1. A compound of formula (I):
a pharmaceutically acceptable salt thereof, wherein:
R1 is hydrogen or hydroxy;
R2 is C1-6 alkyl, or C1-6 haloalkyl, or phenyl optionally substituted by halogen or by C1-6 alkyl, optionally substituted by halogen;
R3 is C3-6 cycloalkyl, optionally substituted by R4;
R4 is hydrogen or phenyl, optionally substituted by C1-6 alkyl, halogen, or C1-6 alkoxy.
2. A compound according to claim 1 which is:
where R1, R2 and R3 are as defined in claim 1.
3. A compound according to claim 2 in which R3 where R3 is
wherein R4 is hydrogen or phenyl, optionally substituted by C1-6 alkyl, halogen, or C1-6 alkoxy.
4. A compound according to claim 1 in which R2 is C1-4 alkyl, or C1-4 haloalkyl, or phenyl, optionally substituted by halogen, or by C1-4 alkyl, optionally substituted by halogen.
5. A compound according to claim 3 in which R2is C1-4 alkyl, or C1-4 haloalkyl, or phenyl, optionally substituted by halogen, or by C1-4 alkyl, optionally substitued by halogen.
6. A compound according to claim 1, in which R3 is cyclopropyl, optionally substituted by R4.
7. A compound according to claim 4, in which R3 is cyclopropyl, optionally substituted by R4.
8. A compound according to claim 5, in which R3 is cyclopropyl, optionally substituted by R4.
9. A compound according to claim 1, in which R4 is hydrogen or phenyl, optionally substituted by halogen or C1-4 alkoxy.
10. A compound according to claim 3, in which R4 is hydrogen or phenyl, optionally substituted by halogen or C1-4 alkoxy.
11. A compound according to claim 5, in which R4 is hydrogen or phenyl, optionally substituted by halogen or C1-4 alkoxy.
12. A compound according to claim 8, in which R4 is hydrogen or phenyl, optionally substituted by halogen or C1-4 alkoxy.
13. A compound according to claim 1 which is:
1R-1\u03b1,2\u03b1,3\u03b2(1R*,2S*)-3-7-(2-Phenylcyclopropyl)amino-5-(propylthio)-3H-1,2,3triazolo4,5-dpyrimidin-3-ylcyclopentane-1,2-diol;
1R-1\u03b12,\u03b13\u03b2(1R*,2S*)-3-7-2-(4-Methylphenyl)cyclopropylamino–5-(propylthio)-3H-1,2,3triazolo4,5-dpyrimidin-3-ylcyclopentane-1,2-diol;
1R-1\u03b1,2\u03b1,3\u03b2(1R*,2S*)-3-7-(2-Phenylcyclopropyl)amino-5-(methylthio)-3H-1,2,3triazolo4,5-dpyrimidin-3-ylcyclopentane-1,2-diol;
1R-1\u03b1,2\u03b1,3\u03b2(1R*,2S*)-3-7-(2-Phenylcyclopropyl)amino-5-(ethylthio)-3H-1,2,3triazolo4,5-dpyrimidin-3-ylcyclopentane-1,2-diol;
1R-(1\u03b1,2\u03b1,3\u03b2)-3-7-(Cyclopropylamino)-5-(propylthio)-3H-1,2,3triazolo4,5-dpyrimidin-3-ylcyclopentane-1,2-diol;
1R-(1\u03b1,2\u03b1,3\u03b2)-3-7-(Cyclopropylamino)-5-(3,4-dichlorophenylthio)-3H-1,2,3triazolo4,5-dpyrimidin-3-ylcyclopentane-1,2-diol;
1R-(1\u03b1,2\u03b1,3\u03b2)-3-7-(Cyclopropylamino)-5-(4-trifluoromethylphenylthio)-3H-1,2,3triazolo4,5-dpyrimidin-3-ylcyclopentane-1,2-diol;
1R-1\u03b1,2\u03b1,3\u03b2(1R*,2S*)-3-7-(2-Phenylcyclopropyl)amino-5-(butylthio)-3H-1,2,3-triazolo4,5-dpyrimidin-3-ylcyclopentane-1,2-diol;
1R-1\u03b1,2\u03b1,3\u03b2(1R*,2S*)-3-7-(2-Phenylcyclopropyl)amino-5-(3,3,3-trifluoropropylthio)-3H-1,2,3-triazolo4,5-dpyrimidin-3-ylcyclopentane-1,2-diol;
1R-1\u03b1,2\u03b1,3\u03b2(1R*,2S*)-3-7-2-(4-Chlorophenyl)cyclopropylamino-5-(butylthio)-3H-1,2,3-triazolo4,5-dpyrimidin-3-ylcyclopentane-1,2-diol;
1R-1\u03b1,2\u03b1,3\u03b2(1R,2S*)-3-72-(4-Fluorophenyl)cyclopropylamino-5-(butylthio)-3H-1,2,3-triazolo4,5-dpyrimidin-3-ylcyclopentane-1,2-diol;
1R-1\u03b1,2\u03b2(1R*,2S*)-2-7(2-Phenylcyclopropyl)amino-5-(propylthio)-3H-1,2,3triazolo4,5-dpyrimidin-3-ylcyclopentanol;
1R-1\u03b1,2\u03b2(1R*,2S*)-2-7-2-(4-Methoxyphenyl)cyclopropylamino-5-(propylthio)-3H-1,2,3triazolo4,5-dpyrimidin-3-ylcyclopentanol;
1R-1\u03b1,2\u03b2(1R*,2S*)-2-7-2-(3,4-Difluorophenyl)cyclopropylamino-5-(propylthio)-3H-1,2,3triazolo4,5-dpyrimidin-3-ylcyclopentanol;
or a pharmaceutically acceptable salt thereof.
