What is claimed is:
1. A chuck device in which a plurality of claws provided at a tip end of a body is slidingly opened and closed to clamp a tool with the claws by rotation of a rotary sleeve, wherein an annular ratchet tooth wheel is provided in the body, an annular nut member that engages with said claws and rotates together with said rotary sleeve is provided inside the rotary sleeve and behind the ratchet wheel within the body, a retainer spring member that is composed of a leaf spring made of metal and detached and attached for engaging said ratchet tooth wheel is disposed outside of said ratchet tooth wheel, said retainer spring member is provided under the condition said retainer spring member is rotated around the ratchet wheel in accordance with a rotation of a retainer spring receiving sleeve within said retainer spring receiving sleeve that rotates together with said nut member and that is fitted around said nut member and made of metal, said retainer spring member is mounted on the retainer spring receiving sleeve by a convexconcave engagement means, a holder spring member that is composed of a metal made leaf spring formed as a detachableattachable separate member from said retainer spring member for holding a retention release condition between said ratchet tooth wheel and said retainer spring member and the retention condition between the ratchet tooth wheel and said retainer spring member is disposed at a position facing said retainer spring member outside said ratchet tooth wheel, said holder spring member is adapted in said retainer spring receiving sleeve to rotate around the ratchet tooth wheel in accordance with the rotation of said retainer spring receiving sleeve, said holder spring member is mounted on the retainer spring receiving sleeve by said concaveconvex engagement means, a metal made working sleeve that rotates together with said rotary sleeve and rotates through a predetermined angle relative to said retainer spring receiving sleeve is provided in said retainer spring receiving sleeve, a retainer working portion is provided in said working sleeve, said retainer working portion being composed of a retainer holder portion for maintaining a retention condition between said ratchet tooth wheel and said retainer spring member and a pressure portion for depressing the projection of said retainer spring member which is to be inserted into a hole portion of said retainer spring receiving sleeve and retaining said retainer spring member to said ratchet tooth wheel, a position holder portion for holding a position of said working sleeve to said retainer spring receiving sleeve to thereby hold the retention condition between said retainer spring member and said ratchet tooth wheel and the release condition between said retainer spring member and said ratchet tooth wheel is provided in said working sleeve, and said position holder portion is constituted by a projection of said holder spring member and a hole portion which is formed in said working sleeve and into which said projection is inserted, said projection is engaged with an elongated hole provided in said retainer spring receiving sleeve, said elongated hole has a tip end opening shape cut away from a tip end edge to a proximal end side of said retainer spring receiving sleeve so that said working sleeve may rotate within a range of said elongated hole to said retainer spring receiving sleeve and said nut member may rotate with said projection in contact with an inner end of said elongated hole, and said hole portion into which said projection of said retainer spring member is inserted has a tip end opening shape cut away from the tip end edge to the proximal end side of said retainer spring receiving sleeve.
2. A chuck device in which a plurality of claws provided at a tip end of a body is slidingly opened and closed to clamp a tool with the claws by rotation of a rotary sleeve, wherein an annular ratchet tooth wheel is provided in the body, an annular nut member that engages with said claws and rotates together with said rotary sleeve is provided inside the rotary sleeve and behind the ratchet wheel within the body, a retainer spring member that is composed of a leaf spring made of metal and detached and attached for engaging said ratchet tooth wheel is disposed outside of said ratchet tooth wheel, said retainer spring member is provided under the condition said retainer spring member is rotated around the ratchet wheel in accordance with a rotation of a retainer spring receiving sleeve within said retainer spring receiving sleeve that rotates together with said nut member and that is fitted around said nut member and made of metal, a structure in which a projection formed in said retainer spring member is fitted in a hole portion formed in said retainer spring receiving sleeve is provided for mounting said retainer spring member onto said retainer spring receiving sleeve, a holder spring member that is composed of a metal made leaf spring formed as a detachableattachable separate member from said retainer spring member for holding a retention release condition between said ratchet tooth wheel and said retainer spring member and the retention condition between the ratchet tooth wheel and said retainer spring member is disposed at a position facing said retainer spring member outside said ratchet tooth wheel, said holder spring member is adapted in said retainer spring receiving sleeve to rotate around the ratchet tooth wheel in accordance with the rotation of said retainer spring receiving sleeve, said holder spring member is mounted on the retainer spring receiving sleeve by said structure in which the projection formed in said retainer spring member is fitted in the hole portion formed in said retainer spring receiving sleeve, a metal made working sleeve that rotates together with said rotary sleeve and rotates