1. A compound of formula (Ia):
its tautomeric forms, its stereoisomers and their pharmaceutically acceptable salts, wherein X and Y may be same or different and independently represent oxygen, sulfur or NR, wherein R represents hydrogen, hydroxyl, acyl, alkyl, alkoxy, aryl, amino, hydroxylamino, alkylamino, arylamino, acylamino, or alkoxyamino group; the ring represented by B is selected from aryl and heteroaryl; R3 represents SR7, wherein R7 represents alkyl or aryl; S(O)pR8, wherein R8 represents alkyl, amino or aryl group and p represents an integer of 1 or 2; R4 represents hydrogen, halogen, hydroxyl, nitro, cyano, azido, nitroso, amino, formyl, alkyl, haloalkyl, acyl, alkoxy, monoalkylamino, dialkylamino, acylamino, alkoxycarbonyl, alkylsulfonyl, alkylsulfinyl, alkylthio, sulfamoyl, alkoxyalkyl groups or carboxylic acids or its derivatives; R5 and R6 may be same or different and independently represent hydrogen, halogen, hydroxyl, formyl, cyano, nitroso, nitro, amino, alkyl, acyl, monoalkylamino, dialkylamino, arylamino, acylamino, alkoxyalkyl or COR9, wherein R9 represents hydroxy, amino, halogen, alkoxy, aryloxy, monoalkylamino, dialkylamino, or arylamino groups; n is an integer and represents 0 to 2.
2. A method of reducing inflammation, inhibiting TNF-\u03b1, inhibiting 11-6 or inhibiting COX-2 in a mammal comprising administering to the mammal in need thereof an effective amount of pyrimidinedione derivatives of the formula (I)
their their tautomeric forms, their stereoisomers, their solvates, their pharmaceutically acceptable salts and their pharmaceutically acceptable compositions, wherein X and Y may be same or different and independently represent oxygen, sulfur or NR, wherein R represents hydrogen, hydroxyl, acyl, alkyl, alkoxy, aryl, amino, hydroxylamino, alkylamino, arylamino, acylamino, or alkoxyamino group; the rings represented by A and B are selected from aryl and heteroaryl; R1 and R3 are different and represent hydrogen or SR7, wherein R7 represents alkyl or aryl; S(O)pR8, wherein R8 represents alkyl, amino or aryl group and p represents an integer of 1 or 2; R2 and R4 may be same or different and independently represent hydrogen, halogen, hydroxyl, nitro, cyano, azido, nitroso, amino, formyl, alkyl, haloalkyl, acyl, alkoxy, monoalkylamino, dialkylamino, acylamino, alkoxycarbonyl, alkylsulfonyl, alkylsulfinyl, alkylsulfanyl, sulfamoyl, alkoxyalkyl groups or carboxylic acids or its derivatives; R5 and R6 may be same or different and independently represent hydrogen, halogen, hydroxyl, formyl, cyano, nitro, nitroso, amino, alkyl, acyl, monoalkylamino, dialkylamino, arylamino, acylamino, alkoxyalkyl or COR9, wherein R9 represents hydroxyl, amino, halogen, alkoxy, aryloxy, monoalkylamino, dialkylamino, or arylamino groups; m is an integer and is in the range of 0 to 2; n is an integer in the range of 0 to 2, inclusive.
3. The method as claimed in claim 2, wherein the ring systems represented by A and B are selected from phenyl, naphthyl, pyrrolidinyl, morpholinyl, thiomorpholinyl, piperidinyl, piperazinyl, pyridyl, thienyl, furyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, oxadiazolyl, thiadiazolyl, tetrazolyl, pyrimidinyl, benzopyranyl, benzofuranyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, benzopyrolyl, benzoxadiazolyl, benzothiadiazolyl, quinolinyl, isoquinolinyl, benzothienyl, benzofuranyl and indolyl.
