1460893628-549a0bc6-c6d0-4552-a987-e3ea72bb862e

1. A compound of Formula (I)
wherein
Y and Z are independently selected from a) or b) such that one of Y and Z is selected from group a) and the other is selected from group b);
Group a) is

i) substituted C6-10 aryl,
ii) C3-8 cycloalkyl,
iii) trifluoromethyl; or
iv) heteroaryl selected from the group consisting of thienyl, furanyl, thiazolyl, isothiazolyl, oxazolyl, pyrrolyl, pyridinyl, isoxazolyl, imidazolyl, furazan-3-yl, benzothienyl, thieno3,2-bthiophen-2-yl, pyrazolyl, triazolyl, tetrazolyl, and 1,2,3thiadiazolyl;
wherein C6-10 aryl is substituted with; and the heteroaryl is optionally substituted with; one to two substituents independently selected from the group consisting of fluoro, chloro, bromo, C1-4alkyl, cyano, and trifluoromethyl;
Group b) is

i) C6-10 aryl;
ii) heteroaryl selected from the group consisting of thiazolyl, pyridinyl, indolyl, indazolyl, pyrrolyl, benzoxazolyl, benzothiazolyl, benzothienyl, benzofuranyl, imidazo1,2-apyridin-2-yl, furo2,3-bpyridinyl, furazan-3-yl, pyrrolo2,3-bpyridinyl, pyrrolo3,2-bpyridinyl, thieno2,3-bpyridinyl, quinolinyl, quinazolinyl, thienyl, and benzimidazolyl;
iii) benzofused heterocyclyl attached via a carbon atom, and when the heterocyclyl portion contains a nitrogen atom, the nitrogen atom is optionally substituted with one substituent selected from the group consisting of C3-7cycloalkylcarbonyl; C3-7cycloalkylsulfonyl; phenyl; phenylcarbonyl; thienylcarbonyl; pyrrolylcarbonyl; phenylsulfonyl; phenyl(C1-4)alkyl; (C1-4alkyl)aminocarbonyl; C1-6alkylcarbonyl; C1-6alkylcarbonyl-C1-4alkyl; C1-6alkylsulfonyl; pyrimidinyl; pyridinyl; and C1-4alkoxycarbonyl; wherein C3-7cycloalkylcarbonyl, phenyl, phenylcarbonyl, phenyl(C1-4)alkyl and phenylsulfonyl are optionally substituted with trifluoromethyl or one to two fluoro substituents;
and wherein benzofused heterocyclyl is optionally substituted at a carbon atom with oxo and optionally independently substituted with one to two additional substituents selected from the group consisting of phenyl, thienyl, bromo, and C1-4alkyl; wherein phenyl and thienyl are each optionally substituted with a trifluoromethyl or chloro substituent;

iv) phenoxathiinyl;
v) 10-oxo-10H-10\u03bb4-phenoxathiin-2-yl;
vi) fluoren-9-one-2-yl;
vii) 9,9-dimethyl-9H-fluorenyl;
viii) 1-chloro-naphtho2,1-bthiophen-2-yl;
ix) xanthen-9-one-3-yl;
x) 9-methyl-9H-carbazol-3-yl;
xi) 6,7,8,9-tetrahydro-5H-carbazol-3-yl;
xii) 3-methyl-6,7-dihydro-5H-1-thia-4a,8-diaza-s-indacen-4-one-2-yl;
xiii) 3-methyl-2-phenyl-4-oxo-chromen-8-yl;
xiv) 1,3-dihydro-benzimidazol-2-one-5-yl optionally substituted with 1-phenyl, 1-(2,2,2-trifluoroethyl), 1-(3,3,3-trifluoropropyl), or 1-(4,4-difluorocyclohexyl), wherein 1-phenyl is optionally substituted with one to two fluoro substituents or trifluoromethyl; or xv) 4-(3-chloro-phenyl)-3a,4,5,9b-tetrahydro-3H-cyclopentacquinolin-8-yl;
wherein C6-10 aryl and heteroaryl of Group b) are optionally independently substituted with one to three substituents selected from the group consisting of

i) C1-8alkyl;
ii) C2-4alkenyl;
iii) C3-6cycloalkyl optionally substituted with one to two fluoro substituents;
iv) 4,4-difluorocyclohexylcarbonyl;
v) C1-4alkoxy;
vi) 2-methoxy-ethoxy;
vii) C1-4alkylthio;
viii) trifluoromethyl;
ix) 2,2,2-trifluoroethyl;
x) 2,2-difluoroethyl;
xi) 3,3,3-trifluoropropyl;
xii) trifluoromethoxy;
xiii) 2,2,2-trifluoroethoxy-methyl;
xiv) 2,2,2-trifluoroethoxy;
xv) trifluoromethylthio;
xvi) di(C1-4alkyl)aminosulfonyl;
xvii) N-phenyl-N-methylaminosulfonyl;
xviii) piperidin-1-ylsulfonyl;
xix) chloro;
xx) cyano;
xxi) hydroxy;
xxii) fluoro;
xxiii) bromo;
xxiv) iodo;
xxv) NRaRb wherein Ra is hydrogen or C1-6alkyl; and Rb is C1-6alkyl, phenyl, C3-8cycloalkyl, C3-8cycloalkylcarbonyl, C3-8cycloalkyl(C1-2alkyl), C1-6alkylcarbonyl optionally substituted with one to three fluoro substituents, C1-4alkoxycarbonyl, C6-10aryl(C1-2)alkyl, phenylcarbonyl, or phenyl(C1-2)alkylcarbonyl;
wherein C3-8cycloalkyl, C3-8cycloalkylcarbonyl, C6-10aryl of C6-10aryl(C1-2)alkyl, phenylcarbonyl, and phenyl of Rb are optionally substituted with one to two substituents selected from C1-4alkyl, trifluoromethyl, chloro, or fluoro;
or Ra and Rb are taken together with the nitrogen atom to which they are attached to form a 5 to 8 membered heterocyclyl ring, optionally substituted with one to two substituents selected from the group consisting of oxo, one to two fluoro substituents, and C1-3alkyl; and optionally containing one additional heteroatom to form morpholinyl, thiomorpholinyl, or piperazinyl; and wherein said heterocyclyl ring is optionally benzofused; and, the heterocyclyl ring is optionally substituted at a nitrogen atom contained in said ring with C1-6alkoxycarbonyl;

xxvi) (1-R2)-pyrrolidin-3-yloxy; wherein R2 is pyrrolidin-1-ylsulfonyl, dimethylaminocarbonyl, dimethylaminosulfonyl, pyrrolidin-1-ylcarbonyl, phenylcarbonyl, C3-7cycloalkylcarbonyl, C1-4alkylcarbonyl, morpholin-4-ylcarbonyl, or C1-4alkoxycarbonyl;
xxvii) a 5 to 8 membered heterocyclyl bound through a carbon atom, wherein when the heterocyclyl contains a nitrogen atom, the nitrogen atom is optionally substituted with C1-4alkoxycarbonyl or C1-4alkylcarbonyl;
xxviii) pyridinyloxy optionally independently substituted with one to two substituents selected from the group consisting of C1-2alkoxy, bromo, trifluoromethyl, chloro, and fluoro;
xxix) pyridinylcarbonyl optionally substituted with a chloro substituent;
xxx) phenylcarbonyl;
xxxi) N-phenyl-N-methylaminosulfonyl;
xxxii) piperidin-1-ylsulfonyl;
xv) phenylsulfonyl optionally substituted with C1-4alkyl, trifluoromethyl, or one to two chloro substituents;
xxxiii) phenyloxy optionally substituted with one to two substituents selected from the group consisting of C1-4alkyl, trifluoromethyl, and chloro;
xxxiv) phenylthio optionally substituted with C1-4alkyl, trifluoromethyl, or one to two chloro substituents;
xxxv) C3-8cycloalkyloxy;
xxxvi) C1-3alkylcarbonyloxy;
xxxvii) ethylaminocarbonyl-methoxy;
xxxviii) 2-methylcarbonylamino-ethoxy;
xxxix) C1-6alkylsulfonyl; and
xl) 2,2,6,6-tetramethyl-3,6-dihydro-2H-pyran-4-yl;
with the proviso that not more than one substituent on C6-10 aryl or heteroaryl is C3-6cycloalkyl; heterocyclyloxy; pyridinyloxy; NRaRb; (1-R2)-pyrrolidin-3-yloxy; phenylcarbonyl; phenylsulfonyl; phenyloxy; phenylthio; or C3-8cycloalkyloxy;
s is 0, 1 or 2; provided that when s is 2, R1 is independently selected from the group consisting of phenyl, C1-3alkyl, and C6-10aryl(C1-3)alkyl;
R1 is C6-10aryl, C1-3alkyl, benzyloxymethyl, hydroxy(C1-3)alkyl, aminocarbonyl, carboxy, trifluoromethyl, spirofused cyclopropyl, 3-oxo, or aryl(C1-3)alkyl; or, when s is 2 and R1 is C1-3alkyl, the C1-3alkyl substituents are taken with the piperizinyl ring to form a 3,8-diaza-bicyclo3.2.1octanyl or 2,5-diaza-bicyclo2.2.2octanyl ring system;
with the proviso that a heteroaryl of Group b) is substituted with other than C1-4alkoxy or C1-4alkylthio;
with the proviso that when phenyl is para-substituted with NRaRb, or when 2- or 3-pyridinyl is 5- or 6-substituted, respectively, with NRaRb, Rb is other than C1-6alkyl, phenyl, or C6-10aryl(C1-2)alkyl;
and, with the proviso that when Ra is C1-6alkyl and either phenyl is para-substituted with NRaRb, or 2- or 3-pyridinyl is 5- or 6-substituted, respectively, with NRaRb, then Rb is other than C1-6alkylcarbonyl; or