through a predetermined angle relative to said retainer spring receiving sleeve is provided in said retainer spring receiving sleeve, a retainer working portion is provided in said working sleeve, said retainer working portion being composed of a retainer holder portion for maintaining a retention condition between said ratchet tooth wheel and said retainer spring member and a pressure portion for depressing the projection of said retainer spring member which is to be inserted into a hole portion of said retainer spring receiving sleeve and retaining said retainer spring member to said ratchet tooth wheel, a position holder portion for holding a position of said working sleeve to said retainer spring receiving sleeve to thereby hold the retention condition between said retainer spring member and said ratchet tooth wheel and the release condition between said retainer spring member and said ratchet tooth wheel is provided in said working sleeve, and said position holder portion is constituted by a projection of said holder spring member and a hole portion which is formed in said working sleeve and into which said projection is inserted, said projection is engaged with an elongated hole provided in said retainer spring receiving sleeve, said elongated hole has a tip end opening shape cut away from a tip end edge to a proximal end side of said retainer spring receiving sleeve so that said working sleeve may rotate within a range of said elongated hole to said retainer spring receiving sleeve and said nut member may rotate with said projection in contact with an inner end of said elongated hole, and said hole portion provided in said retainer spring receiving sleeve has a tip end opening shape cut away from the tip end edge to the proximal end side of said retainer spring receiving sleeve.
3. A chuck device in which a plurality of claws provided at a tip end of a body is slidingly opened and closed to clamp a tool with the claws by rotation of a rotary sleeve, wherein an annular ratchet tooth wheel is provided in the body, an annular nut member that engages with said claws and rotates together with said rotary sleeve is provided inside the rotary sleeve and behind the ratchet wheel within the body, a retainer spring member that is composed of a leaf spring made of metal and detached and attached for engaging said ratchet tooth wheel is disposed outside of said ratchet tooth wheel, said retainer spring member is provided under the condition said retainer spring member is rotated around the ratchet wheel in accordance with a rotation of a retainer spring receiving sleeve within said retainer spring receiving sleeve that rotates together with said nut member and that is fitted around said nut member and made of metal, a structure in which a projection and a hole portion formed in said retainer spring receiving sleeve and a recess portion and a projection formed in said retainer spring member are engaged with each other is provided for mounting said retainer spring member onto said retainer spring receiving sleeve, a holder spring member that is composed of a metal made leaf spring formed as a detachableattachable separate member from said retainer spring member for holding a retention release condition between said ratchet tooth wheel and said retainer spring member and the retention condition between the ratchet tooth wheel and said retainer spring member is disposed at a position facing said retainer spring member outside said ratchet tooth wheel, said holder spring member is adapted in said retainer spring receiving sleeve to rotate around the ratchet tooth wheel in accordance with the rotation of said retainer spring receiving sleeve, said holder spring member is mounted on the retainer spring receiving sleeve by said structure in which the projection and the hole portion formed in said retainer spring receiving sleeve and the recess portion and the projection formed in said retainer spring member are engaged with each other, a metal made working sleeve that rotates together with said rotary sleeve and rotates through a predetermined angle relative to said retainer spring receiving sleeve is provided in said retainer spring receiving sleeve, a retainer working portion is provided in said working sleeve, said retainer working portion being composed of a retainer holder portion for maintaining a retention condition between said ratchet tooth wheel and said retainer spring member and a pressure portion for depressing the projection of said retainer spring member which is to be inserted into a hole portion of said retainer spring receiving sleeve and retaining said retainer spring member to said ratchet tooth wheel, a position holder portion for holding a position of said working sleeve to said retainer spring receiving sleeve to thereby hold the retention condition between said retainer spring member and said ratchet tooth wheel and the release condition between said retainer spring member and said ratchet tooth wheel is provided in said working sleeve, and said position holder portion is constituted by a projection of said holder spring member and a hole portion which is formed in said working sleeve and into which said projection is inserted, said projection is engaged with an elongated hole provided in said retainer spring receiving sleeve, said elongated hole has a tip end opening shape cut away from a tip end edge to a proximal end side of said retainer spring receiving sleeve so that said working sleeve may rotate within a range of said elongated hole to said retainer spring receiving sleeve and said nut member may rotate with said projection in contact with an inner end of said elongated hole, and said hole portion provided in said retainer spring receiving sleeve has a tip end opening shape cut away from the tip end edge to the proximal end side of said retainer spring receiving sleeve.
