1460748816-4b8e3518-cf66-4bc5-8dc5-73fd7375fa9d

1. A compound of Formula (I):
or a stereoisomer or a salt thereof, wherein:
(i) X1 is C-G2, one of X2 and X3 is N, and the other of X2 and X3 is O or S;
(ii) X2 is C-G2, one of X1 and X3 is N, and the other of X1 and X3 is O or S;
(iii) X1 is C-G2, one of X2 and X3 is N, and the other of X2 and X3 is NH or NCH3; or
(iv) X1 is N-G2, X2 is N, and X3 is CH;
wherein the broken circle represents two non-adjacent double bonds within Ring A;
Q1 is CH, C(CH3), or CF;
Q2 is CH;
W is \u2014CH2\u2014, \u2014CH2CH2\u2014, \u2014CH2C(CH3)2\u2014, \u2014CH2CF2\u2014, \u2014CH\u2550CH\u2014, \u2014CH2N(CH3)\u2014, \u2014CH2O\u2014, or \u2014CH2CH2O\u2014;
G1 is \u2014OH, \u2014CH2OH, \u2014CH(OH)CH2OH, \u2014(CH2)0-2COOH, \u2014CH(OH)(CH2)0-2COOH, \u2014CH2NH(CH2)1-2OH, \u2014CH2NRg(CH2)1-2COOH, \u2014CH2NRg(CH2)1-2C(O)NH2, \u2014CH2NRg(CH2)1-2OP(O)(OH)2, \u2014OCH2CH(OH)CH2OH, \u2014(CH2)0-2C(NH2)(CH3)CH2OH, \u2014(CH2)0-2CRg(NH2)C(O)OH, \u2014(CH2)0-2C(NH2)(CH3)(CH2)1-2OP(O)(OH)2, \u2014CH2CH2C(NH2)(CH2OH)2, \u2014CH2NHCH(CH2OH)2, \u2014CH2N(CH2CH2OH)2, \u2014CH2NHCH2CH(OH)CH2OH, \u2014CH(OH)C(O)NHCH2CN, \u2014CH(OH)C(O)NHCH2CH2S(O)2CH3, \u2014CRg(OH)C(O)NHCH2CH2OH, \u2014CH2(hydroxy pyrrolidinyl), \u2014CH2(hydroxymethyl pyrrolidinyl),
G2 is:
(i) pentyl;
(ii) phenyl substituted with one or two substituents independently selected from propyl, butyl, \u2014CN, \u2014CF3, cyclohexyl, \u2014OCH2CH3, andor \u2014OCH(CH3)2;
(iii) pyrazolyl, isoxazolyl, isothiazolyl, or pyrimidinyl substituted with one or two substituents independently selected from \u2014CF3, \u2014CN, butyl, methyl cyclopropyl, cyclohexyl, phenyl, chlorophenyl, pyridinyl, andor fluoropyridinyl;
(iv) cyclohexyl substituted with chlorophenyl;
(v) \u2014NHC(O)\u2014(CH2)0-2-(phenyl) or \u2014NHC(O)(pentyl);
(vi) \u2014C(O)NHCH2C(CH3)3, \u2014C(O)NRg\u2014(CHRg)0-3-A1, \u2014C(O)NRg\u2014CH2C(Rg)(A1)(A1), or \u2014C(O)NHCH2(tetrahydronaphthalenyl), wherein A1 is phenyl substituted with zero to 2 substituents independently selected from Cl, \u2014CH3, \u2014OCH3, \u2014OCH2CH3, \u2014OCH(CH3)2, andor phenoxy;
(vii)
\u2003wherein Re is naphthalenyl or \u2014(CH2)0-2(phenyl) and said phenyl is substituted with zero to 1 substituents selected from F, Cl, or OCH3; or
(viii) \u2014(CR5R5)aCReReB4, \u2014CH\u2550CH\u2014CReReB4, or \u2014(CR5R5)aO(CR5R5)aCReReB4, wherein B4 is phenyl substituted with zero to 2 substituents independently selected from F, Cl, \u2014OH, andor butyl; and each Re is independently H andor \u2014CH3, or two geminal Re along with the carbon atom to which they are attached form a C4-6spirocycloalkyl ring;

each a is independently zero, 1, 2, 3, 4, andor 5;
each R5 is H; and
each Rg is independently H andor \u2014CH3.
2. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein: X1 is C-G2, one of X2 and X3 is N, and the other of X2 and X3 is O or S.
3. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein: X2 is C-G2, one of X1 and X3 is N, and the other of X1 and X3 is O or S.
4. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein: X1 is C-G2, one of X2 and X3 is N, and the other of X2 and X3 is NH or NCH3.
5. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein: X1 is N-G2, X2 is N and X3 is CH.
6. A pharmaceutical composition comprising a compound according to claim 1 or stereoisomers or pharmaceutically acceptable salts thereof, and a pharmaceutically acceptable carrier.
7. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein:
X1 is C-G2, one of X2 and X3 is N, and the other of X2 and X3 is O;
W is \u2014CH2CH2\u2014, \u2014CH2C(CH3)2\u2014, or \u2014CH2CF2\u2014;
Q1 is CH or C(CH3); and
Q2 is CH.
8. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein:
X2 is C-G2, one of X1 and X3 is N, and the other of X1 and X3 is S;
W is \u2014CH2CH2\u2014, \u2014CH2C(CH3)2\u2014, or \u2014CH2CF2\u2014;
Q1 is CH or C(CH3); and
Q2 is CH.
9. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein G1 is: \u2014OH, \u2014CH2OH, \u2014CH(OH)CH2OH, \u2014(CH2)0-2COOH, \u2014CH(OH)(CH2)0-2COOH, \u2014CH2NH(CH2)1-2OH, \u2014CH2NRg(CH2)1-2COOH, \u2014CH2NRg(CH2)1-2C(O)NH2, \u2014CH2NRg(CH2)1-2OP(O)(OH)2, \u2014OCH2CH(OH)CH2OH, \u2014(CH2)0-2 CNH2)(CH3)CH2OH, \u2014(CH2)0-2CRg(NH2)C(O)OH, \u2014(CH2)0-2C(NH2)(CH3)(CH2)1-2OP(O)(OH)2, \u2014CH2CH2C(NH2)(CH2OH)2, \u2014CH2NHCH(CH2OH)2, \u2014CH2N(CH2CH2OH)2, \u2014CH2NHCH2CH(OH)CH2OH, \u2014CH(OH)C(O)NHCH2CN, \u2014CH(OH)C(O)NHCH2CH2S(O)2CH3, \u2014CRg(OH)C(O)NHCH2CH2OH, \u2014CH2(hydroxy pyrrolidinyl), or \u2014CH2(hydroxymethyl pyrrolidinyl).
10. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein G1 is:
11. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein G2 is:
(i) phenyl substituted with one or two substituents independently selected from propyl, butyl, \u2014CN, \u2014CF3, cyclohexyl, \u2014OCH2CH3, andor \u2014OCH(CH3)2;
(ii) pyrazolyl, isoxazolyl, isothiazolyl, or pyrimidinyl substituted with one or two substituents independently selected from \u2014CF3, \u2014CN, butyl, methyl cyclopropyl, cyclohexyl, phenyl, chlorophenyl, pyridinyl, andor fluoropyridinyl; or
(iii) cyclohexyl substituted with chlorophenyl.
12. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein G2 is:
(i) \u2014NHC(O)\u2014(CH2)0-2-(phenyl) or \u2014NHC(O)(pentyl);
(ii) \u2014C(O)NHCH2C(CH3)3, \u2014C(O)NRg\u2014(CHRg)0-3-A1, \u2014C(O)NRg\u2014CH2C(Rg)(A1)(A1), or \u2014C(O)NHCH2(tetrahydronaphthalenyl), wherein A1 is phenyl substituted with zero to 2 substituents independently selected from Cl, \u2014CH3, \u2014OCH3, \u2014OCH2CH3, \u2014OCH(CH3)2, andor phenoxy; or
(iii)
wherein Re is naphthalenyl or \u2014(CH2)0-2(phenyl) and said phenyl is substituted with zero to 1 substituents selected from F, Cl, or OCH3.
13. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein G2 is: \u2014(CR5R5)aCReReB4, \u2014CH\u2550CH\u2014CReReB4, or \u2014(CR5R5)aO(CR5R5)aCReReB4, wherein B4 is phenyl substituted with zero to 2 substituents independently selected from F, Cl, \u2014OH, andor butyl; and each Re is independently H andor \u2014CH3, or two geminal Re along with the carbon atom to which they are attached form a C4-6spirocycloalkyl ring.
14. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein said compound is selected from:
1-((5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(4-propylphenyl)-4H-chromeno4,3-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid, trifluoroacetic acid salt;
1-((3-(4-propylphenyl)-4H-chromeno3,4-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid, trifluoroacetic acid salt;
1-((3-(5-(1-methylcyclopropyl)-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho-1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(5-isobutyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
3-(4-propylphenyl)-4H-indeno1,2-cisoxazol-6-ol;
1-((3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
(R)-3-(3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yloxy)propane-1,2-diol;
(3S)-1-(2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)ethyl)piperidine-3-carboxylic acid;
1-((3-(4-isopropoxy-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-cyano-4-isopropoxyphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
3-((3-(3-cyano-4-isopropoxyphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamine) propanoic acid;
1-((3-(4-isopropoxy-2-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
2-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)-2,5,7-triazaspiro3.4octane-6,8-dione;
2-((3R)-1-(2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)ethyl)piperidin-3-yl)acetic acid;
1-((3-(4-propylphenyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
3-(3-(3-cyano-4-isopropoxyphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propanoic acid;
1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydro-2H-benzogindazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(4-isobutyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
(3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methanol;
1-((3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(4-(4-chlorophenyl)cyclohexyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2-(1-(3,5-dichlorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-(4-chlorophenyl)-3-methylbutyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(((1-(4-fluorophenyl)cyclohexyl)methoxy)methyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)azetidine-3-carboxylic acid;
1-((3-(3-(1-(4-fluorophenyl)cyclohexyl)propyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
3-(5-phenylisoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
3-(5-(2-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
3-(6-phenylpyrimidin-4-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
3-(2-(1-(4-hydroxyphenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
3-(2-(1-(2-chloro-4-fluorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
3-(2-(1-(3,5-difluorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
3-(2-(1-(3,5-dichlorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
3-(2-(1-(3-fluorophenyl)cyclopentyl)ethyl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
(E)-3-(2-(1-(4-chlorophenyl)cyclohexyl)vinyl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
3-(4-isobutylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
1-((2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)naphtho1,2-doxazol-7-yl)methyl)azetidine-3-carboxylic acid;
(S)-3-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-doxazol-7-yloxy) propane-1,2-diol;
1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA salt;
1-((3-(2,2-diphenylethylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid, TFA salt;
1-((3-(2-chlorobenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(neopentylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-doxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((2-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho2,1-doxazol-7-yl)methyl) azetidine-3-carboxylic acid;
2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)butan-1-ol;
(2S)-2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)butanoic acid;
2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)butyl dihydrogen phosphate;
1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno3,4-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(5-phenyl-4-(trifluoromethyl)isoxazole-3-yl)-2,3-dihydrobenzoboxepino-4,5-disoxazol-8-yl)methyl)-azetidine-3-carboxylic acid;
1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)methyl) azetidine-3-carboxylic acid, TFA;
1-((2-(4-(4-chlorophenyl)cyclohexyl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)methyl) azetidine-3-carboxylic acid, TFA;
1-((2-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno3,4-disoxazol-7-yl)methyl)-azetidine-3-carboxylic acid;
1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno4,3-cisoxazol-7-yl)methyl)-azetidine-3-carboxylic acid;
1-((3-(5-Phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno4,3-cisoxazol-7-yl)methyl)-azetidine-3-carboxylic acid;
1-((3-(3-(Pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((8-Methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
(3S)-1-(2-Hydroxy-2-(8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphthol1,2-cisoxazol-7-yl)ethyl)piperidine-3-carboxylic acid;
1-((5,5-difluoro-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((8-fluoro-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)azetidine-3-carboxylic acid;
3-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)amino)propanoic acid;
3-((3-(5-Phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)amino)propanoic acid;
(3S)-1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)piperidine-3-carboxylic acid;
2-((3-(5-Phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)acetic acid;
3-hydroxy-2-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)propanoic acid;
3-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)amino)propanamide;
4-((3-(5-Phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)morpholino-3-yl)methanol;
1-((3-(5-cyclohexyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
3-(5-Cyclohexyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazole-7-carboxylic acid;
1-((5-methyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydroisoxazolo4,3-cquinolin-7-yl)methyl)azetidine-3-carboxylic acid;
1-((1-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydro-1H-benzogindazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA;
1-((2-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydro-2H-benzogindazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA;
1-((3-(3,4-diethoxyphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
(3S)-1-(2-(3-(3,4-diethoxyphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)-2-hydroxyethyl) piperidine-3-carboxylic acid, HCl;
(3S)-1-(2-hydroxy-2-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)ethyl)piperidine-3-carboxylic acid, HCl;
(\xb1)1-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl) ethane-1,2-diol;
2-hydroxy-N-(2-hydroxyethyl)-2-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)acetamide;
N-(1-cyanocyclopropyl)-2-hydroxy-2-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)acetamide;