14. A pharmaceutical composition comprising a compound according to claim 1 in combination with a pharmaceutically acceptable diluent, adjuvent or carrier.
15. A method of treatment of unstable or stable angina, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a compound according to claim 1 to a person in need of treatment for such a condition.
16. A method of treatment of unstable or stable angina which comprises administering a therapeutically effective amount of a compound according to claim 1 to a person in need of treatment for such a condition.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A communication control method comprising:
determining whether or not reception quality of a second reception device satisfies a predetermined reference in a communication system including a first transmission device, a first reception device, a second transmission device secondarily using a frequency having been assigned to the first transmission device, and the second reception device; and
when it is determined that the reception quality of the second reception device does not satisfy the predetermined reference, additionally performing reception beam steering by the first reception device, beam steering by the first transmission device, reception beam steering by the second reception device, or transmission beam steering by the second transmission device in a predetermined order.
2. The communication control method according to claim 1,
wherein the predetermined order is an order of the reception beam steering by the second reception device, the transmission beam steering by the second transmission device, the reception beam steering by the first reception device, and the beam steering by the first transmission device.
3. The communication control method according to claim 2,
wherein the reception beam steering by the second reception device is reception null-steering in a direction-of-arrival of a radio signal transmitted from the first transmission device.
4. The communication control method according to claim 3,
wherein the transmission beam steering by the second transmission device is transmission null-steering in a direction-of-presence of the first reception device.
5. The communication control method according to claim 4,
wherein the reception beam steering by the first reception device is reception null-steering in a direction-of-arrival of a radio signal transmitted from the second transmission device.
6. The communication control method according to claim 5,
wherein the transmission beam steering by the first transmission device is transmission null-steering in a direction-of-presence of the second reception device.
7. The communication control method according to claim 6,
wherein, when reception quality of the first reception device is higher than the predetermined reference due to additional performance of the reception beam steering by the first reception device, transmission power of a radio signal from the first transmission device to the first reception device is reduced within a range in which the reception quality of the first reception device is not lower than the predetermined reference.
8. The communication control method according to claim 6,
wherein, when reception quality of the first reception device is higher than the predetermined reference due to additional performance of the reception beam steering by the first reception device, transmission power of a radio signal from the second transmission device to the second reception device is increased within a range in which the reception quality of the first reception device is not lower than the predetermined reference.
9. The communication control method according to claim 1,
wherein the predetermined order is an order of the reception beam steering by the second reception device, the reception beam steering by the first reception device, the transmission beam steering by the second transmission device, and the beam steering by the first transmission device.
10. A communication system comprising:
a first management server for managing communication between a first transmission device and a first reception device; and
a second management server for managing communication between a second transmission device, which secondarily uses a frequency having been assigned to the first transmission device, and a second reception device,
wherein the second management server determines whether or not reception quality of the second reception device satisfies a predetermined reference in a communication system including the first transmission device, the first reception device, the second transmission device secondarily using the frequency having been assigned to the first transmission device, and the second reception device, and
wherein, when it is determined that the reception quality of the second reception device does not satisfy the predetermined reference, the first management server or the second management server additionally performs reception beam steering by the first reception device, beam steering by the first transmission device, reception beam steering by the second reception device, or transmission beam steering by the second transmission device in a predetermined order.