4. A chuck device in which a plurality of claws provided at a tip end of a body is slidingly opened and closed to clamp a tool with the claws by rotation of a rotary sleeve, wherein an annular ratchet tooth wheel is provided in the body, an annular nut member that engages with said claws and rotates together with said rotary sleeve is provided inside the rotary sleeve and behind the ratchet wheel within the body, a retainer spring member that is composed of a leaf spring made of metal and detached and attached for engaging said ratchet tooth wheel is disposed outside of said ratchet tooth wheel, said retainer spring member is provided under the condition said retainer spring member is rotated around the ratchet wheel in accordance with a rotation of a retainer spring receiving sleeve within said retainer spring receiving sleeve that rotates together with said nut member and that is fitted around said nut member and made of metal, said retainer spring member is mounted on the retainer spring receiving sleeve by a convexconcave engagement means, a holder spring member that is composed of a metal made leaf spring formed as a detachableattachable separate member from said retainer spring member for holding a retention release condition between said ratchet tooth wheel and said retainer spring member and the retention condition between the ratchet tooth wheel and said retainer spring member is disposed at a position facing said retainer spring member outside said ratchet tooth wheel, said holder spring member is adapted in said retainer spring receiving sleeve to rotate around the ratchet tooth wheel in accordance with the rotation of said retainer spring receiving sleeve, said holder spring member is mounted on the retainer spring receiving sleeve by said concaveconvex engagement means, a metal made working sleeve that rotates together with said rotary sleeve and rotates through a predetermined angle relative to said retainer spring receiving sleeve is provided in said retainer spring receiving sleeve, a retainer working portion is provided in said working sleeve, said retainer working portion being composed of a retainer holder portion for maintaining a retention condition between said retainer spring member and said ratchet tooth wheel and a retainer condition release portion for releasing the retained condition between said retainer spring member and said ratchet tooth wheel, a position holder portion for holding a position of said working sleeve to said retainer spring receiving sleeve to thereby hold the retention condition between said retainer spring member and said ratchet tooth wheel and the release condition between said retainer spring member and said ratchet tooth wheel is provided in said working sleeve, and said position holder portion is constituted by a projection of said holder spring member and a hole portion which is formed in said working sleeve and into which said projection is inserted, and said projection is engaged with an elongated hole provided in said retainer spring receiving sleeve, and said elongated hole has a tip end opening shape cut away from a tip end edge to a proximal end side of said retainer spring receiving sleeve so that said working sleeve may rotate within a range of said elongated hole to said retainer spring receiving sleeve and said nut member may rotate with said projection in contact with an inner end of said elongated hole.