4. A method of reducing inflammation, inhibiting TNF-\u03b1, inhibiting IL-6 or inhibiting COX-2 in a mammal comprising administering to the mammal in need thereof an effective amount of one or more compounds selected from the group consisting of:
1-(4-Methylsulfanyl-phenyl)-6-phenyl-pyrimidin-2,4-(1H)-dione;
6-(4-Methylphenyl)-1-(4-methylsulfanyl-phenyl)-pyrimidin-2,4-(1H)-dione;
6-(4-Ethylphenyl)-1-(4-methylsulfanyl-phenyl)-pyrimidin-2,4-(1H)-dione;
1-(4-Methylphenyl)-6-(4-methylsulfanyl-phenyl)-pyrimidin-2,4-(1H)-dione;
1-(4-Bromophenyl)-6-(4-methylsulfanyl-phenyl)-pyrimidin-2,4-(1H)-dione;
6-(4-Chlorophenyl)-1-(4-methylsulfanyl-phenyl)-pyrimidin-2,4-(1H)-dione;
6-(4-Chloro-3-methylphenyl)-1-(4-methylsulfanyl-phenyl)-pyrimidin-2,4-(1H)-dione;
6-(3-Chloro-4-methylphenyl)-1-(4-methylsulfanyl-phenyl)-pyrimidin-2,4-(1H)-dione;
6-(4-Fluoro-3-methylphenyl)-1-(4-methylsulfanyl-phenyl)-pyrimidin-2,4-(1H)-dione;
6-(4-Fluorophenyl)-1-(4-methylsulfanyl-phenyl)-pyrimidin-2,4-(1H)-dione;
6-(4-Methylsulfanyl-phenyl)-1-phenyl-pyrimidin-2,4-(1H)-dione;
6-(4-Methylphenyl)-1-(3-chloro-4-methylsulfonyl-phenyl)-pyrimidin-2,4-(1H)-dione;
6-(4-Methoxy-3-methylphenyl)-1-(4-methylsulfonyl-phenyl)-pyrimidin-2,4-(1H)-dione;
6-(4-Methylphenyl)-1-(4-methylsulfonyl-phenyl)-pyrimidin-2,4-(1H)-dione;
6-(4-Ethylphenyl)-1-(4-methylsulfonyl-phenyl)-pyrimidin-2,4-(1H)-dione;
6-(4-Chlorophenyl)-1-(4-methylsulfonyl-phenyl)-pyrimidin-2,4-(1H)-dione;
6-(4-Chloro-3-methylphenyl)-1-(4-methylsulfonyl-phenyl)-pyrimidin-2,4-(1H)-dione;
6-(4-Chlorophenyl)-1-(3-methoxy-4-methylsulfonyl-phenyl)-pyrimidin-2,4-(1H)-dione;
6-(3-Chloro-4-methylphenyl)-1-(4-methylsulfonyl-phenyl)-pyrimidin-2,4-(1H)-dione;
6-(4-Fluorophenyl)-1-(4-methylsulfonyl-phenyl)-pyrimidin-2,4-(1H)-dione;
1-(4-Methylsulfonyl-phenyl)-6-phenyl-pyrimidin-2,4-(1H)-dione;
1-(4-Methylsulfanyl-phenyl)-6-(pyridin-2-yl)-pyrimidin-2,4-(1H)-dione;
6-(4-Methylpyridin-2-yl)-1-(4-methylsulfanyl-phenyl)-pyrimidin-2,4-(1H)-dione;
6-(4-Chloropyridin-2-yl)-1-(4-methylsulfanyl-phenyl)-pyrimidin-2,4-(1H)-dione;
6-(4-Methylsulfanyl-phenyl)-1-(pyridin-2-yl)-pyrimidin-2,4-(1H)-dione;
1-(4-Methylsulfonyl-phenyl)-6-(pyridin-2-yl)-pyrimidin-2,4-(1H)-dione;
6-(4-Methylpyridin-2-yl)-1-(4-methylsulfonyl-phenyl)-pyrimidin-2,4-(1H)-dione;
6-(4-Chloropyridin-2-yl)-1-(4-methylsulfonyl-phenyl)-pyrimidin-2,4-(1H)-dione;
4-(2,4-Dioxo-6-(4-methylphenyl)-3,4-dihydro-2H-pyrimidin-1-yl)-benzenesulfonamide;
4-(2,4-Dioxo-6-phenyl-3,4-dihydro-2H-pyrimidin-1-yl)-benzenesulfonamide;
4-6-(4-Bromo-phenyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl-benzenesulfonamide;
4-(2,6-Dioxo-3-phenyl-1,2,3,6-tetrahydro-pyrimidin-4-yl)-benzenesulfonamide;
4-(2,6-Dioxo-3-(4-methylsulfanyl-phenyl)-1,2,3,6-tetrahydro-pyrimidin-4-yl)-benzenesulfonamide and
4-3-(4-Chloro-phenyl)-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl-benzenesulfonamide.
5. The method of claim 2, wherein the activity of plasma concentration or the production of either or in combination of the following TNF-\u03b1, IL-1, IL-6, IL-8 and IL-12 are inhibited.
6. The method of claim 2, wherein prostaglandins production is decreased.
7. The method of claim 2, wherein cyclooxygenase enzyme activity is decreased.
8. The method of claim 4, wherein the activity of plasma concentration or the production of either or in combination of the following TNF-\u03b1, IL-1, IL-6, IL-8 and IL-12 are inhibited.
