1. A multi-piece framing square, comprising:
a first arm;
a second arm;
a lever capable of being received by a slot within the second arm; and
a retention portion releasably coupled to receiver slots on the first arm and receiver slots on the lever.
2. The framing square of claim 1, wherein the second arm is longer than the first arm.
3. The framing square of claim 2, wherein the second arm is wider than the first arm.
4. The framing square of claim 1, further comprising a receiver notch at a proximal end of the first arm.
5. The framing square of claim 4, wherein the receiver notch includes the receiver slots.
6. The framing square of claim 1, further comprising catch portions on the second arm for receiving the lever.
7. The framing square of claim 1, further comprising receiver holes on the first arm to receive alignment pins located on the second arm.
8. A separable carpenter’s square, comprising:
a first elongated rectangular arm member having receiver holes formed at a proximal end and a receiver notch formed through a thickness dimension thereof intermediate the receiver holes;
a second elongated rectangular arm member having alignment pins projecting outwardly and adapted to be received in the receiver holes of the first arm member, the second arm member having a slot formed inwardly between the alignment pins; and
a lever mounted in the slot of the second arm member with a retention portion releasably clamping the lever to the first arm to hold the first and second arm members to one another.
9. The carpenter’s square of claim 8, wherein the retention portion is comprised of a flexible material.
10. The carpenter’s square of claim 8, further comprising support pins located at a proximal and distal end of the retention portion.
11. The carpenter’s square of claim 9, wherein the retention portion is comprised of rubber.
12. The carpenter’s square of claim 8, further comprising lever legs coupled to the lever.
13. The carpenter’s square of claim 12, wherein the lever legs rest against catch portions when the lever is in a latched position.
14. A method of manufacturing a multi-piece framing square, comprising the steps of:
creating a first arm;
creating a second arm;
creating a retention portion for coupling the first arm and the second arm together; and
creating a lever capable of coupling to the retention portion.
15. The method of claim 14, wherein the first arm is an elongated arm with a receiving notch having receiving slots within.
16. The method of claim 14, wherein the second arm is larger than the first arm.
17. The method of claim 14, wherein the retention portion is made of a flexible material.
18. The method of claim 15, wherein the first arm has receiver holes located adjacent to the receiving notch.
19. The method of claim 18, wherein the second arm has alignment pins located adjacent a slot.
20. The method of claim 19, wherein the alignment pins can be received by the receiver holes.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of formula (I), or a salt, single enantiomer, or N-oxide thereof:
wherein:
A1 is \u2014COOH, or tetrazolyl, and A2 is hydrogen, \u2014COOH, tetrazolyl;
p is 0 or 1 and A3 is phenyl or cycloalkyl, either of which is optionally substituted with R4 andor R5;
q is 0;
R3 is hydrogen, C1-C4 alkyl, cycloalkyl, \u2014CF3, or \u2014OR9;
R4 and R5 independently \u2014R9, \u2014CN, \u2014F, \u2014Cl, \u2014Br, \u2014OR9, \u2014NR7R8, \u2014NR7COR6, \u2014NR7SO2R6, \u2014COR6, \u2014SR9, \u2014SOR9 or \u2014SO2R6;
R6 is C1-C4 alkyl, cycloalkyl, \u2014CF3 or \u2014NR7R8;
R7 and R8 are independently hydrogen, C1-C4 alkyl or cycloalkyl;
R9 is hydrogen, C1-C4 alkyl, cycloalkyl, or fully or partially fluorinated C1-C4 alkyl;
R1 is (i) a bond, or
(ii) \u2014(CH2)aB1(CH2)b\u2014 wherein a and b are independently 0, 1, 2 or 3 provided that a+b is not greater than 4; or
(iii) \u2014C(R10)(R11)\u2014*, \u2014C(R10)(R11)\u2014O\u2014*, \u2014C(R10)(R11)CH2\u2014*, \u2014C(R10)(R11)CH2\u2014O\u2014*, \u2014CH2C(R10)(R11)\u2014*, \u2014CH2C(R10)(R11)\u2014O\u2014*, \u2014CH2\u2014O\u2014C(R10)(R11)\u2014* or \u2014C(R10)(R11)\u2014O\u2014CH2\u2014*, wherein the bond indicated by an asterisk is attached to the pyrazole ring
R2 is a divalent radical of formula -Q1-A4-
A4 is a monocyclic carbocyclic or monocyclic heterocyclic ring, having 3 to 8 ring atoms, optionally substituted with one or more of \u2014F, \u2014Cl, \u2014Br, \u2014CN, \u2014CF3, C1-C4 alkyl, cycloalkyl, \u2014OR9, oxo, or \u2014NR7R8;
Q1 is \u2014C(R10)(R11)\u2014, \u2014CH2\u2014C(R10)(R11)\u2014CH2\u2014, or in either orientation \u2014C(R10)(R11)CH2\u2014, or \u2014CH2\u2014B\u2014C(R10)(R11)\u2014; and
B is \u2014O\u2014, \u2014CH(OH)\u2014, \u2014SO2\u2014, \u2014CH2\u2014or \u2014NR7\u2014;
B1 is \u2014CO\u2014, \u2014O\u2014, \u2014S\u2014, \u2014SO\u2014, \u2014SO2\u2014, \u2014CH2\u2014, \u2014CHOH\u2014or \u2014NR7;
R10 is hydrogen and R11 is (C1-C3)alkyl; or R10 and R11 are both (C1-C3)alkyl; or R10 and R11 taken together with the carbon atom to which they are attached form a (C3-C5)cycloalkyl ring.