5. The chuck device according to any one of claims 1 to 4, wherein each component is made of metal.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of the following formula:
wherein
A is
in which n is 0, 1, 2, or 3;
each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, furyl, pyrrolyl, pyridyl, or pyrimidyl; and
at least one of R1, R2, R3, R4, R5, and R6 is (CRaRb)pX(CRcRd)qY, and each of the others, independently, is Re, nitro, halogen, \u2014C(O)ORe, \u2014C(O)SRe, \u2014C(O)NRe\u2032Rf\u2032, \u2014(CH2)mORe, \u2014(CH2), SRe, \u2014(CH2)mCN, or \u2014(CH2)mNReC(O)Rf, or R1 and R2 together, or R3 and R4 together, or R5 and R6 together are \u2014O(CH2)mO\u2014; in which X is \u2014O\u2014, \u2014S\u2014, \u2014NRa\u2032, \u2014CRa\u2032Rb, \u2014O\u2014C(O)\u2014, or \u2014C(O)\u2014O\u2014, each of Ra\u2032 and Rb, independently, being H, alkyl, or aryl; Y is C(O)ORc\u2032, NRc\u2032Rd\u2032, C(O)NRc\u2032Rd\u2032, \u2014SO3Rc\u2032, \u2014SO2NRc\u2032Rd\u2032, \u2014SONRc\u2032Rd\u2032, or \u2014P(O)(ORc\u2032)(ORd\u2032), each of Rc\u2032 and Rd\u2032, independently, being H, alkyl, or aryl, or NRc\u2032Rd\u2032 together is a 3-8 membered heterocyclic ring having 1-3 heteroatoms; each of Ra, Rb, Rc, and Rd, independently, is H, halogen, nitro, cyano, alkyl, or aryl; Re and Rf independently, is H, alkyl, or aryl; min is 0, 1, 2, 3, 4, 5, or 6; p is 0, 1, 2, 3, 4, 5, or 6; and q is 1, 2, 3, 4, 5, or 6; or
a salt thereof.
2. The compound of claim 1, wherein Ar2 is 2\u2032-furyl.
3. The compound of claim 2, wherein R3 is H and R4 is (CRaRb)pX(CRcRd)qY bonded to position 5 of furyl.
4. The compound of claim 3, wherein X is \u2014CRa\u2032Rb\u2032 and Y is \u2014NRc\u2032Rd.
5. The compound of claim 3, wherein X is \u2014O\u2014, \u2014S\u2014, \u2014NRa\u2032\u2014, \u2014O\u2014C(O)\u2014, or \u2014C(O)\u2014O\u2014.
6. The compound of claim 5, wherein X is \u2014O\u2014 or \u2014O\u2014C(O)\u2014.
7. The compound of claim 6, wherein Y is \u2014COOH or \u2014NRcRd, in which each of Rc\u2032 and Rd, independently, is H or alkyl.
8. The compound of claim 1, wherein Ar1 is phenyl.
9. The compound of claim 8, wherein A is CH2Ph.
10. The compound of claim 9, wherein one of R3 and R4 is (CRaRb)pX(CRcRd)qY.
11. The compound of claim 10, wherein X is \u2014CRa\u2032Rb\u2032\u2014 and Y is \u2014NRc\u2032Rd\u2032.
12. The compound of claim 10, wherein X is \u2014O\u2014, \u2014S\u2014, \u2014NRa\u2032\u2014, \u2014O\u2014C(O)\u2014, or \u2014C(O)\u2014O\u2014.
13. The compound of claim 12, wherein X is \u2014O\u2014 or \u2014O\u2014C(O)\u2014.
14. The compound of claim 13, wherein Y is \u2014COOH or \u2014NRc\u2032Rd\u2032, in which each of Rc\u2032 and Rd\u2032, independently, is H or alkyl.
