1. A compound of formula (I)
wherein:
X denotes a divalent 4- to 10-membered monocylic, 7- to 12-membered spirocyclic or 6- to 12-membered bicyclic saturated, partially or fully unsaturated group selected from a carbocycle, a monoaza-heterocycle and a diaza-heterocycle, which is linked to the adjacent groups via carbon atoms or, if present, via nitrogen atoms, e.g. via one carbon and one nitrogen atom or via two nitrogen atoms,
\u2003wherein 1 or 2 \u2014CH2\u2014 groups optionally are replaced independently of each other by O, S, carbonyl, or sulfonyl, with the proviso that two heteroatoms are not directly linked together, andor
\u20031 \u2014CH2\u2014 group optionally is replaced by the divalent group >C\u2550C(Rx)2, wherein Rx independently denotes H or C1-3-alkyl, andor
\u2003wherein in an unsaturated group 1 double bond optionally is condensed with an aryl or a 5- or 6-membered hetaryl group, andor
\u2003wherein in any of the resulting groups one or two carbon atoms optionally and independently are substituted by halogen atoms, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, cyclo-C3-7-alkyl, cyclo-C3-7-alkenyl, phenyl, cyano, hydroxy, hydroxy-C1-6-alkyl, hydroxy-C3-6-alkenyl, hydroxy-C3-6-alkynyl, C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl, C1-6-alkoxy-C3-6-alkenyl, C1-6-alkoxy-C3-6-alkynyl, C3-6-alkenoxy-C1-6-alkyl, thiohydroxy, C1-6-alkylthio, C3-6-alkenylthio, C3-6-alkynylthio, amino, C1-6-alkyl-amino, C3-6-alkenyl-amino, C3-6-alkynyl-amino, di-(C1-6-alkyl)-amino, di-(C3-6-alkenyl)-amino, di-(C3-6-alkynyl)-amino, amino-C1-6-alkyl, C1-3-alkyl-amino-C1-6-alkyl, di-(C1-3-alkyl)-amino-C1-6-alkyl, amino-C3-6-alkenyl, C1-3-alkyl-amino-C3-6-alkenyl, di-(C1-3-alkyl)-amino-C3-6-alkenyl, amino-C3-6-alkynyl, C1-3-alkyl-amino-C3-6-alkynyl, di-(C1-3-alkyl)-amino-C3-6-alkynyl, hydroxycarbonyl, C1-6-alkyl-carbonyl, C2-6-alkenyl-carbonyl, C2-6-alkynyl-carbonyl, formyl, C1-6-alkoxy-carbonyl, C3-6-alkenoxy-carbonyl, C3-6-alkynoxy-carbonyl, aminocarbonyl, C1-6-alkyl-aminocarbonyl, C3-6-alkenyl-aminocarbonyl, C3-6-alkynyl-aminocarbonyl, di-(C1-6-alkyl)-aminocarbonyl, di-(C3-6-alkenyl)-aminocarbonyl, di-(C3-6-alkynyl)-aminocarbonyl, formylamino, C1-6-alkyl-carbonylamino, C1-6-alkyl-carbonyl-(C1-3-alkyl)-amino, C2-6-alkenyl-carbonylamino, C2-6-alkynyl-carbonylamino, C1-6-alkyl-sulphonyl, C2-6-alkenyl-sulphonyl, C2-6-alkynyl-sulphonyl, C1-6-alkyl-sulphinyl, C2-6-alkenyl-sulphinyl, C2-6-alkynyl-sulphinyl, C1-6-alkyl-sulphonylamino, C2-6-alkenyl-sulphonylamino, C2-6-alkynyl-sulphonylamino, aminosulphonyl, C1-6-alkylaminosulphonyl, di-(C1-6-alkyl)-aminosulphonyl, C3-6-alkenylaminosulphonyl, di-(C3-6-alkenyl)-aminosulphonyl, C3-6-alkynylaminosulphonyl, or di-(C3-6-alkynyl)-aminosulphonyl groups, while the substituents may be identical or different, andor
\u2003wherein one ring member nitrogen atom optionally is substituted by a C1-6-alkyl, C3-6-alkenyl, C3-6-alkynyl, cyclo-C3-7-alkyl, cyclo-C3-7-alkenyl, hydroxy, hydroxy-C1-6-alkyl, hydroxy-C3-6-alkenyl, hydroxy-C3-6-alkynyl, C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl, C1-6-alkoxy-C3-6-alkenyl, C1-6-alkoxy-C3-6-alkynyl, C3-6-alkenoxy-C1-6-alkyl, C1-6-alkyl-carbonyl, C2-6-alkenyl-carbonyl, C2-6-alkynyl-carbonyl, formyl, C1-6-alkoxy-carbonyl, C3-6-alkenoxy-carbonyl, C3-6-alkynoxy-carbonyl, C1-6-alkyl-sulphonyl, C2-6-alkenyl-sulphonyl, C2-6-alkynyl-sulphonyl, C1-6-alkyl-sulphinyl, C2-6-alkenyl-sulphinyl, C2-6-alkynyl-sulphinyl, aminosulphonyl, phenyl or phenyl-C1-3-alkyl group,
Y is absent or denotes a \u2014(CH2)n\u2014 group, wherein n is 1, 2, 3, 4, 5 or 6 and wherein 1 or 2 \u2014CH2\u2014 groups optionally are replaced independently by O, S, carbonyl, sulfonyl, or \u2014NH\u2014, with the proviso that two heteroatoms are not directly linked together, or
\u2003wherein 1 \u2014CH2\u2014 group is replaced by O, S, carbonyl, sulfonyl, or \u2014NH\u2014, and additionally a \u2014CH2\u2014CH2\u2014 subgroup is replaced by \u2014C(O)\u2014O\u2014, \u2014O\u2014C(O)\u2014, \u2014C(O)\u2014NH\u2014, or \u2014NH\u2014C(O)\u2014, with the proviso that two heteroatoms are not directly linked together, and
\u2003wherein any hydrogen atom of the \u2014NH\u2014 groups mentioned hereinbefore optionally and independently is replaced by a C3-6-cycloalkyl or phenyl group, or by a straight-chained or branched C1-6-alkyl, C3-6-alkenyl, C3-6-alkynyl, phenyl-C1-6-alkyl, C1-6-alkyl-carbonyl, or C1-6-alkyl-sulphonyl group, andor
\u2003wherein 1 or 2 hydrogen atoms attached to carbon atoms optionally are replaced by halogen atoms, trifluoromethyl, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-6-cycloalkyl, phenyl, phenyl-C1-6-alkyl, cyano, hydroxy, hydroxy-C1-6-alkyl, C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl, C1-6-alkyl-carbonyl, C1-6-alkoxy-carbonyl, C1-6-alkyl-carbonylamino, C1-6-alkyl-carbonyl-(C1-3-alkyl)-amino, C1-3-alkyl-aminocarbonyl, di-(C1-3-alkyl)-aminocarbonyl or C1-6-alkyl-sulphonyl groups, while the substituents may be identical or different, or 2 geminal hydrogen atoms are replaced by a \u2014(CH2)m\u2014 bridge, wherein m is 2, 3, 4, or 5,
W denotes H or an optionally substituted straight-chained or branched C1-6-alkyl, C2-6-alkenyl or C2-6-alkynyl group, wherein 1 or 2 methyl groups optionally are replaced by optionally substituted phenyl groups or
\u2003an optionally substituted cyclo-C3-9-alkyl group, wherein independently
in a cyclo-C4-9-alkyl group 2 hydrogen atoms attached to adjacent carbon atoms optionally are replaced to form a double bond within the ring, which optionally is condensed with an optionally substituted aryl or an optionally substituted 5- or 6-membered hetaryl group, and the resulting group is bound via a saturated or unsaturated carbon atom, or
