1. A method of creating redirection rules for routing a resource access request from a computer to a network, comprising:
creating an inclusion redirection rule for at least one existing resource definition defining a resource, wherein the inclusion redirection rule redirects the resource access request to the network, the inclusion redirection rule being stored in memory;
receiving exclusion input with an exclusion resource definition defining at least one exclusion resource, the exclusion input being received over a communication network; and
creating an exclusion redirection rule for the at least one exclusion resource, wherein the exclusion redirection rule instructs the computer to locally handle the resource access request, the exclusion redirection rule being stored in memory.
2. The method recited in claim 1, further comprising combining the inclusion redirection rule with the exclusion redirection rule into a redirection rule list.
3. The method recited in claim 1, wherein the existing resource definition is maintained by a policy server for controlling access to the resource defined in the at least one existing resource definition.
4. The method recited in claim 1, further comprising receiving input with a second resource definition; and creating a second inclusion redirection rule for the second resource definition.
5. The method recited in claim 1, wherein the existing resource definition includes an Internet protocol (IP) address for the resource.
6. The method recited in claim 1, wherein the existing resource definition includes a name for the resource.
7. The method recited in claim 6, wherein the name is a domain name.
8. The method recited in claim 6, wherein the name is a host name.
9. The method recited in claim 1, wherein the existing resource definition includes a universal resource locator (URL) address for the resource.
10. The method recited in claim 1, wherein the existing resource definition includes an Internet protocol (IP) address for the resource.
11. The method recited in claim 1, wherein the exclusion resource definition includes a name for the exclusion resource.
12. The method recited in claim 11, wherein the name is a domain name.
13. The method recited in claim 11, wherein the name is a host name.
14. The method recited in claim 1, wherein the exclusion resource definition includes a universal resource locator (URL) address for the exclusion resource.
15. An apparatus for creating a redirection rule list for routing a resource access request from a computer to a network, comprising:
a policy server that maintains a plurality of resource definitions in memory, each resource definition defining a resource, and
a rule redirection server that stores an inclusion redirection rule in memory, each inclusion redirection rule for each resource in the redirection rule list, wherein the inclusion redirection rule redirects the resource access request to the network;
wherein the policy server maintains at least one exclusion resource definition in memory, the at least one exclusion resource definition defining an exclusion resource, and the rule redirection server stores an exclusion redirection rule for the exclusion resource in the redirection rule list, wherein the exclusion redirection rule instructs the computer to locally handle the resource access request.
16. The apparatus for creating a redirection rule list recited in claim 15, wherein the policy server receives input with at least one exclusion resource definition.
17. The apparatus for creating a redirection rule list recited in claim 15, wherein the rule redirection server provides the redirection rule list to at least one client in a virtual private network.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A probe for measurement of UDP-glucuronosyltransferase which comprises a fluorescein derivative, wherein, in the fluorescein derivative, the 2-carboxy group on the benzene ring of fluorescein is replaced with another monovalent substituent, provided that said substituent is a substituent other than sulfo group, and the substituent does not have carboxy group or sulfo group, and wherein the fluorescein derivative may have an arbitrary substituent at a position on the benzene ring other than the 2-position, and the fluorescein derivative may have a substituent selected from the group consisting of an alkoxy group and a halogen atom at the 2-position andor the 7-position of fluorescein.
2. The probe according to claim 1, which is for fluorescence or absorbance measurement.
3. The probe according to claim 1, wherein the fluorescein derivative is a fluorescein derivative in which the 2-carboxy group on the benzene ring of fluorescein is replaced with an alkyl group; a fluorescein derivative in which the 2-carboxy group on the benzene ring of fluorescein is replaced with an alkyl group, and an alkoxy group is introduced at the 4-position of the benzene ring; or such a fluorescein derivative as mentioned above in which an alkoxy group is introduced at the 2-position andor the 7-position.
4. The probe according to claim 1, wherein the fluorescein derivative is a fluorescein derivative in which the 2-carboxy group on the benzene ring of fluorescein is replaced with 2-naphthoylamino group.
5. The probe according to claim 1, wherein the fluorescein derivative is a fluorescein derivative in which the 2-carboxy group on the benzene ring of fluorescein is replaced with nitro group, and methyl group is introduced at the 4-position of the benzene ring.
6. The probe according to claim 1, wherein UDP-glucuronosyltransferase is UGT1A1.
7. A method for measurement of UDP-glucuronosyltransferase activity, which comprises the step of reacting UDP-glucuronosyltransferase and the fluorescein derivative according to claim 1, and detecting change of fluorescence or absorbance before and after the reaction.
8. A method for screening candidate compounds of medicament, which comprises the step of reacting UDP-glucuronosyltransferase and the fluorescein derivative according to claim 1 in the presence and absence of a test compound, and detecting changes of fluorescence or absorbance before and after the reactions, and the step of, when difference is observed between the changes of fluorescence or absorbance detected in the presence and absence of the test compound, determining that the test compound has an action on UDP-glucuronosyltransferase, and is unsuitable as a candidate compound of medicament.