15. The compound of claim 14, wherein Ar2 is furyl.
16. The compound of claim 1, wherein the compound is
succinic acid mono-5-(1-benzyl-1H-indazol-3-yl)-furan-2-ylmethylester, sodium salt,
succinic acid mono-5-(1-benzyl-1H-indazol-3-yl)-furan-2-ylmethylester, sodium salt,
succinic acid mono-5-(1-benzyl-6-methoxy-1H-indazol-3-yl)-furan-2-ylmethylester,
succinic acid mono-5-(1-benzyl-5-methoxy-1H-indazol-3-yl)-furan-2-ylmethylester,
succinic acid mono-5-(1-benzyl-6-fluoro-1H-indazol-3-yl)furan-2-ylmethyester,
succinic acid mono-5-(1-benzyl-6-methyl-1H-indazol-3-yl)-furan-2-ylmethylester,
succinic acid mono-5-(1-benzyl-5-methyl-1H-furo3,2-Cpyrazol-3-yl)-furan-2-ylmethylester,
succinic acid mono-5-(1-benzyl-1H-thieno3,2-Cpyrazol-3-yl)-furan-2-ylmethylester
succinic acid mono-4-(1-benzyl-1H-indazol-3-yl)benzylester,
succinic acid mono-5-(1-(4-chloro-benzyl)-1H-indazol-3-yl)-furan-2-ylmethyester,
succinic acid mono-5-(6-methoxy-1-phenyl-1H-indazol-3-yl)-furan-2-ylmethylester,
succinic acid mono-5-(1-(4-bromo-phenyl)-1H-indazol-3-yl)-furan-2-ylmethylester,
{2-5-(1-benzyl-1H-indazol-3yl)-furan-2-ylmethoxy-ethyl}-dimethylamine,
5-(1-benzyl-1H-indazol-3-yl)-furan-2-ylmethoxyacetic acid,
5-1-benzyl-(5-methylfuro3,2-Cpyrazol-3-yl)furan-2-ylmethoxyacetic acid,
3-5\u2032-(\u03b2-dimethylaminoethoxy)methyl-2\u2032-furyl-5,6-methylenedioxy-1-benzylindazole, or
succinic acid mono-5-(1-benzyl-1H-indazol-3-yl)-furan-2-ylmethylester, ammonium salt.
17. A compound of the following formula:
wherein
A is H or alkyl;
each of Ar1 and Ar2, independently, is phenyl, thienyl, furyl, pyrrolyl, pyridyl, or pyrimidyl; and
at least one of R1, R2, R3, and R4 is (CRaRb)pX(CRcRd)qY, and each of the others, independently, is Re, nitro, halogen, \u2014C(O)ORe, \u2014C(O)SRe, \u2014C(O)NReRf, \u2014(CH2)mORe, (CH2)mSRe, \u2014(CH2)mCN, or \u2014(CH2)mNReC(O)Rf, or R1 and R2 together, or R3 and R4 together, or R5 and R6 together are \u2014O(CH2)mO\u2014; in which X is \u2014O\u2014, \u2014S\u2014, \u2014NRa\u2014, \u2014CRaRb\u2032, \u2014O\u2014C(O)\u2014, or \u2014C(O)\u2014O\u2014, each of Ra\u2032 and Rb\u2032, independently, being H, alkyl, or aryl; Y is \u2014C(O)ORc\u2032, \u2014NRc\u2032Rd\u2032, \u2014C(O)NRc\u2032Rd\u2032, \u2014SO3Rc\u2032, \u2014SO2NRc\u2032Rd\u2032, \u2014SONRc\u2032Rd\u2032, or \u2014P(O)(ORc\u2032)(ORd\u2032), each of Rc\u2032 and Rd\u2032, independently, being H, alkyl, or aryl, or NRc\u2032Rd\u2032 together is a 3-8 membered heterocyclic ring having 1-3 heteroatoms; each of Ra, Rb, Rc, and Rd, independently, is H, halogen, nitro, cyano, alkyl, or aryl; Re and Rf independently, is H, alkyl, or aryl; m is 0, 1, 2, 3, 4, 5, or 6; p is 1, 2, 3, 4, 5, or 6; and q is 1, 2, 3, 4, 5, or 6; or a salt thereof.
18. The compound of claim 17, wherein Ar2 is 2\u2032-furyl.
19. The compound of claim 18, wherein R3 is H and R4 is (CRaRb)pX(CRcRd)qY bonded to position 5 of furyl.
20. The compound of claim 19, wherein X is \u2014CRa\u2032Rb\u2032 and Y is \u2014NRc\u2032Rd\u2032.
21. The compound of claim 19, wherein X is \u2014O\u2014, \u2014S\u2014, \u2014NRa\u2014, \u2014O\u2014C(O)\u2014, or \u2014C(O)\u2014O\u2014.
22. The compound of claim 21, wherein X is \u2014O\u2014.
23. The compound of claim 22, wherein Y is \u2014COOH or NRc\u2032Rd, in which each of Rc\u2032 and Rd\u2032, independently, is H or alkyl.