in a cyclo-C4-9-alkyl group 2 hydrogen atoms attached to the same carbon atom (relative 1,1-position) optionally are replaced by a C2-5-alkylenyl bridge or 2 hydrogen atoms attached to carbon atoms in relative 1,2-, 1,3- or 1,4-position optionally are replaced by a C1-5-alkylenyl bridge, wherein any of the resulting polycyclic groups one or two \u2014CH2\u2014 groups optionally are replaced by \u2014NH\u2014 (or N-atoms for replacement of \u2014CH< members), >N\u2014(C1-6-alkyl), O, S, carbonyl, or sulfonyl, andor two \u2014CH2\u2014 groups in relative 1,3-position within a C4-5-alkylenyl bridge optionally are replaced by O atoms, andor 2 hydrogen atoms attached to adjacent carbon atoms within a C4-5-alkylenyl bridge optionally are replaced to form a double bond, which optionally is condensed with an optionally substituted aryl or an optionally substituted 5- or 6-membered hetaryl group, andor
in a cyclo-C4-8-alkyl group one, two or three ring members optionally are replaced independently of each other by \u2014NH\u2014, >N\u2014(C1-6-alkyl) (or N-atoms for replacement of \u2014CH< members), O, S, carbonyl, or sulfonyl, with the proviso that two heteroatoms are not directly linked together, and additionally but optionally 2 or 4 hydrogen atoms attached to adjacent ring carbon atoms are replaced to form a double bond or two conjugated double bonds within the ring, either of the double bonds optionally being condensed with an optionally substituted aryl or an optionally substituted 5- or 6-membered hetaryl group,
and any of the resulting groups is bound via a saturated or unsaturated carbon atom or a nitrogen atom,
\u2003and wherein any of the resulting open-chained or cyclic groups independently 1 to 4 hydrogen atoms optionally are replaced by C1-6-alkyl or C1-6-alkoxy groups, andor
\u2003any 1 to 6 hydrogen atoms attached to carbon atoms optionally are replaced by fluorine atoms,
or W denotes an optionally substituted aryl or hetaryl group,
\u2003an optionally substituted cyclo-C3-8-alkyl-aryl or cyclo-C3-8-alkyl-hetaryl group, wherein the cyclo-C5-8-alkyl-submoieties one or two ring members optionally are replaced independently of each other by \u2014NH\u2014 (or N-atoms for replacement of \u2014CH< members), >N(C1-3-alkyl), O, S, carbonyl, or sulfonyl, with the proviso that two heteroatoms are not directly linked together, or
if Y is absent W additionally denotes
\u2003a divalent \u2014(CH2)p\u2014 group, wherein p is 2, 3, 4, 5, 6 or 7, attached in relative 1,1-position (geminal) to a carbon atom of group X, including the options:
if p is 3, 4, 5, 6 or 7 it follows that 1 \u2014CH2\u2014 group optionally is replaced by O, S, carbonyl, sulfonyl, \u2014NH\u2014 or \u2014N(C1-6-alkyl)-, or
if p is 4, 5, 6 or 7 it follows that a \u2014CH2\u2014CH2\u2014 group optionally is replaced by \u2014C(O)\u2014O\u2014, \u2014O\u2014C(O)\u2014, \u2014C(O)\u2014NH\u2014, \u2014NH\u2014C(O)\u2014, \u2014C(O)\u2014N(C1-6-alkyl)-, \u2014N(C1-6-alkyl)-C(O)\u2014, or \u2014CH\u2550CH\u2014, wherein the double bond optionally is condensed with an aryl or a 5- or 6-membered hetaryl group,
\u2003a divalent \u2014(CH2)q\u2014 group, wherein q is 3, 4, or 5, attached in relative 1,2-position (vicinal) to carbon atoms of group X, including the options:
that 1 \u2014CH2\u2014 group optionally is replaced by O, S, carbonyl, sulfonyl, \u2014NH\u2014 or \u2014N(C1-6-alkyl)-, or
a \u2014CH2\u2014CH2\u2014 group optionally is replaced by \u2014C(O)\u2014O\u2014, \u2014O\u2014C(O)\u2014, \u2014C(O)\u2014NH\u2014, \u2014NH\u2014C(O)\u2014, \u2014C(O)\u2014N(C1-6-alkyl)-, \u2014N(C1-6-alkyl)-C(O)\u2014, or
that in the resulting 5-, 6- and 7-membered carbocyclic ring 2, 4 or 6 hydrogen atoms optionally are replaced by 1, 2 or 3 bonds to form a partially or fully unsaturated ring with isolated or conjugated double bonds, wherein 1 \u2014CH2\u2014 group optionally is replaced by O, S, carbonyl, sulfonyl, \u2014NH\u2014 or \u2014N(C1-6-alkyl)-, andor one \u2014CH\u2550 unit is replaced by \u2014N\u2550,
\u2003a divalent \u2014(CH2)r\u2014 group, wherein r is 5, 6 or 7, attached in relative 1,3-position to carbon atoms as binding sites of group X, including the options:
that in the resulting 8-, 9- or 10-membered carbocyclic ring 2, 4, 6, 8 or 10 hydrogen atoms optionally are replaced by 1, 2, 3, 4 or 5 bonds to form a partially or fully unsaturated ring with isolated or conjugated double bonds, andor
that in the resulting 8-, 9- or 10-membered carbocyclic ring 1 hydrogen atom attached to the carbon atom in position 2 relative to the binding sites of group X and 1 hydrogen atom attached to a carbon atom of the \u2014(CH2)r\u2014 group in position 6 or 7 relative to the binding sites of group X optionally are replaced by a bond (C0-bridge) to form a bicyclic ring system condensed with the group X,
R1 denotes H, C1-6-alkyl, C3-6-alkenyl or C3-6-alkynyl, any of those groups being optionally substituted by 1 to 3 fluorine, chlorine or bromine atoms, or by a cyano, hydroxy, C1-3-alkoxy or cyclo-C3-7-alkyl-group,
R2 and R3 independently denote H, halogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, hydroxy or C1-6-alkoxy, any of those C1-6-alkyl, C2-6-alkenyl or C3-6-alkynyl groups being optionally substituted by 1 to 3 fluorine, chlorine or bromine atoms, or by a cyano or cyclo-C3-7-alkyl-group,
R4 and R5 independently denote H, halogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, cyclo-C3-7-alkyl, hydroxy or C1-3-alkoxy, any of those C1-6-alkyl, C2-6-alkenyl or C3-6-alkynyl groups being optionally substituted by 1 to 3 fluorine, chlorine or bromine atoms, by a cyano, hydroxy, C1-3-alkoxy, or cyclo-C3-5-alkyl-group, or by a phenyl or pyridyl group both optionally substituted independently by 1, 2 or 3 substituents selected from halogen atoms, C1-6-alkyl, cyclo-C3-7-alkyl, cyano, hydroxy, C1-6-alkoxy, amino, C1-6-alkyl-amino, or di-(C1-6-alkyl)-amino groups,
wherein, if not specified otherwise, any alkyl groups or subgroups mentioned hereinbefore are straight-chained or branched,
the term \u201caryl\u201d as used hereinbefore, either alone or as a sub-moiety within another substituent, if not otherwise specified means either an optionally substituted aromatic monocyclic or multicyclic system, for example a phenyl or a naphthyl group,
the term \u201chetaryl\u201d as used hereinbefore, either alone or as a sub-moiety within another substituent, if not otherwise specified denotes five- or six-membered heterocyclic aromatic groups or 5-10 membered, bicyclic heteroaromatic groups comprising one, two or three heteroatoms selected from oxygen, sulphur and nitrogen, linked through a carbon atom or, if present, through a nitrogen atom, and optionally substituted at carbon atoms andor a nitrogen atoms,