1-((2-pentyl-4,5-dihydronaphtho2,1-dthiazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA;
1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-indeno1,2-cisoxazol-6-yl)methyl) azetidine-3-carboxylic acid;
2-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)amino)acetic acid;
(\xb1)2-(hydroxy(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)furan-3-carboxylic acid;
(\xb1)2-(amino(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)furan-3-carboxylic acid;
(\xb1)2-amino-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)butanoic acid;
2-amino-2-(2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)ethyl)propane-1,3-diol;
2-amino-2-methyl-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)butan-1-ol;
2-amino-2-methyl-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)butanoic acid;
2-amino-2-methyl-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)butyl dihydrogen phosphate;
(\xb1)2-amino-2-methyl-3-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)propyl dihydrogen phosphate;
2-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)ethyl dihydrogen phosphate;
2-amino-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propyl dihydrogen phosphate;
(1-amino-3-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)cyclopentyl)methyl dihydrogen phosphate;
(1-amino-3-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)methyl dihydrogen phosphate;
2-(1-amino-3-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)ethyl dihydrogen phosphate;
1-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl) ethane-1,2-diol;
1-((3-(3-phenyl-4-(trifluoromethyl)isothiazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)butyl dihydrogen phosphate;
1-((3-(5-phenyl-4-(trifluoromethyl)isothiazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(4-cyano-3-phenylisothiazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
2-amino-2-methyl-3-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propan-1-ol;
2-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)ethanol;
(\xb1)4-hydroxy-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)butanoic acid;
2,2\u2032-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylazanediyl)diethanol;
(2R)-3-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)propane-1,2-diol;
(2S)-3-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)ethylamino)propane-1,2-diol;
2-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)ethylamino)propane-1,3-diol;
(3R)-1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)pyrrolidin-3-ol;
(3S)-1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)pyrrolidin-3-ol;
((2R)-1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)pyrrolidin-2-yl)methanol;
((2S)-1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)pyrrolidin-2-yl)methanol;
1-((3-(4-cyclohexyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
2-amino-2-methyl-4-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)butan-1-ol;
2-amino-2-methyl-4-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)butyl dihydrogen phosphate;
(1-amino-3-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)cyclopentyl)methanol;
1-((3-(1-(5-fluoropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
(1-amino-3-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)methanol;
2-(1-amino-3-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)ethanol;
2-amino-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propan-1-ol;
N-(methylsulfonyl)-1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxamide;
(\xb1)-2-hydroxy-2-(3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetic acid;
(\xb1)-N-(cyanomethyl)-2-hydroxy-2-(3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl) acetamide;
(\xb1)-2-Hydroxy-N-(2-hydroxyethyl)-2-(3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetamide;
(\xb1)-2-hydroxy-N-(2-(methylsulfonyl)ethyl)-2-(3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetamide;
2-hydroxy-N-(2-(methylsulfonyl)ethyl)-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetamide;
N-(1-cyanocyclopropyl)-2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetamide;
2-hydroxy-N-(2-hydroxyethyl)-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetamide;
2-hydroxy-N-(2-hydroxyethyl)-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propanamide;
2-hydroxy-N-(2-(methylsulfonyl)ethyl)-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propanamide;
1-((3-(4-propylphenyl)-4,5-dihydro-3H-benzoeindazol-7-yl)methyl)azetidine-3-carboxylic acid;
(1-amino-3-(2-pentyl-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)methanol;
(1-amino-3-(2-pentyl-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)methyl dihydrogen phosphate;
N-(7-hydroxy-4,5-dihydronaphtho1,2-dthiazol-2-yl)benzamide;
N-(7-hydroxy-4,5-dihydronaphtho1,2-dthiazol-2-yl)-2-phenylacetamide;
N-(7-hydroxy-4,5-dihydronaphtho1,2-dthiazol-2-yl)-3-phenylpropanamide;
N-(7-hydroxy-4,5-dihydronaphtho1,2-dthiazol-2-yl)hexanamide;
1-((3-(2-methoxybenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(2-ethoxybenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2-methylbenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(4-chlorobenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2,2-diphenylpropylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(2-phenylpropylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1((3-(phenethylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2-chlorophenethylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-phenylpropylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(benzyl(methyl)carbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-chlorobenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-chlorophenethylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-phenylpyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-benzylpyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-phenethylpyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(2-(4-methoxyphenyl)-2-phenylethylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-(naphthalen-1-yl)piperidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-phenylpiperidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-((1,2,3,4-tetrahydronaphthalen-1-yl)methylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-(4-fluorophenyl)pyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-(2-chlorophenyl)pyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-(3-methoxyphenyl)pyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2-isopropoxybenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(2-phenoxybenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-methylbenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1S,3S)-3-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)cyclobutanecarboxylic acid;
(1S,3S)-3-(cyano(3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)cyclobutanecarboxylic acid;
(1R,3R)-3-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)cyclobutanecarboxylic acid; and
(1R,3R)-3-(cyano(3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)cyclobutanecarboxylic acid.