24. The compound of claim 17, wherein Ar1 is phenyl.
25. A compound of the following formula:
wherein
A is
in which n is 0, 1, 2, or 3;
each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, furyl, pyrrolyl, pyridyl, or pyrimidyl; and
at least one of R1, R2, R3, R4, R5, and R6 is (CRaRb)pX(CRcRd)qY, and each of the others, independently, is Re, nitro, halogen, \u2014C(O)ORe, \u2014C(O)SRe, \u2014C(O)NReRf, \u2014(CH2)mORe, \u2014(CH2)mSRe, \u2014(CH2)mCN, or \u2014(CH2)mNReC(O)Rf, or R1 and R2 together, or R3 and R4 together, or R5 and R6 together are \u2014O(CH2)mO\u2014; in which X is \u2014C(O)\u2014N\u2014; Y is \u2014C(O)ORc\u2032, Rc\u2032 being H, alkyl, or aryl, each of Ra, Rb, Rc, and Rd, independently, is H, halogen, nitro, cyano, alkyl, or aryl; Re and Rf independently, is H, alkyl, or aryl; m is 0, 1, 2, 3, 4, 5, or 6; p is 0, 1, 2, 3, 4, 5, or 6; and q is 1, 2, 3, 4, 5, or 6; or a salt thereof.
26. The compound of claim 25, wherein Ar2 is 2\u2032-furyl.
27. The compound of claim 26, wherein one of R3 and R4 is (CRaR)pX(CRcRd\u2032)y.
28. The compound of claim 27, wherein R3 is H and R4 is (CRaRb)pX(CRcRd)qY bonded to position 5 of furyl.
29. The compound of claim 28, wherein A is CH2Ph.
30. The compound of claim 29, wherein p is 0 and q is 1 or 2.
31. A pharmaceutical composition, comprising an effective amount of a compound of the following formula:
wherein
A is
in which n is 0, 1, 2, or 3;
each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, furyl, pyrrolyl, pyridyl, or pyrimidyl; and
at least one of R1, R2, R3, R4, R5, and R is (CRaRb)pX(CRcRd)qY, and each of the others, independently, is Re, nitro, halogen, \u2014C(O)ORe, \u2014C(O)SRe, \u2014C(O)NReRf, \u2014(CH2)mORe, \u2014(CH2)mSRe, \u2014(CH2), CN, or \u2014(CH2)mNReC(O)Rf, or R1 and R2 together, or R3 and R4 together, or R5 and R6 together are \u2014O(CH2)mO\u2014; in which X is \u2014O\u2014, \u2014S\u2014, \u2014NRa\u2014, \u2014CRaRa, \u2014O\u2014C(O)\u2014, or \u2014C(O)\u2014O\u2014, each of Ra\u2032 and Rb\u2032, independently, being H, alkyl, or aryl; Y is C(O)ORc\u2032, NRc\u2032Rd\u2032, \u2014C(O)NRc\u2032Rd\u2032, \u2014SO3Rc\u2032, \u2014SO2NRc\u2032Rd\u2032, \u2014SONRc\u2032Rd\u2032 or \u2014P(O)(ORc\u2032)(ORd\u2032), each of Rc\u2032 and Rd\u2032, independently, being H, alkyl, or aryl, or NRc\u2032Rd\u2032 together is a 3-8 membered heterocyclic ring having 1-3 heteroatoms; each of Ra, Rb, Rc, and Rd, independently, is H, halogen, nitro, cyano, alkyl, or aryl; Re and Rf independently, is H, alkyl, or aryl; m is 0, 1, 2, 3, 4, 5, or 6; p is 0, 1, 2, 3, 4, 5, or 6; and q is 1, 2, 3, 4, 5, or 6; or
a pharmaceutically acceptable salt thereof; and
a pharmaceutically acceptable carrier.
32. The composition of claim 31, wherein Ar2 is 2\u2032-furyl.
33. The composition of claim 32, wherein R3 is H and R4 is (CRaRb)pX(CRcRd)qY bonded to position 5 of furyl.
34. The composition of claim 33, wherein X is \u2014CRaRb\u2014 and Y is \u2014NRc\u2032Rd\u2032.
35. The composition of claim 33, wherein X is \u2014O\u2014, \u2014S\u2014, \u2014NRa\u2032\u2014, \u2014O\u2014C(O)\u2014, or \u2014C(O)\u2014O\u2014.
