with the second distance, and the gap becomes smaller as the second distance increases.
13. The display device as claim 1, wherein, the reflective cover is implemented with a reflective tape.
14. The display device as claim 1, wherein the display device is selected from a group consisting of electrophoresis display, MEMS (micro electro mechanical system) display, cholesteric liquid crystal display, electrowetting display, liquid crystal display, organicinorganic electroluminescence display, and electrochromic display.
15. The display device as claim 1, wherein the opening of the reflective cover has a vertical width smaller than a total thickness of the light guide plate and the display device to provide a clamping force to expel air between the light guide plate and the display device.
16. A display device, comprising:
a reflective cover having a first opening confined by a first top inner surface, at least one first side inner surfaces, and a first bottom inner surface of the reflective cover;
a light guide plate, having a top surface, a bottom surface, and a side face connected to the top surface and the bottom surface, a part of the top surface being covered by the first top inner surface of the reflective cover;
a display device, placed under the light guide plate, and a partial surface of the display device being covered by the first bottom inner surface of the reflective cover; and
a fixing frame having a second opening confined by a second top inner surface, at least one second side inner surface, and a second bottom inner surface thereof, a part of the top surface of the light guide plate being covered by the second top inner surface, and a partial surface of the display device being covered by the second bottom inner surface;
wherein the fixing frame cooperates with the reflective cover to bond the light guide plate and the display device together.
17. The display device as claim 16, wherein the part of the top surface of the light guide plate covered by the first top inner surface of the reflective cover is in contact with the first top inner surface of the reflective cover, the partial surface of the display device covered by the first bottom inner surface of the reflective cover is in contact with the first bottom inner surface of the reflective cover, the part of the top surface of the light guide plate covered by the second top inner surface of the fixing frame is in contact with the second top inner surface of the fixing frame, and the partial surface of the display device covered by the second bottom inner surface of the fixing frame is in contact with the second bottom inner surface of the fixing frame.
18. The display device as claim 16, further including a plurality of pillar structures placed under the bottom surface of the light guide plate.
19. The display device as claim 16, wherein the first opening has a first vertical width, the second opening has a second vertical width, and both the first vertical width and the second vertical width are smaller than a total thickness of the light guide plate and the display device to provide a clamping force to expel air between the light guide plate and the display device to promote display quality.
20. The display device as claim 18, wherein the first opening has a first vertical width, the second opening has a second vertical width, and both the first vertical width and the second vertical width are smaller than a total thickness of the light guide plate, the pillar structures, and the display device to provide a clamping force to expel air between the light guide plate and the pillar structures, and air between the pillar structures and the display device, so as to promote display quality.