15. A compound of Formula (I):
or a stereoisomer or a salt thereof, wherein:
(i) X1 is C-G2, one of X2 and X3 is N, and the other of X2 and X3 is O or S;
(ii) X2 is C-G2, one of X1 and X3 is N, and the other of X1 and X3 is O or S;
(iii) X1 is C-G2, one of X2 and X3 is N, and the other of X2 and X3 is NH or NCH3; or
(iv) X1 is N-G2, X2 is N, and X3 is CH;
wherein the broken circle represents two non-adjacent double bonds within Ring A;
Q1 is CH, C(CH3), or CF;
Q2 is CH;
W is \u2014CH2\u2014, \u2014CH2CH2\u2014, \u2014CH2C(CH3)2\u2014, \u2014CH2CF2\u2014, \u2014CH\u2550CH\u2014, \u2014CH2N(CH3)\u2014, \u2014CH2O\u2014, or \u2014CH2CH2O\u2014;
G1 is \u2014CH2OH, \u2014CH(OH)CH2OH, \u2014(CH2)0-2COOH, \u2014CH(OH)(CH2)0-2COOH, \u2014CH2NH(CH2)1-2OH, \u2014CH2NRg(CH2)1-2COOH, \u2014CH2NRg(CH2)1-2C(O)NH2, \u2014CH2NRg(CH2)1-2OP(O)(OH)2, \u2014OCH2CH(OH)CH2OH, \u2014(CH2)0-2C(NH2)(CH3)CH2OH, \u2014(CH2)0-2CRg(NH2)C(O)OH, \u2014(CH2)0-2C(NH2)(CH3)(CH2)1-2OP(O)(OH)2, \u2014CH2CH2C(NH2)(CH2OH)2, \u2014CH2NHCH(CH2OH)2, \u2014CH2N(CH2CH2OH)2, \u2014CH2NHCH2CH(OH)CH2OH, \u2014CH(OH)C(O)NHCH2CN, \u2014CH(OH)C(O)NHCH2CH2S(O)2CH3, \u2014CRg(OH)C(O)NHCH2CH2OH, \u2014CH2(hydroxy pyrrolidinyl), \u2014CH2(hydroxymethyl pyrrolidinyl),
G2 1 S:
(i) pentyl or \u2014NH2;

(ii) phenyl substituted with one or two substituents independently selected from propyl, butyl, \u2014CN, \u2014CF3, cyclohexyl, \u2014OCH2CH3, andor \u2014OCH(CH3)2;
(iii) pyrazolyl, isoxazolyl, isothiazolyl, or pyrimidinyl substituted with one or two substituents independently selected from \u2014CF3, \u2014CN, butyl, methyl cyclopropyl, cyclohexyl, phenyl, chlorophenyl, pyridinyl, andor fluoropyridinyl;
(iv) cyclohexyl substituted with chlorophenyl;
(v) \u2014NHC(O)\u2014(CH2)0-2-(phenyl) or \u2014NHC(O)(pentyl);
(vi) \u2014C(O)NHCH2C(CH3)3, \u2014C(O)NRg\u2014(CHRg)0-3-A1, \u2014C(O)NRg\u2014CH2C(Rg)(A1)(A1), or \u2014C(O)NHCH2(tetrahydronaphthalenyl), wherein A1 is phenyl substituted with zero to 2 substituents independently selected from Cl, \u2014CH3, \u2014OCH3, \u2014OCH2CH3, \u2014OCH(CH3)2, andor phenoxy;
(vii)
\u2003wherein Re is naphthalenyl or \u2014(CH2)0-2(phenyl) and said phenyl is substituted with zero to 1 substituents selected from F, Cl, or OCH3; or
(viii) \u2014(CR5R5)aCReReB4, \u2014CH\u2550CH\u2014CReReB4, or \u2014(CR5R5)a0 (CR5R5)aCReReB4, wherein B4 is phenyl substituted with zero to 2 substituents independently selected from F, Cl, \u2014OH, andor butyl; and each Re is independently H andor \u2014CH3, or two geminal Re along with the carbon atom to which they are attached form a C4-6spirocycloalkyl ring;

each a is independently zero, 1, 2, 3, 4, andor 5;
each R5 is H; and
each Rg is independently H andor \u2014CH3.
