1. A prefilled syringe filled with a drug comprising:
a hollow cylinder having a nozzle coupled to the opening of the cylinder at a first end and configured to be fitted with an injection needle, and a guard-shaped extension proximate to the nozzle and axially projecting from a shoulder section of the cylinder;
a plunger having a plunger rod and a gasket fixedly coupled to a first end of the plunger rod, the plunger arranged to freely move backwards and forwards within the opening of the cylinder at a second end; and
a barrier package that covers the peripheral surface of the cylinder between the first end thereof proximate to the guard-shaped extension and the second end thereof proximate to the opening.
2. The prefilled syringe according to claim 1, further comprising:
a cap fitted onto an end of the nozzle; and
a shrink film that covers the entire outer peripheral surface of the cap fitted onto the nozzle and the guard-shaped extension.
3. The prefilled syringe according to claim 1, further comprising:
a cap fitted onto an end of the nozzle; and
a shrink film that covers the entire outer peripheral surface of the prefilled syringe, the shrink film also covers the barrier package, the cap fitted onto the nozzle and the plunger.
4. The prefilled syringe according to claim 3, further comprising:
a filter member that is permeable to moisture,
the plunger rod includes a disc-shaped flange with at least one air through-hole, the disc-shaped flange is coupled to a second end of the plunger rod, the filter member arranged adjacent to an outside surface of the disc-shaped flange so as to cover the air through-hole.
5. The prefilled syringe according to claim 4, wherein
the outer surface of the disc-shaped flange has an undulating surface, the undulating surface includes a recess with the air through-hole.
6. The prefilled syringe according to claim 4, wherein
the plunger rod further includes a first disc-shaped rib projecting from a central part thereof, the first disc-shaped rib has at least one air through-hole.
7. The prefilled syringe according to claim 6, wherein
the hollow cylinder further having at least one second disc-shaped rib projecting from the outer peripheral surface of the cylinder.
8. The prefilled syringe according to claim 4, further comprising:
a lid member that supports the filter member, the lid member is arranged on the outside surface of the disc-shaped flange.
9. The prefilled syringe according to claim 7, wherein
the shrink film is heat-shrunk and firmly attached to the first disc-shaped rib and the second disc-shaped rib so as to cover the entire prefilled syringe.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A leak diagnosis device comprising:
a diagnosing device for performing leak diagnosis of determining whether a leak hole is formed in a purge device, which adsorbs fuel vapor generated in a fuel tank with an adsorbent in a canister and purges the fuel vapor adsorbed by the adsorbent into an intake passage of an internal combustion engine;
a state sensing device, when the fuel vapor adsorbed by the adsorbent separates from the adsorbent and produces a mixture gas, for sensing a state of the fuel vapor in the mixture gas; and
a period calculating device for causing the state sensing device to perform the state sensing multiple times from a period in which the pressure in the purge device increases due to generation of the fuel vapor after an operation of the engine is stopped and for calculating a state stabilization period in which a change of the fuel vapor state becomes equal to or less than a reference value based on the result of the multiple times of the state sensing, wherein
the diagnosing device performs the leak diagnosis in the state stabilization period calculated by the period calculating device.
2. The leak diagnosis device as in claim 1, wherein
the state sensing device includes:
a measurement passage provided with a restrictor;
a gas flow generating device for generating a gas flow in the measurement passage;
a pressure measuring device for measuring pressure downstream of the restrictor when the gas flow generating device generates the gas flow;
a first switching device for switching between a first measurement state in which the measurement passage opens into an atmosphere such that the gas flowing through the measurement passage is an air and a second measurement state in which the measurement passage communicates with the canister such that the gas flowing through the measurement passage is the mixture gas containing the fuel vapor; and
a state calculating device for calculating the state of the fuel vapor based on first pressure measured by the pressure measuring device in the first measurement state and second pressure measured by the pressure measuring device in the second measurement state,
the diagnosing device has a second switching device for forming a third measurement state in which the mixture gas containing the fuel vapor flows from the canister to the measurement passage downstream of the restrictor not through the restrictor, and
the diagnosing device performs the leak diagnosis of the purge device based on the first pressure measured by the pressure measuring device in the first measurement state and third pressure measured by the pressure measuring device in the third measurement state.
3. The leak diagnosis device as in claim 1, wherein
the period calculating device causes the state sensing device to perform the state sensing for each elapse of a predetermined time after the operation of the engine is stopped and determines that the state stabilization period is reached if a difference between a previously sensed state and a presently sensed state is equal to or less than a predetermined value.
4. The leak diagnosis device as in claim 3, wherein
the period calculating device determines that the state stabilization period is reached if the difference between the previously sensed state and the presently sensed state is equal to or less than the predetermined value certain times successively.
5. The leak diagnosis device as in claim 1, wherein
the period calculating device estimates the state stabilization period, in which the change of the fuel vapor state is equal to or less than the reference value, based on magnitude of the state change occurring over two or more times of the state sensing.
6. The leak diagnosis device as in claim 1, further comprising:
an ambient temperature measuring device for measuring ambient temperature, wherein
the diagnosing device sustains the leak diagnosis if the state sensing of the fuel vapor state performed after the operation of the engine is stopped detects a state in which a margin of an adsorbing ability of the adsorbent is short and the ambient temperature measured by the ambient temperature measuring device is equal to or higher than certain temperature.
7. A leak diagnosis method of performing leak diagnosis of determining whether a leak hole is formed in a purge device, which adsorbs fuel vapor with an adsorbent, the leak diagnosis method comprising the steps of:
sensing a state of the fuel vapor in a mixture gas produced by the fuel vapor separating from the adsorbent; and
calculating a state stabilization period in which a change of the state of the fuel vapor is equal to or less than a reference value based on the result of multiple times of the sensing, wherein
the leak diagnosis is performed in the state stabilization period.