1. In combination with a spa having a container (20) for holding water with a top rim (15) the improvement being a waterfall structure comprising:
a plenum chamber (23) having walls (24, 26), a water inlet (39) and a water outlet (30), the outlet being formed from the walls (24, 26) of the plenum chamber;
a spout (13) formed from the walls (24, 26) of the plenum chamber as a continuation of the water outlet (30), the spout (13) passing through the top rim and having a narrow and elongated mouth (14) and a top (17) and bottom (16);
a mounting plate (25) bordering the top and the bottom of the spout where the spout passes through the top rim; and
a light source (43) attached through the mounting plate at the bottom (16) of the spout (13) to inject light directly into water falling out of the spout (13).
2. The waterfall of claim 1 wherein the plenum chamber has a baffle (27) to prevent pressure surges.
3. The waterfall of claim 1 wherein the water inlet (29) of the plenum chamber (23) is larger in cross-section than the water outlet (30).
4. The waterfall of claim 1 further comprising a bezel (21) attached to the mounting plate (25) and encompassing the spout and the light source.
5. The waterfall of claim 4 wherein the light source (43) is a flat fiber-optic array.
6. The waterfall of claim 5 wherein the flat fiber-optic array directs light in a direction parallel to water flow through the spout to intersect the water falling out of the spout.
7. The waterfall of claim 1 further comprising a bezel (21) shaped to fit over the spout after it is mounted.
8. The waterfall of claim 1 wherein the water inlet (29) is a separate structure from the plenum chamber (23) that fits into and is permanently fastened to the walls (24, 26) of the plenum chamber (23).
9. The waterfall of claim 8 wherein the water inlet (29) has an inlet orifice (39) and water pipe connector (37).
10. The waterfall of claim 1 wherein the water inlet (29) has a baffle plate (27) mounted some distance from and over the inlet orifice (39), causing water flowing through the inlet orifice to strike the baffle plate and flow around it.
11. The waterfall of claim 1 wherein the mounting plate is formed from the walls (24, 26) of the plenum chamber.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A process for producing crystals of a GLP-1 analogue comprising:
a) preparing an aqueous solution comprising a GLP-1 analogue, a salt, and an organic solvent, and
b) isolation of the crystals after formation.
2. The process according to claim 1 wherein in step a) adjusting pH to pl\u22124<pH<pl, or to pl<pH<pl+4, wherein pl is the isoelectric point of the GLP-1 analogue.
3. The process according to claim 1 wherein the crystals are needle shaped crystals of a GLP-1 analogue.
4. The process according to claim 1 wherein the crystals has a length of at least 0.5 \u03bcm.
5. The process according to claim 1 wherein the GLP-1 analogue in the aqueous solution has a purity of less than 95%, as measured by HPLC.
6. The process according to claim 1 wherein the GLP-1 analogue in the aqueous solution is present in a concentration of at least 0.5 mgml.
7. The process according to claim 1 wherein the GLP-1 analogue is selected from non-synthetic GLP-1 analogues.
8. The process according to claim 1 wherein the GLP-1 analogue is Arg34GLP-1 (7-37) or Arg26GLP-1 (7-37).
9. The process according to claim 1 wherein the salt is present in a concentration of at least 25 mM.
10. The process according to claim 1 wherein the organic solvent is present in a concentration of from 0.5 to 50% (volvol).
11. The process according to claim 1 wherein the organic solvent is selected from C1-6alkanol, C16-alkenol, C1-6alkynol, urea, guanidine, C1-6alkanoic acid, ketone, DMSO, C2-4-glycol, C3-7-polyalcohol including sugars, or mixtures thereof.
12. A method for producing a GLP-1 analogue or a GLP-1 analogue whereto is attached a lipophilic substituent comprising the steps:
a) preparing an aqueous solution comprising a GLP-1 analogue, a salt, and an organic solvent, and
b) isolation of the crystals after formation.
13. Crystals of a GLP-1 analogue optainable by the method according to claim 12.
14. Needle shaped crystals of a GLP-1 analogue.
15. A pharmaceutical composition comprising needle shaped crystals of a GLP-1 analogue and a pharmaceutically acceptable carrier.