16. The compound according to claim 15 or a stereoisomer or a salt thereof, wherein said compound is selected from:
1-((5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(4-propylphenyl)-4H-chromeno4,3-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid, trifluoroacetic acid salt;
1-((3-(4-propylphenyl)-4H-chromeno3,4-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid, trifluoroacetic acid salt;
1-((3-(5-(1-methylcyclopropyl)-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho-1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(5-isobutyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl) methyl)azetidine-3-carboxylic acid;
1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
(R)-3-(3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yloxy)propane-1,2-diol;
(3S)-1-(2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)ethyl)piperidine-3-carboxylic acid;
1-((3-(4-isopropoxy-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-cyano-4-isopropoxyphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
3-((3-(3-cyano-4-isopropoxyphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamine) propanoic acid;
1-((3-(4-isopropoxy-2-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
2-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)-2,5,7-triazaspiro3.4octane-6,8-dione;
2-((3R)-1-(2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)ethyl)piperidin-3-yl)acetic acid;
1-((3-(4-propylphenyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
3-(3-(3-cyano-4-isopropoxyphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propanoic acid;
1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydro-2H-benzogindazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(4-isobutyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
(3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methanol;
1-((3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(4-(4-chlorophenyl)cyclohexyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2-(1-(3,5-dichlorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-(4-chlorophenyl)-3-methylbutyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(((1-(4-fluorophenyl)cyclohexyl)methoxy)methyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)azetidine-3-carboxylic acid;
1-((3-(3-(1-(4-fluorophenyl)cyclohexyl)propyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)naphtho1,2-doxazol-7-yl)methyl)azetidine-3-carboxylic acid;
(S)-3-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-doxazol-7-yloxy) propane-1,2-diol;
1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA salt;
1-((3-(2,2-diphenylethylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid, TFA salt;
1-((3-(2-chlorobenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(neopentylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-doxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((2-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho2,1-doxazol-7-yl)methyl) azetidine-3-carboxylic acid;
2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)butan-1-ol;
(2S)-2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)butanoic acid;
2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)butyl dihydrogen phosphate;
1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno3,4-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(5-phenyl-4-(trifluoromethyl)isoxazole-3-yl)-2,3-dihydrobenzoboxepino-4,5-disoxazol-8-yl)methyl)-azetidine-3-carboxylic acid;
1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)methyl) azetidine-3-carboxylic acid, TFA;
1-((2-(4-(4-chlorophenyl)cyclohexyl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)methyl) azetidine-3-carboxylic acid, TFA;
1-((2-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno3,4-disoxazol-7-yl)methyl)-azetidine-3-carboxylic acid;
1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno4,3-cisoxazol-7-yl)methyl)-azetidine-3-carboxylic acid;
1-((3-(5-Phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno4,3-cisoxazol-7-yl)methyl)-azetidine-3-carboxylic acid;
1-((3-(3-(Pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((8-Methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
(3S)-1-(2-Hydroxy-2-(8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphthol1,2-cisoxazol-7-yl)ethyl)piperidine-3-carboxylic acid;
1-((5,5-difluoro-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((8-fluoro-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)azetidine-3-carboxylic acid;
3-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)amino)propanoic acid;
3-((3-(5-Phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)amino)propanoic acid;
(3S)-1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)piperidine-3-carboxylic acid;
2-((3-(5-Phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)acetic acid;
3-hydroxy-2-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)propanoic acid;
3-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)amino)propanamide;
4-((3-(5-Phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)morpholino-3-yl)methanol;
1-((3-(5-cyclohexyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
3-(5-Cyclohexyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazole-7-carboxylic acid;
1-((5-methyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydroisoxazolo4,3-cquinolin-7-yl)methyl)azetidine-3-carboxylic acid;
1-((l-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydro-1H-benzogindazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA;
1-((2-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydro-2H-benzogindazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA;
1-((3-(3,4-diethoxyphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
(3S)-1-(2-(3-(3,4-diethoxyphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)-2-hydroxyethyl) piperidine-3-carboxylic acid, HCl;
(3S)-1-(2-hydroxy-2-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)ethyl)piperidine-3-carboxylic acid, HCl;
(\xb1)1-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl) ethane-1,2-diol;
2-hydroxy-N-(2-hydroxyethyl)-2-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)acetamide;
N-(1-cyanocyclopropyl)-2-hydroxy-2-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)acetamide;
1-((2-pentyl-4,5-dihydronaphtho2,1-dthiazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA;
1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-indeno1,2-cisoxazol-6-yl)methyl) azetidine-3-carboxylic acid;
2-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)amino)acetic acid;
(\xb1)2-(hydroxy(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)furan-3-carboxylic acid;
(\xb1)2-(amino(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)furan-3-carboxylic acid;
(\xb1)2-amino-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)butanoic acid;
2-amino-2-(2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)ethyl)propane-1,3-diol;
2-amino-2-methyl-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)butan-1-ol;
