1. An implantable drug delivery device, comprising
a reservoir containing a beneficial agent formulation that comprises
a stable non-aqueous single phase biocompatible viscous vehicle, comprising a solvent component and a polymer component, wherein the solvent component is a carboxylic acid ester or lauryl alcohol and the polymer component is polyvinylpyrrolidone; and
a beneficial agent uniformly suspended in the vehicle, wherein the beneficial agent is glucagon-like peptide-1 (GLP-1) or a peptide analog thereof;
said implantable drug delivery device further comprising an osmotic engine, a piston, and a rate controlling membrane.
2. The device of claim 1, wherein the vehicle further comprises a surfactant component, wherein the surfactant is glycerol monolaurate or a polysorbate.
3. The device of claim 1, wherein the formulation further comprises an antioxidant.
4. The device of claim 3, wherein the antioxidant is selected from the group consisting of tocopherol, ascorbic acid, ascorbyl palmitate, butylated hydroxyanisole, butylated hydroxytoluene, and propyl gallate.
5. The device of claim 1, wherein the formulation can be delivered from the implantable drug delivery device such that the exit shear rate of the formulation is between about 1 and 1\xd710\u22127 reciprocal second.
6. The device of claim 1, wherein the formulation is stable at body temperature for extended periods of time.
7. The device of claim 1, wherein the formulation comprises at least about 0.1% (ww) beneficial agent.
8. The device of claim 1, wherein the formulation comprises at least about 10% (ww) beneficial agent.
9. The device of claim 1, wherein the formulation is stable at 65\xb0 C. for at least about 2 months.
10. The device of claim 1, wherein the formulation is stable at 37\xb0 C. for at least about 3 months.
11. The device of claim 1, wherein the formulation is stable at 37\xb0 C. for at least about one year.
12. The device of claim 1, wherein the beneficial agent is dried to a low moisture content prior to incorporation in the formulation.
13. The device of claim 1, wherein the carboxylic acid ester is lauryl lactate.
14. The device of claim 2, wherein the ratios of the vehicle components are in the range of about 5% (ww) to about 60% (ww) for solvent, about 5% (ww) to about 40% for surfactant, and about 5% (ww) to about 60% (wW) for polymer.
15. The device of claim 1, wherein the flow rate from the implantable device is 0.3 to 100 ulday.
16. The device claim 1, wherein the beneficial agent is prepared by spray-drying.
17. The device of claim 1, wherein the ratios of the components are in the range of 40:60 to 60:40.
18. An implantable drug delivery device, comprising
a reservoir containing a beneficial agent formulation that comprises
a stable non-aqueous single phase biocompatible viscous vehicle, comprising a solvent component and a polymer component, wherein the solvent component is a carboxylic acid ester or lauryl alcohol and the polymer component is polyvinylpyrrolidone; and
a beneficial agent uniformly suspended in the vehicle, wherein the beneficial agent is GLP-1;
said implantable drug delivery device further comprising an osmotic engine, a piston, and a rate controlling membrane.
19. The device claim 18, wherein the beneficial agent is prepared by spray-drying.
20. The device of claim 18, wherein the ratios of the components are in the range of 40:60 to 60:40.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A shallow water anchoring system for automatically moving a rod-shaped anchor between a lowered orientation for operation and use and a raised orientation for transportation and storage, the moving of the anchor being done in a safe, convenient and economical manner comprising, in combination:
a boat having a periphery with an above-water support surface;
an anchor having a cylindrical lower section and a cylindrical intermediate section and a cylindrical upper section, the lower and intermediate and upper sections having a common axis vertically oriented during operation and use;
coupling components removably coupling the anchor with respect to the support surface of the boat at a location laterally spaced from the boat;
the lower section having an upper end and a lower end, the lower section having an exterior surface of a common circumference and shape along its length, the lower end of the lower section being formed with a point adapted to penetrate a floor of a water body;
the intermediate section having an upper end and a lower end, the intermediate section being hollow with an interior surface of a common circumference and shape along its length along its length and an exterior surface of a common circumference and shape along its length along its length, the interior surface of the intermediate section having a greater circumference than the circumference of the exterior surface of the lower section whereby the lower section is adapted to move into and out of the intermediate section;
the upper section having an upper end and a lower end, the upper section being hollow with an interior surface of a common circumference and shape along its length along its length and an exterior surface of a common circumference and shape along its length along its length, the interior surface of the upper section having a greater circumference than the circumference of the exterior surface of the intermediate section whereby the intermediate section is adapted to move into and out of the upper section;
a rotatable spool fixedly positioned with respect to the anchor;
a flexible cable having an interior end and an exterior end, the exterior end coupled to the anchor, the interior end coupled to the spool;
an electric motor adapted to rotate the spool, the rotation of the spool in a first direction adapted to reel in the cable and raise the lower section into the intermediate section and raise the lower and intermediate sections into the upper section whereby the anchor is in an inoperative orientation, the rotation of the spool in a second direction adapted to reel out the cable and lower the lower section from the intermediate section and lower the lower and intermediate sections from the upper section whereby the anchor is in an operative orientation; and
a hand held control device remote from the motor for activating and inactivating the motor at the discretion of a user.