1460727796-123902e0-95ef-4ba9-9fe3-aa00cbb4a119

1. A method for improving the aesthetic appearance of the skin of a human in need thereof comprising topically applying to the skin of the human in need thereof at least once daily for a period of at least four weeks 0.01 wt. % to 10 wt. % of the total weight of a composition of a water, alcohol, andor aqueous-organic solvent extract of the stems and leaves of Maesa japonica to improve the aesthetic appearance of said human skin wherein said skin of the human is in need of at least one of the following: increasing collagen synthesis, increasing hyaluronic acid synthesis, increasing epidermal synthesis and reducing melanin synthesis.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A display medium comprising:
a pair of substrates;
a spacing member that maintain a gap between the pair of substrates and has a first portion projecting in an intersecting direction, the intersecting direction intersecting a direction in which the pair of substrates face each other; and
a holding layer that is provided on at least one of the pair of substrates such that
the holding layer fills a space between the at least one of the pair of substrates and an end face of the spacing member,
the holding layer covers the first portion from the end face of the spacing member, and
the holding layer holds an end part of the spacing member in the direction in which the pair of substrates face each other.
2. The display medium according to claim 1, wherein the holding layer has electrical conductivity.
3. The display medium according to claim 1, further comprising a liquid disposed between the pair of substrates.
4. A method of producing the display medium according to claim 1, the method comprising:
forming, on a substrate, a coating layer containing a stimulus-curable material that is cured by application of a stimulus;
embedding the first portion of the spacing member into the coating layer; and
applying a stimulus to the coating layer.
5. A display device comprising:
the display medium according to claim 1, and
a voltage application unit that applies a voltage between the pair of substrates of the display medium.
6. A display medium comprising:
a pair of substrates;
a spacing member that maintains a gap between the pair of substrates, and that, within an entire region spanning from one end to the other end in a direction in which the pair of substrates face each other, and has a first portion that has a cross-sectional area perpendicular to the direction in which the pair of substrates face each other that is larger than that of another portion joined to one of the pair of substrates; and
a holding layer that is provided on at least one of the pair of substrates such that
the holding layer fills a space between the at least one of the pair of substrates and an end face of the spacing member,
the holding layer covers the first portion from the end face of the spacing member, and
the holding layer holds an end part of the spacing member in the direction in which the pair of substrates face each other.
7. The display medium according to claim 6, wherein the holding layer has electrical conductivity.
8. The display medium according to claim 6, further comprising a liquid disposed between the pair of substrates.
9. A method of producing the display medium according to claim 6, the method comprising:
forming, on a substrate, a coating layer containing a stimulus-curable material that is cured by application of a stimulus;
embedding the first portion of the spacing member into the coating layer; and
applying a stimulus to the coating layer.
10. A display device comprising:
the display medium according to claim 6, and
a voltage application unit that applies a voltage between the pair of substrates of the display medium.