1. A method of lowering andor controlling intraocular pressure in an eye of a patient in need thereof, comprising administering to the patient a pharmaceutically effective amount of a compound of Formula I:
wherein G is chosen from hydrogen, halogen, or C1\u22124alkyl;
R is hydroxyl, C1-C4 alkyl, NR6R7, N(R6)CH2(CH2)nN(R7)(R8), OC1-6alkyl, optionally substituted with halogen, hydroxyl, wherein R6, R7, and R8 are independently hydrogen or C1-4alkyl, and n is 1 or 2;
X is O or CH2;
R1 and R2 are independently hydrogen or C1-4alkyl, or NR1R2 can be incorporated into a five or six membered saturated heterocyclic ring which, in the case of a six membered ring, may contain an additional heteroatom selected from N and O;
R3 and R4 are independently chosen from hydrogen, C1-4alkyl or R3, R4 and the carbon atom to which they are attached can form a cyclopropyl ring, or R1 and R3 together can be (CH2)n to form a saturated heterocycle, where n=3-5; and
R5 is hydrogen or methyl; and
pharmaceutically acceptable salts, solvates, or prodrugs thereof.
2. The method of claim 1, wherein the compound is administered topically.
3. The method of claim 1, wherein the compound is administered as a solution, suspension or emulsion in an ophthalmically acceptable vehicle.
4. The method of claim 1, wherein the concentration of the compound is from about 0.01 to about 2 percent by weight.
5. The method of claim 2, wherein for the compound of Formula I:
G=H or C1\u22124 alkyl;
R1, R2=H;
R3=H; and
R4=C1\u22124 alkyl; and
pharmaceutically acceptable salts, solvates and prodrugs thereof.
6. The method of claim 5, wherein for the compound of Formula I:
R=NR6R7 or OC1\u22126alkyl optionally substituted with halogen or hydroxyl, wherein R6 and R7 are independently hydrogen or C1\u22124alkyl; and
pharmaceutically acceptable salts, solvates and prodrugs thereof.
7. The method of claim 5, wherein the compound is administered as a solution, suspension or emulsion in an ophthalmically acceptable vehicle.
8. The method of claim 7, wherein the compound is administered as a solution having a pH from about 6.5 to about 7.5.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A light emitting device comprising:
an excitation light emitting section that emits excitation light;
a light emitting section that receives the excitation light emitted from the excitation light emitting section and generates fluorescence;
an optical member that reflects excitation light which is radiated to the vicinity of the light emitting section, among excitation light emitted from the excitation light emitting section, toward the excitation light emitting section, or that emits wavelength-converted light, in which a wavelength of the excitation light is converted, toward the excitation light emitting section; and
a reflection mirror that collects the excitation light reflected by the optical member or the wavelength-converted light emitted from the optical member, in the light emitting section.
2. The light emitting device according to claim 1, wherein
the optical member includes a reflection layer that reflects light toward the excitation light emitting section and
the reflection layer diffuses and reflects light.
3. The light emitting device according to claim 1, wherein
the optical member further includes a fluorescence absorbing layer that absorbs fluorescence generated by the light emitting section, on a second surface opposite a first surface facing the excitation light emitting section.
4. The light emitting device according to claim 1, wherein
the optical member includes a phosphor layer that includes a phosphor and an excitation light absorbing layer that absorbs excitation light emitted from the excitation light emitting section and transmitted through the phosphor layer.
5. The light emitting device according to claim 1, wherein
the optical member has a light-transmitting hole on an optical axis of excitation light emitted from the excitation light emitting section and
the light emitting section is disposed so as to close the light-transmitting hole.
6. The light emitting device according to claim 2, wherein
the optical member has a light-transmitting hole on an optical axis of excitation light emitted from the excitation light emitting section and
the light emitting section is disposed so as to close the light-transmitting hole.
7. The light emitting device according to claim 3, wherein
the optical member has a light-transmitting hole on an optical axis of excitation light emitted from the excitation light emitting section and
the light emitting section is disposed so as to close the light-transmitting hole.
8. The light emitting device according to claim 4, wherein
the optical member has a light-transmitting hole on an optical axis of excitation light emitted from the excitation light emitting section and
the light emitting section is disposed so as to close the light-transmitting hole.