9. The method of claim 4, wherein prostaglandins production is decreased.
10. The method of claim 4, wherein cyclooxygenase enzyme activity is decreased.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A swivel mount apparatus for coupling an antenna to a vehicle, the swivel mount apparatus comprising:
a first member configured to couple to a mounting interface on a vehicle;
a second member rotatably coupled to the first member;
a mounting post affixed to the first member and extending upwardly relative to the first member wherein the mounting post receives the second member and causes the second member to be rotatably coupled to the first member, the mounting post defining an azimuth pivot axis extending perpendicular to the first member;
an antenna including an antenna post and antenna blades supported by the antenna post for pivoting movement about an elevational pivot axis extending perpendicular to the azimuth pivot axis; and
a coupler coupling the antenna post to the second member.
2. The swivel mount apparatus of claim 1, wherein:
the second member includes a first receiving wall and a second receiving wall; and
a receiving space is defined by the first receiving wall and the second receiving wall, the antenna post received within the receiving space, wherein the first receiving wall and the second receiving wall are configured to prevent rotation of the antenna post about an axis extending perpendicular to a longitudinal axis of the antenna post and parallel to the first receiving wall and the second receiving wall, and are configured to prevent translational movement in a direction perpendicular to the first receiving wall and the second receiving wall.
3. The swivel mount apparatus of claim 2, further including a first angle member defining the first receiving wall and a second angle member defining the second receiving wall, wherein the second member includes a vertical wall, and the first angle member and the second angle member are affixed to the vertical wall of the second member.
4. The swivel mount apparatus of claim 1, wherein the second member supports the antenna for rotation about the azimuth pivot axis.
5. The swivel mount apparatus of claim 1, wherein the coupler includes at least one fastener received within at least one threaded hole in the second member, wherein the at least one fastener secures the antenna post to the second member.
6. The swivel mount apparatus of claim 1, wherein the first member includes a lower surface and an upper surface, and the post is inserted from the lower surface and extends upwardly relative to the upper surface.
7. The swivel mount apparatus of claim 1, wherein the first member includes a thru-hole configured to receive a fastener, wherein the fastener secures the first member to a pre-existing coupling point defined by the mounting interface of the vehicle.
8. The swivel mount apparatus of claim 1, further including a first washer and a second washer, wherein the first washer receives the mounting post and is disposed between the first member and the second member, and the second washer receives the mounting post and is disposed atop the second member.
9. The swivel mount apparatus of claim 8, further including a lock washer disposed atop the second washer and a wing nut disposed atop the lock washer, wherein the lock washer and the wing nut secure the second member in a desired rotational position about the azimuth axis.
10. A method of installing a swivel mount apparatus on a vehicle, the method comprising the steps of:
locating a pre-existing mounting interface on a vehicle, the mounting interface including a coupling point configured to secure a first member to the vehicle;
mechanically coupling the first member to the coupling point of the mounting interface;
rotatably coupling a second member to the first member for rotation about an azimuth pivot axis;
installing at least one retaining member atop the second member;
coupling an antenna post of an antenna to the second member;
wherein the second member includes a first receiving wall, a second receiving wall, and a receiving space defined between the first receiving wall and the second receiving wall, the antenna post being received within the receiving space.
11. The method of claim 10, further including the steps of installing a first washer between the first member and the second member, and installing a second washer atop the second member.
12. The method of claim 11, wherein the step of installing at least one retaining member atop the second member includes installing a lock washer atop the second washer, and installing a wing nut atop the lock washer.
13. The method of claim 10, wherein the vehicle includes a hood and a passenger compartment including a driver side and a passenger side, wherein the mounting interface is integral to the hood and is located longitudinally forward of the passenger compartment and laterally on the passenger side.
14. The method of claim 13, further including rotating the antenna about the azimuth axis, and rotating the antenna about an elevational axis extending perpendicular to the azimuth axis.
15. The method of claim 14, wherein rotating the antenna is performed while the antenna post is coupled to the second member, the second member is coupled to the first member, and the first member is coupled to the vehicle.
16. The method of claim 14, wherein the steps of rotating the antenna about the azimuth axis, and rotating the antenna about the elevational axis are performed by an occupant supported within the passenger compartment.
