1. A pharmaceutical composition for treating gastric adenocarcinoma, comprising p43 protein and pharmaceutically acceptable carriers, wherein the pharmaceutical composition does not include paclitaxel.
2. The pharmaceutical composition according to claim 1, wherein the amount of p43 protein is from 0.1% to 99.9%.
3. The pharmaceutical composition according to claim 1, wherein the amount of p43 protein is from 5% by weight to 95% by weight.
4. The pharmaceutical composition according to claim 1, wherein the amount of p43 protein is from 10% by weight to 60% by weight.
5. The pharmaceutical composition according to claim 1, wherein the amount of p43 protein is from 20% by weight to 40% by weight.
6. The pharmaceutical composition according to claim 1, wherein the pharmaceutically acceptable carrier is selected from physiological saline.
7. The pharmaceutical composition according to claim 1, wherein the pharmaceutical composition further comprises human albumin.
8. The pharmaceutical composition according to claim 7, wherein the amount of the human albumin is from 0.01% by weight to 10% by weight.
9. Use of p43 protein in preparation of a medicament for treating gastric adenocarcinoma.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A weldable, workable steel comprising, in combination:
a secondary hardened, stable, generally mixed bainite and martensite phase steel having a BCC copper precipitation phase and M2C carbide strengthening particles, said steel including in weight percent about:
0.030 to 0.055 carbon (C);
3.5 to 5.0 copper (Cu);
6.0 to 7.5 nickel (Ni);
1.6 to 2.0 chromium (Cr);
0.2 to 0.6 molybdenum (Mo);
0.05 to 0.20 vanadium (V); and
the balance Fe.
2. The steel of claim 1 characterized by a yield strength exceeding about 140 ksi.
3. A steel having enhanced toughness, weldability strength and workability, said steel comprising, in combination in weight percent about:
0.030 to 0.055 carbon (C);
3.50 to 5.0 copper (Cu);
6.0 to 7.5 nickel (Ni);
1.6 to 2.0 chromium (Cr);
0.2 to 0.6 molybdenum (Mo);
0.05 to 0.20 vanadium (V), and
the balance iron (Fe) characterized by a yield strength exceeding about 140 ksi, a generally martensitic microstructure, BCC copper precipitate hardening, M2C carbide particle strengthening where M is one or more materials selected from the group consisting of Cr, Mo and V, and Ni stabilized, precipitated austenite.
4. The steel of claim 3 wherein the steel is characterized by a mixed bainite and martensite microstructure.
5. The steel of claim 3 wherein the steel is characterized by secondary hardening.
6. The steel of claim 3 characterized by a first tempering step in the range of about 450\xb0 C. for a period of about 30 to 90 minutes.
7. The steel of claim 5 characterized by a second tempering step in the range of about 300\xb0 C. to 450\xb0 C. for a period of about 1 to 10 hours.
8. The steel of claim 1 having a nominal composition in weight percent of about:
0.05\xb10.01 C;
3.65\xb10.05 Cu;
6.5\xb10.02 Ni;
1.84\xb10.05 Cr;
0.60\xb10.05 Mo;
0.10\xb10.01 V; and
the balance Fe.
9. A method for manufacture of a hardened steel alloy comprising the steps of:
(a) forming a melt into a casting comprised in weight percent of about 0.030 to 0.055 carbon (C), 3.5 to 5.0 copper (Cu), 6.0 to 7.5 nickel (Ni), 1.6 to 2.0 chromium (Cr), 0.2 to 0.6 molybdenum (Mo), 0.05 to 0.20 vanadium (V) and the balance iron;
(b) homogenizing the casting at a temperature in the range of about 1200\xb0 C.\xb150\xb0 for about 6 to 8 hours;
(c) hot working said alloy;
(d) ambient cooling said alloy;
(e) annealing said alloy at a temperature in the range of about 480\xb0 C.\xb140\xb0 C. for about 8 to 12 hours;
(f) solution heating said alloy at a temperature of about 900\xb0 C.\xb150\xb0 C. for about 30 to 90 minutes;
(g) cooling said alloy to form a generally martensitic microstructure;
(h) tempering said alloy at a temperature of about 500\xb0 C. to 575\xb0 C. for about 5 to 90 minutes to achieve austenite precipitation; and
(i) further tempering said alloy at a temperature of about 400\xb0 C. to 500\xb0 C. for about 1 to 10 hours to achieve M2C carbide particle formation.
10. A method for manufacture of a hardened steel alloy comprising the steps of:
(a) forming a melt into a casting comprised in weight percent of about 0.030 to 0.055 carbon (C), 3.5 to 5.0 copper (Cu), 6.0 to 7.5 nickel (Ni), 1.6 to 2.0 chromium (Cr), 0.2 to 0.6 molybdenum (Mo), 0.05 to 0.20 vanadium (V) and the balance iron;
(b) heat treating and working said alloy to form a material characterized by a substantially martentsitic microstructure;
(c) tempering said alloy at a temperature of about 500\xb0 C. to 575\xb0 C. for about 5 to 90 minutes to achieve dispersed austenite precipitation; and
(d) further tempering said alloy at a temperature of about 400\xb0 C. to 500\xb0 C. for about 1 to 10 hours to achieve M2C carbide particle formation where M is selected from the group consisting of Cr, V and Mo.
11. A method for manufacture of a hardened steel alloy comprising the steps of:
(a) forming a melt into a casting comprised in weight percent of about 0.030 to 0.055 carbon (C), 3.5 to 5.0 copper (Cu), 6.0 to 7.5 nickel (Ni), 1.6 to 2.0 chromium (Cr), 0.2 to 0.6 molybdenum (Mo), 0.05 to 0.20 vanadium (V) and the balance iron;
(b) working and heat treating said alloy to form a generally bainitic and martensitic microstructure;
(c) tempering said alloy at a temperature of about 500\xb0 C. to 575\xb0 C. for about 5 to 90 minutes to achieve austenite dispersion precipitation; and
(d) further tempering said alloy at a temperature of about 400\xb0 C. to 500\xb0 C. for about 1 to 10 hours to achieve M2C carbide particle formation wherein M is selected from the group consisting of Cr, Mo and V, said alloy including BCC Cu, Ni dispersed austenite and M2C carbides in a mixed bainite and martensite microstructure.