1. A device for back-injection of an implant comprising:
a grip for a user to hold the device;
an injection needle;
a retaining element for retaining the implant proximal to the injection needle;
a plunger including a distal part for injecting the implant during withdrawal of the injection needle, the plunger comprising two separable parts, the distal part and a proximal part, the distal part for positioning the implant flush with the distal end of the injection needle;
a protective sleeve adopting an injection position leaving the injection needle uncovered prior to use of the device and a safety position covering the injection needle after use of the device; and
a compressible spring moving the protective sleeve automatically into the safety position, the movement of the compressible spring being controllable by the user at least partially opposing the release of the compressible spring;
wherein the distal part of the plunger is fastenable to the protective sleeve, and the distal part separates from the proximal part and the compressible spring moves the distal part into the injection needle to keep the implant in place while the protective sleeve moves together with the distal part of the plunger into safety position by the compressible spring.
2. The device according to claim 1, comprising retractable lugs for securing the protective sleeve to the grip.
3. The device according to claim 1, wherein the retaining element performs a retaining function with flexible fingers exerting light pressure on the implant.
4. The device according to claim 1 comprising:
a housing for receiving the implant located proximal to the injection needle, wherein the retaining element also retains the implant in the housing,
a deactivating element for deactivating the retaining element,
the retaining element being configured so as not to exert any stress on the implant.
5. The device according to claim 4, wherein the retaining element is operated by the plunger, more precisely by the movement of plunger into a pre-determined position.
6. The device according to claim 4, wherein the retaining element comprises a stop, which can adopt an activated retaining position prior to the injection needle being in the insertion position and a deactivated position once the injection needle is in the injection position.
7. The device according to claim 6, wherein the retaining is supported by a rubber tab.
8. The device according to claim 4, wherein deactivation comprises, firstly, interaction between the retaining element and the housing and, secondly, interaction between the retaining element and the plunger.
9. The device according to claim 4, wherein deactivating element is configured to shift the retaining element radially.
10. The device according to claim 4, comprising a verification window configured so that the implant is visible to a user when the implant is held by the retaining element, notably when the injection needle is in a position not visible to the user.
11. The device according to claim 1, wherein the grip is configured to receive a force at least partially opposing the release of the compressible spring.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A process for the preparation of a compound of formula I
wherein R1, R2 and R3 are each independently of the others hydrogen or methyl, which comprises
a) reaction of a compound of formula II
wherein R1, R2 and R3 are as defined for formula I, either
a1) with triphenylphosphine dibromide or triphenylphosphine dichloride or
a2) with RSO2Cl, wherein R is C1-C4alkyl, C1-C4fluoroalkyl, benzyl, phenyl, nitrophenyl, halophenyl or C1-C6alkylphenyl, in the presence of a base,
to form a compound of formula III
wherein X is OSO2R, wherein R is C1-C4alkyl, C1-C4fluoroalkyl, benzyl, phenyl, nitrophenyl, halophenyl or C1-C6alkylphenyl, or is bromine or chlorine and R1, R2 and R3 are as defined for formula I; and
b) reaction of that compound in the presence of a base to form a compound of formula IV
wherein R1, R2 and R3 are as defined for formula 1; and
c) conversion of that compound in the presence of a reducing agent into a compound of formula I.
2. A process according to claim 1, which comprises, after carrying out Process Step b) and before carrying out Process Step c), isomerisation of the compound of formula IV
wherein R1, R2 and R3 are as defined for formula I in claim 1,
bb) in the presence of a base to form a compound of formula IV wherein the ratio of the compound of formula IVa (trans)
wherein R1, R2 and R3 are as defined for formula I in claim 1, to the compound of formula IVb (cis)
wherein R1, R2 and R3 are as defined for formula I in claim 1, is more than 6:1.
3. A compound of formula III
wherein R1, R2 and R3 are as defined for formula I in claim 1 and X is as defined for formula III in claim 1.
4. (canceled)
5. A compound of formula IV
wherein R1, R2 and R3 are as defined for formula I in claim 1, and wherein the ratio of the compound of formula IVa (trans)
wherein R1, R2 and R3 are as defined for formula I in claim 1, to the compound of formula IVb (cis)
wherein R1, R2 and R3 are as defined for formula I in claim 1, is from 2:1 to 20:1.
6. (canceled)
7. A compound of formula IV
wherein R1, R2 and R3 are as defined for formula I in claim 1, prepared in accordance with a process according to claim 1.