with the proviso that a compound of formula (I) is other than
a compound wherein Y is thiazol-4-yl, Z is 2-hydroxy-3-methylcarbonylamino-phenyl, and s is 0;
a compound wherein Y is 2-methoxyphenyl, Z is 4-cyclohexylphenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is thiazol-2-yl, s is 1, and R1 is 3-phenyl; a compound wherein Y is thiazol-4-yl, Z is 2-methyl-1-(4,4-difluorocyclohexyl)-benzimidazol-5-yl, and s is 0; a compound wherein Y is 3-methyl-2-phenyl-chromen-4-one-8-yl, Z is thiazol-4-yl, s is 1, and R1 is 3-phenyl; a compound wherein Y is thiazol-2-yl, Z is 2-phenylmethyl-1,2,3,4-tetrahydro-isoquinolin-8-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 5-fluoro-3H-benzimidazol-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5-fluoro-1H-benzimidazol-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 5-chloro-benzofuran-2-yl, and s is 0; a compound wherein Y is isothiazol-5-yl, Z is 6-trifluoromethyl-1H-indol-2-yl, and s is 0; a compound wherein Y is 1H-pyrrol-2-yl, Z is 6-trifluoromethyl-furo2,3-bpyridin-2-yl, and s is 0; a compound wherein Y is 1H-pyrrol-2-yl, Z is 6-trifluoromethyl-1H-pyrrolo2,3-bpyridin-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 5-bromo-furo2,3-bpyridin-2-yl, and s is 0;
a compound wherein Y is 5-bromo-furo2,3-bpyridin-2-yl, Z is thiazol-4-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 5-trifluoromethyl-1H-pyrrolo3,2-bpyridin-2-yl, and s is 0; a compound wherein Y is 1H-pyrrol-2-yl, Z is 6-bromo-7-methyl-imidazo1,2-apyridin-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 8-bromo-6-chloro-imidazo1,2-apyridin-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 6-trifluoromethyl-imidazo1,2-apyridin-2-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is thiazol-4-yl, s is 1, and R1 is 3-phenyl; a compound wherein Y is thiazol-2-yl, Z is thiazol-4-yl, s is 1, and R1 is 3-phenyl; a compound wherein Y is thiazol-2-yl, Z is thiazol-2-yl, s is 1, and R1 is 3-phenyl; a compound wherein Y is thiazol-4-yl, Z is 2-hydroxy-3-methylcarbonylamino-phenyl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 2-phenylmethyl-1,2,3,4-tetrahydro-isoquinolin-8-yl, and s is 0; a compound wherein Y is trifluoromethyl, Z is 4-(3-trifluoromethylphenylsulfonyl)phenyl, and s is 0; a compound wherein Y is trifluoromethyl, Z is 6-(2-chlorophenyloxy)pyridin-3-yl, and s is 0; and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof.
2. The compound of claim 1 wherein
Group a) is
i) substituted C6-10 aryl,
ii) trifluoromethyl; or
iii) heteroaryl selected from the group consisting of thienyl, furanyl, thiazolyl, isothiazolyl, oxazolyl, pyrrolyl, pyridinyl, and 1,2,3thiadiazolyl;
wherein C6-10 aryl is substituted with; and the heteroaryl is optionally substituted with; one to two substituents independently selected from the group consisting of fluoro, chloro, bromo, and trifluoromethyl.
3. The compound of claim 2 wherein
Group a) is
i) substituted C6-10 aryl,
ii) trifluoromethyl; or
iii) heteroaryl selected from the group consisting of thienyl, furanyl, thiazolyl, isothiazolyl, oxazolyl, and pyrrolyl;
wherein C6-10 aryl is substituted with; and the heteroaryl is optionally substituted with; one to two substituents independently selected from the group consisting of fluoro, chloro, bromo, and trifluoromethyl.
4. The compound of claim 3 wherein
Group a) is
i) substituted C6-10 aryl, or
ii) heteroaryl selected from the group consisting of thienyl, furanyl, thiazolyl, isothiazolyl, oxazolyl, and pyrrolyl;
wherein C6-10 aryl is substituted with; and the heteroaryl is optionally substituted with; one to two substituents independently selected from the group consisting of fluoro, chloro, bromo, and trifluoromethyl.
5. The compound of claim 1 wherein
Group b) is
i) C6-10 aryl;
ii) heteroaryl selected from the group consisting of thiazolyl, pyridinyl, indolyl, pyrrolyl, benzoxazolyl, benzothiazolyl, benzothienyl, benzofuranyl, pyrrolo2,3-bpyridinyl, thieno2,3-bpyridinyl, quinolinyl, thienyl, and benzimidazolyl;
iii) benzofused heterocyclyl attached via a carbon atom, and when the heterocyclyl portion contains a nitrogen atom, the nitrogen atom is optionally substituted with one substituent selected from the group consisting of C3-7cycloalkylcarbonyl; C3-7cycloalkylsulfonyl; phenyl; phenylcarbonyl; thienylcarbonyl; pyrrolylcarbonyl; phenylsulfonyl; phenyl(C1-4)alkyl; (C1-4alkyl)aminocarbonyl; C1-6alkylcarbonyl; C1-6alkylcarbonyl-C1-4alkyl; C1-6alkylsulfonyl; pyrimidinyl; and pyridinyl; wherein C3-7cycloalkylcarbonyl, phenyl, phenylcarbonyl, phenyl(C1-4)alkyl and phenylsulfonyl are optionally substituted with trifluoromethyl or one to two fluoro substituents;
and wherein benzofused heterocyclyl is optionally substituted at a carbon atom with oxo and optionally independently substituted with one to two additional substituents selected from the group consisting of phenyl, bromo, and C1-4alkyl; wherein phenyl and thienyl are each optionally substituted with a trifluoromethyl substituent;

iv) phenoxathiinyl;
v) fluoren-9-one-2-yl;
vi) 1-chloro-naphtho2,1-bthiophen-2-yl;
vii) xanthen-9-one-3-yl;
viii) 9-methyl-9H-carbazol-3-yl;
ix) 6,7,8,9-tetrahydro-5H-carbazol-3-yl; or
x) 4-(3-chloro-phenyl)-3a,4,5,9b-tetrahydro-3H-cyclopentacquinolin-8-yl;
wherein C6-10 aryl and heteroaryl of Group b) are optionally independently substituted with one to three substituents selected from the group consisting of
i) C1-8alkyl;
ii) C2-4alkenyl;
iii) C3-6cycloalkyl optionally substituted with one to two fluoro substituents;
iv) C1-4alkoxy;
v) 2-methoxy-ethoxy;
vi) C1-4alkylthio;
vii) trifluoromethyl;
viii) 2,2,2-trifluoroethyl;
ix) 2,2-difluoroethyl;
x) 3,3,3-trifluoropropyl;
xi) trifluoromethoxy;
xii) 2,2,2-trifluoroethoxy-methyl;
xiii) 2,2,2-trifluoroethoxy;
xiv) trifluoromethylthio;
xv) di(C1-4alkyl)aminosulfonyl;
xvi) chloro;
xvii) cyano;
xviii) fluoro;
xix) bromo;
xx) iodo;
xxi) NRaRb wherein Ra is hydrogen or C1-6alkyl; and Rb is C1-6alkyl, phenyl, C3-8cycloalkyl, C3-8cycloalkylcarbonyl, C3-8cycloalkyl(C1-2alkyl), C1-6alkylcarbonyl optionally substituted with one to three fluoro substituents, C1-4alkoxycarbonyl, C6-10aryl(C1-2)alkyl, phenylcarbonyl, or phenyl(C1-2)alkylcarbonyl;
wherein C3-8cycloalkyl, C3-8cycloalkylcarbonyl, C6-10aryl of C6-10aryl(C1-2)alkyl, phenylcarbonyl, and phenyl of Rb are optionally substituted with one to two substituents selected from C1-4alkyl, trifluoromethyl, chloro, or fluoro;
or Ra and Rb are taken together with the nitrogen atom to which they are attached to form a 5 to 8 membered heterocyclyl ring, optionally substituted with one to two substituents selected from the group consisting of one to two fluoro substituents and C1-3alkyl; and optionally containing one additional heteroatom to form piperazinyl; and wherein said heterocyclyl ring is optionally benzofused; and, the heterocyclyl ring is optionally substituted at a nitrogen atom contained in said ring with C1-6alkoxycarbonyl;

xxii) (1-R2)-pyrrolidin-3-yloxy; wherein R2 is pyrrolidin-1-ylsulfonyl, dimethylaminocarbonyl, dimethylaminosulfonyl, pyrrolidin-1-ylcarbonyl, phenylcarbonyl, C3-7cycloalkylcarbonyl, C1-4alkylcarbonyl, morpholin-4-ylcarbonyl, or C1-4alkoxycarbonyl;
xxiii) a 5 to 8 membered heterocyclyl bound through a carbon atom, wherein when the heterocyclyl contains a nitrogen atom, the nitrogen atom is optionally substituted with C1-4alkoxycarbonyl or C1-4alkylcarbonyl;
xxiv) pyridinyloxy optionally independently substituted with one to two substituents selected from the group consisting of C1-2alkoxy, bromo, trifluoromethyl, chloro, and fluoro;
xv) phenylsulfonyl optionally substituted with C1-4alkyl, trifluoromethyl, or one to two chloro substituents;
xxv) phenyloxy optionally substituted with one to two substituents selected from the group consisting of C1-4alkyl, trifluoromethyl, and chloro;
xxvi) phenylthio optionally substituted with C1-4alkyl, trifluoromethyl, or one to two chloro substituents; and
xxvii) 2,2,6,6-tetramethyl-3,6-dihydro-2H-pyran-4-yl;