and wherein the expression \u201csubstituted\u201d or \u201coptionally substituted\u201d as used hereinbefore if not otherwise specified means substitution with one, two, three, four or more substituents attached to carbon atoms selected from the group consisting of
halogen atoms (fluorine, chlorine, bromine or iodine atoms), C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, cyclo-C3-8-alkyl, cyclo-C3-7-alkenyl, cyano, hydroxy, hydroxy-C1-6-alkyl, hydroxy-C3-6-alkenyl, hydroxy-C3-6-alkynyl, C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl, C1-6-alkoxy-C3-6-alkenyl, C1-6-alkoxy-C3-6-alkynyl, C3-6-alkenoxy-C1-6-alkyl, C3-6-alkenoxy-C3-6-alkenyl, C3-6-alkenoxy-C3-6-alkynyl, C3-6-alkynoxy-C1-6-alkyl, C3-6-alkynoxy-C3-6-alkenyl, C3-6-alkynoxy-C3-6-alkynyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidino, piperidino, thiohydroxy, C1-6-alkylthio, C3-6-alkenylthio, C3-6-alkynylthio, amino, C1-6-alkyl-amino, C3-6-alkenyl-amino, C3-6-alkynyl-amino, di-(C1-6-alkyl)-amino, di-(C3-6-alkenyl)-amino, di-(C3-6-alkynyl)-amino, amino-C1-6-alkyl, C1-3-alkyl-amino-C1-6-alkyl, di-(C1-3-alkyl)-amino-C1-6-alkyl, amino-C3-6-alkenyl, C1-3-alkyl-amino-C3-6-alkenyl, di-(C1-3-alkyl)-amino-C3-6-alkenyl, amino-C3-6-alkynyl, C1-3-alkyl-amino-C3-6-alkynyl, di-(C1-3-alkyl)-amino-C3-6-alkynyl, hydroxycarbonyl, phenyl, phenyl-C1-3-alkyl, phenyloxy, phenyl-C1-3-alkoxy, phenyloxy-C1-3-alkyl, phenylcarbonyl, pyridyl, thiazolyl; pyridyl-carbonyl, C1-6-alkyl-carbonyl, C2-6-alkenyl-carbonyl, C2-6-alkynyl-carbonyl, formyl, C1-6-alkoxy-carbonyl, C3-6-alkenoxy-carbonyl, C3-6-alkynoxy-carbonyl, aminocarbonyl, C1-6-alkyl-aminocarbonyl, C3-6-alkenyl-aminocarbonyl, C3-6-alkynyl-aminocarbonyl, di-(C1-6-alkyl)-aminocarbonyl, di-(C3-6-alkenyl)-aminocarbonyl, di-(C3-6-alkynyl)-aminocarbonyl, formylamino, C1-6-alkyl-carbonylamino, C2-6-alkenyl-carbonylamino, C2-6-alkynyl-carbonylamino, formyl-C1-6-alkyl-amino, formyl-C3-6-alkenyl-amino, formyl-C3-6-alkynyl-amino, C1-6-alkyl-carbonyl-C1-6-alkyl-amino, C2-6-alkenyl-carbonyl-C1-6-alkyl-amino, C2-6-alkynyl-carbonyl-C1-6-alkyl-amino, C1-6-alkyl-carbonyl-C3-6-alkenyl-amino, C2-6-alkenyl-carbonyl-C3-6-alkenyl-amino, C2-6-alkynyl-carbonyl-C3-6-alkenyl-amino, C1-6-alkyl-carbonyl-C3-6-alkynyl-amino, C2-6-alkenyl-carbonyl-C3-6-alkynyl-amino, C2-6-alkynyl-carbonyl-C3-6-alkynyl-amino, C1-6-alkyl-sulphonyl, C2-6-alkenyl-sulphonyl, C2-6-alkynyl-sulphonyl, C1-6-alkyl-sulphinyl, C2-6-alkenyl-sulphinyl, C2-6-alkynyl-sulphinyl, C1-6-alkyl-sulphonylamino, C2-6-alkenyl-sulphonylamino, C2-6-alkynyl-sulphonylamino, C1-6-alkyl-sulphonyl-C1-6-alkylamino, C1-6-alkyl-sulphonyl-C3-6-alkenylamino, C1-6-alkyl-sulphonyl-C3-6-alkynylamino, C2-6-alkenyl-sulphonyl-C1-6-alkylamino, C2-6-alkenyl-sulphonyl-C3-6-alkenylamino, C2-6-alkenyl-sulphonyl-C3-6-alkynylamino, C2-6-alkynyl-sulphonyl-C1-6-alkylamino, C2-6-alkynyl-sulphonyl-C3-6-alkenylamino, C2-6-alkynyl-sulphonyl-C3-6-alkynylamino, aminosulphonyl, C1-6-alkylaminosulphonyl, di-(C1-6-alkyl)-aminosulphonyl, C3-6-alkenylaminosulphonyl, di-(C3-6-alkenyl)-aminosulphonyl, C3-6-alkynylaminosulphonyl and di-(C3-6-alkynyl)-aminosulphonyl groups, while the substituents may be identical or different and wherein any alkyl groups or alkyl sub-moieties optionally are partially or fully fluorinated,
and wherein any phenyl, pyridyl and thiazolyl groups or phenyl-, pyridyl and thiazolyl-submoieties optionally are substituted with 1 or 2 substituents independently of each other selected from fluorine, chlorine, bromine, iodine, C1-3-alkyl, C1-3-alkoxy, amino, C1-3-alkyl-amino, di-(C1-3-alkyl)-amino C1-3-alkylcarbonyl-amino, C1-3-alkylcarbonyl-C1-3-alkyl-amino, cyano or hydroxy,
or with substituents attached to a nitrogen atom selected from the group consisting of
C1-6-alkyl, C3-6-alkenyl, C3-6-alkynyl, cyclo-C3-7-alkyl, cyclo-C3-7-alkenyl, cyclo-C3-7-alkyl-C1-6-alkyl, pyrrolidino, piperidino, morpholino, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, cyano, hydroxy, hydroxy-C1-6-alkyl, hydroxy-C3-6-alkenyl, hydroxy-C3-6-alkynyl, C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl, C1-6-alkoxy-C3-6-alkenyl, C1-6-alkoxy-C3-6-alkynyl, C3-6-alkenoxy-C1-6-alkyl, C3-6-alkenoxy-C3-6-alkenyl, C3-6-alkenoxy-C3-6-alkynyl, C3-6-alkynoxy-C1-6-alkyl, C3-6-alkynoxy-C3-6-alkenyl, C3-6-alkynoxy-C3-6-alkynyl, amino-C1-6-alkyl, C1-3-alkyl-amino-C1-6-alkyl, di-(C1-3-alkyl)-amino-C1-6-alkyl, amino-C3-6-alkenyl, C1-3-alkyl-amino-C3-6-alkenyl, di-(C1-3-alkyl)-amino-C3-6-alkenyl, amino-C3-6-alkynyl, C1-3-alkyl-amino-C3-6-alkynyl, di-(C1-3-alkyl)-amino-C3-6-alkynyl, hydroxycarbonyl, phenyl, phenyl-C1-6-alkyl, phenylcarbonyl, pyridyl, pyridylcarbonyl, C1-6-alkyl-carbonyl, C2-6-alkenyl-carbonyl, C2-6-alkynyl-carbonyl, C1-6-alkoxy-carbonyl, C3-6-alkenoxy-carbonyl, C3-6-alkynoxy-carbonyl, aminocarbonyl, C1-6-alkyl-aminocarbonyl, C3-6-alkenyl-aminocarbonyl, C3-6-alkynyl-aminocarbonyl, di-(C1-6-alkyl)-aminocarbonyl, di-(C3-6-alkenyl)-aminocarbonyl, di-(C3-6-alkynyl)-aminocarbonyl, C1-6-alkyl-sulphonyl, C2-6-alkenyl-sulphonyl, C2-6-alkynyl-sulphonyl, C1-6-alkyl-sulphinyl, C2-6-alkenyl-sulphinyl, C2-6-alkynyl-sulphinyl, aminosulphonyl, C1-6-alkylaminosulphonyl, di-(C1-6-alkyl)-aminosulphonyl, C3-6-alkenylaminosulphonyl, di-(C3-6-alkenyl)-aminosulphonyl, C3-6-alkynylaminosulphonyl and di-(C3-6-alkynyl)-aminosulphonyl groups, while the substituents may be identical or different and wherein any alkyl groups or alkyl sub-moieties optionally are partially or fully fluorinated,
and wherein any of the di-(C1-3-alkyl)-amino or di-(C1-6-alkyl)-amino moieties may form optionally with the nitrogen atom a 4 to 8 membered ring system,
and wherein any phenyl and pyridyl groups or phenyl- and pyridyl-submoieties optionally are substituted with 1 or 2 substituents independently of each other selected from fluorine, chlorine, bromine, iodine, C1-3-alkyl, C1-3-alkoxy, amino, C1-3-alkyl-amino, C1-3-alkylcarbonyl-amino, cyano or hydroxy,
or a salt thereof.
