What is claimed is:
1. A compound of the formula:
76
wherein:
R1 and R2 each independently is hydrogen, alkyl, aryl, acyl, halo, nitro, amino, cyano, alkoxy, hydroxy, aryloxy, alkylthio, arylthio, thiol, carbonylamino, aminocarbonyl, or haloalkyl;
R3 and R4 each independently is hydrogen, halo, alkyl, acyl, aryl, or arylalkyl;
R5 is:
77
n is 0 to 4;
R6 in each independent occurrence is hydrogen, alkyl, alkoxy, or halo;
R7 and R8 each independently is hydrogen or alkyl; and
R9 is hydrogen, alkyl, or arylalkyl;
or an individual isomer, a racemic or non racemic mixture of isomers, a prodrug, or a pharmaceutically acceptable salt or solvate thereof.
2. The compound of claim 1, wherein R3 and R4 each independently is hydrogen, halo or alkyl.
3. The compound of claim 1, wherein R1 and R2 each independently is hydrogen, halo, or alkoxy.
4. The compound of claim 1, wherein n is 1 and wherein R6 is hydrogen or halo.
5. The compound of claim 1, wherein R7 and R8 are hydrogen.
6. The compound of claim 1, wherein R9 is hydrogen or alkyl.
7. The compound of claim 1, wherein:
R1 and R2 each independently is hydrogen, halo, or alkoxy;
R3 and R4 each independently is hydrogen, halo or alkyl;
n is 1 and R6 is hydrogen or halo;
R7 and R8 are hydrogen; and
R9 is hydrogen or alkyl.
8. The compound of claim 7, wherein said compound has the formula:
78
9. The compound of claim 7, wherein said compound has the formula:
79
10. The compound of claim 7, wherein said compound has the formula:
80
11. The compound of claim 8, wherein one of R1 and R2 is halo and the other is hydrogen.
12. The compound of claim 10, wherein one of R1 and R2 is halo and the other is hydrogen.
13. The compound of claim 12, wherein n is 1 and R6 is halo.
14. The compound of claim 12, wherein n is 0.
15. The compound of claim 10, wherein R1 and R2 are hydrogen.
16. The compound of claim 15, wherein n is 1 and R6 is halo.
17. The compound of claim 15, wherein n is 0.
18. The compound of claim 12, wherein R9 is hydrogen.
19. The compound of claim 12, wherein R9 is methyl.
20. The compound of claim 13, wherein R9 is hydrogen.
21. The compound of claim 13, wherein R9 is methyl.
22. The compound of claim 14, wherein R9 is hydrogen.
23. The compound of claim 14, wherein R9 is methyl.
24. The compound of claim 15, wherein R9 is hydrogen.
25. The compound of claim 15, wherein R9 is methyl.
26. The compound of claim 16, wherein R9 is hydrogen.
27. The compound of claim 16, wherein R9 is methyl.
28. The compound of claim 17, wherein R9 is hydrogen.
29. The compound of claim 17, wherein R9 is methyl.
30. A pharmaceutical composition comprising, comprising a compound of claim 1 together with a pharmaceutically acceptable carrier.
31. A method for treating a central nervous system disease state in a subject, said method comprising administering to said subject a therapeutically effective amount of a compound of claim 1.
32. The method of claim 31, wherein the disease state comprises a disease selected from psychoses, schizophrenia, manic depressions, neurological disorders, memory disorders, attention deficit disorder, Parkinson’s disease, amyotrophic lateral sclerosis, Alzheimer’s disease and Huntington’s disease.
33. A method for treating a disorder of the gastrointestinal tract in a subject, said method comprising administering to said subject a therapeutically effective amount of a compound of claim 1.
34. A method for treating obesity in a subject, said method comprising administering to said subject a therapeutically effective amount of a of a compound of claim 1.