with the proviso that not more than one substituent on C6-10 aryl or heteroaryl is C3-6cycloalkyl; heterocyclyloxy; pyridinyloxy; NRaRb; (1-R2)-pyrrolidin-3-yloxy; phenylcarbonyl; phenylsulfonyl; phenyloxy; phenylthio; or C3-8cycloalkyloxy.
6. The compound of claim 5 wherein
Group b) is
i) C6-10 aryl;
ii) heteroaryl selected from the group consisting of pyridinyl, indolyl, benzothiazolyl, benzothienyl, benzofuranyl, pyrrolo2,3-bpyridinyl, thieno2,3-bpyridinyl, quinolinyl, thienyl, and benzimidazolyl;
iii) benzofused heterocyclyl attached via a carbon atom, and when the heterocyclyl portion contains a nitrogen atom, the nitrogen atom is optionally substituted with one substituent selected from the group consisting of C3-7cycloalkylcarbonyl; C3-7cycloalkylsulfonyl; phenyl; phenylcarbonyl; thienylcarbonyl; pyrrolylcarbonyl; phenylsulfonyl; phenyl(C1-4)alkyl; (C1-4alkyl)aminocarbonyl; C1-6alkylcarbonyl; C1-6alkylcarbonyl-C1-4alkyl; C1-6alkylsulfonyl; pyrimidinyl; and pyridinyl; wherein C3-7cycloalkylcarbonyl, phenyl, phenylcarbonyl, phenyl(C1-4)alkyl and phenylsulfonyl are optionally substituted with trifluoromethyl or one to two fluoro substituents;
and wherein benzofused heterocyclyl is optionally substituted at a carbon atom with oxo and optionally independently substituted with one to two additional substituents selected from the group consisting of phenyl, bromo, and C1-4alkyl;

iv) phenoxathiinyl;
v) fluoren-9-one-2-yl;
vi) 1-chloro-naphtho2,1-bthiophen-2-yl;
vii) xanthen-9-one-3-yl;
viii) 9-methyl-9H-carbazol-3-yl;
ix) 6,7,8,9-tetrahydro-5H-carbazol-3-yl; or
x) 4-(3-chloro-phenyl)-3a,4,5,9b-tetrahydro-3H-cyclopentacquinolin-8-yl;
wherein C6-10 aryl and heteroaryl of Group b) are optionally independently substituted with one to three substituents selected from the group consisting of
i) C1-8alkyl;
ii) C2-4alkenyl;
iii) C3-6cycloalkyl optionally substituted with one to two fluoro substituents;
iv) C1-4alkoxy;
v) C1-4alkylthio;
vi) trifluoromethyl;
vii) 2,2,2-trifluoroethyl;
viii) 2,2-difluoroethyl;
ix) 3,3,3-trifluoropropyl;
x) trifluoromethoxy;
xi) 2,2,2-trifluoroethoxy-methyl;
xii) 2,2,2-trifluoroethoxy;
xiii) trifluoromethylthio;
xiv) di(C1-4alkyl)aminosulfonyl;
xv) chloro;
xvi) cyano;
xvii) fluoro;
xviii) bromo;
xix) iodo;
xx) NRaRb wherein Ra is hydrogen or C1-6alkyl; and Rb is C1-6alkyl, phenyl, C3-8cycloalkyl, C3-8cycloalkylcarbonyl, C3-8cycloalkyl(C1-2alkyl), C1-6alkylcarbonyl optionally substituted with one to three fluoro substituents, C1-4alkoxycarbonyl, C6-10aryl(C1-2)alkyl, phenylcarbonyl, or phenyl(C1-2)alkylcarbonyl;
wherein C3-8cycloalkyl, C3-8cycloalkylcarbonyl, C6-10aryl of C6-10aryl(C1-2)alkyl, phenylcarbonyl, and phenyl of Rb are optionally substituted with one to two substituents selected from C1-4alkyl, trifluoromethyl, chloro, or fluoro;
or Ra and Rb are taken together with the nitrogen atom to which they are attached to form a 5 to 8 membered heterocyclyl ring, optionally substituted with one to two substituents selected from the group consisting of one to two fluoro substituents and C1-3alkyl; and optionally containing one additional heteroatom to form piperazinyl; and wherein said heterocyclyl ring is optionally benzofused; and, the heterocyclyl ring is optionally substituted at a nitrogen atom contained in said ring with C1-6alkoxycarbonyl;

xxi) (1-R2)-pyrrolidin-3-yloxy; wherein R2 is pyrrolidin-1-ylsulfonyl, dimethylaminocarbonyl, dimethylaminosulfonyl, pyrrolidin-1-ylcarbonyl, phenylcarbonyl, C3-7cycloalkylcarbonyl, C1-4alkylcarbonyl, morpholin-4-ylcarbonyl, or C1-4alkoxycarbonyl;
xxii) a 5 to 8 membered heterocyclyl bound through a carbon atom, wherein when the heterocyclyl contains a nitrogen atom, the nitrogen atom is optionally substituted with C1-4alkoxycarbonyl or C1-4alkylcarbonyl;
xxiii) pyridinyloxy optionally independently substituted with one to two substituents selected from the group consisting of C1-2alkoxy, bromo, trifluoromethyl, chloro, and fluoro;
xv) phenylsulfonyl optionally substituted with C1-4alkyl, trifluoromethyl, or one to two chloro substituents;
xxiv) phenyloxy optionally substituted with one to two substituents selected from the group consisting of C1-4alkyl, trifluoromethyl, and chloro;
xxv) phenylthio optionally substituted with C1-4alkyl, trifluoromethyl, or one to two chloro substituents; and
xxvi) 2,2,6,6-tetramethyl-3,6-dihydro-2H-pyran-4-yl;
with the proviso that not more than one substituent on C6-10 aryl or heteroaryl is C3-6cycloalkyl; heterocyclyloxy; pyridinyloxy; NRaRb; (1-R2)-pyrrolidin-3-yloxy; phenylcarbonyl; phenylsulfonyl; phenyloxy; phenylthio; or C3-8cycloalkyloxy.
7. The compound of claim 6 wherein
Group b) is
i) C6-10 aryl;
ii) heteroaryl selected from the group consisting of pyridinyl, indolyl, benzothiazolyl, benzothienyl, pyrrolo2,3-bpyridinyl, and thieno2,3-bpyridinyl;
iii) benzofused heterocyclyl attached via a carbon atom, and when the heterocyclyl portion contains a nitrogen atom, the nitrogen atom is optionally substituted with one substituent selected from the group consisting of C3-7cycloalkylcarbonyl; C3-7cycloalkylsulfonyl; phenyl; phenylcarbonyl; thienylcarbonyl; pyrrolylcarbonyl; phenylsulfonyl; phenyl(C1-4)alkyl; C1-6alkylsulfonyl; pyrimidinyl; and pyridinyl; wherein C3-7cycloalkylcarbonyl, phenyl, phenylcarbonyl, phenyl(C1-4)alkyl and phenylsulfonyl are optionally substituted with trifluoromethyl or one to two fluoro substituents;
and wherein benzofused heterocyclyl is optionally substituted at a carbon atom with oxo and optionally independently substituted with one to two additional substituents selected from the group consisting of phenyl;

iv) phenoxathiinyl;
v) fluoren-9-one-2-yl;
vi) 1-chloro-naphtho2,1-bthiophen-2-yl; or
vii) 4-(3-chloro-phenyl)-3a,4,5,9b-tetrahydro-3H-cyclopentacquinolin-8-yl;
wherein C6-10 aryl and heteroaryl of Group b) are optionally independently substituted with one to three substituents selected from the group consisting of
i) C1-8alkyl;
ii) C2-4alkenyl;
iii) C3-6cycloalkyl;
iv) C1-4alkoxy;
v) trifluoromethyl;
vi) trifluoromethoxy;
vii) 2,2,2-trifluoroethoxy-methyl;
viii) di(C1-4alkyl)aminosulfonyl;
ix) chloro;
x) fluoro;
xi) bromo;
xii) iodo;
xiii) NRaRb wherein Ra is C1-6alkyl; and Rb is C1-6alkyl, C3-8cycloalkyl, C3-8cycloalkyl(C1-2alkyl), C1-6alkylcarbonyl optionally substituted with one to three fluoro substituents, C1-4alkoxycarbonyl, phenylcarbonyl, or phenyl(C1-2)alkylcarbonyl;
wherein C3-8cycloalkyl, C3-8cycloalkylcarbonyl, C6-10aryl of C6-10aryl(C1-2)alkyl, phenylcarbonyl, and phenyl of Rb are optionally substituted with one to two substituents selected from trifluoromethyl, chloro, or fluoro;
or Ra and Rb are taken together with the nitrogen atom to which they are attached to form a 5 to 8 membered heterocyclyl ring, optionally substituted with one to two substituents selected from the group consisting of one to two fluoro substituents and C1-3alkyl; and optionally containing one additional heteroatom to form piperazinyl; and wherein said heterocyclyl ring is optionally benzofused; and, the heterocyclyl ring is optionally substituted at a nitrogen atom contained in said ring with C1-6alkoxycarbonyl;