2. A compound as claimed in claim 1 wherein in the phenyl ring carrying R4 and R5, R4 is hydrogen and R5 is in the para position to \u2014(CH2)q-.
3. A compound as claimed in claim 1 wherein the ring A3 is phenyl and in ring A3 R4 is hydrogen and R5 is in the ortho position to \u2014(CH2)p-.
4. A compound as claimed in claim 1 wherein p is 0.
5. A compound as claimed in claim 1 wherein R4 and R5 are independently selected from hydrogen, \u2014F, \u2014CN and \u2014Cl.
6. A compound as claimed in claim 1 wherein the radical \u2014R1\u2014is \u2014C(R10)(R11)\u2014*, \u2014C(R10)(R11)\u2014O\u2014*, \u2014C(R10)(R11)\u2014O\u2014CH2\u2014*, and R10 is hydrogen and R11 is methyl; or R10 and R11 are both methyl; or R10 and R11 taken together with the carbon atom to which they are attached form a cyclopropyl ring.
7. A compound as claimed in 1 wherein R1 is \u2014(CH2)aB1(CH2)b\u2014, and B1 is \u2014CH2\u2014or \u2014O\u2014.
8. A compound as claimed in claim 1 wherein the radical \u2014R1\u2014is \u2014CH2\u2014, \u2014CH(CH3)\u2014, \u2014CH(OH)\u2014, \u2014CH2O\u2014* wherein the bond indicated by an asterisk is attached to the pyrazole ring, or \u2014CH2OCH2\u2014.
9. A compound as claimed in claim 1 wherein, in the radical R2, R10 is hydrogen and R11 is methyl; or R10 and R11 are both methyl; or R10 and R11 taken together with the carbon atom to which they are attached form a cyclopropyl ring.
10. A compound as claimed in claim 9 wherein, in the radical R2, A4 is a divalent piperidine, piperazine, piperazine optionally substituted by methyl on one of the ring nitrogens, morpholine, cyclopropane, cyclobutane, cyclopentane, cyclohexane, cycloheptane, or 2-oxo-pyrrolidine radical, or a divalent phenylene or monocyclic heteroarylene radical having from 5 or 6 ring atoms, optionally substituted with R4 andor R5 wherein R4 and R5 are independently \u2014R9, \u2014CN, \u2014F, \u2014Cl, \u2014Br, \u2014OR9, \u2014NR7R8, \u2014NR7COR6, \u2014NR7SO2R6, \u2014COR6, \u2014SR9, \u2014SOR9, or \u2014SO2R6.
11. A compound as claimed in claim 9 wherein the radical \u2014R2\u2014 is selected from
wherein the bond attached to the amide nitrogen is indicated by an asterisk, and the phenyl ring may optionally be substituted by \u2014F, \u2014Cl, \u2014Br, \u2014CN, \u2014CF3, C1-C4 alkyl, cyclopropyl, \u2014OR9, oxo, or \u2014NR7R8, wherein R6 is C1-C4 alkyl, cycloalkyl, NR7R8, R9 is hydrogen, C1-C4 alkyl or \u2014CF3, and R7 and R8 are independently hydrogen or C1-C4 alkyl.
12. A compound as claimed in claim 1 wherein R3 is hydrogen.
13. A compound as claimed in claim 1 wherein the radical \u2014C(\u2550O)\u2014N(R3)\u2014R2-A2 has formula (E):
wherein R10 is hydrogen and R11 is (C1-C3)alkyl; or R10 and R11 are both (C1-C3)alkyl; or R10 and R11 taken together with the carbon atom to which they are attached form a (C3-C5)cycloalkyl ring, and R18 and R19 are independently selected from hydrogen, (C1-C6)alkyl, \u2014F, \u2014CF3, \u2014OCF3, \u2014Br, \u2014Cl, \u2014OCH3, \u2014CH3, \u2014CN, \u2014COOH, and tetrazolyl.