2-8. (canceled)
9. The compound according to claim 1, wherein
X denotes a divalent 4- to 8-membered monocylic, 7- to 10-membered spirocyclic or 6- to 12-membered bicyclic saturated, partially or fully unsaturated group selected from a carbocycle, a monoaza-heterocycle and a diaza-heterocycle, which is linked to the adjacent groups via carbon atoms or, if present, via nitrogen atoms, e.g. via one carbon and one nitrogen atom or via both nitrogen atoms,
wherein 1 to 2 \u2014CH2\u2014 groups optionally are replaced independently of each other by O, S, carbonyl, or sulfonyl, with the proviso that two heteroatoms are not directly linked together, andor
wherein 1 double bond optionally is condensed with an aryl or a 5- or 6-membered hetaryl group, andor
wherein in all groups falling under the above definition of X one or two carbon atoms optionally and independently are substituted by halogen atoms, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, cyclo-C3-7-alkyl, cyclo-C3-7-alkenyl, phenyl, cyano, hydroxy, hydroxy-C1-6-alkyl, C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl, C1-6-alkoxy-C1-6-alkyl-carbonyl, formyl, aminocarbonyl, C1-6-alkyl-aminocarbonyl, C3-6-alkenyl-aminocarbonyl, C3-6-alkynyl-aminocarbonyl, di-(C1-6-alkyl)-aminocarbonyl, di-(C3-6-alkenyl)-aminocarbonyl, di-(C3-6-alkynyl)-aminocarbonyl, formylamino, C1-6-alkyl-carbonylamino, C1-6-alkyl-carbonyl-(C1-3-alkyl)-amino C2-6-alkenyl-carbonylamino or C2-6-alkynyl-carbonylamino groups, while the substituents may be identical or different, andor,
wherein one ring member nitrogen atom optionally is substituted by a C1-3-alkyl, cyclo-C3-6-alkyl, C1-3-alkoxy, C1-3-alkoxy-C1-3-alkyl, C1-3-alkyl-carbonyl, C1-3-alkoxy-carbonyl or C1-3-alkyl-sulphonyl group;
Y and W are defined as in claim 1,
R1 denotes H, C1-4-alkyl, C3-4-alkenyl or C3-4-alkynyl, any of those groups being optionally substituted by 1 to 3 fluorine, chlorine or bromine atoms, or by a cyano, hydroxy, C1-3-alkoxy or cyclo-C3-6-alkyl-group,
R2 and R3 independently denote H, halogen, C1-3-alkyl, hydroxy or C1-3-alkoxy, any of those C1-3-alkyl groups being optionally substituted by 1 to 3 fluorine atoms,
R4 and R5 independently denote H, halogen, C1-3-alkyl, C2-4-alkenyl, C2-3-alkynyl, cyclo-C3-6-alkyl, hydroxy or C1-3-alkoxy, any of those C1-3-alkyl, C2-4-alkenyl or C2-3-alkynyl groups being optionally substituted by 1 to 3 fluorine atoms, by a methyl, hydroxy, C1-3-alkoxy, or cyclo-C3-5-alkyl-group, or by a phenyl or pyridyl group both optionally substituted independently by 1, 2 or 3 substituents selected from
halogen atoms, C1-3-alkyl, cyclo-C3-6-alkyl, cyano, hydroxy, C1-3-alkoxy, amino, C1-3-alkyl-amino, and di-(C1-3-alkyl)-amino groups,
or a salt thereof.
10. The compound according to claim 1, wherein
X denotes a divalent 4- to 8-membered monocylic, 7- to 10-membered spirocyclic or 6- to 12-membered bicyclic saturated, partially or fully unsaturated group selected from a carbocycle, a monoaza-heterocycle and a diaza-heterocycle, which is linked to the adjacent groups via carbon atoms or, if present, via nitrogen atoms, e.g. via one carbon and one nitrogen atom or via both nitrogen atoms,
wherein 1 to 2 \u2014CH2\u2014 groups optionally are replaced independently of each other by O, S, carbonyl, or sulfonyl, with the proviso that two heteroatoms are not directly linked together, andor
wherein 1 double bond optionally is condensed with an aryl or a 5- or 6-membered hetaryl group, andor
wherein in all groups falling under the above definition of X one or two carbon atoms optionally and independently are substituted by halogen atoms, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, cyclo-C3-7-alkyl, cyclo-C3-7-alkenyl, phenyl, cyano, hydroxy, hydroxy-C1-6-alkyl, C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl, C1-6-alkoxy-C1-6-alkyl-carbonyl, formyl, aminocarbonyl, C1-6-alkyl-aminocarbonyl, C3-6-alkenyl-aminocarbonyl, C3-6-alkynyl-aminocarbonyl, di-(C1-6-alkyl)-aminocarbonyl, di-(C3-6-alkenyl)-aminocarbonyl, di-(C3-6-alkynyl)-aminocarbonyl, formylamino, C1-6-alkyl-carbonylamino, C1-6-alkyl-carbonyl-(C1-3-alkyl)-amino C2-6-alkenyl-carbonylamino or C2-6-alkynyl-carbonylamino groups, while the substituents may be identical or different, andor,
wherein one ring member nitrogen atom optionally is substituted by a C1-3-alkyl, cyclo-C3-6-alkyl, C1-3-alkoxy, C1-3-alkoxy-C1-3-alkyl, C1-3-alkyl-carbonyl, C1-3-alkoxy-carbonyl or C1-3-alkyl-sulphonyl group;
Y is absent or denotes a \u2014(CH2)n\u2014 group, wherein n is 1, 2, 3, 4, 5 or 6 and wherein 1 \u2014CH2\u2014 group optionally is replaced by O, carbonyl or \u2014NH\u2014, or
wherein 1 \u2014CH2\u2014 group is replaced by O or \u2014NH\u2014, and additionally a second \u2014CH2\u2014 group is replaced by carbonyl, or
wherein 1 \u2014CH2\u2014 group is replaced by O and additionally a \u2014CH2\u2014CH2\u2014 subgroup is replaced by \u2014C(O)\u2014NH\u2014, or \u2014NH\u2014C(O)\u2014, and
wherein any hydrogen atom of the \u2014NH\u2014 groups mentioned hereinbefore optionally and independently is replaced by a C3-6-cycloalkyl or phenyl group, or by a straight-chained or branched C1-4-alkyl, phenyl-C1-3-alkyl, C1-4-alkyl-carbonyl, or C1-4-alkyl-sulphonyl group, andor
wherein 1 or 2 hydrogen atoms attached to carbon atoms optionally are replaced by halogen atoms, trifluoromethyl, C1-4-alkyl, C2-4-alkenyl, C3-6-cycloalkyl, phenyl, phenyl-C1-3-alkyl, hydroxy, hydroxy-C1-3-alkyl, C1-3-alkoxy, C1-3-alkoxy-C1-3-alkyl, C1-4-alkyl-carbonyl, C1-4-alkoxy-carbonyl, C1-4-alkyl-carbonylamino, C1-4-alkyl-carbonyl-(C1-3-alkyl)-amino, C1-3-alkyl-aminocarbonyl, or di-(C1-3-alkyl)-aminocarbonyl groups, while the substituents may be identical or different, or 2 geminal hydrogen atoms are replaced by a \u2014(CH2)m\u2014 bridge, wherein m is 2, 3, 4, or 5;
W is defined as in claim 1, and
R1 denotes H, C1-4-alkyl, C3-4-alkenyl or C3-4-alkynyl, any of those groups being optionally substituted by 1 to 3 fluorine, chlorine or bromine atoms, or by a cyano, hydroxy, C1-3-alkoxy or cyclo-C3-6-alkyl-group,
R2 and R3 independently denote H, halogen, C1-3-alkyl, hydroxy or C1-3-alkoxy, any of those C1-3-alkyl groups being optionally substituted by 1 to 3 fluorine atoms,
R4 and R5 independently denote H, halogen, C1-3-alkyl, C2-4-alkenyl, C2-3-alkynyl, cyclo-C3-6-alkyl, hydroxy or C1-3-alkoxy, any of those C1-3-alkyl, C2-4-alkenyl or C2-3-alkynyl groups being optionally substituted by 1 to 3 fluorine atoms, by a methyl, hydroxy, C1-3-alkoxy, or cyclo-C3-5-alkyl-group, or by a phenyl or pyridyl group both optionally substituted independently by 1, 2 or 3 substituents selected from
halogen atoms, C1-3-alkyl, cyclo-C3-6-alkyl, cyano, hydroxy, C1-3-alkoxy, amino, C1-3-alkyl-amino, and di-(C1-3-alkyl)-amino groups,
or a salt thereof.