xiv) a 5 to 8 membered heterocyclyl bound through a carbon atom, wherein when the heterocyclyl contains a nitrogen atom, the nitrogen atom is optionally substituted with C1-4alkoxycarbonyl or C1-4alkylcarbonyl;
xv) pyridinyloxy optionally independently substituted with one to two substituents selected from the group consisting of C1-2alkoxy, bromo, trifluoromethyl and chloro;
xv) phenylsulfonyl optionally substituted with C1-4alkyl or trifluoromethyl;
xvi) phenyloxy optionally substituted with one to two substituents selected from the group consisting of C1-4alkyl, trifluoromethyl, and chloro; and
xvii) phenylthio optionally substituted with C1-4alkyl, trifluoromethyl, or one to two chloro substituents;
with the proviso that not more than one substituent on C6-10 aryl or heteroaryl is C3-6cycloalkyl; heterocyclyloxy; pyridinyloxy; NRaRb; (1-R2)-pyrrolidin-3-yloxy; phenylcarbonyl; phenylsulfonyl; phenyloxy; phenylthio; or C3-8cycloalkyloxy.
8. The compound of claim 1 wherein s is 0 or 1.
9. The compound of claim 1 wherein R1 is C6-10aryl, C1-3alkyl, or trifluoromethyl.
10. The compound of claim 9 wherein R1 is phenyl, C1-3alkyl, or trifluoromethyl.
11. The compound of claim 10 wherein R1 is phenyl.
12. A compound of Formula (I)
wherein
Y and Z are independently selected from a) or b) such that one of Y and Z is selected from group a) and the other is selected from group b);
Group a) is

i) trifluoromethyl; or
ii) heteroaryl selected from the group consisting of thienyl, furanyl, thiazolyl, isothiazolyl, oxazolyl, pyrrolyl, pyridinyl, and 1,2,3thiadiazolyl;
wherein heteroaryl is optionally substituted with one to two substituents independently selected from the group consisting of fluoro, chloro, bromo, and trifluoromethyl;
Group b) is

i) C6-10 aryl;
ii) heteroaryl selected from the group consisting of thiazolyl, pyridinyl, indolyl, pyrrolyl, benzoxazolyl, benzothiazolyl, benzothienyl, benzofuranyl, pyrrolo2,3-bpyridinyl, thieno2,3-bpyridinyl, quinolinyl, thienyl, and benzimidazolyl;
iii) benzofused heterocyclyl attached via a carbon atom, and when the heterocyclyl portion contains a nitrogen atom, the nitrogen atom is optionally substituted with one substituent selected from the group consisting of C3-7cycloalkylcarbonyl; C3-7cycloalkylsulfonyl; phenyl; phenylcarbonyl; thienylcarbonyl; pyrrolylcarbonyl; phenylsulfonyl; phenyl(C1-4)alkyl; (C1-4alkyl)aminocarbonyl; C1-6alkylcarbonyl; C1-6alkylcarbonyl-C1-4alkyl; C1-6alkylsulfonyl; pyrimidinyl; and pyridinyl; wherein C3-7cycloalkylcarbonyl, phenyl, phenylcarbonyl, phenyl(C1-4)alkyl and phenylsulfonyl are optionally substituted with trifluoromethyl or one to two fluoro substituents;
and wherein benzofused heterocyclyl is optionally substituted at a carbon atom with oxo and optionally independently substituted with one to two additional substituents selected from the group consisting of phenyl, bromo, and C1-4alkyl; wherein phenyl and thienyl are each optionally substituted with a trifluoromethyl substituent;

i) C1-8alkyl;
ii) C2-4alkenyl;
iii) C3-6cycloalkyl optionally substituted with one to two fluoro substituents;
iv) C1-4alkoxy;
v) 2-methoxy-ethoxy;
vi) C1-4alkylthio;
vii) trifluoromethyl;
viii) 2,2,2-trifluoroethyl;
ix) 2,2-difluoroethyl;
x) 3,3,3-trifluoropropyl;
xi) trifluoromethoxy;
xii) 2,2,2-trifluoroethoxy-methyl;
xiii) 2,2,2-trifluoroethoxy;
xiv) trifluoromethylthio;
xv) di(C1-4alkyl)aminosulfonyl;
xvi) chloro;
xvii) cyano;
xviii) fluoro;
xix) bromo;
xx) iodo;
xxi) NRaRb wherein Ra is hydrogen or C1-6alkyl; and Rb is C1-6alkyl, phenyl, C3-8cycloalkyl, C3-8cycloalkylcarbonyl, C3-8cycloalkyl(C1-2alkyl), C1-6alkylcarbonyl optionally substituted with one to three fluoro substituents, C1-4alkoxycarbonyl, C6-10aryl(C1-2)alkyl, phenylcarbonyl, or phenyl(C1-2)alkylcarbonyl;
wherein C3-8cycloalkyl, C3-8cycloalkylcarbonyl, C6-10aryl of C6-10aryl(C1-2)alkyl, phenylcarbonyl, and phenyl of Rb are optionally substituted with one to two substituents selected from C1-4alkyl, trifluoromethyl, chloro, or fluoro;
or Ra and Rb are taken together with the nitrogen atom to which they are attached to form a 5 to 8 membered heterocyclyl ring, optionally substituted with one to two substituents selected from the group consisting of one to two fluoro substituents and C1-3alkyl; and optionally containing one additional heteroatom to form piperazinyl; and wherein said heterocyclyl ring is optionally benzofused; and, the heterocyclyl ring is optionally substituted at a nitrogen atom contained in said ring with C1-6alkoxycarbonyl;

s is 0 or 1;
R1 is C6-10aryl, C1-3alkyl, or trifluoromethyl;
with the proviso that a heteroaryl of Group b) is substituted with other than C1-4alkoxy or C1-4alkylthio;
with the proviso that when phenyl is para-substituted with NRaRb, or when 2- or 3-pyridinyl is 5- or 6-substituted, respectively, with NRaRb, Rb is other than C1-6alkyl, phenyl, or C6-10aryl(C1-2)alkyl;
and, with the proviso that when Ra is C1-6alkyl and either phenyl is para-substituted with NRaRb, or 2- or 3-pyridinyl is 5- or 6-substituted, respectively, with NRaRb, then Rb is other than C1-6alkylcarbonyl; or

with the proviso that a compound of formula (I) is other than
a compound wherein Y is thiazol-4-yl, Z is thiazol-2-yl, s is 1, and R1 is 3-phenyl; a compound wherein Y is thiazol-4-yl, Z is 2-methyl-1-(4,4-difluorocyclohexyl)-benzimidazol-5-yl, and s is 0; a compound wherein Y is 3-methyl-2-phenyl-chromen-4-one-8-yl, Z is thiazol-4-yl, s is 1, and R1 is 3-phenyl; a compound wherein Y is thiazol-2-yl, Z is 2-phenylmethyl-1,2,3,4-tetrahydro-isoquinolin-8-yl, and s is 0; a compound wherein Y is thiazol-4-yl, Z is 5-fluoro-3H-benzimidazol-2-yl, and s is 0; a compound wherein Y is thiazol-2-yl, Z is 5-fluoro-1H-benzimidazol-2-yl, and s is 0; a compound wherein Y is isothiazol-5-yl, Z is 6-trifluoromethyl-1H-indol-2-yl, and s is 0; a compound wherein Y is 1H-pyrrol-2-yl, Z is 6-trifluoromethyl-1H-pyrrolo2,3-bpyridin-2-yl, and s is 0;

i) trifluoromethyl; or
ii) heteroaryl selected from the group consisting of thienyl, furanyl, thiazolyl, isothiazolyl, pyrrolyl, pyridinyl, and 1,2,3thiadiazolyl; wherein heteroaryl is optionally substituted with one to two substituents independently selected from the group consisting of fluoro, chloro, bromo, and trifluoromethyl;
Group b) is

i) C6-10 aryl;
ii) heteroaryl selected from the group consisting of pyridinyl, indolyl, benzothiazolyl, benzothienyl, benzofuranyl, pyrrolo2,3-bpyridinyl, thieno2,3-bpyridinyl, quinolinyl, thienyl, and benzimidazolyl;
iii) benzofused heterocyclyl attached via a carbon atom, and when the heterocyclyl portion contains a nitrogen atom, the nitrogen atom is optionally substituted with one substituent selected from the group consisting of C3-7cycloalkylcarbonyl; C3-7cycloalkylsulfonyl; phenyl; phenylcarbonyl; thienylcarbonyl; pyrrolylcarbonyl; phenylsulfonyl; phenyl(C1-4)alkyl; (C1-4alkyl)aminocarbonyl; C1-6alkylcarbonyl; C1-6alkylcarbonyl-C1-4alkyl; C1-6alkylsulfonyl; pyrimidinyl; and pyridinyl; wherein C3-7cycloalkylcarbonyl, phenyl, phenylcarbonyl, phenyl(C1-4)alkyl and phenylsulfonyl are optionally substituted with trifluoromethyl or one to two fluoro substituents;
and wherein benzofused heterocyclyl is optionally substituted at a carbon atom with oxo and optionally independently substituted with one to two additional substituents selected from the group consisting of phenyl, bromo, and C1-4alkyl;