14. A compound as claimed in claim 13 wherein R10 is hydrogen or methyl, R11 is methyl or ethyl, and R18 and R19 are independently selected from hydrogen, \u2014F, \u2014Cl, \u2014Br, \u2014CN, \u2014CF3, and \u2014OCF3.
15. A compound as claimed in claim 1 wherein A1 is tetrazolyl.
16. A compound as claimed in claim 1 having formula (IA) or a salt, single enantiomer or N-oxide thereof:
wherein
\u2014R1\u2014 is \u2014CH2\u2014, \u2014CH(OH)\u2014, \u2014CH(CH3)\u2014, \u2014CH2O\u2014* wherein the bond indicated by an asterisk is attached to the pyrazole ring, or \u2014CH2OCH2\u2014;
R10 is hydrogen and R11 is methyl; or R10 and R11 are both methyl; or R10 and R11 taken together with the carbon atom to which they are attached form a cyclopropyl ring;
R4, R5, R4\u2032 and R5\u2032 are independently selected from hydrogen, \u2014F, \u2014CN and \u2014Cl; and
R18 and R19 are independently selected from hydrogen, \u2014F, \u2014Cl, \u2014Br, \u2014CN, CF3, and \u2014OCF3.
17. A compound as claimed in claim 16 wherein R10 is hydrogen and R11 is methyl and the stereochemical configuration at the carbon to which R10 and R11 are attached is R.
18. A compound as claimed in claim 1 selected from the group consisting of:
3-(R)-1-(4-Bromo-phenyl)-ethylcarbamoyl-1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-1H-pyrazol-4-yl-acetic acid,
(1-(2-Chloro-phenyl)-5-(4-chloro-phenyl)-3- {methyl-(R)-1-(4-trifluoro methyl-phenyl)-ethyl-carbamoyl}-1H-pyrazol-4-yl)-acetic acid,
1-(2-Chloro-phenyl)-5-(4-chloro-phenyl)-4-(2H-tetrazol-5-ylmethyl)-1H-pyrazole-3-carboxylic acid (R)-1-(3-fluoro-4-chloro-phenyl)-ethyl-amide,
1-(2-Flouro-phenyl)-5-(4-chloro-phenyl)-4-(1H-tetrazol-5-ylmethyl)-1H-pyrazole-3-carboxylic acid (R)-1-(4-trifluoromethoxy-phenyl)-ethyl-amide,
{1-(2-Chloro-phenyl)-5-(4-chloro-phenyl)-3-(R)-1-(4-trifluoromethyl-p henyl)-ethylcarbamoyl-1H-pyrazol-4-yl}-acetic acid,
1-(2-Chloro-phenyl)-5-(4-chloro-phenyl)-4-(1H-tetrazol-5-ylmethyl)-1H-pyrazole-3-carboxylic acid methyl-(R)-1-(4-trifluoromethoxy-phenyl)-ethyl-amide,
5-(4-Chloro-phenyl)-1-(2-chloro-phenyl)-4-(2H-tetrazol-5-ylmethyl)-1H-pyrazole-3-carboxylic acid (R)-1-(4-trifluoromethyl-phenyl)-ethyl-amide,
1-(2-Chloro-phenyl)-5-(4-chloro-phenyl)-4-(1H-tetrazol-5-ylmethyl)-1H-pyrazole-3-carboxylic acid (R)-1-(3-trifluoromethyl-phenyl)-ethyl-amide,
1-(2-Flouro-phenyl)-5-(4-chloro-phenyl)-4-(1H-tetrazol-5-ylmethyl)-1H-pyrazole-3-carboxylic acid (R)-1-(4-trifluoromethyl-phenyl)-ethyl-amide,
1-(2-Chloro-phenyl)-5-(4-chloro-phenyl)-4-(2H-tetrazol-5-ylmethyl)-1H-pyrazole-3-carboxylic acid (R)-1-(4-trifluoromethoxyl-phenyl)-ethyl-amide,
1-(2-Chloro-phenyl)-5-(4-chloro-phenyl)-4-(1H-tetrazol-5-ylmethyl)-1H-pyrazole-3-carboxylic acid methyl-(R)-1-(3-chloro-4-fluoro-phenyl)-ethyl-amide,
1-(2-Chloro-phenyl)-5-(4-chloro-phenyl)-4-(1H-tetrazol-5-ylmethyl)-1H-pyrazole-3-carboxylic acid (R)-1-(3-fluoro-phenyl)-ethyl-amide,
1-(2-Chloro-phenyl)-5-(4-chloro-phenyl)-4-(2H-tetrazol-5-ylmethyl)-1H-pyrazole-3-carboxylic acid (R)-1-(3,4-dichloro-phenyl)-ethyl-amide, and salts, thereof.
19. A pharmaceutical composition comprising a compound as claimed in claim 1, together with one or more pharmaceutically acceptable carriers or excipients.