What is claimed is:
1. An oligopeptide having the terminal pharmacophore group Cys-Asn-Ser, said oligopeptide being capable of inhibiting the NF- signaling pathway.
2. The oligopeptide of claim 1 which is the three amino acid peptide Cys-Asn-Ser.
3. The oligopeptide of claim 1 wherein the NF- signaling pathway is inhibited in vivo in a subject.
4. The oligopeptide of claim 3 which inhibits the NF- signaling pathway by the nuclear translocation of MyD88 and NF- in cells.
5. The oligopeptide of claim 1 which confers innate immunity to a subject following administration.
6. The oligopeptide of claim 1 where the cells are human monocyte cells.
7. The oligopeptide of claim 1 which induces the production of IL-10 in vivo.
8. A pharmaceutical composition comprising the oligopeptide of claim 1 and suitable adjuvants.
9. A method for inhibiting the NF- signaling pathway in vivo in a subject by administering to the subject an effective amount of the pharmaceutical composition of claim 8.
10. The method of claim 9 wherein the oligopeptide is MLIF.
11. The method of claim 9 wherein the oligopeptide is Cys-Asn-Ser.
12. A method for inhibiting scar formation comprising administering to a subject the pharmaceutical composition of claim 8.
13. The method of claim 12 wherein the oligopeptide is Cys-Asn-Ser.
14. The method of claim 12 wherein the oligopeptide blocks the activity of fibroblast growth factor receptor signaling adaptor.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method of hand laundering a fabric comprising the steps of:
A. providing a laundering system comprising:
i. a laundry detergent suitable for overnight soaking comprising a bactericide, which comprises a bleach, an enzyme, and an anionic surfactant, wherein the laundry detergent is free of a quaternary ammonium-based fabric softening active and wherein the laundry detergent retards bacterial growth upon soaking in a wash liquor thereof with a fabric contaminated with bacteria; and
ii. a rinsing composition, which comprises a quaternary ammonium-based fabric softening active and a suds suppressing system, wherein the rinsing composition is free of anionic surfactant;
B. adding water to a wash basin;
C. dispersing the laundry detergent in a wash basin;
D. adding a fabric to the wash basin;
E. forming a wash liquor by combining the water and the laundry detergent;
F. soaking the fabric in the wash liquor for a washing time period of from about 2 hours to about 8 hours to form a soaked fabric;
G. removing the soaked fabric from the wash liquor;
H. removing wash liquor from the soaked fabric;
I. dispersing the rinsing composition in water in a rinse basin to form a rinse solution;
J. adding the soaked fabric to the rinse solution;
K. soaking the soaked fabric in the rinse solution for a rinsing time period of from about 1 minute to about 1 hour to form a rinsed fabric;
L. removing the rinsed fabric from the rinse solution;
M. removing rinse solution from the rinsed fabric; and
N. drying the rinsed fabric.
2. (canceled)
3. The method according to claim 1, wherein the wash liquor is removed from the soaked fabric by wringing.
4. The method according to claim 1, wherein the rinse solution is removed from the rinsed fabric by wringing.
5. The method according to claim 1, wherein the fabric is added to the wash basin without pre-wetting.
6. The method according to claim 1, comprising the step of agitating the rinse solution.
7. The method according to claim 1, wherein the fabric comprises a soil, and wherein the soaked fabric is not scrubbed to remove the soil.
8. The method according to claim 1, wherein the drying step comprises hanging the rinsed fabric.
9. (canceled)
10. The method according to claim 1, wherein the rinsing time period is from about 2 minutes to about 30 minutes.
11. The method according to claim 1, wherein the soaked fabric is not scrubbed to remove the soil thereby prolonging fabric life by reducing fabric abrasion.
12. The method according to claim 1, wherein the soaked fabric is not scrubbed to remove the soil thereby reducing skin abrasion on hands as compared to a regular hand washing method requiring scrubbing.
13. The method according to claim 1, wherein the laundering system comprises a laundering kit, wherein the laundering detergent and the rinsing composition are sold together, and wherein the laundering kit comprises a predetermined number of laundry detergent doses and a predetermined number of rinsing composition doses.
14. The method according to claim 1, wherein the soaked fabric is soaked in the rinse solution once, and wherein no additional rinsing step with water is conducted.
15. (canceled)
16. (canceled)
17. The method according to claim 10, wherein the rinsing time period is from about 3 minutes to about 20 minutes.
18. The method according to claim 1, wherein the washing time period is from about 4 hours to about 7 hours.
19. The method according to claim 17, wherein the rinsing time period is from about 4 minutes to about 10 minutes.
20. The method according to claim 1, wherein the rinsing composition further comprises an anionic surfactant scavenger.