17. A swivel mount apparatus for coupling an accessory to a vehicle, the swivel mount apparatus comprising:
a first member configured to couple to a mounting interface on a vehicle;
a second member rotatably coupled to the first member;
a mounting post affixed to the first member and extending upwardly relative to the first member, wherein the mounting post receives the second member, the mounting post defining an azimuth pivot axis extending perpendicular to the first member, and the second member being rotatable about the azimuth pivot axis relative to the first member;
a first receiving wall and a second receiving wall affixed to the second member such that a receiving space is formed between the first receiving wall and the second receiving wall;
a retaining member disposed atop the second member and operably coupled to the mounting post, the retaining member configured to secure the second member in a desired rotational position about the azimuth axis; and
a coupler configured to couple an antenna post within the receiving space; and
a first angle member defining the first receiving wall and a second angle member defining the second receiving wall, wherein the second member includes a vertical wall, and the first angle member and the second angle member are affixed to the vertical wall of the second member;
wherein the first receiving wall and the second receiving wall are configured to prevent rotation of the antenna post about an axis extending perpendicular to a longitudinal axis of the antenna post, and are configured to prevent translational movement in a direction perpendicular to the first receiving wall and the second receiving wall.
18. The swivel mount apparatus of claim 17, further comprising a spacing member received by the mounting post and disposed between the first member and the second member.
19. (canceled)
20. The swivel mount apparatus of claim 17, wherein the second member supports the antenna for rotation about the azimuth pivot axis.
21. The swivel mount apparatus of claim 17, wherein the coupler includes at least one fastener received within at least one threaded hole in the second member, wherein the at least one fastener secures the accessory to the second member.
22. The swivel mount apparatus of claim 17, wherein the first member includes a thru-hole configured to receive a fastener, wherein the fastener secures the first member to a pre-existing coupling point defined by the mounting interface of the vehicle.
23. The swivel mount apparatus of claim 17, wherein the accessory comprises an antenna including an antenna post supported within the receiving space.
24. A method of manufacturing a swivel mount antenna comprising the steps of:
providing a vehicle;
identifying on the vehicle a first mounting interface and a coupling point for an equipment item;
identifying form, fit and function of the equipment item;
supporting the equipment item to rotate 360 degrees in an azimuth direction at a lower section of a support member; and
coupling the lower section of the support member with the first mounting interface located on an opposing end of the support member from the equipment item;
wherein identifying on the vehicle the first mounting interface and the coupling point for the equipment item includes identifying at least one fastener to secure the equipment item to the first mounting interface configured to adjustably support and orient the equipment item relative to the first mounting interface on the vehicle.
25. The method of claim 24, further including a quick disconnect member configured to receive and releasably couple with the support member of the equipment item wherein the support member is configured to position and support the equipment item, and the quick disconnect member includes a threaded member that is configured to provide a variable and repositionable coupling pressure against the support member, wherein the coupling pressure is sufficient to prevent the support member from decoupling from the quick disconnect member up to a predetermined force.
26. The method of claim 24, wherein the equipment item comprises an antenna, and the support member comprises an antenna post.
27. A method of mounting an equipment item on a mobile equipment item comprising the steps of:
identifying and analyzing candidate mounting support surfaces on a mobile equipment item to determine a target mounting location;
wherein the mobile equipment item includes a first mobile equipment section and a second mobile equipment section, wherein the first mobile equipment section includes an operator section and the second mobile equipment section includes portions which are external to the operator section and areas which surround the operator section or extend away from the operator section;
wherein the target mounting location is within a first distance from an aperture in the second mobile equipment section, wherein the target mounting location includes an existing coupling member that is accessible from outside the mobile equipment item without disassembly of the mobile equipment item comprising a structure adapted to couple at least two parts of the mobile equipment item together; and
wherein a retaining member rotationally secures an antenna about an azimuth pivot axis, wherein the retaining member is within a second distance from the aperture in the second mobile equipment section configured to enable at least one of an occupant and a robotic armature disposed within the control chamber to reposition the antenna.
28. The method of claim 27, further including providing an adapter member having a first section and a second section, wherein the first section is adapted to releasably couple with the retaining member and the existing coupling member so as to avoid interference between the adapter member and the first and second mobile equipment sections.
29. The method of claim 27, wherein the retaining member comprises a threaded post extending upwardly from the first section, and a wing nut operably coupled to the threaded post and positioned above the second section.
30. The method of claim 27, further includes providing for a dual use nature of the antenna, wherein the antenna may be mounted on a tripod separate from a vehicle and used on the ground as part of communications with a satellite.
31. The method of claim 27, wherein the mobile equipment item comprises a vehicle, the first mobile equipment section comprises a passenger compartment, and the second mobile equipment section comprises a hood.
32. The method of claim 31, wherein the aperture comprises a passenger side window.
33. The method of claim 32, wherein the at least two parts comprises the hood and a grille.