11. The compound according to claim 1, wherein
X denotes a divalent phenyl group or a group selected from formulas (II) to (XIII),
wherein 1 \u2014CH2\u2014 group optionally is replaced by O, S, carbonyl, or sulfonyl, with the proviso that two heteroatoms are not directly linked together, andor
wherein a double bond, if present, optionally is condensed with an aryl or a 5- or 6-membered hetaryl group, andor
wherein in all groups falling under the above definition of X one or two carbon atoms optionally and independently are substituted by halogen atoms, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, cyclo-C3-7-alkyl, cyclo-C3-7-alkenyl, phenyl, cyano, hydroxy, hydroxy-C1-6-alkyl, C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl, C1-6-alkoxy-C1-6-alkyl-carbonyl, formyl, aminocarbonyl, C1-6-alkyl-aminocarbonyl, C3-6-alkenyl-aminocarbonyl, C3-6-alkynyl-aminocarbonyl, di-(C1-6-alkyl)-aminocarbonyl, di-(C3-6-alkenyl)-aminocarbonyl, di-(C3-6-alkynyl)-aminocarbonyl, formylamino, C1-6-alkyl-carbonylamino, C1-6-alkyl-carbonyl-(C1-3-alkyl)-amino C2-6-alkenyl-carbonylamino or C2-6-alkynyl-carbonylamino groups, while the substituents may be identical or different, andor,
wherein one ring member nitrogen atom, if present, optionally is substituted by a C1-3-alkyl, cyclo-C3-6-alkyl, C1-3-alkoxy, C1-3-alkoxy-C1-3-alkyl, C1-3-alkyl-carbonyl, C1-3-alkoxy-carbonyl or C1-3-alkyl-sulphonyl group;
Y is absent;
W denotes H or an optionally substituted straight-chained or branched C1-6-alkyl, C2-6-alkenyl or C2-6-alkynyl group, wherein 1 or 2 methyl groups optionally are replaced by optionally substituted phenyl groups or
an optionally substituted cyclo-C3-9-alkyl group, wherein independently
in a cyclo-C4-7-alkyl group 2 hydrogen atoms attached to adjacent carbon atoms optionally are replaced to form a double bond within the ring, which optionally is condensed with an optionally substituted aryl or an optionally substituted 5- or 6-membered hetaryl group, and the resulting group is bound via a saturated or unsaturated carbon atom, or
in a cyclo-C4-9-alkyl group 2 hydrogen atoms attached to the same carbon atom (relative 1,1-position) optionally are replaced by a C2-5-alkylenyl bridge, or 2 hydrogen atoms attached to carbon atoms in relative 1,2-, 1,3- or 1,4-position optionally are replaced by a C1-5-alkylenyl bridge, wherein any of the resulting polycyclic groups one or two \u2014CH2\u2014 groups optionally are replaced by \u2014NH\u2014, >N\u2014(C1-6-alkyl), (or N-atoms for replacement of \u2014CH< members), O, or carbonyl, andor two \u2014CH2\u2014 groups in relative 1,3-position of a C4-5-alkylenyl bridge optionally are replaced by O atoms, andor 2 hydrogen atoms attached to adjacent carbon atoms within a C4-5-alkylenyl bridge optionally are replaced to form a double bond, which optionally is condensed with an optionally substituted aryl or an optionally substituted 5- or 6-membered hetaryl group, andor
in a cyclo-C4-8-alkyl group one, two or three ring members optionally are replaced independently of each other by \u2014NH\u2014, >N\u2014(C1-6-alkyl), (or N-atoms for replacement of \u2014CH< members), O, or carbonyl, with the proviso that two heteroatoms are not directly linked together, and additionally but optionally 2 or 4 hydrogen atoms attached to adjacent ring carbon atoms are replaced to form a double bond or two conjugated double bonds within the ring, either of the double bonds optionally being condensed with an optionally substituted aryl or an optionally substituted 5- or 6-membered hetaryl group,
and any of the resulting groups is bound via a saturated or unsaturated carbon atom or a nitrogen atom,
and wherein any of the resulting open-chained or cyclic groups independently 1 to 3 hydrogen atoms optionally are replaced by C1-4-alkyl or C1-4-alkoxy groups, andor
any 1 to 6 hydrogen atoms attached to carbon atoms optionally are replaced by fluorine atoms,
or W denotes an optionally substituted aryl or hetaryl group,
an optionally substituted cyclo-C3-8-alkyl-aryl or cyclo-C3-8-alkyl-hetaryl group, wherein the cyclo-C5-8-alkyl-submoieties one or two ring members optionally are replaced independently of each other by \u2014NH\u2014 (or N-atoms for replacement of \u2014CH< members), O, or carbonyl, with the proviso that two heteroatoms are not directly linked together, or
a divalent \u2014(CH2)p\u2014 group, wherein p is 2, 3, 4, or 5, attached in relative 1,1-position (geminal) to a carbon atom of group X, including the options:
if p is 3, 4, or 5 it follows that 1 \u2014CH2\u2014 group optionally is replaced by O, carbonyl, \u2014NH\u2014 or \u2014N(C1-6-alkyl)-, or
if p is 4 or 5 it follows that a \u2014CH2\u2014CH2\u2014 group optionally is replaced by \u2014C(O)\u2014NH\u2014, \u2014NH\u2014C(O)\u2014, \u2014C(O)\u2014N(C1-6-alkyl)-, \u2014N(C1-6-alkyl)-C(O)\u2014, or \u2014CH\u2550CH\u2014, wherein the double bond optionally is condensed with an aryl or a 5- or 6-membered hetaryl group,
a divalent \u2014(CH2)q\u2014 group, wherein q is 3, or 4 attached in relative 1,2-position (vicinal) to carbon atoms of group X, including the options:
that 1 \u2014CH2\u2014 group optionally is replaced by O, carbonyl, \u2014NH\u2014 or \u2014N(C1-6-alkyl)-, or
a \u2014CH2\u2014CH2\u2014 group optionally is replaced by \u2014C(O)\u2014NH\u2014, \u2014NH\u2014C(O)\u2014, \u2014C(O)\u2014N(C1-6-alkyl)-, \u2014N(C1-6-alkyl)-C(O)\u2014, or
that in the resulting 5- or 6-membered carbocyclic ring 2, 4 or, in case of the 6-membered ring, also 6 hydrogen atoms optionally are replaced by 1, 2 or 3 bonds to form a partially or fully unsaturated ring with isolated or conjugated double bonds, wherein 1 \u2014CH2\u2014 group optionally is replaced by O, S, carbonyl, \u2014NH\u2014 or \u2014N(C1-6-alkyl)-, andor one \u2014CH\u2550 unit is replaced by \u2014N\u2550,
a divalent \u2014(CH2)7\u2014 group, attached in relative 1,3-position to carbon atoms as binding sites of group X, including the options:
that in the resulting 10-membered carbocyclic ring 2, 4, 6, 8 or 10 hydrogen atoms optionally are replaced by 1, 2, 3, 4 or 5 bonds to form a partially or fully unsaturated ring with isolated or conjugated double bonds, andor
that in the resulting 10-membered carbocyclic ring 1 hydrogen atom attached to the carbon atom in position 2 relative to the binding sites of group X and 1 hydrogen atom attached to a carbon atom of the \u2014(CH2)r\u2014 group in position 7 relative to the binding sites of group X optionally are replaced by a bond (C0-bridge) to form a bicyclic ring system condensed with the group X,
e.g. X and W together denote the group
wherein any aryl groups or subgroups mentioned above in the definition of W are selected from optionally substituted phenyl, naphthyl, and tetrahydronaphthyl groups, and
wherein any hetaryl groups or subgroups mentioned above in the definition of W are selected from optionally substituted pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyrazolyl, imidazolyl, triazolyl, furyl, thienyl, oxazolyl, benzoxazolyl, thiazolyl, benzthiazolyl, indolyl, indolinyl, benzimidazolyl, tetrahydrobenzimidazolyl, tetrahydrocyclopentaimidazolyl, indazolyl, tetrahydroindazolyl, tetrahydrocyclopentapyrazolyl, hexahydrocycloheptapyrazolyl, benztriazolyl, quinolyl, tetrandyroquinolinly, isoquinolyl, tetrandyroisoquinolinly, cinnolyl, quinoxazolyl and benzpyrimidinyl groups,
wherein the expression \u201csubstituted\u201d or \u201coptionally substituted\u201d as used herein has the same meaning as in claim 1;
and
R1 denotes H, C1-4-alkyl, C3-4-alkenyl or C3-4-alkynyl, any of those groups being optionally substituted by 1 to 3 fluorine, chlorine or bromine atoms, or by a cyano, hydroxy, C1-3-alkoxy or cyclo-C3-6-alkyl-group,
R2 and R3 independently denote H, halogen, C1-3-alkyl, hydroxy or C1-3-alkoxy, any of those C1-3-alkyl groups being optionally substituted by 1 to 3 fluorine atoms,
R4 and R5 independently denote H, halogen, C1-3-alkyl, C2-4-alkenyl, C2-3-alkynyl, cyclo-C3-6-alkyl, hydroxy or C1-3-alkoxy, any of those C1-3-alkyl, C2-4-alkenyl or C2-3-alkynyl groups being optionally substituted by 1 to 3 fluorine atoms, by a methyl, hydroxy, C1-3-alkoxy, or cyclo-C3-5-alkyl-group, or by a phenyl or pyridyl group both optionally substituted independently by 1, 2 or 3 substituents selected from
halogen atoms, C1-3-alkyl, cyclo-C3-6-alkyl, cyano, hydroxy, C1-3-alkoxy, amino, C1-3-alkyl-amino, and di-(C1-3-alkyl)-amino groups,
or a salt thereof.
