1. A transistor device comprising:
a gate region formed on a substrate;
a well region formed within the substrate; and
a drain region comprising at least one retrograde well placed in the substrate next to the gate region,
wherein the retrograde well reduces a dopant concentration near the surface of the substrate, and the retrograde well and the well region substantially have the same dopant distribution profile.
2. The transistor device of claim 1 wherein the gate region further comprises one or more spacers.
3. The transistor device of claim 1 further comprising a doped region formed in the drain region.
4. The transistor device of claim 3 wherein at least a portion of the doped region is formed within the retrograde well.
5. The transistor device of claim 4 further comprising an isolation structure placed between the doped region and the gate region.
6. The transistor device of claim 1 further comprising a deep well, in which the drain region is formed.
7. The transistor device of claim 6 wherein the drain region is a well shallower than the deep well.
8. A transistor device comprising:
a substrate;
a gate region formed on the substrate;
a deep well formed in the substrate;
a well region formed within the substrate;
a source region formed directly in the deep well on a first side of the gate region;
one or more retrograde wells placed in the substrate next to the gate region and on a second side thereof;
the one or more retrograde wells forming a doped drain region, and
wherein the one or more retrograde wells further form a drain extension surrounding the doped drain region to have a lower dopant concentration toward the surface of the substrate, and the one or more retrograde wells and the well region substantially have the same dopant distribution profile.
9. The transistor device of claim 8 wherein the gate region further comprises one or more spacers.
10. The transistor device of claim 8 further comprising at least one isolation structure between the doped drain region and the gate region.
11. The transistor device of claim 8 wherein the deep well and the retrograde wells have different types of dopant.
12. The transistor device of claim 8 wherein the retrograde wells have a shallower doping profile than the deep well.
13. A transistor device comprising:
a substrate including a surface;
a gate region formed on the substrate;
a deep well formed in the substrate;
a well region formed within the substrate;
a source region formed directly in the deep well on a first side of the gate region; and
a doped drain region formed of a plurality of retrograde wells formed in the substrate next to the gate region and on a second opposed side of the gate region, at least one of the plurality of retrograde wells forming a drain extension surrounding the doped drain region and the retrograde wells having a lower dopant concentration toward the surface of the substrate, wherein the retrograde wells and the well region substantially have the same dopant distribution profile.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An isolated nucleic acid encoding the humanized antibody MLN02, comprising a first nucleotide sequence and a second nucleotide sequence, wherein
said first nucleotide sequence encodes the humanized light chain, comprises nucleotides 58-714 of SEQ ID NO:9 and encodes amino acids 20-238 of SEQ ID NO:11; and
said second nucleotide sequence encodes the humanized heavy chain, comprises nucleotides 58-1410 of SEQ ID NO:10 and encodes amino acids 20-470 of SEQ ID NO:12.
2. The isolated nucleic acid of claim 1, wherein said first nucleotide sequence comprises nucleotides 79-735 of SEQ ID NO:2 or nucleotides 78-734 of SEQ ID NO:4.
3. The isolated nucleic acid of claim 1, wherein said second nucleotide sequence comprises nucleotides 77-1429 of SEQ ID NO:1 or nucleotides 76-1428 of SEQ ID NO:3.
4. An isolated nucleic acid encoding the humanized immunoglobulin light chain of the humanized antibody MLN02, wherein said isolated nucleic acid comprises nucleotides 58-714 of SEQ ID NO:9 and encodes amino acids 20-238 of SEQ ID NO:11.
5. The isolated nucleic acid of claim 4, wherein said isolated nucleic acid comprises nucleotides 78-734 of SEQ ID NO:4.
6. The isolated nucleic acid of claim 4, wherein said isolated nucleic acid comprises nucleotides 79-735 of SEQ ID NO:2.
7. An isolated nucleic acid encoding the humanized immunoglobulin heavy chain of the humanized antibody MLN02, wherein said isolated nucleic acid comprises nucleotides 58-1410 of SEQ ID NO:10 and encodes amino acids 20-470 of SEQ ID NO:12.
8. The isolated nucleic acid of claim 7, wherein said isolated nucleic acid comprises nucleotides 76-1428 of SEQ ID NO:3.