i) C1-8alkyl;
ii) C2-4alkenyl;
iii) C3-6cycloalkyl optionally substituted with one to two fluoro substituents;
iv) C1-4alkoxy;
v) C1-4alkylthio;
vi) trifluoromethyl;
vii) 2,2,2-trifluoroethyl;
viii) 2,2-difluoroethyl;
ix) 3,3,3-trifluoropropyl;
x) trifluoromethoxy;
xi) 2,2,2-trifluoroethoxy-methyl;
xii) 2,2,2-trifluoroethoxy;
xiii) trifluoromethylthio;
xiv) di(C1-4alkyl)aminosulfonyl;
xv) chloro;
xvi) cyano;
xvii) fluoro;
xviii) bromo;
xix) iodo;
xx) NRaRb wherein Ra is hydrogen or C1-6alkyl; and Rb is C1-6alkyl, phenyl, C3-8cycloalkyl, C3-8cycloalkylcarbonyl, C3-8cycloalkyl(C1-2alkyl), C1-6alkylcarbonyl optionally substituted with one to three fluoro substituents, C1-4alkoxycarbonyl, C6-10aryl(C1-2)alkyl, phenylcarbonyl, or phenyl(C1-2)alkylcarbonyl;
wherein C3-8cycloalkyl, C3-8cycloalkylcarbonyl, C6-10aryl of C6-10aryl(C1-2)alkyl, phenylcarbonyl, and phenyl of Rb are optionally substituted with one to two substituents selected from C1-4alkyl, trifluoromethyl, chloro, or fluoro;
or Ra and Rb are taken together with the nitrogen atom to which they are attached to form a 5 to 8 membered heterocyclyl ring, optionally substituted with one to two substituents selected from the group consisting of one to two fluoro substituents and C1-3alkyl; and optionally containing one additional heteroatom to form piperazinyl; and wherein said heterocyclyl ring is optionally benzofused; and, the heterocyclyl ring is optionally substituted at a nitrogen atom contained in said ring with C1-6alkoxycarbonyl;

s is 0 or 1;
R1 is phenyl, C1-3alkyl, or trifluoromethyl;
with the proviso that a heteroaryl of Group b) is substituted with other than C1-4alkoxy or C1-4alkylthio;
with the proviso that when phenyl is para-substituted with NRaRb, or when 2- or 3-pyridinyl is 5- or 6-substituted, respectively, with NRaRb, Rb is other than C1-6alkyl, phenyl, or C6-10aryl(C1-2)alkyl;
and, with the proviso that when Ra is C1-6alkyl and either phenyl is para-substituted with NRaRb, or 2- or 3-pyridinyl is 5- or 6-substituted, respectively, with NRaRb, then Rb is other than C1-6alkylcarbonyl;

i) trifluoromethyl; or
ii) heteroaryl selected from the group consisting of thienyl, furanyl, thiazolyl, isothiazolyl, and pyrrolyl;
wherein heteroaryl is optionally substituted with one to two substituents independently selected from the group consisting of fluoro, chloro, bromo, and trifluoromethyl;
Group b) is

i) C6-10 aryl;
ii) heteroaryl selected from the group consisting of pyridinyl, indolyl, benzothiazolyl, benzothienyl, pyrrolo2,3-bpyridinyl, and thieno2,3-bpyridinyl;
iii) benzofused heterocyclyl attached via a carbon atom, and when the heterocyclyl portion contains a nitrogen atom, the nitrogen atom is optionally substituted with one substituent selected from the group consisting of C3-7cycloalkylcarbonyl; C3-7cycloalkylsulfonyl; phenyl; phenylcarbonyl; thienylcarbonyl; pyrrolylcarbonyl; phenylsulfonyl; phenyl(C1-4)alkyl; C1-6alkylsulfonyl; pyrimidinyl; and pyridinyl; wherein C3-7cycloalkylcarbonyl, phenyl, phenylcarbonyl, phenyl(C1-4)alkyl and phenylsulfonyl are optionally substituted with trifluoromethyl or one to two fluoro substituents;
and wherein benzofused heterocyclyl is optionally substituted at a carbon atom with oxo and optionally independently substituted with one to two additional substituents selected from the group consisting of phenyl;

i) C1-8alkyl;
ii) C2-4alkenyl;
iii) C3-6cycloalkyl;
iv) C1-4alkoxy;
v) trifluoromethyl;
vi) trifluoromethoxy;
vii) 2,2,2-trifluoroethoxy-methyl;
viii) di(C1-4alkyl)aminosulfonyl;
ix) chloro;
x) fluoro;
xi) bromo;
xii) iodo;
xiii) NRaRb wherein Ra is C1-6alkyl; and Rb is C1-6alkyl, C3-8cycloalkyl, C3-8cycloalkyl(C1-2alkyl), C1-6alkylcarbonyl optionally substituted with one to three fluoro substituents, C1-4alkoxycarbonyl, phenylcarbonyl, or phenyl(C1-2)alkylcarbonyl;
wherein C3-8cycloalkyl, C3-8cycloalkylcarbonyl, C6-10aryl of C6-10aryl(C1-2)alkyl, phenylcarbonyl, and phenyl of Rb are optionally substituted with one to two substituents selected from trifluoromethyl, chloro, or fluoro;
or Ra and Rb are taken together with the nitrogen atom to which they are attached to form a 5 to 8 membered heterocyclyl ring, optionally substituted with one to two substituents selected from the group consisting of one to two fluoro substituents and C1-3alkyl; and optionally containing one additional heteroatom to form piperazinyl; and wherein said heterocyclyl ring is optionally benzofused; and, the heterocyclyl ring is optionally substituted at a nitrogen atom contained in said ring with C1-6alkoxycarbonyl;

xiv) a 5 to 8 membered heterocyclyl bound through a carbon atom, wherein when the heterocyclyl contains a nitrogen atom, the nitrogen atom is optionally substituted with C1-4alkoxycarbonyl or C1-4alkylcarbonyl;
xv) pyridinyloxy optionally independently substituted with one to two substituents selected from the group consisting of C1-2alkoxy, bromo, trifluoromethyl and chloro;
xv) phenylsulfonyl optionally substituted with C1-4alkyl or trifluoromethyl;
xvi) phenyloxy optionally substituted with one to two substituents selected from the group consisting of C1-4alkyl, trifluoromethyl, and chloro; and
xvii) phenylthio optionally substituted with C1-4alkyl, trifluoromethyl, or one to two chloro substituents;
with the proviso that not more than one substituent on C6-10 aryl or heteroaryl is C3-6cycloalkyl; heterocyclyloxy; pyridinyloxy; NRaRb; (1-R2)-pyrrolidin-3-yloxy; phenylcarbonyl; phenylsulfonyl; phenyloxy; phenylthio; or C3-8cycloalkyloxy;
s is 0 or 1;
R1 is phenyl;
with the proviso that a heteroaryl of Group b) is substituted with other than C1-4alkoxy or C1-4alkylthio;
with the proviso that when phenyl is para-substituted with NRaRb, or when 2- or 3-pyridinyl is 5- or 6-substituted, respectively, with NRaRb, Rb is other than C1-6alkyl, phenyl, or C6-10aryl(C1-2)alkyl;
and, with the proviso that when Ra is C1-6alkyl and either phenyl is para-substituted with NRaRb, or 2- or 3-pyridinyl is 5- or 6-substituted, respectively, with NRaRb, then Rb is other than C1-6alkylcarbonyl;

