1. A method of for the treatment of venous thromboembolic events in a patient with deep thrombosis which comprises parenterally administering once a week to said patient a dose of 2.5 mg of the pentasaccharide methyl O-(2,3,4-tri-O-methyl-6-O-sulfo-\u03b1-D-glucopyranosyl)-(1\u21924)-O-(2,3-di-O-methyl-\u03b2-D-glucopyranosyl uronic acid)-(1\u21924)-O-(2,3,6-tri-O-sulfo-\u03b1-D-glucopyranosyl)-(1\u21924)-O-(2,3-di-O-methyl-\u03b1-L-idopyranosyl uronic acid)-(1\u21924)-2,3,6-tri-O-sulfo-\u03b1-D-glucopyranoside or a pharmaceutically acceptable salt thereof.
2. A method according to claim 1, wherein the pentasaccharide is in the form of its nonasodium salt (SanOrg 34006).
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An apparatus for continuous production of aligned carbon nanotubes, comprising:
a reactor defining a hollow interior;
a conveyor for continuously passing a substrate through the hollow interior of the reactor at a predetermined rate of travel; and
an injector for delivering a hydrocarbon feed solution dispersed in an inert carrier gas into the hollow interior of the reactor;
whereby aligned carbon nanotubes are formed on the substrate.
2. The apparatus of claim 1, wherein the reactor and conveyer are fabricated from an inert material which substantially inhibits nanotube growth thereon.
3. The apparatus of claim 2, wherein the inert material is any non-reactive metal or ceramic which substantially inhibits nanotube growth thereon.
4. The apparatus of claim 3, wherein the inert material is selected from the group consisting of alumina, silicon carbide, Nichrome, and any mixture thereof.
5. The apparatus of claim 1, wherein the conveyor passes the substrate through the hollow interior of the reactor at a rate of travel providing a substrate residence time within the reactor of from about 10 minutes to about 120 minutes.
6. The apparatus of claim 1, wherein the injector comprises:
a first hollow tube for delivering a feed solution; and
a second hollow tube for delivering an inert carrier gas;
wherein the first hollow tube is disposed in an interior of the second hollow tube, thereby defining an annulus between the first hollow tube and the second hollow tube; and
wherein an end of the second tube extends beyond a corresponding end of the first tube to define a dispersion chamber having a length and a diameter for dispersing the feed solution into the inert carrier gas.
7. The apparatus of claim 6, wherein the first hollow tube has an outer cross-sectional area of from about 50 percent to about 90 percent of an internal cross-sectional area of the second hollow tube.
8. The apparatus of claim 7, wherein the injector is adapted whereby the inert carrier gas is delivered through the annulus at a Reynold’s number of between about 1 and about 2000.
9. The apparatus of claim 8, wherein the injector is adapted whereby the inert carrier gas is delivered through the annulus at a Reynold’s number of between about 50 and about 200.
10. The apparatus of claim 6, wherein the dispersion chamber has a length of from about 1 to about 15 times the diameter of the dispersion chamber.
11. The apparatus of claim 10, wherein the dispersion chamber has a length of from about 8 to about 10 times the diameter of the dispersion chamber.
12. The apparatus of claim 1, further comprising an inert, porous medium through which the feed solution dispersed in the inert carrier gas is passed prior to entry into the reactor.
13. The apparatus of claim 12, wherein the inert, porous medium is fabricated from the group consisting of transition metal elements, transition metal element alloys, zirconia, silicon carbide, silica ceramics, and combinations thereof.
14. The apparatus of claim 12, wherein the inert, porous medium is a sinter fabricated from the group of materials consisting of ceramic, alumina, steel, stainless steel, titanium, and any mixture thereof.
15. The apparatus of claim 12, wherein the inert, porous medium contains a plurality of pores having a diameter of from about 0.1 \u03bcm to about 1 \u03bcm.
16. The apparatus of claim 1, further including a temperature controller for selectively controlling a temperature of the hollow interior of the reactor.
17. The apparatus of claim 1, further including an actuator for selectively displacing an end of the injector within the hollow interior of the reactor.
18. The apparatus of claim 1, further including means for excluding ambient air from the hollow interior.
19. The apparatus of claim 18, wherein the means for excluding ambient air from the interior of the reactor comprises a purge box adjacent an opening of the reactor.
20. The apparatus of claim 18, wherein the means for excluding ambient air from the interior of the reactor comprises a gas curtain adjacent an opening of the reactor.