36. The composition of claim 35, wherein X is \u2014O\u2014 or \u2014O\u2014C(O)\u2014.
37. The composition of claim 36, wherein Y is \u2014COOH or \u2014NRc\u2032Rd\u2032, in which each of Rc\u2032 and Rd\u2032, independently, is H or alkyl.
38. The composition of claim 31, wherein Ar1 is phenyl.
39. The composition of claim 38, wherein A is CH2Ph.
40. The composition of claim 39, wherein one of R3 and R4 is (CRaRb)pX(CRcRd)qY.
41. The composition of claim 40, wherein X is \u2014CRa\u2032Rb\u2032\u2014 and Y is \u2014NRc\u2032Rd\u2032.
42. The composition of claim 40, wherein X is \u2014O\u2014, \u2014S\u2014, \u2014NRa\u2032\u2014O\u2014C(O)\u2014, or \u2014C(O)\u2014O\u2014.
43. The composition of claim 42, wherein X is \u2014O\u2014 or \u2014O\u2014C(O)\u2014.
44. The composition of claim 43, wherein Y is \u2014COOH or NRc\u2032Rd\u2032 in which each of Rc\u2032 and Rd\u2032, independently, is H or alkyl.
45. The composition of claim 44, wherein Ar2 is furyl.
46. The composition of claim 31, wherein the compound is
succinic acid mono-5-(1-benzyl-1H-indazol-3-yl)-furan-2-ylmethylester, sodium salt,
succinic acid mono-5-(1-benzyl-1H-indazol-3-yl)-furan-2-ylmethylester, sodium salt,
succinic acid mono-5-(1-benzyl-6-methoxy-1H-indazol-3-yl)-furan-2-ylmethylester,
succinic acid mono-5-(1-benzyl-5-methoxy-1H-indazol-3-yl)-furan-2-ylmethylester,
succinic acid mono-5-(1-benzyl-6-fluoro-1H-indazol-3-yl)furan-2-ylmethyester,
succinic acid mono-5-(1-benzyl-6-methyl-1H-indazol-3-yl)furan-2-ylmethylester,
succinic acid mono-5-(1-benzyl-5-methyl-1H-furo3,2-Cpyrazol-3-yl)-furan-2-ylmethylester,
succinic acid mono-5-(1-benzyl-1H-thieno3,2-Cpyrazol-3-yl)-furan-2-ylmethylester
succinic acid mono-4-(1-benzyl-1H-indazol-3-yl)benzylester,
succinic acid mono-5-(1-(4-chloro-benzyl)-1H-indazol-3-yl)-furan-2-ylmethyester,
succinic acid mono-5-(6-methoxy-1-phenyl-1H-indazol-3-yl)-furan-2-ylmethylester,
succinic acid mono-5-(1-(4-bromo-phenyl)-1H-indazol-3-yl)-furan-2-ylmethylester,
{2-5-(1-benzyl-1H-indazol-3yl)-furan-2-ylmethoxy-ethyl}-dimethylamine,
5-(1-benzyl-1H-indazol-3-yl)-furan-2-ylmethoxyacetic acid,
5-1-benzyl-(5-methylfuro3,2-Cpyrazol-3-yl)furan-2-ylmethoxyacetic acid,
3-5\u2032-(\u03b2-dimethylaminoethoxy)methyl-2\u2032-furyl-5,6-methylenedioxy-1-benzylindazole, or
succinic acid mono-5-(1-benzyl-1H-indazol-3-yl)-furan-2-ylmethylester, ammonium salt.