a compound wherein Y is thiazol-4-yl, Z is thiazol-4-yl, s is 1, and R1 is 3-phenyl; a compound wherein Y is thiazol-2-yl, Z is thiazol-4-yl, s is 1, and R1 is 3-phenyl; a compound wherein Y is thiazol-2-yl, Z is thiazol-2-yl, s is 1, and R1 is 3-phenyl; a compound wherein Y is thiazol-4-yl, Z is 2-phenylmethyl-1,2,3,4-tetrahydro-isoquinolin-8-yl, and s is 0; and enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof.
15. A compound of Formula (I)
selected from the group consisting of:
a compound wherein Y is furan-2-yl, Z is 4-cyclohexylphenyl, and s is 0;
a compound wherein Y is 1-methyl-1H-imidazol-2-yl, Z is 4-cyclohexylphenyl, and s is 0;
a compound wherein Y is pyridin-2-yl, Z is 4-cyclohexylphenyl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 4-bromo-3-methoxyphenyl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 4-bromo-2-chlorophenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-phenoxyphenyl, and s is 1, and R1 is 2-methyl;
a compound wherein Y is thiazol-2-yl, Z is 4-phenoxyphenyl, and s is and R1 is 3-methyl;
a compound wherein Y is thiazol-2-yl, Z is 3-phenoxyphenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-bromophenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 5-bromonaphth-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 6-bromo-1H-benzimidazol-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 5-trifluoromethylbenzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 6-trifluoromethylbenzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-chloro-6-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 6-bromo-3-chloro-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-trifluoromethylbenzothien-3-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 7-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 7-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 6-bromo-3-chloro-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 4-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-chloro-6-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 6-trifluoromethylbenzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1H-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(3-trifluoromethylphenylcarbonyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(cyclohexylcarbonyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(methanesulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 1-(methanesulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(cyclobutylcarbonyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(4-trifluoromethylphenylcarbonyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(phenylsulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(3-trifluoromethylphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(3-fluorophenylsulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(4-trifluoromethylphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(phenylmethyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(4-trifluoromethylphenylmethyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-phenyl-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(4-trifluoromethylphenyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(pyrimidin-2-yl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(3-trifluoromethylphenyl)-1,2,3,4-tetrahydroquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(methylcarbonyl)-6-bromo-1,2,3,4-tetrahydroquinolin-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 1-(methylcarbonyl)-6-bromo-1,2,3,4-tetrahydroquinolin-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(4-chlorophenoxy)phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(3-chlorophenoxy)phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(3,4-dichlorophenoxy)phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(3-trifluoromethylphenoxy)phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(3-chlorophenylthio)-phenyl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 4-(3-chlorophenylthio)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(3-trifluoromethylphenylthio)phenyl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 4-(3-trifluoromethylphenylthio)phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-iodo-4-(1-(pyrrolidin-1-ylcarbonyl)-pyrrolidin-3-yloxy)phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-methylcarbonyloxyphenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-methyl-4-oxo-2-phenyl-chromen-8-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 2-(4-methylphenylthio)pyridin-3-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-methoxy-6-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-chloro-6-trifluoromethyl-7-fluoro-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(3-trifluoromethylphenyl-sulfonyl)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(4-trifluoromethylpyridin-2-yloxy)-phenyl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-fluoro-6-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is phenoxathiin-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-n-propyl-phenyl, and s is 0;
a compound wherein Y is trifluoromethyl, Z is 3-chloro-6-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is 1H-pyrrol-2-yl, Z is 3-methyl-6-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(N,N-(dipropyl)aminosulfonyl)phenyl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-chloro-5-trifluoromethyl-6-fluoro-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 6-(3-trifluoromethylphenoxy)pyridin-3-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-(pyridin-2-yl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-fluoro-4-(3-chlorophenoxy)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-trifluoromethyl-6-chloro-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-(thien-2-ylcarbonyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-chloro-5-fluoro-6-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(3-chlorophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopentacquinolin-8-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-(pyrimidin-2-yl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-pyrrolidin-1-yl-phenyl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-chloro-6-trifluoromethyl-7-fluoro-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-(4,4-difluoropiperidin-1-yl)-benzothiazol-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-t-butyl-phenyl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-trifluoromethyl-5-chloro-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-methyl-6-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-bromo-6-trifluoromethyl-1H-pyrrolo2,3-bpyridin-2-yl), and s is 0;
a compound wherein Y is 5-trifluoromethyl-benzothien-2-yl, Z is thiazol-2-yl, and s is 0;
a compound wherein Y is trifluoromethyl, Z is 4-(3-chlorophenylthio)-phenyl, and s is 0;
a compound wherein Y is pyrrol-2-yl, Z is phenoxathiin-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-(3-trifluoromethylcarbonyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-(phenylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 7-bromo-1-methyl-1H-indol-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-methyl-5-bromo-1H-indol-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 6-(3-chlorophenoxy)-pyridin-3-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-methyl-6-fluoro-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(4-trifluoromethyl-cyclohexylcarbonyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-methyl-6-trifluoromethyl-thieno2,3-bpyridin-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-n-propyl-indol-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-methyl-5-chloro-1H-indol-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 6-(3-trifluoromethylphenoxy)pyridin-3-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-(pyrrol-2-ylcarbonyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-trifluoromethyl-6-methyl-benzothien-2-yl, and s is 0;
a compound wherein Y is isothiazol-5-yl, Z is 3-methyl-6-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-chloro-4-trifluoromethoxy-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(2,2,2-trifluoroethoxy-methyl)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-cyclobutyl-6-fluoro-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1,3-dimethyl-5-chloro-indol-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-chloro-6-fluoro-7-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is fluoren-9-one-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-trifluoromethyl-6-chloro-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-methoxy-6-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-methyl-3-iodo-indol-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(2-chloro-5-fluoro-phenylcarbonylamino)-phenyl, and s is 0;
a compound wherein Y is 5-trifluoromethyl-benzothien-2-yl, Z is isothiazol-5-yl, and s is 0;
a compound wherein Y is 3-methyl-6-trifluoromethyl-benzothien-2-yl, Z is thiazol-2-yl, and s is 0;
a compound wherein Y is 3-methyl-6-trifluoromethyl-benzothien-2-yl, Z is thiazol-4-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(2,2,6,6-tetramethyl-3,6-dihydro-2H-pyran-4-yl)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-trifluoromethyl-6-methyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 6-(2-chlorophenoxy)-pyridin-3-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(cyclohexylcarbonylamino)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is xanthen-9-one-3-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(2,2-difluoroethyl)-indol-5-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-trifluoromethyl-6-methyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-(phenylmethylamino)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-cyclopropyl-6-fluoro-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(6-fluoropyridin-2-yloxy)-phenyl, and s is 0;
a compound wherein Y is 5-trifluoromethyl-benzothien-2-yl, Z is thiazol-4-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(5-chloro-pyridin-2-yloxy)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-trifluoromethyl-benzothiazol-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-methyl-5-fluoro-1H-indol-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-methyl-6-methoxy-benzofuran-2-yl, and s is 0;
a compound wherein Y is 5-trifluoromethyl-benzothien-2-yl, Z is 1H-pyrrol-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 5-bromo-4-methyl-thien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is (1-phenylcarbonyl)-2,3-dihydro-1H-indol-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-ethyl-phenyl, and s is 0;
a compound wherein Y is 3-methyl-6-trifluoromethyl-benzothien-2-yl, Z is thiazol-4-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-bromo-3-methyl-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 5-chloro-benzothiazol-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-(4,4-difluoro-cyclohexylcarbonyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(2,2,2-trifluoroethoxy)-phenyl, and s is 0;
a compound wherein Y is 1H-pyrrol-2-yl, Z is 3-methyl-6-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-cyclohexyl-2-methyl-benzimidazol-5-yl, and s is 0;
a compound wherein Y is 1H-pyrrol-2-yl, Z is 1,3-dimethyl-5-chloro-indol-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-pyridin-3-yloxy-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-cyclohexyl-1H-benzimidazol-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-(phenylcarbonyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-trifluoromethyl-5-methyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 4-(3-trifluoromethylphenylsulfonyl)-phenyl, and s is 0;
a compound wherein Y is 1H-pyrrol-2-yl, Z is 3-bromo-6-trifluoromethyl-1H-pyrrolo2,3-bpyridin-2-yl), and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-isopropyl-2-trifluoromethyl-benzimidazol-5-yl, and s is 0;
a compound wherein Y is 5-trifluoromethyl-benzothien-2-yl, Z is 1H-pyrrol-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-methyl-6-fluoro-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 6,7-dichloro-quinolin-3-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-(2,3-dimethyl-phenylamino)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-bromo-5-methyl-thien-2-yl, and s is 0;
a compound wherein Y is 3-bromo-6-trifluoromethyl-1H-pyrrolo2,3-bpyridin-2-yl, Z is thiazol-2-yl, and s is 0;
a compound wherein Y is 5-trifluoromethyl-1H-indol-2-yl, Z is thiazol-2-yl, and s is 0;
a compound wherein Y is 3-methyl-6-trifluoromethyl-benzothien-2-yl, Z is 1H-pyrrol-3-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-methyl-6-trifluoromethyl-thieno2,3-bpyridin-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 9-methyl-9H-carbazol-3-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-methyl-5-fluoro-benzofuran-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-chloro-4-(pyridin-2-yloxy)-phenyl, and s is 0;