35. A method for producing a compound of claim 1, comprising contacting a 4-halobenzenesulfonyl-indole of the formula:
81
with a piperazine of the formula:
82
to produce a compound of the formula:
83
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
I claim as my invention:
1. A method for dynamic regulation of resource splitting over a plurality of data streams competing for the resources in a communications network, the resources to be split being made available in a resource pool from which, for each competing data stream, a resource share is taken and is allocated to this data stream, comprising the steps of:
dynamically aligning a resource requirement for a data stream on the basis that, if the resource requirement has arisen, a correspondingly greater resource share is allocated if possible or resources which are no longer required are returned to the resource pool, where
a resource share which is no longer required is returned to the resource pool if
the resource share has not been required for a prescribed number of successive resource inquiries or if
no new resource inquiries are received for a prescribed time period.
2. The method for the dynamic regulation of resource splitting over a plurality of data streams competing for the resources in a communications network of claim 1, where the prescribed time period is proportioned such that the prescribed number of successive resource inquires could be expected therein.
3. The method for the dynamic regulation of resource splitting over a plurality of data streams competing for the resources in a communications network of claim 1, where
if the resource requirement has arisen, an allocated resource share is increased, provided that there are still other resources available in the resource pool, or otherwise
further attempts to increase a resource share are prevented until a second prescribed number of successive resource inquiries has been received.
4. The method for the dynamic regulation of resource splitting over a plurality of data streams competing for the resources in a communications network of claim 1 where
if the resource requirement has risen, an allocated resource share is increased, provided that there are still other resources available in the resource pool, or otherwise further attempts to increase a resource share are prevented until the prescribed time period has elapsed.
5. The method for the dynamic regulation of resource splitting over a plurality of data streams competing for the resources in a communications network of claim 3, where the first and second prescribed numbers of successive resource inquiries adopt a same value.
6. The method for dynamic regulation of resource splitting over a plurality of data streams competing for the resources in a communications network of claim 1, where
a time profile is ascertained for the resource requirement of the data stream and is compared with a prescribed threshold value, where
the associated resource share is increased if there are still other resources available in the resource pool,
as soon as the resource requirement reaches or exceeds the threshold value.
7. The method for the dynamic regulation of resource splitting over a plurality of data streams competing for these resources in a communications network of claim 1 where
a resource share which is no longer required is returned to the resource pool only if
upon return there is no drop below a prescribed minimum value for the resource share.
8. An apparatus for dynamic regulation of resource splitting over a plurality of data streams competing for the resources in a communications network, comprising:
a resource pool for making available resources which are to be split and from which, for each competing data stream, a resource share can be taken and can be allocated to the data stream, where
a system for dynamically aligning the resource requirement for a data stream is provided which can be used, if the resource requirement has increased, to allocate a correspondingly greater resource share if possible or to return resources which are no longer required to the resource pool, where
a resource share which is no longer required can be returned to the resource pool if
the resource share has not been required for a prescribed number of successive resource inquiries or if
no new resource inquiries are received for a prescribed time period.
9. The apparatus for the dynamic regulation of resource splitting over a plurality of data streams competing for the resources in a communications network of claim 8, where the system for dynamically aligning the resource requirement can proportion the prescribed time period such that the prescribed number of successive resource inquiries could be expected therein.
10. The apparatus for the dynamic regulation of resource splitting over a plurality of data streams competing for the resources in a communications network of claim 8, where the system for dynamically aligning the resource requirement
can increase an allocated resource share when the resource requirement has risen, provided that there are still other resources available in the resource pool, or otherwise
can prevent further attempts to increase a resource share until a second prescribed number of successive resource inquiries has been received.
11. The apparatus for the dynamic regulation of resource splitting over a plurality of data streams competing for the resources in a communications network of claim 8 where the system for dynamically aligning the resource requirement
can increase an allocated resource share when the resource requirement has risen, provided that there are still other resources available in the resource pool, or otherwise
can prevent further attempts to increase a resource share until a prescribed time period has elapsed.
12. The apparatus for the dynamic regulation of resource splitting over a plurality of data streams competing for the resources in a communications network of claim 8, where the system for dynamically aligning the resource requirement
can ascertain a time profile for the resource requirement of the data stream and can compare it with a prescribed threshold value, where
the allocated resource share can be increased if there are still other resources available in the resource pool
as soon as the resource requirement reaches or exceeds the threshold value.