1. A method for inhibiting the activity of BAFF-R in a cell comprising the step of contacting the cell with:
(a) an isolated soluble polypeptide that binds to BAFF and comprises:
(1) an amino acid sequence that binds to BAFF and is at least 80% identical to SEQ ID NO:13, or
(2) a fragment of (1) that binds to BAFF; or
(b) an isolated antibody, or an antigen binding fragment thereof, that specifically binds to the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:10.
2. The method of claim 1, wherein the polypeptide of (a)(1) comprises an amino acid sequence that is at least 90% identical to SEQ ID NO:13.
3. The method of claim 1, wherein the polypeptide of (a)(1) comprises an amino acid sequence that is at least 95% identical to SEQ ID NO:13.
4. The method of claim 1, wherein the polypeptide of (a)(1) comprises the amino acid sequence of SEQ ID NO:13 modified by one or more conservative amino acid substitutions, additions or deletions.
5. The method of claim 1, wherein the polypeptide of (a)(2) comprises amino acids 19-35 of SEQ ID NO:10.
6. The method of claim 1, wherein the polypeptide of (a)(1) consists of the amino acid sequence set forth in SEQ ID NO:13.
7. The method of claim 1, wherein the polypeptide of (a)(1) comprises an amino acid sequence selected from SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:25, SEQ ID NO:26, SEQ ID NO:27, SEQ ID NO:28, SEQ ID NO:29, SEQ ID NO:30, SEQ ID NO:31, and SEQ ID NO:32.
8. The method of claim 1, wherein the polypeptide of (a)(1) comprises an amino acid sequence selected from SEQ ID NO:19, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:25, SEQ ID NO:26, and SEQ ID NO:27.
9. The method of claim 1, wherein the polypeptide of (a)(1) comprises the amino acid sequence set forth in SEQ ID NO:13, except that at least one amino acid residue in the region from C19 to L27 is altered to diminish protein aggregation.
10. The method of claim 9, wherein the altered residue(s) comprise(s) one or more residues selected from V20, P21, A22, and L27.
11. The method of claim 9, wherein the altered residue(s) include one or more residues selected from V20N, P21Q, A22T, and L27P.
12. The method of claim 9, wherein the altered residue(s) isare selected from:
(a) V20N, P21Q, A22T, and L27P;
(b) L27P and V20N;
(c) P21Q and L27P;
(d) L27P;
(e) V20N and L27A; and
(f) V20N and L27S.
13. The method of claim 1, wherein the antibody or antigen binding fragment of (b) specifically binds to the amino acid sequence of SEQ ID NO:10.
14. The method of claim 1, wherein the antibody or antigen binding fragment of (b) specifically binds to the amino acid sequence of SEQ ID NO:13.
15. The method of claim 1, wherein the antibody or antigen binding fragment of (b) is chimeric.
16. The method of claim 1, wherein the antibody or antigen binding fragment of (b) is humanized.
17. The method of claim 1, wherein the antibody or antigen binding fragment of (b) is monoclonal.
18. The method of claim 1, wherein the antibody or antigen binding fragment of (b) is polyclonal.
19. The method of claim 1, wherein the antibody or antigen binding fragment is a single chain antibody.
20. The method of claim 1, wherein the antibody or antigen binding fragment of (b) is a Fab fragment.
21. The method of claim 1, wherein the antibody or antigen binding fragment of (b) is a F(ab\u2032)2 fragment.
22. The method of claim 1, wherein the antibody or antigen binding fragment of (b) blocks binding of B Cell Activating Factor of the TNF family (BAFF) to its receptor.
23. The method of claim 1, wherein the antibody or antigen binding fragment of (b) is produced by hybridoma clone #2.1, deposited under ATCC No. PTA-3689 or binds to the same epitope as the antibody produced by hybridoma clone #2.1.
24. The method of claim 1, wherein the antibody or antigen binding fragment of (b) is produced by hybridoma clone #9.1 deposited under ATCC No. PTA-3688 or binds to the same epitope as the antibody produced by hybridoma clone #9.1.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A wall assembly, comprising:
a first panel and a second panel;
the first panel is configured to reside within an internal cavity of the second panel;
the first panel is configured to extend beyond the second panel such that the first panel and second panel collectively form at least part of a wall;
a cable connecting the first panel to an overhead structure;
the overhead structure comprising a storage space; and
the cable is configured to pull the first panel into the storage space of the overhead structure;
wherein the storage space of the overhead structure comprises a storage height greater than a collective height of the panels when the first panel resides substantially within the second panel.
2. The assembly of claim 1, wherein the internal cavity of the second panel comprises dimensions capable of enclosing the first panel.
3. The assembly of claim 1, wherein the second panel further comprises an overhang formed proximate a top end of the second panel, wherein the overhang is configured to hang off a lower surface of the storage space.
4. The assembly of claim 1, wherein the first panel comprises a flange configured to engage the second panel when the first panel is raised.
5. An assembly incorporating claim 4, wherein the flange also is configured to substantially seal off an opening that the panels pass through in the overhead structure, when the panels are fully retracted.
6. The assembly of claim 1, wherein the bottom of the first panel comprises magnets that may laterally lock the first panel to a floor.
7. The assembly of claim 1, wherein the panels slide against adjoining walls along adjoining edges, wherein the adjoining edges comprise a planar bearing surface to facilitate the movement of the wall assembly along any adjoining surface.
8. The assembly of claim 7, wherein the adjoining edges are biased towards the adjoining walls.
9. The assembly of claim 1, wherein the cable is at least partially wound about a spool attached to an upper surface of the overhead structure.
10. The assembly of claim 9, wherein the cable connects the spool to the first panel through the internal cavity of second panel.
11. The assembly of claim 9, wherein the spool is driven by a motor.
12. The assembly of claim 1, wherein the first panel comprises another internal cavity that comprises an expandable element configured to adjust the thickness of the first panel.
13. The assembly of claim 12, wherein the first panel is configured to reduce its thickness by compressing the expandable element as the first panel is pulled into the other internal cavity of the second panel.
14. The assembly of claim 1, wherein the assembly comprises a third panel that is substantially co-planar with the first and second panel.
15. The assembly of claim 1, wherein the first and second panels are supported by the cable.
16. The assembly of claim 1, wherein the assembly forms at least part of an internal wall of a structure.
17. The assembly of claim 1, wherein a locking mechanism supports the panels while retracted into the storage space.
18. The assembly of claim 1, wherein the assembly is incorporated into an exterior wall of a structural.
19. The assembly of claim 1, wherein the panels are made of materials that are collectively light enough for a person to lift manually.