1. A brush configured to engage a rotating component to transfer an electrical signal andor power to the rotating component, comprising:
a body formed from a core material and including a portion configured to contact the rotating component; and
a coating material disposed over the portion of the body configured to contact the rotating component, wherein a contact area between the brush and the rotating component increases as the coating material wears due to operation of the rotating component.
2. The brush according to claim 1, wherein an end of the brush is configured to contact an outer diameter of the rotating component.
3. The brush according to claim 1, wherein the portion of the body configured to contact the rotating component includes a radial cut.
4. The brush according to claim 3, wherein the radial cut is generally complementary to a curvature of the rotating component.
5. The brush according to claim 1, wherein the end of the body configured to contact the rotating component is substantially flat.
6. The brush according to claim 1, wherein the core material is carbon.
7. The brush according to claim 1, wherein the coating material is at least one of soft nickel, copper, carbon, and a silver containing conductive compound or paint.
8. The brush according to claim 1, wherein the core material and the coating material are integrally formed.
9. The brush according to claim 1, wherein the coating material is configured to wear faster than the core material.
10. An assembly for transferring electrical power from a stationary component to a rotating component, comprising:
a shaft configured to rotate about a shaft axis;
a slip ring assembly mounted concentrically about the shaft, the slip ring assembly including a slip ring mounted to a plate face of a slip ring plate; and
a brush assembly including a brush including a first portion configured to contact the slip ring, a coating material disposed over the first portion such that a contact area between the brush and the slip ring increases as the coating material wears due to rotation of the slip ring assembly.
11. The assembly according to claim 10, wherein the first portion of the brush includes a radial cut complementary to a curvature of the slip ring assembly.
12. The assembly according to claim 10, wherein the coating material is at least one of soft nickel, copper, carbon, and a silver containing conductive compound or paint.
13. The assembly according to claim 10, wherein the brush generally includes a core material.
14. The assembly according to claim 13, wherein the core material is carbon.
15. The assembly according to claim 15, wherein the core material and the coating material are integrally formed.
16. The assembly according to claim 15, wherein the coating material is configured to wear faster than the core material.
17. The assembly according to claim 10, wherein the shaft is connected to a hub configured to support a plurality of propeller blades, each of the propeller blades including a heating element.
18. The assembly according to claim 17, wherein the slip ring assembly is configured to provide power to the heating elements.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of formula (I):
or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is F or H.
2. The compound of claim 1 of formula (Ia):
or a pharmaceutically acceptable salt or solvate thereof.
3. The compound according to claim 1 of formula (Ib):
or a pharmaceutically acceptable salt or solvate thereof.
4. A method of treating asthma, allergic rhinitis or chronic obstructive pulmonary disease (COPD) in a mammal having asthma, allergic rhinitis or chronic obstructive pulmonary disease, the method comprising administering to the mammal a compound of claim 1 or a pharmaceutically acceptable salt or solvate thereof.
5. The method of claim 4, wherein said asthma
atopic asthma, non-atopic asthma, allergic asthma, atopic bronchial lgE-mediated asthma, bronchial asthma, essential asthma, true asthma, intrinsic asthma caused by pathophysiologic disturbances, extrinsic asthma caused by environmental factors, essential asthma of unknown or inapparent cause, bronchitic asthma, emphysematous asthma, exercise-induced asthma, allergen induced asthma, cold air induced asthma, occupational asthma, infective asthma caused by bacterial, fungal, protozoal, or viral infection, non-allergic asthma, incipient asthma, wheezy infant syndrome or bronchiolytis.
6. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt or solvate thereof and a pharmaceutically acceptable excipient.
7. A process for preparing a compound of claim 2, said process comprising the steps of contacting a compound of formula (V):
with N,N\u2032-dimethylformamide dimethyl acetal followed by treatment with methylhydrazine.
8. A process for preparing a compound of claim 3, said process comprising the step of contacting a compound of formula (II):
with a compound of formula (VII)
in the presence of a suitable catalyst.
9. The compound of formula (V):
10. The pharmaceutical composition of claim 6 further comprising a histamine antagonist.
11. The pharmaceutical composition of claim 10 wherein said histamine antagonist is a histamine (H1) antagonist.
12. A method of treating asthma, allergic rhinitis or chronic obstructive pulmonary disease (COPD) in a mammal having asthma, allergic rhinitis or chronic obstructive pulmonary disease, the method comprising administering to the mammal a pharmaceutical composition of claim 10.
13. The method of claim 12, wherein said asthma is atopic asthma, non-atopic asthma, allergic asthma, atopic bronchial IgE-mediated asthma, bronchial asthma, essential asthma, true asthma, intrinsic asthma caused by pathophysiologic disturbances, extrinsic asthma caused by environmental factors, essential asthma of unknown or inapparent cause, bronchitic asthma, emphysematous asthma, exercise-induced asthma, allergen induced asthma, cold air induced asthma, occupational asthma, infective asthma caused by bacterial, fungal, protozoal, or viral infection, non- allergic asthma, incipient asthma, wheezy infant syndrome or bronchiolytis.