9. The isolated nucleic acid of claim 7, wherein said isolated nucleic acid comprises nucleotides 77-1429 of SEQ ID NO:1.
10. A recombinant vector comprising the isolated nucleic acid of claim 1.
11. A recombinant vector comprising the isolated nucleic acid of claim 4.
12. A recombinant vector comprising the isolated nucleic acid of claim 7.
13. The recombinant vector of claim 11, wherein said isolated nucleic acid comprises nucleotides 79-735 of SEQ ID NO:2 or nucleotides 78-734 of SEQ ID NO:4.
14. The recombinant vector of claim 12, wherein said isolated nucleic acid comprises nucleotides 77-1429 of SEQ ID NO:1 or nucleotides 76-1428 of SEQ ID NO:3.
15. A recombinant vector encoding the humanized antibody MLN02, wherein said recombinant vector comprises a first nucleic acid that encodes the heavy chain and a second nucleic acid that encodes the light chain, wherein said first nucleic acid comprises nucleotides 77-1429 of SEQ ID NO:1, and said second nucleic acid comprises nucleotides 79-735 of SEQ ID NO:2.
16. A recombinant vector encoding the humanized antibody MLN02, wherein said recombinant vector comprises a first nucleic acid that encodes the heavy chain and a second nucleic acid that encodes the light chain, wherein said first nucleic acid comprises nucleotides 76-1428 of SEQ ID NO:3, and said second nucleic acid comprises nucleotides 78-734 of SEQ ID NO:4.
17. An isolated host cell comprising the isolated nucleic acid of claim 1.
18. An isolated host cell comprising the recombinant vector of claim 10.
19. An isolated host cell comprising the isolated nucleic acid of claim 4.
20. An isolated host cell comprising the recombinant vector of claim 11.
21. An isolated host cell comprising the isolated nucleic acid of claim 7.
22. An isolated host cell comprising the recombinant vector of claim 12.
23. An isolated host cell comprising the recombinant vector of claim 15.
24. An isolated host cell comprising the recombinant vector of claim 16.
25. A method of producing the humanized antibody MLN02 comprising maintaining a host cell of claim 17 under conditions suitable for expression of a nucleic acid encoding the MLN02 chains, whereby humanized antibody MLN02 chains are expressed and the humanized antibody MLN02 is produced.
26. A method of producing the humanized antibody MLN02 comprising providing the isolated nucleic acid of claim 1 and expressing said isolated nucleic acid, whereby the humanized light and heavy chains are expressed and the humanized antibody MLN02 is produced.
27. A method of producing the humanized antibody MLN02 comprising providing the recombinant vector of claim 15 and expressing said recombinant vector, whereby the humanized light and heavy chains are expressed and the humanized antibody MLN02 is produced.
28. A method of producing the humanized light chain of MLN02 comprising maintaining a host cell of claim 19 under conditions suitable for expression of the nucleic acid encoding the light chain of MLN02, whereby the humanized light chain of MLN02 is expressed and the humanized light chain of MLN02 is produced.
29. A method of producing the humanized light chain of MLN02 comprising providing the isolated nucleic acid of claim 4 and expressing said isolated nucleic acid, whereby the humanized light chain is expressed and the humanized light chain of MLN02 is produced.
30. A method of producing the humanized light chain of MLN02 comprising providing the recombinant vector of claim 11 and expressing said recombinant vector, whereby the humanized light chain is expressed and the humanized light chain of MLN02 is produced.
31. A method of producing the humanized heavy chain of MLN02 comprising maintaining a host cell of claim 21 under conditions suitable for expression of the nucleic acid encoding the heavy chain of MLN02, whereby the humanized heavy chain of MLN02 is expressed and the humanized heavy chain of MLN02 is produced.
32. A method of producing the humanized heavy chain of MLN02 comprising providing the isolated nucleic acid of claim 7 and expressing said isolated nucleic acid, whereby the humanized heavy chain is expressed and the humanized heavy chain of MLN02 is produced.
33. A method of producing the humanized heavy chain of MLN02 comprising providing the recombinant vector of claim 12 and expressing said recombinant vector, whereby the humanized heavy chain is expressed and the humanized heavy chain of MLN02 is produced.