1. An electrical junction box comprising:
a frame;
a bus bar and an electronic component to be attached to the frame; and
a junction terminal interconnecting a plate-like terminal portion of the bus bar and a plate-like terminal portion of the electronic component,
wherein the junction terminal includes a tubular portion having a pair of opposing walls and a spring portion arranged in the tubular portion,
wherein the spring portion is arranged such that the plate-like terminal portion of the bus bar inserted into the tubular portion from one side is sandwiched between the spring portion and one of the opposing walls and that the plate-like terminal portion of the electronic component inserted into the tubular portion from the other side is sandwiched between the spring portion and the other one of the opposing walls, and
wherein the frame includes a receiving portion and an engagement portion arranged to hold the junction terminal inserted into the receiving portion.
2. The electrical junction box according to claim 1, wherein the electrical junction box is assembled by inserting the junction terminal alone into the receiving portion, and then attaching the bus bar and the electronic component to the frame, and inserting the plate-like terminal portion of the bus bar and the plate-like terminal portion of the electronic component into the tubular portion.
3. The electrical junction box according to claim 1, wherein the receiving portion allows the junction terminal to enter only when the junction terminal is inserted in a predetermined position.
4. The electrical junction box according to claim 2, wherein the receiving portion allows the junction terminal to enter only when the junction terminal is inserted in a predetermined position.
5. The electrical junction box according to claim 3, wherein the junction terminal is provided with a preventive projection for preventing wrong insertion which projects from an outer surface of the tubular portion, and the receiving portion is provided with a preventive groove for preventing wrong insertion which positions the preventive projection.
6. The electrical junction box according to claim 4, wherein the junction terminal is provided with a preventive projection for preventing wrong insertion which projects from an outer surface of the tubular portion, and the receiving portion is provided with a preventive groove for preventing wrong insertion which positions the preventive projection.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A process for the preparation of a 6-keto morphinan having formula (I) prepared from a 6-keto nor-morphinan (X) having the formula:
the process comprising reacting the 6-keto nor-morphinan (X) with an aldehyde of the formula CH(O)R9 in a solvent to form the 6-keto morphinan (I) having the formula:
wherein
R1 is hydrogen, hydrocarbyl, substituted hydrocarbyl, halo, or \u2014OR111;
R2 is hydrogen, hydrocarbyl, substituted hydrocarbyl, halo, or \u2014OR211;
R3 is hydrogen, hydrocarbyl, substituted hydrocarbyl, or \u2014OR311;
R7 is hydrogen, hydrocarbyl, substituted hydrocarbyl, or \u2014OR711;
R8 is hydrogen, hydrocarbyl, substituted hydrocarbyl, or \u2014OR811;
R9 is hydrogen, acyl, hydrocarbyl, substituted hydrocarbyl, or heterocyclo;
R14 is hydrogen or hydroxy;
R111 is hydrogen, hydrocarbyl, substituted hydrocarbyl, or a hydroxy protecting group;
R211 is hydrogen, hydrocarbyl, substituted hydrocarbyl, or a hydroxy protecting group;
R311 is hydrogen, hydrocarbyl, substituted hydrocarbyl, or a hydroxy protecting group;
R711 is hydrogen, hydrocarbyl, substituted hydrocarbyl, or a hydroxy protecting group;
R811 is hydrogen, hydrocarbyl, substituted hydrocarbyl, or a hydroxy protecting group; and
Z1 is >N+\u2550CH(R9).
2. The process of claim 1, wherein the solvent is an organic solvent.
3. The process of claim 2, wherein the solvent is acetonitrile, methanol, toluene, ethyl acetate, or a combination thereof.
4. The process of claim 1, wherein R3 is hydrogen or \u2014OR311 and R311 is hydrogen, alkyl, acyl, alkaryl, aryl, or a hydroxy protecting group.
5. The process of claim 4, wherein R311 is hydrogen or alkyl.
6. The process of claim 1, wherein the 6-keto nor-morphinan (X) is noroxymorphone.
7. The process of claim 1, wherein R9 is hydrogen, acyl, substituted or unsubstituted C1-8 alkyl, C2-8 alkenyl, aryl, or heterocyclo.
8. The process of claim 1, wherein R9 is hydrogen, methyl, cyclopropyl, cyclobutyl, or allyl.
9. The process of claim 1, wherein R9 is cyclobutyl.
10. The process of claim 1, further comprising a process for the preparation of a 6-hydroxy morphinan (II) having the formula
the process comprising reducing the 6-keto morphinan (I) in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source, the 6-keto morphinan (I) having the formula:
wherein
R1 is hydrogen, hydrocarbyl, substituted hydrocarbyl, halo, or \u2014OR111;
R2 is hydrogen, hydrocarbyl, substituted hydrocarbyl, halo, or \u2014OR211;
R3 is hydrogen, hydrocarbyl, substituted hydrocarbyl, or \u2014OR311;
R7 is hydrogen, hydrocarbyl, substituted hydrocarbyl, or \u2014OR711;
R8 is hydrogen, hydrocarbyl, substituted hydrocarbyl, or \u2014OR811;
R9 is hydrogen, acyl, hydrocarbyl, substituted hydrocarbyl, or heterocyclo;
R14 is hydrogen or hydroxy;
R111 is hydrogen, hydrocarbyl, substituted hydrocarbyl, or a hydroxy protecting group;
R211 is hydrogen, hydrocarbyl, substituted hydrocarbyl, ora hydroxy protecting group;
R311 is hydrogen, hydrocarbyl, substituted hydrocarbyl, ora hydroxy protecting group;
R711 is hydrogen, hydrocarbyl, substituted hydrocarbyl, or a hydroxy protecting group;
R811 is hydrogen, hydrocarbyl, substituted hydrocarbyl, or a hydroxy protecting group;
Z1 is >N+\u2550CH(R9); and
Z2 is >NCH2(R9).