47. A pharmaceutical composition, comprising an effective amount of a compound of the following formula:
wherein
A is H or alkyl;
each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, furyl, pyrrolyl, pyridyl, or pyrimidyl; and
at least one of R1, R2, R3, R4, R5, and R6 is (CRaRb)pX(CRcRd)qY, and each of the others, independently, is Re, nitro, halogen, \u2014C(O)\u2014ORe, \u2014C(O)\u2014SRe, \u2014C(O)_NReRf, (CH2)mORe, \u2014(CH2)mSRe, \u2014(CH2)mCN, or \u2014(CH2)mNReC(O)\u2014R, or R1 and R2 together, or R3 and R4 together, or R5 and R6 together are \u2014O(CH2)mO\u2014; in which X is \u2014O\u2014, \u2014S\u2014, \u2014NRa\u2014, \u2014CRaRb, \u2014O\u2014C(O)\u2014, or \u2014C(O)\u2014O\u2014, each of Ra\u2032 and Rb\u2032, independently, being H, alkyl, or aryl; Y is C(O)ORc\u2032, NRc\u2032Rd\u2032, \u2014C(O)NRc\u2032Rd\u2032, \u2014SO3Rc\u2032, \u2014SO2NRc\u2032Rd\u2032, \u2014SONRc\u2032Rd\u2032, or \u2014P(O)(ORc\u2032)(ORd\u2032), each of Rc and Rd\u2032, independently, being H, alkyl, or aryl; each of Ra, Rb, Rc, and Rd, independently, is H, halogen, nitro, cyano, alkyl, or aryl; Re and Rf independently, is H, alkyl, or aryl; m is 0, 1, 2, 3, 4, 5, or 6; p is 1, 2, 3, 4, 5, or 6; and q is 1, 2, 3, 4, 5, or 6; or
a pharmaceutically acceptable salt thereof; and
a pharmaceutically acceptable carrier.
48. The composition of claim 47, wherein Ar2 is 2\u2032-furyl.
49. The composition of claim 48, wherein R3 is H and R4 is (CRaRb)pX(CRcRd)qY bonded to position 5 of furyl.
50. The composition of claim 49, wherein X is \u2014CRaR\u2014 and Y is \u2014NRc\u2032Rd\u2032.
51. The composition of claim 49, wherein X is \u2014O\u2014, \u2014S\u2014, \u2014NRa\u2032, \u2014O\u2014C(O)\u2014, or \u2014C(O)\u2014O\u2014.
52. The composition of claim 50, wherein X is \u2014O\u2014.
53. The composition of claim 52, wherein Y is \u2014COOH or \u2014NRc\u2032Rd\u2032, in which each of Rc\u2032 and Rd, independently, is H or alkyl.
54. The composition of claim 47, wherein Ar1 is phenyl.
55. A pharmaceutical composition of the following formula:
wherein
A is
in which n is 0, 1, 2, or 3;
each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, furyl, pyrrolyl, pyridyl, or pyrimidyl; and
at least one of R1, R2, R3, R4, R5, and R6 is (CRaRb)pX(CRcRd)qY, and each of the others, independently, is Re, nitro, halogen, \u2014C(O)ORe, \u2014C(O)SRe, \u2014C(O)NReRf, (CH2)mORe, \u2014(CH2)mSRe, \u2014(CH2)mCN, or \u2014(CH2)mNReC(O)Rf, or R1 and R2 together, or R3 and R4 together, or R5 and R6 together are \u2014O(CH2)mO\u2014; in which X is \u2014C(O)\u2014N\u2014; Y is \u2014C(O)ORc\u2032, Rc\u2032 being H, alkyl, or aryl, each of Ra, Rb, Rc, and Rd, independently, is H, halogen, nitro, cyano, alkyl, or aryl; Re and Rf independently, is H, alkyl, or aryl; m is 0, 1, 2, 3, 4, 5, or 6; p is 0, 1, 2, 3, 4, 5, or 6; and q is 1, 2, 3, 4, 5, or 6; or a salt thereof.
56. The composition of claim 55, wherein Ar2 is 2\u2032-furyl.
57. The composition of claim 56, wherein one of R3 and R4 is (CRaRb)pX(CRcRd)qY.
58. The composition of claim 57, wherein R3 is H and R4 is (CRaRb)pX(CRcRd)qY bonded to position 5 of furyl.
59. The composition of claim 58, wherein A is CH2Ph.
60. The composition of claim 59, wherein p is 0 and q is 1 or 2.