2-amino-2-methyl-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)butanoic acid;
2-amino-2-methyl-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)butyl dihydrogen phosphate;
(\xb1)2-amino-2-methyl-3-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)propyl dihydrogen phosphate;
2-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)ethyl dihydrogen phosphate;
2-amino-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propyl dihydrogen phosphate;
(1-amino-3-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)cyclopentyl)methyl dihydrogen phosphate;
(1-amino-3-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)methyl dihydrogen phosphate;
2-(1-amino-3-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)ethyl dihydrogen phosphate;
1-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl) ethane-1,2-diol;
1-((3-(3-phenyl-4-(trifluoromethyl)isothiazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)butyl dihydrogen phosphate;
1-((3-(5-phenyl-4-(trifluoromethyl)isothiazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(4-cyano-3-phenylisothiazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
2-amino-2-methyl-3-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propan-1-ol;
2-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)ethanol;
(\xb1)4-hydroxy-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)butanoic acid;
2,2\u2032-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylazanediyl)diethanol;
(2R)-3-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)propane-1,2-diol;
(2S)-3-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)ethylamino)propane-1,2-diol;
2-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)ethylamino)propane-1,3-diol;
(3R)-1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)pyrrolidin-3-ol;
(3S)-1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl) methyl)pyrrolidin-3-ol;
((2R)-1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)pyrrolidin-2-yl)methanol;
((2S)-1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)pyrrolidin-2-yl)methanol;
1-((3-(4-cyclohexyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
2-amino-2-methyl-4-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)butan-1-ol;
2-amino-2-methyl-4-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)butyl dihydrogen phosphate;
(1-amino-3-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)cyclopentyl)methanol;
1-((3-(1-(5-fluoropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
(1-amino-3-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)methanol;
2-(1-amino-3-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)ethanol;
2-amino-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propan-1-ol;
N-(methylsulfonyl)-1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxamide;
(\xb1)-2-hydroxy-2-(3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetic acid;
(\xb1)-N-(cyanomethyl)-2-hydroxy-2-(3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl) acetamide;
(\xb1)-2-Hydroxy-N-(2-hydroxyethyl)-2-(3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetamide;
(\xb1)-2-hydroxy-N-(2-(methylsulfonyl)ethyl)-2-(3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetamide;
2-hydroxy-N-(2-(methylsulfonyl)ethyl)-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetamide;
N-(1-cyanocyclopropyl)-2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetamide;
2-hydroxy-N-(2-hydroxyethyl)-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetamide;
2-hydroxy-N-(2-hydroxyethyl)-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propanamide;
2-hydroxy-N-(2-(methylsulfonyl)ethyl)-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propanamide;
1-((3-(4-propylphenyl)-4,5-dihydro-3H-benzoeindazol-7-yl)methyl)azetidine-3-carboxylic acid;
(1-amino-3-(2-pentyl-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)methanol;
(1-amino-3-(2-pentyl-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)methyl dihydrogen phosphate;
(R)-3-(2-amino-4,5-dihydronaphthol1,2-dthiazol-7-yloxy)propane-1,2-diol;
1-((3-(2-methoxybenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(2-ethoxybenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2-methylbenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(4-chlorobenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2,2-diphenylpropylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(2-phenylpropylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(phenethylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2-chlorophenethylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-phenylpropylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(benzyl(methyl)carbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-chlorobenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-chlorophenethylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-phenylpyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-benzylpyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-phenethylpyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(2-(4-methoxyphenyl)-2-phenylethylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-(naphthalen-1-yl)piperidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-phenylpiperidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-((1,2,3,4-tetrahydronaphthalen-1-yl)methylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-(4-fluorophenyl)pyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-(2-chlorophenyl)pyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-(3-methoxyphenyl)pyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2-isopropoxybenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(2-phenoxybenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-methylbenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1S,3S)-3-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)cyclobutanecarboxylic acid;
(1S,3S)-3-(cyano(3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)cyclobutanecarboxylic acid;
(1R,3R)-3-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)cyclobutanecarboxylic acid; and
(1R,3R)-3-(cyano(3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)cyclobutanecarboxylic acid.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method for processing circuitry, comprising:
acquiring a single carrier signal based on a determined time slot boundary, the single carrier signal comprising primary carrier data;
receiving a dual carrier radio frequency signal based on the determined time slot boundary, the dual carrier radio frequency signal comprising the primary carrier data and secondary carrier data;
generating a baseband dual carrier signal by demodulating the dual carrier radio frequency signal;
separating the primary carrier data from the baseband dual carrier signal by filtering the baseband dual carrier signal; and
separating the secondary carrier data from the baseband dual carrier signal by filtering the baseband dual carrier signal.