12. The compound according to claim 1, wherein
X denotes a group selected from formulas (II), (III), (VI) or (XIII),
wherein 1 \u2014CH2\u2014 group optionally is replaced independently of each other by O or carbonyl,
wherein one or two carbon atoms optionally and independently are substituted by halogen atoms, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, cyclo-C3-7-alkyl, cyclo-C3-7-alkenyl, phenyl, cyano, hydroxy, hydroxy-C1-6-alkyl, C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl, C1-6-alkoxy-C1-6-alkyl-carbonyl, formyl, aminocarbonyl, C1-6-alkyl-aminocarbonyl, C3-6-alkenyl-aminocarbonyl, C3-6-alkynyl-aminocarbonyl, di-(C1-6-alkyl)-aminocarbonyl, di-(C3-6-alkenyl)-aminocarbonyl, di-(C3-6-alkynyl)-aminocarbonyl, formylamino, C1-6-alkyl-carbonylamino, C1-6-alkyl-carbonyl-(C1-3-alkyl)-amino C2-6-alkenyl-carbonylamino or C2-6-alkynyl-carbonylamino groups, while the substituents may be identical or different;
Y denotes a \u2014(CH2)n\u2014 group, wherein n is 1, 2, 3, 4, 5 or 6 and wherein 1 \u2014CH2\u2014 group optionally is replaced by O, carbonyl or \u2014NH\u2014, or
wherein 1 \u2014CH2\u2014 group is replaced by O or \u2014NH\u2014, and additionally a second \u2014CH2\u2014 group is replaced by carbonyl, or
wherein 1 \u2014CH2\u2014 group is replaced by O and additionally a \u2014CH2\u2014CH2\u2014 subgroup is replaced by \u2014C(O)\u2014NH\u2014, or \u2014NH\u2014C(O)\u2014, and
wherein any hydrogen atom of the \u2014NH\u2014 groups mentioned hereinbefore optionally and independently is replaced by a C3-6-cycloalkyl or phenyl group, or by a straight-chained or branched C1-4-alkyl, phenyl-C1-3-alkyl, or C1-3-alkyl-carbonyl, andor
wherein 1 or 2 hydrogen atoms attached to carbon atoms optionally are independently replaced by F, Cl, C1-4-alkyl or trifluoromethyl, or 1 hydrogen atom attached to a carbon atom optionally is replaced by C3-6-cycloalkyl, phenyl, phenyl-C1-3-alkyl, hydroxy, or C1-3-alkoxy groups, while the substituents may be identical or different, or 2 geminal hydrogen atoms are replaced by a \u2014(CH2)m\u2014 bridge, wherein m is 2, 3, or 4;
W denotes H or an optionally substituted straight-chained or branched C1-6-alkyl, C2-6-alkenyl or C2-6-alkynyl group, wherein 1 or 2 methyl groups optionally are replaced by optionally substituted phenyl groups or
an optionally substituted cyclo-C3-9-alkyl group, wherein independently
in a cyclo-C4-7-alkyl group 2 hydrogen atoms attached to adjacent carbon atoms optionally are replaced to form a double bond within the ring, which optionally is condensed with an optionally substituted aryl or an optionally substituted 5- or 6-membered hetaryl group, and the resulting group is bound via a saturated or unsaturated carbon atom, or
in a cyclo-C4-9-alkyl group 2 hydrogen atoms attached to the same carbon atom (relative 1,1-position) optionally are replaced by a C2-5-alkylenyl bridge, or 2 hydrogen atoms attached to carbon atoms in relative 1,2-, 1,3- or 1,4-position optionally are replaced by a C1-5-alkylenyl bridge, wherein any of the resulting polycyclic groups one or two \u2014CH2\u2014 groups optionally are replaced by \u2014NH\u2014, >N\u2014(C1-6-alkyl), (or N-atoms for replacement of \u2014CH< members), O, or carbonyl, andor two \u2014CH2\u2014 groups in relative 1,3-position of a C4-5-alkylenyl bridge optionally are replaced by O atoms, andor 2 hydrogen atoms attached to adjacent carbon atoms within a C4-5-alkylenyl bridge optionally are replaced to form a double bond, which optionally is condensed with an optionally substituted aryl or an optionally substituted 5- or 6-membered hetaryl group, andor
in a cyclo-C4-8-alkyl group, two or three ring members optionally are replaced independently of each other by \u2014NH\u2014, >N\u2014(C1-6-alkyl), (or N-atoms for replacement of a \u2014CH< members), O, or carbonyl, with the proviso that two heteroatoms are not directly linked together, and additionally but optionally 2 or 4 hydrogen atoms attached to adjacent ring carbon atoms are replaced to form a double bond or two conjugated double bonds within the ring, either of the double bonds optionally being condensed with an optionally substituted aryl or an optionally substituted 5- or 6-membered hetaryl group,
and any of the resulting groups is bound via a saturated or unsaturated carbon atom or a nitrogen atom,
and wherein any of the resulting open-chained or cyclic groups independently 1 to 3 hydrogen atoms optionally are replaced by C1-4-alkyl or C1-4-alkoxy groups, andor
any 1 to 6 hydrogen atoms attached to carbon atoms optionally are replaced by fluorine atoms,
or W denotes an optionally substituted aryl or hetaryl group,
an optionally substituted cyclo-C3-6-alkyl-aryl or cyclo-C3-6-alkyl-hetaryl group, wherein the cyclo-C5-6-alkyl-submoieties one or two ring members optionally are replaced independently of each other by \u2014NH\u2014 (or a N-atom for replacement of a \u2014CH< member), O, or carbonyl, with the proviso that two heteroatoms are not directly linked together,
R1 denotes H, C1-4-alkyl, C3-4-alkenyl or C3-4-alkynyl, any of those groups being optionally substituted by 1 to 3 fluorine, chlorine or bromine atoms, or by a cyano, hydroxy, C1-3-alkoxy or cyclo-C3-6-alkyl-group,
R2 and R3 independently denote H, halogen, C1-3-alkyl, hydroxy or C1-3-alkoxy, any of those C1-3-alkyl groups being optionally substituted by 1 to 3 fluorine atoms,
R4 and R5 independently denote H, halogen, C1-3-alkyl, C2-4-alkenyl, C2-3-alkynyl, cyclo-C3-6-alkyl, hydroxy or C1-3-alkoxy, any of those C1-3-alkyl, C2-4-alkenyl or C2-3-alkynyl groups being optionally substituted by 1 to 3 fluorine atoms, by a methyl, hydroxy, C1-3-alkoxy, or cyclo-C3-5-alkyl-group, or by a phenyl or pyridyl group both optionally substituted independently by 1, 2 or 3 substituents selected from
halogen atoms, C1-3-alkyl, cyclo-C3-6-alkyl, cyano, hydroxy, C1-3-alkoxy, amino, C1-3-alkyl-amino, and di-(C1-3-alkyl)-amino groups,
or a salt thereof.