a compound wherein Y is 5-trifluoromethyl-benzothien-2-yl, Z is 1,2,3-thiadiazol-4-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-(3-fluoro-phenylamino)-phenyl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-methyl-5-chloro-1H-indol-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 6-trifluoromethyl-1H-indol-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 4-(5-chloro-pyridin-2-yloxy)-phenyl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 1,3-dimethyl-5-chloro-indol-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(4,4-difluoro-cyclohexyl)-benzimidazol-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-methyl-7-methoxy-1H-indol-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(2,2,2-trifluoroethyl)-benzimidazol-5-yl, and s is 0;
a compound wherein Y is 1,3-dimethyl-5-chloro-indol-2-yl, Z is thiazol-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 6,7,8,9-tetrahydro-5H-carbazol-3-yl, and s is 0;
a compound wherein Y is 5-chloro-benzothiazol-2-yl, Z is thiazol-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 4-(5-bromo-pyridin-2-yloxy)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2,2-dimethyl-2,3-dihydro-benzofuran-5-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 9-methyl-9H-carbazol-3-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-(3-trifluoromethyl-phenylamino)-phenyl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 4-(4-trifluoromethylpyridin-2-yloxy)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3,4-dihydro-2H-benzob1,4dioxepin-7-yl, and s is 0;
a compound wherein Y is 5-trifluoromethyl-1H-indol-2-yl, Z is thiazol-4-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(cyclopropylcarbonyl)-2,3-dihydro-1H-indol-5-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-bromo-6-trifluoromethyl-1H-pyrrolo2,3-bpyridin-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-(phenylmethylamino)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3,5-di-t-butyl-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-methyl-1-(3,3,3-trifluoro-propyl)-1H-benzimidazol-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-chloro-6-trifluoromethyl-benzothien-2-yl, s is 1, and R1 is 2-trifluoromethyl;
a compound wherein Y is thiazol-2-yl, Z is 4-chloro-2-trifluoromethyl-quinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(3,3,3-trifluoro-propyl)-1H-benzimidazol-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-(phenylamino)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(2-methoxy-ethoxy)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-methyl-benzothiazol-5-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 4-(6-fluoro-pyridin-2-yloxy)-phenyl, and s is 0;
a compound wherein Y is 5-chloro-benzofuran-2-yl, Z is thiazol-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-bromo-2-methyl-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 7-chloro-quinolin-3-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2,6-dimethyl-1-(2,2,2-trifluoro-ethyl)-pyrrol-3-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-methyl-1-(2,2,2-trifluoro-ethyl)-1H-benzimidazol-5-yl, and s is 0;
a compound wherein Y is trifluoromethyl, Z is 4-(3-trifluoromethyl-phenylthio)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 5-chloro-2-methyl-quinolin-3-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 6-bromo-1H-indol-2-yl, and s is 0;
a compound wherein Y is 1-cyclohexyl-2-methyl-1H-benzimidazol-5-yl, Z is thiazol-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 7-fluoro-3-methyl-benzofuran-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-(phenylmethylamino)-thiazol-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1,2-dimethyl-1H-indol-3-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 6-chloro-quinolin-3-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-methyl-1-(4,4-difluoro-cyclohexyl)-benzimidazol-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 6-trifluoromethyl-1H-pyrrolo2,3-bpyridin-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 2-cyclohexyl-1H-benzimidazol-5-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-chloro-6-trifluoromethyl-benzothien-2-yl, s is 1, and R1 is 2(R,S)-trifluoromethyl;
a compound wherein Y is trifluoromethyl, Z is 4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-phenyl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 6-(3-chloro-phenoxy)-pyridin-3-yl, and s is 0;
a compound wherein Y is 5-trifluoromethyl-benzothien-2-yl, Z is thiazol-2-yl, and s is 1, and R1 is 3-phenyl;
a compound wherein Y is thiazol-2-yl, Z is 2-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-bromo-thien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 10-oxo-10H-10\u03bb4-phenoxathiin-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 6-trifluoromethyl-furo2,3-bpyridin-2-yl, and s is 0;
a compound wherein Y is 5-chloro-benzofuran-2-yl, Z is thiazol-4-yl, and s is 0;
a compound wherein Y is pyridin-2-yl, Z is 3-chloro-6-fluoro-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 6-(2-chloro-phenoxy)-pyridin-3-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 5-bromo-benzofuran-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 1-(2,2-difluoro-ethyl)-1H-indol-5-yl, and s is 0;
a compound wherein Y is 3-methyl-6-trifluoromethyl-benzothien-2-yl, Z is 4-trifluoromethyl-thiazol-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(morpholin-4-yl)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(ethylaminocarbonyl-methoxy)-phenyl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 6,7,8,9-tetrahydro-5H-carbazol-3-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 5-chloro-benzofuran-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-(pyrimidin-2-yl)-1,2,3,4-tetrahydro-isoquinolin-8-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1H-indazol-5-yl, and s is 0;
a compound wherein Y is 5-chloro-benzothiazol-2-yl, Z is thiazol-4-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 4-(phenylsulfonyl)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 5,7-dichloro-2-methyl-quinolin-3-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-methyl-6,7-dihydro-5H-1-thia-4a,8-diaza-s-indacen-4-one-2-yl, and s is 0;
a compound wherein Y is 1H-pyrrol-2-yl, Z is 6-bromo-3-methyl-imidazo1,2-apyridin-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 7-chloro-2-methyl-quinolin-3-yl, and s is 0;
a compound wherein Y is 2-cyclohexyl-1H-benzimidazol-5-yl, Z is thiazol-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 6-trifluoromethyl-1H-indol-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2,3-dihydro-1H-indol-5-yl, and s is 0;
a compound wherein Y is 5-trifluoromethyl-1H-pyrrolo3,2-bpyridin-2-yl, Z is thiazol-4-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 1-(isopropyl)-2-trifluoromethyl-benzimidazol-5-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 1-(cyclohexyl)-2-methyl-benzimidazol-5-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-chloro-6-trifluoromethyl-benzothien-2-yl, s is 1, and R1 is 3-trifluoromethyl;
a compound wherein Y is thiazol-4-yl, Z is 1-(4,4-difluoro-cyclohexyl)-benzimidazol-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 6-chloro-2-methyl-quinolin-3-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(2-methylcarbonylamino-ethoxy)-phenyl, and s is 0;
a compound wherein Y is trifluoromethyl, Z is 4-(4-trifluoromethylpyridin-2-yloxy)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-methyl-indol-3-yl, and s is 0;
a compound wherein Y is 1,3-dimethyl-5-chloro-indol-2-yl, Z is 1H-pyrrol-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-methyl-7-methoxy-1H-indol-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 1-(2,2,2-trifluoroethyl)-benzimidazol-5-yl, and s is 0;
a compound wherein Y is 4-chloro-2-trifluoromethyl-quinolin-6-yl, Z is thiazol-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(1,1-dioxo-thiomorpholin-4-yl)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 6-trifluoromethyl-furo2,3-bpyridin-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-methyl-7-methoxy-quinolin-3-yl, and s is 0;
a compound wherein Y is 3-methyl-7-methoxy-1H-indol-2-yl, Z is thiazol-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-hydroxyphenyl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 4-chloro-2-trifluoromethyl-quinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-methoxy-5-t-butyl-phenyl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-methyl-6-methoxy-benzofuran-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 1-(3,3,3-trifluoro-propyl)-1H-benzimidazol-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 6-bromo-7-methyl-imidazo1,2-apyridin-2-yl, and s is 0;
a compound wherein Y is 2-cyclohexyl-1H-benzimidazol-5-yl, Z is thiazol-4-yl, and s is 0;
a compound wherein Y is 3-methyl-2-phenyl-4-oxo-chromen-8-yl, Z is thiazol-2-yl, s is 1, and R1 is 3-phenyl;
a compound wherein Y is thiazol-4-yl, Z is 5-chloro-benzothiazol-2-yl, and s is 0;
a compound wherein Y is 1H-pyrrol-2-yl, Z is 1H-indol-5-yl, and s is 0;
a compound wherein Y is 3-methyl-7-methoxy-1H-indol-2-yl, Z is thiazol-4-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 1-(2,2,2-trifluoroethyl)-2-methyl-benzimidazol-5-yl, and s is 0;
a compound wherein Y is 4-chloro-2-trifluoromethyl-quinolin-6-yl, Z is thiazol-4-yl, and s is 0;
a compound wherein Y is 6-trifluoromethyl-furo2,3-bpyridin-2-yl, Z is thiazol-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 2-t-butoxycarbonyl-3,4-dihydro-1H-isoquinolin8-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 5-fluoro-3-methyl-benzofuran-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 5-trifluoromethyl-1H-pyrrolo3,2-bpyridin-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 5-bromo-furo2,3-bpyridin-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 6-trifluoromethyl-1H-pyrrolo2,3-bpyridin-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 1-(3,3,3-trifluoro-propyl)-2-methyl-1H-benzimidazol-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 6-bromo-3-methyl-imidazo1,2-apyridin-2-yl), and s is 0;
a compound wherein Y is trifluoromethyl, Z is 4-(pyridin-2-yloxy)-phenyl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 7-fluoro-3-methyl-benzofuran-2-yl, and s is 0;
a compound wherein Y is trifluoromethyl, Z is 4-(5-bromopyridin-2-yloxy)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 6-bromo-imidazo1,2-apyridin-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-phenylcarbonyl-1H-pyrrol-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(3-chlorophenoxy)-3-fluoro-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(3-chlorophenylsulfonyl)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(5-bromopyridin-2-yloxy)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 6-(2-fluoro-5-trifluoromethylphenoxy)-pyridin-3-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-(3-trifluoromethylphenyl-methyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-(4-trifluoromethylphenyl-methyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(3-trifluoromethylphenyl-methyl)-2,3-dihydro-1H-indol-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(4-trifluoromethylphenyl-methyl)-2,3-dihydro-1H-indo1-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-phenyl-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(4-fluorophenyl)-2,3-dihydro-1H-indol-4-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(4-fluorophenyl)-2,3-dihydro-1H-indol-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is phenoxathiin-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(1,1-dimethylpropyl)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-azepan-1-yl-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-cyclohexyl-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-chloro-naphtho2,1-bthiophen-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-isobutyl-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-heptyl-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-pentyl-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-n-butyl-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-fluoro-6-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 5-chloro-3-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-methyl-5-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-methyl-5-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-methyl-6-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-chloro-5-fluoro-6-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-chloro-5-trifluoromethyl-6-fluoro-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-chloro-6-fluoro-7-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 4-(1-t-butoxycarbonyl-piperidin-4-yl)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(5-methoxypyridin-3-yloxy)-phenyl, and s is 0;
a compound wherein Y is 5-trifluoromethyl-benzothien-2-yl, Z is thiazol-4-yl, s is 1, and R1 is 3-phenyl;
a compound wherein Y is thiazol-2-yl, Z is 2-(cyclohexylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-(4-trifluoromethylphenylcarbonyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 5-trifluoromethyl-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-pyridin-2-yloxy-3-fluoro-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-bromo-5-trifluoromethylphenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1H-indol-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-bromo-5-fluorophenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-pyridin-2-yloxy-phenyl, and s is 0;