2. The method of claim 1, wherein the determined time slot boundary is determined from a primary synchronization signal;
3. The method of claim 2, wherein the time slot boundary is a frame boundary.
4. The method of claim 1, wherein the dual carrier radio frequency signal is received from a base station.
5. The method of claim 1, wherein the dual carrier radio signal is received in response to a request for additional bandwidth.
6. The method of claim 5, wherein the request is sent from a wireless device configured to receive the dual carrier signal.
7. The method of claim 1, wherein separating the primary carrier data from the baseband dual carrier signal comprises identifying a center frequency of the baseband dual carrier signal.
8. The method of claim 7, wherein separating the primary carrier data from the baseband dual carrier signal further comprises translating the identified center frequency.
9. The method of claim 8, wherein separating the primary carrier data from the baseband dual carrier signal further comprises applying a filter to filter out a secondary carrier baseband frequency range, the secondary carrier data being encoded within the secondary carrier baseband frequency range, wherein the filter comprises hardcoded coefficients.
10. The method of claim 1, further comprising transmitting the primary carrier data and the secondary carrier data to baseband processing circuitry according to a predetermined latency.
11. The method of claim 10, wherein the predetermined latency is based on a latency caused by separating the primary carrier data from the baseband dual carrier signal and separating the secondary carrier data from the baseband dual carrier signal.
12. A system for signal processing, comprising:
circuitry that receives a dual carrier radio frequency signal comprising primary carrier data transmitted from a base station and secondary carrier data transmitted by the base station;
a demodulator that generates a baseband dual carrier signal based on the dual carrier radio frequency signal;
a first filter that suppresses adjacent carrier frequencies to separate the primary carrier data from the baseband dual carrier signal; and
a second filter that suppresses adjacent carrier frequencies to separate the secondary carrier data from the baseband dual carrier signal.
13. The system of claim 12, further comprising circuitry that acquires a single carrier signal based on a determined time slot boundary, the single carrier signal comprising the primary carrier data.
14. The system of claim 13, wherein the circuitry that receives the dual carrier radio frequency signal further comprises circuitry that receives the dual carrier radio frequency signal based on the determined time slot boundary.
15. The system of claim 12, wherein the dual carrier radio signal is received in response to a request for additional bandwidth.
16. The system of claim 12, further comprising a digital mixer for performing a frequency translation, the digital mixer preparing the baseband dual carrier signal for filtering by the first filter
17. The system of claim 12, further comprising a delay line for transmitting the primary carrier data and the secondary carrier data to baseband processing circuitry according to a predetermined latency.
18. A carrier separation circuit comprising:
circuitry that receives a dual carrier radio frequency signal comprising primary carrier data and secondary carrier data, the primary carrier data and the secondary carrier data being transmitted by a base station;
circuitry that generates a secondary carrier baseband signal by extracting the secondary carrier data from the dual carrier radio frequency signal; and
circuitry that delays a transmission of the secondary carrier baseband signal to baseband processing circuitry according to a predetermined dual carrier latency.
19. The carrier separation circuit of claim 18, further comprising:
circuitry that receives a single carrier radio frequency signal comprising the primary carrier data transmitted from the base station; and
circuitry that generates a single carrier frequency baseband signal based on single carrier radio frequency signal, the circuitry that generates the single carrier frequency baseband signal causing an intrinsic single carrier latency, the predetermined dual carrier latency being determined based on the intrinsic single carrier latency.
20. The carrier separation circuit of claim 18, wherein the circuitry that delays a transmission comprises circuitry that selects one of a plurality of predetermined dual carrier latency values, each predetermined dual carrier latency value corresponding to a respective operating condition.