13. The compound according to claim 1, wherein
X denotes a group selected from formulas (II), (III), (VI), (VII) or (XIII),
wherein 1 \u2014CH2\u2014 group optionally is replaced independently of each other by O, S, carbonyl, or sulfonyl, with the proviso that two heteroatoms are not directly linked together,
wherein one or two carbon atoms optionally and independently are substituted by halogen atoms, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, cyclo-C3-7-alkyl, cyclo-C3-7-alkenyl, phenyl, cyano, hydroxy, hydroxy-C1-6-alkyl, C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl, C1-6-alkoxy-C1-6-alkyl-carbonyl, formyl, aminocarbonyl, C1-6-alkyl-aminocarbonyl, C3-6-alkenyl-amino-carbonyl, C3-6-alkynyl-aminocarbonyl, di-(C1-6-alkyl)-aminocarbonyl, di-(C3-6-alkenyl)-aminocarbonyl, di-(C3-6-alkynyl)-aminocarbonyl, formylamino, C1-6-alkyl-carbonylamino, C1-6-alkyl-carbonyl-(C1-3-alkyl)-amino C2-6-alkenyl-carbonylamino or C2-6-alkynyl-carbonylamino groups, while the substituents may be identical or different,
andor one ring member nitrogen atom is substituted by C1-6-alkyl, C3-6-alkenyl, C3-6-alkynyl, cyclo-C3-7-alkyl or cyclo-C3-7-alkenyl;
Y denotes a carbonyl group;
W denotes H or an optionally substituted straight-chained or branched C1-6-alkyl, C2-6-alkenyl or C2-6-alkynyl group, wherein 1 or 2 methyl groups optionally are replaced by optionally substituted phenyl groups or
an optionally substituted cyclo-C3-8-alkyl group, wherein independently
in a cyclo-C4-8-alkyl group one or two ring members optionally are replaced independently of each other by \u2014NH\u2014, >N\u2014(C1-6-alkyl) (or N-atoms for replacement of \u2014CH< members), O, or carbonyl, with the proviso that two heteroatoms are not directly linked together, and additionally but optionally 2 or 4 hydrogen atoms attached to adjacent ring carbon atoms are replaced to form a double bond or two conjugated double bonds within the ring, either of the double bonds optionally being condensed with an optionally substituted aryl or an optionally substituted 5- or 6-membered hetaryl group, andor
in a cyclo-C4-5-alkyl group 2 hydrogen atoms attached to the same carbon atom (relative 1,1-position) optionally are replaced by a C2-5-alkylenyl bridge, wherein one \u2014CH2\u2014 group optionally is replaced by \u2014NH\u2014, >N\u2014(C1-6-alkyl), O, or carbonyl or wherein two \u2014CH2\u2014 groups in relative 1,3-position of a C4-5-alkylenyl bridge optionally are replaced O atoms, or wherein a \u2014CH2\u2014CH2\u2014 group optionally is replaced by \u2014C(O)\u2014NH\u2014, \u2014NH\u2014C(O)\u2014, \u2014C(O)\u2014N(C1-6-alkyl)- or \u2014N(C1-6-alkyl)-C(O)\u2014 andor 2 hydrogen atoms attached to adjacent carbon atoms within a C4-5-alkylenyl bridge optionally are replaced to form a double bond, which optionally is condensed with an optionally substituted aryl or an optionally substituted 5- or 6-membered hetaryl group, or
an optionally substituted cyclo-C5-9-alkyl group, wherein independently
2 hydrogen atoms attached to carbon atoms in relative 1,2-, 1,3-, 1, 4 or 1,5-position optionally are replaced by a C1-3-alkylenyl bridge, wherein any of the resulting polycyclic groups one \u2014CH2\u2014 group optionally is replaced by \u2014NH\u2014, >N\u2014(C1-6-alkyl), O, or carbonyl,
wherein any of the resulting groups is bound via a saturated or unsaturated carbon atom or a nitrogen atom,
and wherein any of the resulting open-chained or cyclic groups independently 1 to 3 hydrogen atoms optionally are replaced by C1-4-alkyl or C1-4-alkoxy groups, andor
any 1 to 6 hydrogen atoms attached to carbon atoms optionally are replaced by fluorine atoms,
or W denotes an optionally substituted aryl or hetaryl group,
an optionally substituted cyclo-C3-6-alkyl-aryl or cyclo-C3-6-alkyl-hetaryl group, wherein the cyclo-C5-6-alkyl-submoieties one or two ring members optionally are replaced independently of each other by \u2014NH\u2014 (or a N-atom for replacement of a \u2014CH< member), O, or carbonyl, with the proviso that two heteroatoms are not directly linked together, or
if Y is absent W additionally denotes
a divalent \u2014(CH2)p\u2014 group, wherein p is 2, 3, 4, or 5, attached in relative 1,1-position (geminal) to a carbon atom of group X, including the options:
if p is 4 or 5 it follows that 1 \u2014CH2\u2014 group optionally is replaced by O, \u2014NH\u2014 or \u2014N(C1-4-alkyl)-, or that a \u2014CH2\u2014CH2\u2014 group optionally is replaced by \u2014C(O)\u2014NH\u2014, \u2014NH\u2014C(O)\u2014, \u2014C(O)\u2014N(C1-4-alkyl)-, \u2014N(C1-4-alkyl)-C(O)\u2014, or \u2014CH\u2550CH\u2014, wherein the double bond optionally is condensed with an aryl or a 5- or 6-membered hetaryl group,
a divalent \u2014(CH2)q\u2014 group, wherein q is 3 or 4 attached in relative 1,2-position (vicinal) to carbon atoms of group X, including the options:
a \u2014CH2\u2014CH2\u2014 group optionally is replaced by \u2014C(O)\u2014NH\u2014, \u2014NH\u2014C(O)\u2014, \u2014C(O)\u2014N(C1-6-alkyl)-, \u2014N(C1-6-alkyl)-C(O)\u2014, or
that in the resulting 5- or 6-membered carbocyclic ring 2, 4 or, in case of the 6-membered ring, also 6 hydrogen atoms optionally are replaced by 1, 2 or 3 bonds to form a partially or fully unsaturated ring with isolated or conjugated double bonds, wherein 1 \u2014CH2\u2014 group optionally is replaced by O, \u2014NH\u2014 or \u2014N(C1-6-alkyl)-, andor one \u2014CH\u2550 unit is replaced by \u2014N\u2550,
the trivalent group
attached in relative 1,2,3-position to carbon atoms * as binding sites of group X,
wherein any aryl groups or aryl-subgroups mentioned above in the definition of W are selected from optionally substituted phenyl, naphthyl, and tetrahydronaphthyl groups, and
wherein any hetaryl groups or hetaryl-subgroups mentioned above in the definition of W are selected from optionally substituted pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyrazolyl, imidazolyl, triazolyl, furyl, thienyl, oxazolyl, benzoxazolyl, thiazolyl, benzthiazolyl, indolyl, indolinyl, benzimidazolyl, tetrahydrobenzimidazolyl, tetrahydrocyclopentaimidazolyl, indazolyl, tetrahydroindazolyl, tetrahydrocyclopentapyrazolyl, hexahydrocycloheptapyrazolyl, benztriazolyl, quinolyl, tetrandyroquinolinly, isoquinolyl, tetrandyroisoquinolinly, cinnolyl, quinoxazolyl and benzpyrimidinyl groups,
wherein the expression \u201coptionally substituted\u201d means that 1, 2 or 3 hydrogen atoms of the respective group independently are optionally replaced by substituents selected from
fluorine, chlorine and bromine atoms, atoms, by C1-6-alkyl, trifluoromethyl, C2-6-alkenyl, C2-6-alkynyl, cyclo-C3-7-alkyl, cyclo-C3-7-alkenyl, cyano, hydroxy, hydroxy-C1-6-alkyl, C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl, C1-6-alkoxy-C1-6-alkyl-carbonyl, formyl, amino, C1-4-alkyl-amino, (C1-4-alkyl)2-amino, phenylamino, N-phenyl-N\u2014(C1-4-alkyl)-amino, pyrrolidino, piperidino, aminocarbonyl, C1-6-alkyl-aminocarbonyl, C3-6-alkenyl-amino-carbonyl, C3-6-alkynyl-aminocarbonyl, di-(C1-6-alkyl)-aminocarbonyl, di-(C3-6-alkenyl)-aminocarbonyl, di-(C3-6-alkynyl)-aminocarbonyl, formylamino, C1-6-alkyl-carbonylamino, C1-6-alkyl-carbonyl-(C1-3-alkyl)-amino C2-6-alkenyl-carbonylamino or C2-6-alkynyl-carbonylamino groups, or
the expression \u201coptionally substituted\u201d means that 4 hydrogen atoms of the respective group independently are optionally replaced by substituents selected from fluorine atoms and C1-6-alkyl groups,
andor
wherein a hydrogen atom attached to a nitrogen atom, if present in the respective group, optionally is replaced by a C1-4-alkyl, C2-4-alkenyl, C2-4-alkynyl, cyclo-C3-6-alkyl, cyclo-C3-7-alkyl-C1-3-alkyl, cyclo-C3-7-alkyl-carbonyl, pyrrolidino, piperidino, morpholino, C1-3-alkoxy, C1-3-alkoxy-C1-3-alkyl, phenyl, phenyl-C1-3-alkyl, C1-4-alkyl-carbonyl, C1-3-alkoxy-carbonyl or C1-3-alkyl-sulphonyl group