a compound wherein Y is trifluoromethyl, Z is 4-(3-chlorophenylsulfonyl)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-fluoro-5-bromophenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2H-isoquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(methylcarbonyl)-6-(3-trifluoromethylphenyl)-3,4-dihydro-quinolin-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-oxo-1,3-dihydro-indol-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(methylcarbonyl)-6-(4-trifluoromethylphenyl)-3,4-dihydro-quinolin-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(methylcarbonyl)-6-(5-chlorothien-2-yl)-3,4-dihydro-quinolin-2-yl, and s is 0;
a compound wherein Y is 5-trifluoromethyl-benzothien-2-yl, Z is furazan-3-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 4-pyridin-2-yloxy-phenyl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-bromo-5-trifluoromethylphenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(methylcarbonyl)-6-phenyl-3,4-dihydro-quinolin-2-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 2-fluoro-5-bromophenyl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-fluoro-5-bromophenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-(phenylsulfonyl)-3,4-dihydro-isoquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 2-(4-trifluoromethylphenylsulfonyl)-3,4-dihydro-isoquinolin-6-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 3-chloro-6-fluoro-benzothien-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-chloro-6-fluoro-benzothien-2-yl, and s is 0;
a compound wherein Y is trifluoromethyl, Z is 4-(3-chlorophenoxy)-3-fluoro-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(4,4-difluoro-cyclohexyl)-1,3-dihydro-benzoimidazol-2-on-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-phenyl-1,3-dihydro-benzoimidazol-2-on-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(4-fluorophenyl)-1,3-dihydro-benzoimidazol-2-on-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(3,4-difluorophenyl)-1,3-dihydro-benzoimidazol-2-on-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(4-trifluoromethylphenyl)-1,3-dihydro-benzoimidazol-2-on-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(2,2,2-trifluoroethyl)-1,3-dihydro-benzoimidazol-2-on-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(3,3,3-trifluoropropyl)-1,3-dihydro-benzoimidazol-2-on-5-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 1-phenyl-1,3-dihydro-benzoimidazol-2-on-5-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 1-(4-fluorophenyl)-1,3-dihydro-benzoimidazol-2-on-5-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 1-(3,4-difluorophenyl)-1,3-dihydro-benzoimidazol-2-on-5-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 1-(4-trifluoromethylphenyl)-1,3-dihydro-benzoimidazol-2-on-5-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 1-(2,2,2-trifluoroethyl)-1,3-dihydro-benzoimidazol-2-on-5-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 1-(3,3,3-trifluoropropyl)-1,3-dihydro-benzoimidazol-2-on-5-yl, and s is 0;
a compound wherein Y is thiazol-4-yl, Z is 1-(4,4-difluoro-cyclohexyl)-1,3-dihydro-benzoimidazol-2-on-5-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(N-phenyl-N-methylaminosulfonyl)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 4-(piperidin-1-ylsulfonyl)-phenyl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-(4,4-difluorocyclohexylcarbonyl)-1H-indol-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-(6-chloropyridin-3-ylcarbonyl)-1H-indol-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 3-(pyridin-3-ylcarbonyl)-1H-indol-6-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 1-(4-thiomorpholin-4-yl-quinazolin-7-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 9,9-dimethyl-9H-fluoren-2-yl, and s is 0;
a compound wherein Y is thiazol-2-yl, Z is 6-trifluoromethyl-benzothien-2-yl, s is 2, and R1 is cis-2,6-dimethyl;
a compound wherein Y is thiazol-2-yl, Z is 6-trifluoromethyl-benzothien-2-yl, s is 2, and R1 is cis-3,5-dimethyl;
or a pharmaceutically acceptable salt form thereof.
16. A pharmaceutical composition comprising a compound of claim 1 or 14 and at least one of a pharmaceutically acceptable carrier, a pharmaceutically acceptable excipient, and a pharmaceutically acceptable diluent.
17. A pharmaceutical composition of claim 15, wherein the composition is a solid oral dosage form.
18. A pharmaceutical composition of claim 15, wherein the composition is a syrup, an elixir, or a suspension.
19. A method for treating inflammatory pain in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a compound of claim 1 or 14.
20. The method of claim 19 wherein the inflammatory pain is due to inflammatory bowel disease, visceral pain, migraine, post operative pain, osteoarthritis, rheumatoid arthritis, back pain, lower back pain, joint pain, abdominal pain, chest pain, labor, musculoskeletal diseases, skin diseases, toothache, pyresis, burn, sunburn, snake bite, venomous snake bite, spider bite, insect sting, neurogenic bladder, interstitial cystitis, urinary tract infection, rhinitis, contact dermatitishypersensitivity, itch, eczema, pharyngitis, mucositis, enteritis, irritable bowel syndrome, cholecystitis, pancreatitis, postmastectomy pain syndrome, menstrual pain, endometriosis, pain, pain due to physical trauma, headache, sinus headache, tension headache, or arachnoiditis.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A user interface, comprising:
a first view transmitted from a server computer system to the client computer system, the first view including a search identifier, a user interacting with the search identifier causing transmission of a search request from the client computer system at the server computer system, wherein the search request is compared with first and second fields of each of a plurality of search results in a data source and at least one search result is extracted due to a comparison between the search request and the first field of the search result or the search result is extracted due to a comparison between the search request and the second field of the search result, the search result including information relating to a geographic location; and
a second view, at least part of which is transmitted from the server computer system to the client computer system for display at the client computer system, wherein the second view includes the search result.
2. The user interface of claim 1, wherein the first field is a name of a movie and the second field is an actor of the movie.
3. The user interface of claim 1, wherein the information relating to the geographic location includes an address.
4. The user interface of claim 1, wherein the second view includes a map and the information relating to the geographic location is used to indicate the geographic location on the map.
5. A method of interfacing with a client computer system, comprising:
transmitting a first view from a server computer system to the client computer system, the first view including a search identifier;
in response to a user interacting with the search identifier, receiving a search request from a client computer system at the server computer system, wherein the search request is compared with first and second fields of each of a plurality of search results in a data source and at least one search result is extracted due to a comparison between the search request and the first field of the search result or the search result is extracted due to a comparison between the search request and the second field of the search result, the search result including information relating to a geographic location; and
transmitting at least part of a second view from the server computer system to the client computer system for display at the client computer system, wherein the second view includes the search result.
6. The method of claim 5, wherein the first field is a name of a movie and the second field is an actor of the movie.
7. The method of claim 5, wherein the information relating to the geographic location includes an address.
8. The method of claim 5, wherein the second view includes a map and the information relating to the geographic location is used to indicate the geographic location on the map.
9. The method of claim 8, wherein a plurality of search results is transmitted, each including information relating to a different geographic location, wherein information relating to a respective one of the search results is displayed on the map upon selection of at least one component of the respective search result.
10. The method of claim 8, wherein the search request includes an area and a boundary of the area is displayed on the map.
11. The method of claim 8, wherein the view is configured to make an addition to the map.
12. The method of claim 8, wherein the first view includes a map and the second view includes at least a first static location marker at a first fixed location on the map of the second view due to selection of a location marker at the fixed location on the map of the first view.
13. The method of claim 5, further comprising:
storing a profile page, wherein the first view includes a plurality of verticals, selection of a respective vertical causing the display of a respective search identifier associated with the respective vertical, the search request received from a client computer system at the server computer system being in response to the user interacting with one of the search identifiers, and display of the profile page independent of the search identifier that the user interacts with.
14. The method of claim 5, wherein a plurality of search results is extracted and included in the second view, further comprising:
receiving a driving direction request relating to a select one of the search results from the client computer system at the server computer system;
in response to the driving direction request, calculating driving directions to the selected search result; and
transmitting at least part of a third view from the server computer system to the client computer system, the third view including the driving directions to the selected search result and at least one of the search results other than the selected search result.
15. The method of claim 5, wherein the second view includes at least one component that is in substantially the same location as in the first view.
16. The method of claim 5, further comprising:
transmitting a third view from the server computer system to the client computer system, the third view including a reproduction selector; and
in response to a reproduction command transmitted from the client computer system to the server computer system upon selection of the reproduction selector, transmitting a fourth view from the server computer system to the client computer system, the fourth view including the search result included in the second view.
17. The method of claim 5, wherein the first view includes a plurality of vertical search determinators, wherein the search result depends on a respective one of the vertical search determinators.
18. The method of claim 5, wherein the search request is used to extract a plurality of related search suggestions and the second view includes the plurality of related search identifiers, selection of a respective related search identifier causing transmission of a related search request from the client computer system to the server computer system.
19. The method of claim 5, wherein the first view includes a location identifier, a selected location being transmitted from the client computer system to the server computer system due to interaction of the user with the location identifier, causing at least one of the search results to be based on the selected location.
20. The method of claim 5, wherein a plurality of search results is extracted, further comprising:
determining a number of the search results that have geographic locations within a selected area, wherein the search results that are included in the second view include search results with geographic locations outside the selected area if the number of the search results that have geographic locations within the selected area is less than a predetermined threshold value.
21. A computer-readable medium having stored thereon a set of instructions which, when executed by at least one processor of at least one computer, executes a method comprising:
transmitting a first view from a server computer system to the client computer system, the first view including a search identifier;
in response to a user interacting with the search identifier, receiving a search request from a client computer system at the server computer system, wherein the search request is compared with first and second fields of each of a plurality of search results in a data source and at least one search result is extracted due to a comparison between the search request and the first field of the search result or the search result is extracted due to a comparison between the search request and the second field of the search result, the search result including information relating to a geographic location; and
transmitting at least part of a second view from the server computer system to the client computer system for display at the client computer system, wherein the second view includes the search result.