I claim:
1. In a valve of the type including:
a. a body constructed to have
(i) a fluid path;
(ii) a stem bore connected in fluid communication with the fluid path; and
(iii) a seat;
b. a stem packing located in the stem bore;
c. a valve member having a valve stem and a sealing member, the valve member being positionable in the stem bore so that the sealing member may engage the seat, the valve stem engaging the stem packing in the stem bore, the valve stem made of a base material; and
d. an actuating member connected to the valve stem for actuating the valve member; the improvement comprising:
the valve stem including a reduced diameter recessed section aligned with the stem packing and a section of welded hardfaced material filling the reduced diameter recessed section, having a thickness of between about 0.010 inches and about 0.125 inches thereby preventing damage to the hardfaced material under the action of foreign materials in the stem packing, and having a Brinell hardness number of between about 220 and about 380 in contact with said stem packing so that upon relative movement between the valve stem and the stem packing the welded hardfaced material filling the reduced diameter recessed section of the valve stem resists corrosion, erosion, and scratching due to foreign materials in the stem packing over a prolonged period of time; and
an improved stem packing located in the stem bore in engagement with the hardfaced material and comprising at least one metal pressure ring and at least one sealing member.
2. The improvement according to claim 1 wherein sealing member of the improved stem packing comprising a graphite seal.
3. The improvement according to claim 2 further characterized by a plurality of metal pressure rings arranged in a vertically stacked array and a plurality of graphite seals, each of the graphite seals being positioned between two of the metal pressure rings comprising the array.
4. The improvement according to claim 3 wherein each of the metal pressure rings and each of the graphite seals is chevron shaped in cross section.
5. The improvement according to claim 3 wherein each of the metal pressure rings and each of the graphite seals have the cross sectional configuration illustrated in FIG. 9.
6. The improvement according to claim 3 wherein each of the metal pressure rings and each of the graphite seals have the cross sectional configuration illustrated in FIG. 10.
7. The improvement according to claim 3 wherein each of the metal pressure rings and each of the graphite seals have the cross sectional configuration illustrated in FIG. 11.
8. The improvement according to claim 3 wherein each of the metal pressure rings and each of the graphite seals have the cross sectional configuration illustrated in FIG. 12.
9. The improvement according to claim 3 further characterized by scrapers located at the opposite ends of the stacked array for engagement with the valve stem to prevent debris from entering the packing member.
10. The improvement according to claim 9 further including thrust plates positioned on the opposite sides of the packing members.
11. In a valve having a body constructed having a fluid path, a stem bore and a seat, a valve member having a valve stem and a sealing member, said valve member being positionable in said stem bore so that said sealing member may engage said seat, said valve stem engaging stem packing located between said valve stem and said stem bore, and an actuating member connected to said valve member wherein the improvement comprises:
said valve stem comprising a recessed portion aligned with the stem packing, said recessed portion being filled with a weldment of hardfaced material selected from the group consisting of one or more materials having Brinell hardness numbers of between about 220 and about 380, said welded hardfaced material having a thickness of between about 0.010 inches and about 0.125 inches thereby preventing damage to the hardfaced material due to foreign material in the stem packing over a prolonged period of time;
said stem engaging packing comprising at least one metal pressure ring and at least one sealing member.
12. The improvement according to claim 11 wherein sealing member of the improved stem packing comprises a graphite seal.
13. The improvement according to claim 11 further characterized by a plurality of metal pressure rings arranged in a vertically stacked array and a plurality of graphite seals, each of the graphite seals being positioned between two of the metal pressure rings comprising the array.
14. The improvement according to claim 13 wherein each of the metal pressure rings and each of the graphite seals is chevron shaped in cross section.
15. The improvement according to claim 13 wherein each of the metal pressure rings and each of the graphite seals have the cross sectional configuration illustrated in FIG. 9.
16. The improvement according to claim 13 wherein each of the metal pressure rings and each of the graphite seals have the cross sectional configuration illustrated in FIG. 10.
17. The improvement according to claim 13 wherein each of the metal pressure rings and each of the graphite seals have the cross sectional configuration illustrated in FIG. 11.
18. The improvement according to claim 13 wherein each of the metal pressure rings and each of the graphite seals have the cross sectional configuration illustrated in FIG. 12.
19. The improvement according to claim 13 further characterized by scrapers located at the opposite ends of the stacked array for engagement with the valve stem to prevent debris from entering the packing member.
20. The improvement according to claim 19 further including thrust plates positioned on the opposite sides of the packing members.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A metoclopramide oral dosage formulation comprising a solid oral dosage containing metoclopramide, or a pharmaceutically acceptable salt thereof, wherein the solid oral dosage dissolves within the mouth within a time period of from about 60 seconds or less.
2. The metoclopramide oral dosage formulation of claim 1, wherein the time period is from about 30 seconds or less.
3. The metoclopramide oral dosage formulation of claim 2, wherein the time period is from about 1 second to about 15 seconds.
4. The metoclopramide oral dosage formulation of claim 3, wherein the time period is from about 3 seconds to 15 seconds.
5. The metoclopramide oral dosage formulation of claim 4, wherein the time period is from about 3 seconds to 10 seconds.
6. The metoclopramide oral dosage formulation of claim 5, wherein the time period is from about 3 seconds to about 5 seconds.
7. The metoclopramide oral dosage formulation of claim 1, wherein the metoclopramide oral dosage comprises from about 40 mg of metoclopramide or less.
8. The metoclopramide oral dosage formulation of claim 7, wherein the metoclopramide oral dosage comprises about 20 mg of metoclopramide.
9. The metoclopramide oral dosage formulation of claim 1, wherein the solid oral dosage formulation comprises a lyophilized dosage form.
10. The metoclopramide oral dosage formulation of claim 1, wherein the solid oral dosage formulation comprises a dosage form selected from the group consisting of tablet, pill, capsule and melt.
11. The metoclopramide oral dosage formulation of claim 1, wherein the solid oral dosage formulation comprises a dosage form selected from the group consisting of a tablet.
12. The metoclopramide oral dosage formulation of claim 1, wherein the solid oral dosage formulation comprises a dosage form selected from the group consisting of a pill.
13. The metoclopramide oral dosage formulation of claim 1, wherein the solid oral dosage formulation comprises a dosage form selected from the group consisting of a capsule.
14. The metoclopramide oral dosage formulation of claim 1, wherein the solid oral dosage formulation comprises a dosage form selected from the group consisting of a melt.
15. A process for formulating a lyophilized metoclopramide tablet, comprising the steps of:
forming a solution of metoclopramide; and,
drying by freezing in a high vacuum to form a lyophilized metoclopramide formulation.
16. A metoclopramide lyophilized tablet product produced by the process of claim 15.
17. The metoclopramide lyophilized tablet product of claim 16, where the metoclopramide comprises a dosage of 10 mg.
18. A method for abating manifestations of gastroparesis in a patient comprising the steps of:
providing a metoclopramide oral dosage formulation of claim 1; and,
administering the oral dosage formulation effective to dissolve within the mouth within a time period of from about 60 seconds or less.
19. The method of claim 18, wherein the step of administering metoclopramide occurs without administration fluids.
20. The method of claim 19, wherein the step of administering metoclopramide occurs without administration of water.