and wherein any phenyl and pyridyl groups or phenyl- and pyridyl-submoieties optionally are substituted with 1 or 2 substituents independently of each other selected from fluorine, chlorine, bromine, C1-3-alkyl, C1-3-alkoxy, amino, C1-3-alkyl-amino, C1-3-alkylcarbonyl-amino or hydroxy;
R1 denotes H, C1-4-alkyl, C3-4-alkenyl or C3-4-alkynyl, any of those groups being optionally substituted by 1 to 3 fluorine or chlorine atoms, or by a or cyclo-C3-6-alkyl-group,
R2 and R3 independently denote H, halogen, C1-3-alkyl, any of those C1-3-alkyl groups being optionally substituted by 1 to 3 fluorine atoms,
R4 and R5 independently denote H, halogen, C1-3-alkyl, cyclo-C3-6-alkyl, any of those C1-3-alkyl, groups being optionally substituted by 1 to 3 fluorine atoms, by a methyl, or cyclo-C3-5-alkyl group, or by a phenyl or pyridyl group, both optionally substituted independently by 1, 2 or 3 substituents selected from
halogen atoms, C1-3-alkyl, hydroxy, C1-3-alkoxy, amino, and C1-3-alkyl-amino groups.
or a salt thereof.
14. A physiologically acceptable salt of a compound according to claim 1 with inorganic or organic acids or bases.
15. A pharmaceutical composition containing a compound according to claim 1, or a physiologically acceptable salt with inorganic or organic acids or bases, optionally together with one or more inert carriers andor diluents.
16. A method of using a compound according to claim 1, or a physiologically acceptable salt with inorganic or organic acids or bases, for treatment or prevention of diseases or conditions which can be influenced by agonising the activity of the 5-HT2C receptor, such as metabolic and CNS-related disorders.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A server cabinet for accommodating a plurality of servers each comprising an electrical plug at an outer side thereof, the server cabinet comprising:
a rack comprising a top wall, an opposite bottom wall and two sidewalls respectively connected between two corresponding opposite sides of the top and the bottom walls, and defining an interior space for accommodating the servers therein, each of the top and bottom walls defining an opening therein;
a common power supply received in the rack and extending between the top and bottom walls of the rack, the common power supply comprising:
an elongated, hollow casing arranged between the top and the bottom walls of the rack, the casing defining a plurality of through holes in top and bottom surfaces thereof, the top and bottom surfaces being mounted in the openings of the top and bottom walls of the rack, respectively, and an interior of the casing communicating with an exterior of the server cabinet via the through holes and the openings;
a power input socket disposed on an outer surface of the casing; and
a plurality of power output sockets disposed on the outer surface of the casing and spaced equally from each other, the power output sockets for electrically connecting to the electrical plugs, respectively, the common power supply being configured for receiving AC power from an external power source via the power input socket, and then converting the AC power into DC power and outputting the DC power to the servers via the power output sockets; and
a plurality of drawing fans mounted at the outer surface of the casing, each drawing fan defining an air inlet communicating with the interior of the casing and an opposite air outlet.
2. The server cabinet of claim 1, further comprising a plurality of fixing elements at top and bottom ends of the common power supply, each of the fixing elements at the top end comprising a fixing tab connected with the top wall and another fixing tab connected with the common power supply, and each of the fixing elements at the bottom end comprising a fixing tab connected with the bottom wall and another fixing tab connected with the common power supply.
3. The server cabinet of claim 1, wherein the rack further comprises a front door and a back plate each connected between another two corresponding opposite sides of the top and the bottom walls, respectively, each of the front door and the back plate defining a plurality of air ventilation holes therein.
4. The server cabinet of claim 1, further comprising a supporting frame received in the rack, the supporting frame comprising two first vertical walls adjacent to a front side of the rack, two second vertical walls adjacent to the back of the rack, and a plurality of pairs of rails arranged between the first vertical walls and the second vertical walls, each pair of rails being configured for supporting a server thereon.
5. The server cabinet of claim 4, wherein each pair of rails comprises a first rail connected between one of the first vertical walls and one of the second vertical walls, and a second rail connected between the other first vertical wall and the other second vertical wall, the first rail and the second rail of each pair of rails being level with each other.
6. A computer server system comprising:
a rack comprising a top wall, an opposite bottom wall and two sidewalls each connected between two corresponding opposite sides of the top and the bottom walls, respectively, wherein an interior space is defined among the top wall, the opposite bottom wall and the sidewalls, and each of the top and the bottom walls defines an opening;
a plurality of servers received in the interior space of the rack and stacked bottom-to-top, each server comprising an electrical plug at an outer side thereof;
a common power supply extended between the top and the bottom walls, and comprising:
an elongated, hollow casing between the top and the bottom walls of the rack, the casing defining a plurality of through holes in each of top and bottom surfaces thereof, and the openings of the top and the bottom walls of the rack facing the top and the bottom surfaces of the casing, respectively;
a power input socket; and
a plurality of power output sockets, the power output sockets arranged bottom-to-top corresponding to the server electrical plugs, the power output sockets configured to electrically connect to the server electrical plugs, respectively, the common power supply configured for receiving AC power from an external power source via the power input socket, then converting the AC power to DC power and finally outputting the DC power to the servers via the power output sockets; and
a plurality of drawing fans mounted at an outer surface of the casing, each of the drawing fans defining an air inlet communicating with the interior of the casing and an opposite air outlet.
7. The computer server system of claim 6, wherein the rack further comprises a front door and a back plate each respectively connected between another two corresponding opposite sides of the top and the bottom walls, each of the front door and the back plate defining a plurality of air ventilation holes therein.
8. The computer server system of claim 6, further comprising a plurality of fixing elements at top and bottom ends of the casing, each of the fixing elements at the top end comprising two fixing tabs respectively connected with the top wall and the top end of the casing, and each of the fixing elements at the bottom end comprising two fixing tabs respectively connected with the bottom wall and the bottom end of the casing.
9. The computer server system of claim 6, further comprising a supporting frame received in the rack, the supporting frame comprising two first vertical walls adjacent to a front side of the rack, two second vertical walls adjacent to the back of the rack, and a plurality of pairs of rails connected between the first vertical walls and the second vertical walls, each pair of rails comprising a first rail connected between one of the first vertical walls and one of the second vertical walls and a second rail connected between the other first vertical wall and the other second vertical wall, and the first rail and the second rail of each pair of rails being on the same level and adapted for supporting one server thereon.